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Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1.

Yousef H, Czupalla CJ, Lee D, Chen MB, Burke AN, Zera KA, Zandstra J, Berber E, Lehallier B, Mathur V, Nair RV, Bonanno LN, Yang AC, Peterson T, Hadeiba H, Merkel T, Körbelin J, Schwaninger M, Buckwalter MS, Quake SR, Butcher EC, Wyss-Coray T.

Nat Med. 2019 Jun;25(6):988-1000. doi: 10.1038/s41591-019-0440-4. Epub 2019 May 13.


Inhibitory effect of TGF-β gene modified human amniotic mesenchymal stem cells on rejection after xenotransplantation of peripheral nerves.

Chai HH, Chen MB, Chen GZ, Li ZZ, Xiu JG, Liu Y, Guo YW, Li SP.

Eur Rev Med Pharmacol Sci. 2019 Apr;23(8):3198-3205. doi: 10.26355/eurrev_201904_17678.


Balance of mechanical forces drives endothelial gap formation and may facilitate cancer and immune-cell extravasation.

Escribano J, Chen MB, Moeendarbary E, Cao X, Shenoy V, Garcia-Aznar JM, Kamm RD, Spill F.

PLoS Comput Biol. 2019 May 2;15(5):e1006395. doi: 10.1371/journal.pcbi.1006395. eCollection 2019 May.


Platelet decoys inhibit thrombosis and prevent metastatic tumor formation in preclinical models.

Papa AL, Jiang A, Korin N, Chen MB, Langan ET, Waterhouse A, Nash E, Caroff J, Graveline A, Vernet A, Mammoto A, Mammoto T, Jain A, Kamm RD, Gounis MJ, Ingber DE.

Sci Transl Med. 2019 Feb 13;11(479). pii: eaau5898. doi: 10.1126/scitranslmed.aau5898.


B-Cell Deficiency Lowers Blood Pressure in Mice.

Dingwell LS, Shikatani EA, Besla R, Levy AS, Dinh DD, Momen A, Zhang H, Afroze T, Chen MB, Chiu F, Simmons CA, Billia F, Gommerman JL, John R, Heximer S, Scholey JW, Bolz SS, Robbins CS, Husain M.

Hypertension. 2019 Mar;73(3):561-570. doi: 10.1161/HYPERTENSIONAHA.118.11828.


Triptonide inhibits human nasopharyngeal carcinoma cell growth via disrupting Lnc-RNA THOR-IGF2BP1 signaling.

Wang SS, Lv Y, Xu XC, Zuo Y, Song Y, Wu GP, Lu PH, Zhang ZQ, Chen MB.

Cancer Lett. 2019 Feb 28;443:13-24. doi: 10.1016/j.canlet.2018.11.028. Epub 2018 Nov 29.


Engineered Models of Metastasis with Application to Study Cancer Biomechanics.

Chen MB, Kamm RD, Moeendarbary E.

Adv Exp Med Biol. 2018;1092:189-207. doi: 10.1007/978-3-319-95294-9_10.


Prognostic value of NM23 in patients with gastric cancer: A systematic review and meta-analysis.

Wang QH, Han W, Chen MB, Bao J, Wang BF.

J Cancer Res Ther. 2018 Sep;14(Supplement):S556-S564. doi: 10.4103/0973-1482.183188.


Phase 2 Study of Cyclophosphamide, Etoposide, and Estramustine in Patients With Castration-Resistant Prostate Cancer.

Laber DA, Chen MB, Jaglal M, Patel A, Visweshwar N.

Clin Genitourin Cancer. 2018 Dec;16(6):473-481. doi: 10.1016/j.clgc.2018.06.007. Epub 2018 Jun 28.


Epithelial-Mesenchymal Transition Induces Podocalyxin to Promote Extravasation via Ezrin Signaling.

Fröse J, Chen MB, Hebron KE, Reinhardt F, Hajal C, Zijlstra A, Kamm RD, Weinberg RA.

Cell Rep. 2018 Jul 24;24(4):962-972. doi: 10.1016/j.celrep.2018.06.092.


Prognostic significance of CIP2A expression in solid tumors: A meta-analysis.

Tang M, Shen JF, Li P, Zhou LN, Zeng P, Cui XX, Chen MB, Tian Y.

PLoS One. 2018 Jul 25;13(7):e0199675. doi: 10.1371/journal.pone.0199675. eCollection 2018.


[Accumulation Characteristics and Health Risk Assessment of Heavy Metals in Wild Fish Species from Diaojiang River, Guangxi].

Wang JN, Ma PC, Zhang LJ, Chen MB, Huang CS, Liu XL, Hu GC, Xu ZC.

Huan Jing Ke Xue. 2017 Jun 8;38(6):2600-2606. doi: 10.13227/j.hjkx.201611188. Chinese.


Inflamed neutrophils sequestered at entrapped tumor cells via chemotactic confinement promote tumor cell extravasation.

Chen MB, Hajal C, Benjamin DC, Yu C, Azizgolshani H, Hynes RO, Kamm RD.

Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):7022-7027. doi: 10.1073/pnas.1715932115. Epub 2018 Jun 18.


Itraconazole-Induced Inhibition on Human Esophageal Cancer Cell Growth Requires AMPK Activation.

Chen MB, Liu YY, Xing ZY, Zhang ZQ, Jiang Q, Lu PH, Cao C.

Mol Cancer Ther. 2018 Jun;17(6):1229-1239. doi: 10.1158/1535-7163.MCT-17-1094. Epub 2018 Mar 28.


Prognostic value of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in gastric cancer.

Zhang Y, Lu JJ, Du YP, Feng CX, Wang LQ, Chen MB.

Medicine (Baltimore). 2018 Mar;97(12):e0144. doi: 10.1097/MD.0000000000010144.


microRNA-200a downregulation in human glioma leads to Gαi1 over-expression, Akt activation, and cell proliferation.

Liu YY, Chen MB, Cheng L, Zhang ZQ, Yu ZQ, Jiang Q, Chen G, Cao C.

Oncogene. 2018 May;37(21):2890-2902. doi: 10.1038/s41388-018-0184-5. Epub 2018 Mar 9.


Hypothermia-Modulating Matrix Elasticity of Injured Brain Promoted Neural Lineage Specification of Mesenchymal Stem Cells.

Dong HJ, Zhao ML, Li XH, Chen YS, Wang J, Chen MB, Wu S, Wang JJ, Liang HQ, Sun HT, Tu Y, Zhang S, Xiong J, Chen C.

Neuroscience. 2018 May 1;377:1-11. doi: 10.1016/j.neuroscience.2018.02.013. Epub 2018 Feb 23.


Prognostic value of HPV DNA status in cervical cancer before treatment: a systematic review and meta-analysis.

Li P, Tan Y, Zhu LX, Zhou LN, Zeng P, Liu Q, Chen MB, Tian Y.

Oncotarget. 2017 Jun 16;8(39):66352-66359. doi: 10.18632/oncotarget.18558. eCollection 2017 Sep 12.


Prognostic value of CD146 in solid tumor: A Systematic Review and Meta-analysis.

Zeng P, Li H, Lu PH, Zhou LN, Tang M, Liu CY, Chen MB.

Sci Rep. 2017 Jun 26;7(1):4223. doi: 10.1038/s41598-017-01061-3.


AMPKα phosphatase Ppm1E upregulation in human gastric cancer is required for cell proliferation.

Chen MB, Liu YY, Cheng LB, Lu JW, Zeng P, Lu PH.

Oncotarget. 2017 May 9;8(19):31288-31296. doi: 10.18632/oncotarget.16126.


Identification of DNA-PKcs as a primary resistance factor of TIC10 in hepatocellular carcinoma cells.

Cheng L, Liu YY, Lu PH, Peng Y, Yuan Q, Gu XS, Jin Y, Chen MB, Bai XM.

Oncotarget. 2017 Apr 25;8(17):28385-28394. doi: 10.18632/oncotarget.16073.


Ulk1 over-expression in human gastric cancer is correlated with patients' T classification and cancer relapse.

Chen MB, Ji XZ, Liu YY, Zeng P, Xu XY, Ma R, Guo ZD, Lu JW, Feng JF.

Oncotarget. 2017 May 16;8(20):33704-33712. doi: 10.18632/oncotarget.16734.


On-chip human microvasculature assay for visualization and quantification of tumor cell extravasation dynamics.

Chen MB, Whisler JA, Fröse J, Yu C, Shin Y, Kamm RD.

Nat Protoc. 2017 May;12(5):865-880. doi: 10.1038/nprot.2017.018. Epub 2017 Mar 30.


The role of NM23 in patients with colorectal cancer: A systematic review and meta-analysis.

Han W, Ma J, Cao F, Zhang C, Zhu R, Hu YW, Chen MB, Ding HZ.

J Huazhong Univ Sci Technolog Med Sci. 2017 Feb;37(1):1-10. doi: 10.1007/s11596-017-1686-z. Epub 2017 Feb 22. Review.


Identification of sphingosine kinase 1 (SphK1) as a primary target of icaritin in hepatocellular carcinoma cells.

Lu PH, Chen MB, Liu YY, Wu MH, Li WT, Wei MX, Liu CY, Qin SK.

Oncotarget. 2017 Apr 4;8(14):22800-22810. doi: 10.18632/oncotarget.15205.


AMPK-autophagy inhibition sensitizes icaritin-induced anti-colorectal cancer cell activity.

Zhou C, Gu J, Zhang G, Dong D, Yang Q, Chen MB, Xu D.

Oncotarget. 2017 Feb 28;8(9):14736-14747. doi: 10.18632/oncotarget.14718.


Randomized, controlled trial of a brief family-centred care programme for hospitalized patients with bipolar disorder and their family caregivers.

Lee HJ, Lin EC, Chen MB, Su TP, Chiang LC.

Int J Ment Health Nurs. 2018 Feb;27(1):61-71. doi: 10.1111/inm.12294. Epub 2016 Dec 21.


Prognostic value of increased KPNA2 expression in some solid tumors: A systematic review and meta-analysis.

Zhou LN, Tan Y, Li P, Zeng P, Chen MB, Tian Y, Zhu YQ.

Oncotarget. 2017 Jan 3;8(1):303-314. doi: 10.18632/oncotarget.13863. Review.


[The clinical application of lumbar plexus-the first posterior sacral foramina block for hip arthroplasty in elderly patients].

Li J, Ke XJ, Liu Y, Chen K, Chen MB, Mei W.

Zhonghua Yi Xue Za Zhi. 2016 Nov 22;96(43):3470-3473. doi: 10.3760/cma.j.issn.0376-2491.2016.43.006. Chinese.


Preclinical study of cinobufagin as a promising anti-colorectal cancer agent.

Lu XS, Qiao YB, Li Y, Yang B, Chen MB, Xing CG.

Oncotarget. 2017 Jan 3;8(1):988-998. doi: 10.18632/oncotarget.13519.


Tetraspanin CD151 as an emerging potential poor prognostic factor across solid tumors: a systematic review and meta-analysis.

Zeng P, Wang YH, Si M, Gu JH, Li P, Lu PH, Chen MB.

Oncotarget. 2017 Jan 17;8(3):5592-5602. doi: 10.18632/oncotarget.13532. Review.


A Chemomechanical Model for Nuclear Morphology and Stresses during Cell Transendothelial Migration.

Cao X, Moeendarbary E, Isermann P, Davidson PM, Wang X, Chen MB, Burkart AK, Lammerding J, Kamm RD, Shenoy VB.

Biophys J. 2016 Oct 4;111(7):1541-1552. doi: 10.1016/j.bpj.2016.08.011.


Impact of TROP2 expression on prognosis in solid tumors: A Systematic Review and Meta-analysis.

Zeng P, Chen MB, Zhou LN, Tang M, Liu CY, Lu PH.

Sci Rep. 2016 Sep 20;6:33658. doi: 10.1038/srep33658. Review.


Prognostic Value of NME1 (NM23-H1) in Patients with Digestive System Neoplasms: A Systematic Review and Meta-Analysis.

Han W, Shi CT, Cao FY, Cao F, Chen MB, Lu RZ, Wang HB, Yu M, He DW, Wang QH, Wang JF, Xu XX, Ding HZ.

PLoS One. 2016 Aug 12;11(8):e0160547. doi: 10.1371/journal.pone.0160547. eCollection 2016. Review.


TMPRSS4 as an emerging potential poor prognostic factor for solid tumors: A systematic review and meta-analysis.

Zeng P, Zhang P, Zhou LN, Tang M, Shen YX, Jin J, Zhu YQ, Chen MB.

Oncotarget. 2016 Nov 15;7(46):76327-76336. doi: 10.18632/oncotarget.10153. Review.


Aqueous Oldenlandia diffusa extracts inhibits colorectal cancer cells via activating AMP-activated protein kinase signalings.

Lu PH, Chen MB, Ji C, Li WT, Wei MX, Wu MH.

Oncotarget. 2016 Jul 19;7(29):45889-45900. doi: 10.18632/oncotarget.9969.


Neutrophils Suppress Intraluminal NK Cell-Mediated Tumor Cell Clearance and Enhance Extravasation of Disseminated Carcinoma Cells.

Spiegel A, Brooks MW, Houshyar S, Reinhardt F, Ardolino M, Fessler E, Chen MB, Krall JA, DeCock J, Zervantonakis IK, Iannello A, Iwamoto Y, Cortez-Retamozo V, Kamm RD, Pittet MJ, Raulet DH, Weinberg RA.

Cancer Discov. 2016 Jun;6(6):630-49. doi: 10.1158/2159-8290.CD-15-1157. Epub 2016 Apr 12.


Elucidation of the Roles of Tumor Integrin β1 in the Extravasation Stage of the Metastasis Cascade.

Chen MB, Lamar JM, Li R, Hynes RO, Kamm RD.

Cancer Res. 2016 May 1;76(9):2513-24. doi: 10.1158/0008-5472.CAN-15-1325. Epub 2016 Mar 17.


KU-0060648 inhibits hepatocellular carcinoma cells through DNA-PKcs-dependent and DNA-PKcs-independent mechanisms.

Chen MB, Zhou ZT, Yang L, Wei MX, Tang M, Ruan TY, Xu JY, Zhou XZ, Chen G, Lu PH.

Oncotarget. 2016 Mar 29;7(13):17047-59. doi: 10.18632/oncotarget.7742.


Microfluidics: A new tool for modeling cancer-immune interactions.

Boussommier-Calleja A, Li R, Chen MB, Wong SC, Kamm RD.

Trends Cancer. 2016 Jan 1;2(1):6-19.


Using microfluidics to investigate tumor cell extravasation and T-cell immunotherapies.

Pavesi A, Tan AT, Chen MB, Adriani G, Bertoletti A, Kamm RD.

Conf Proc IEEE Eng Med Biol Soc. 2015;2015:1853-6. doi: 10.1109/EMBC.2015.7318742.


Prognostic Value of SPARC in Patients with Pancreatic Cancer: A Systematic Review and Meta-Analysis.

Han W, Cao F, Chen MB, Lu RZ, Wang HB, Yu M, Shi CT, Ding HZ.

PLoS One. 2016 Jan 5;11(1):e0145803. doi: 10.1371/journal.pone.0145803. eCollection 2016. Review.


Targeting sphingosine kinase 2 (SphK2) by ABC294640 inhibits colorectal cancer cell growth in vitro and in vivo.

Xun C, Chen MB, Qi L, Tie-Ning Z, Peng X, Ning L, Zhi-Xiao C, Li-Wei W.

J Exp Clin Cancer Res. 2015 Sep 4;34:94. doi: 10.1186/s13046-015-0205-y.


C6 ceramide dramatically increases vincristine sensitivity both in vivo and in vitro, involving AMP-activated protein kinase-p53 signaling.

Chen MB, Jiang Q, Liu YY, Zhang Y, He BS, Wei MX, Lu JW, Ji Y, Lu PH.

Carcinogenesis. 2015 Sep;36(9):1061-70. doi: 10.1093/carcin/bgv094. Epub 2015 Jun 25.


MicroRNA-101 down-regulates sphingosine kinase 1 in colorectal cancer cells.

Chen MB, Yang L, Lu PH, Fu XL, Zhang Y, Zhu YQ, Tian Y.

Biochem Biophys Res Commun. 2015 Aug 7;463(4):954-60. doi: 10.1016/j.bbrc.2015.06.041. Epub 2015 Jun 9.


Association of Interleukin-10 -3575T>A and -1082A>G polymorphisms with non-Hodgkin lymphoma susceptibility: a comprehensive review and meta-analysis.

Zhang Y, Xia ZG, Zhu JH, Chen MB, Wang TM, Shen WX, He J.

Mol Genet Genomics. 2015 Dec;290(6):2063-73. doi: 10.1007/s00438-015-1058-y. Epub 2015 May 15. Review.


The preclinical evaluation of the dual mTORC1/2 inhibitor INK-128 as a potential anti-colorectal cancer agent.

Li C, Cui JF, Chen MB, Liu CY, Liu F, Zhang QD, Zou J, Lu PH.

Cancer Biol Ther. 2015;16(1):34-42. doi: 10.4161/15384047.2014.972274.

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