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Pannexin-1 promotes NLRP3 activation during apoptosis but is dispensable for canonical or Non-canonical inflammasome activation.

Chen KW, Demarco B, Broz P.

Eur J Immunol. 2019 Aug 14. doi: 10.1002/eji.201948254. [Epub ahead of print]


Dental Pulp Stem Cell-Derived Factors Alleviate Subarachnoid Hemorrhage-Induced Neuroinflammation and Ischemic Neurological Deficits.

Chen TF, Chen KW, Chien Y, Lai YH, Hsieh ST, Ma HY, Wang KC, Shiau CY.

Int J Mol Sci. 2019 Jul 31;20(15). pii: E3747. doi: 10.3390/ijms20153747.


Phage-guided modulation of the gut microbiota of mouse models of colorectal cancer augments their responses to chemotherapy.

Zheng DW, Dong X, Pan P, Chen KW, Fan JX, Cheng SX, Zhang XZ.

Nat Biomed Eng. 2019 Jul 22. doi: 10.1038/s41551-019-0423-2. [Epub ahead of print]


Cyclodehydration of 1,4-butanediol over Zr-Al Catalysts: Effect of Reaction Medium.

Li KT, Chen KW.

Materials (Basel). 2019 Jun 28;12(13). pii: E2092. doi: 10.3390/ma12132092.


A hypoallergenic peptide mix containing T cell epitopes of the clinically relevant house dust mite allergens.

Huang HJ, Curin M, Banerjee S, Chen KW, Garmatiuk T, Resch-Marat Y, Carvalho-Queiroz C, Blatt K, Gafvelin G, Grönlund H, Valent P, Campana R, Focke-Tejkl M, Valenta R, Vrtala S.

Allergy. 2019 Jun 22. doi: 10.1111/all.13956. [Epub ahead of print]


Pannexin-1 channels bridge apoptosis to NLRP3 inflammasome activation.

Demarco B, Chen KW, Broz P.

Mol Cell Oncol. 2019 May 7;6(4):1610324. doi: 10.1080/23723556.2019.1610324. eCollection 2019.


Enhanced thermoelectric performance of heavy-fermion compounds YbTM 2Zn20 (TM = Co, Rh, Ir) at low temperatures.

Wei K, Neu JN, Lai Y, Chen KW, Hobbis D, Nolas GS, Graf DE, Siegrist T, Baumbach RE.

Sci Adv. 2019 May 31;5(5):eaaw6183. doi: 10.1126/sciadv.aaw6183. eCollection 2019 May.


Acute Posttraumatic Cerebral Venous Sinus Thrombosis-Induced Malignant Increased Intracranial Pressure Treated with Endovascular Dural Sinus Thrombectomy and Stenting: A Case Report.

Chen KW, Lin YH, Lee CW.

World Neurosurg. 2019 May 21. pii: S1878-8750(19)31379-8. doi: 10.1016/j.wneu.2019.05.105. [Epub ahead of print]


Novel circulating tumor cell-based blood test for the assessment of PD-L1 protein expression in treatment-naïve, newly diagnosed patients with non-small cell lung cancer.

Chen YL, Huang WC, Lin FM, Hsieh HB, Hsieh CH, Hsieh RK, Chen KW, Yen MH, Lee J, Su S, Marfatia T, Chang SE, Sundar P, Patterson B, Watson D, Mei R, Javey M.

Cancer Immunol Immunother. 2019 Jul;68(7):1087-1094. doi: 10.1007/s00262-019-02344-6. Epub 2019 May 14.


Are Mindful Exercises Safe and Beneficial for Treating Chronic Lower Back Pain? A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Zou L, Zhang Y, Yang L, Loprinzi PD, Yeung AS, Kong J, Chen KW, Song W, Xiao T, Li H.

J Clin Med. 2019 May 8;8(5). pii: E628. doi: 10.3390/jcm8050628. Review.


Cardamonin Induces Cell Cycle Arrest, Apoptosis and Alters Apoptosis Associated Gene Expression in WEHI-3 Mouse Leukemia Cells.

Liao NC, Shih YL, Chou JS, Chen KW, Chen YL, Lee MH, Peng SF, Leu SJ, Chung JG.

Am J Chin Med. 2019;47(3):635-656. doi: 10.1142/S0192415X19500332. Epub 2019 Apr 25.


Ultrasound Findings Disclose the Mutual Impact of Vertebrobasilar Dolichoectasia and Vertebral Artery Hypoplasia.

Chi HY, Chen KW, Hsu CF, Shen CY, Chen AC, Su CH, Fu WM.

J Ultrasound Med. 2019 Apr 25. doi: 10.1002/jum.15011. [Epub ahead of print]


Phosphine-catalyzed regiospecific (3 + 2) cyclization of 3-nitroindoles with allene esters.

Jin LW, Jiang F, Chen KW, Du BX, Mei GJ, Shi F.

Org Biomol Chem. 2019 Apr 17;17(16):3894-3901. doi: 10.1039/c9ob00432g.


Extrinsic and intrinsic apoptosis activate pannexin-1 to drive NLRP3 inflammasome assembly.

Chen KW, Demarco B, Heilig R, Shkarina K, Boettcher A, Farady CJ, Pelczar P, Broz P.

EMBO J. 2019 May 15;38(10). pii: e101638. doi: 10.15252/embj.2019101638. Epub 2019 Mar 22.


Antibacterial activity of ovatodiolide isolated from Anisomeles indica against Helicobacter pylori.

Lien HM, Wu HY, Hung CL, Chen CJ, Wu CL, Chen KW, Huang CL, Chang SJ, Chen CC, Lin HJ, Lai CH.

Sci Rep. 2019 Mar 12;9(1):4205. doi: 10.1038/s41598-019-40735-y.


Ouabain promotes immune responses in WEHI-3 cells to generate leukemia mice through enhancing phagocytosis and natural killer cell activities in vivo.

Shih YL, Shang HS, Chen YL, Hsueh SC, Chou HM, Lu HF, Lee MZ, Hou HT, Chuang YY, Lee MH, Chen KW, Chung JG.

Environ Toxicol. 2019 May;34(5):659-665. doi: 10.1002/tox.22732. Epub 2019 Feb 13.


Divide to conquer: NLRP3 is activated on dispersed trans-Golgi network.

Chen KW, Boucher D, Broz P.

Cell Res. 2019 Mar;29(3):181-182. doi: 10.1038/s41422-018-0138-z. No abstract available.


Phosphine-catalyzed [4 + 2] cyclization of para-quinone methide derivatives with allenes.

Yuan FR, Jiang F, Chen KW, Mei GJ, Wu Q, Shi F.

Org Biomol Chem. 2019 Feb 27;17(9):2361-2369. doi: 10.1039/c8ob02979b.


Sex-Specific Association Between Serum Uric Acid and Elevated Alanine Aminotransferase in a Military Cohort: The CHIEF Study.

Lin JW, Tsai KZ, Chen KW, Su FY, Li YH, Lin YP, Han CL, Lin F, Lin YK, Hsieh CB, Lin GM.

Endocr Metab Immune Disord Drug Targets. 2019;19(3):333-340. doi: 10.2174/1871530319666181129163802.


Diagnosis and referral delays in primary care for oral squamous cell cancer: a systematic review.

Grafton-Clarke C, Chen KW, Wilcock J.

Br J Gen Pract. 2019 Feb;69(679):e112-e126. doi: 10.3399/bjgp18X700205. Epub 2018 Nov 19.


Selection of house dust mite-allergic patients by molecular diagnosis may enhance success of specific immunotherapy.

Chen KW, Zieglmayer P, Zieglmayer R, Lemell P, Horak F, Bunu CP, Valenta R, Vrtala S.

J Allergy Clin Immunol. 2019 Mar;143(3):1248-1252.e12. doi: 10.1016/j.jaci.2018.10.048. Epub 2018 Nov 14. No abstract available.


Effects of Mind⁻Body Exercises (Tai Chi/Yoga) on Heart Rate Variability Parameters and Perceived Stress: A Systematic Review with Meta-Analysis of Randomized Controlled Trials.

Zou L, Sasaki JE, Wei GX, Huang T, Yeung AS, Neto OB, Chen KW, Hui SS.

J Clin Med. 2018 Oct 31;7(11). pii: E404. doi: 10.3390/jcm7110404. Review.


Bufalin Enhances Immune Responses in Leukemic Mice Through Enhancing Phagocytosis of Macrophage In Vivo.

Shih YL, Chou JS, Chen YL, Hsueh SC, Chung HY, Lee MH, Chen CP, Lee MZ, Hou HT, Lu HF, Chen KW, Chung JG.

In Vivo. 2018 Sep-Oct;32(5):1129-1136. doi: 10.21873/invivo.11355.


Noncanonical inflammasome signaling elicits gasdermin D-dependent neutrophil extracellular traps.

Chen KW, Monteleone M, Boucher D, Sollberger G, Ramnath D, Condon ND, von Pein JB, Broz P, Sweet MJ, Schroder K.

Sci Immunol. 2018 Aug 24;3(26). pii: eaar6676. doi: 10.1126/sciimmunol.aar6676.


Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion.

Monteleone M, Stanley AC, Chen KW, Brown DL, Bezbradica JS, von Pein JB, Holley CL, Boucher D, Shakespear MR, Kapetanovic R, Rolfes V, Sweet MJ, Stow JL, Schroder K.

Cell Rep. 2018 Aug 7;24(6):1425-1433. doi: 10.1016/j.celrep.2018.07.027.


Effects of Meditative Movements on Major Depressive Disorder: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Zou L, Yeung A, Li C, Wei GX, Chen KW, Kinser PA, Chan JSM, Ren Z.

J Clin Med. 2018 Aug 1;7(8). pii: E195. doi: 10.3390/jcm7080195. Review.


Underestimation of house dust mite-specific IgE with extract-based ImmunoCAPs compared with molecular ImmunoCAPs.

Huang HJ, Resch-Marat Y, Rodriguez-Dominguez A, Chen KW, Kiss R, Zieglmayer P, Zieglmayer R, Lemell P, Horak F, Valenta R, Vrtala S.

J Allergy Clin Immunol. 2018 Nov;142(5):1656-1659.e9. doi: 10.1016/j.jaci.2018.07.010. Epub 2018 Jul 27. No abstract available.


Bulk Fermi Surfaces of the Dirac Type-II Semimetallic Candidates MAl_{3} (Where M=V, Nb, and Ta).

Chen KW, Lian X, Lai Y, Aryal N, Chiu YC, Lan W, Graf D, Manousakis E, Baumbach RE, Balicas L.

Phys Rev Lett. 2018 May 18;120(20):206401. doi: 10.1103/PhysRevLett.120.206401.


Ragweed Pollen Allergy: Burden, Characteristics, and Management of an Imported Allergen Source in Europe.

Chen KW, Marusciac L, Tamas PT, Valenta R, Panaitescu C.

Int Arch Allergy Immunol. 2018;176(3-4):163-180. doi: 10.1159/000487997. Epub 2018 May 22. Review.


Cutting Edge: Blockade of Inhibitor of Apoptosis Proteins Sensitizes Neutrophils to TNF- but Not Lipopolysaccharide-Mediated Cell Death and IL-1β Secretion.

Chen KW, Lawlor KE, von Pein JB, Boucher D, Gerlic M, Croker BA, Bezbradica JS, Vince JE, Schroder K.

J Immunol. 2018 May 15;200(10):3341-3346. doi: 10.4049/jimmunol.1701620. Epub 2018 Apr 16.


Sex-Specific Association between Metabolic Abnormalities and Elevated Alanine Aminotransferase Levels in a Military Cohort: The CHIEF Study.

Chen KW, Meng FC, Shih YL, Su FY, Lin YP, Lin F, Lin JW, Chang WK, Lee CJ, Li YH, Hsieh CB, Lin GM.

Int J Environ Res Public Health. 2018 Mar 19;15(3). pii: E545. doi: 10.3390/ijerph15030545.


Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity.

Boucher D, Monteleone M, Coll RC, Chen KW, Ross CM, Teo JL, Gomez GA, Holley CL, Bierschenk D, Stacey KJ, Yap AS, Bezbradica JS, Schroder K.

J Exp Med. 2018 Mar 5;215(3):827-840. doi: 10.1084/jem.20172222. Epub 2018 Feb 6.


Similar localization of conformational IgE epitopes on the house dust mite allergens Der p 5 and Der p 21 despite limited IgE cross-reactivity.

Curin M, Garmatiuk T, Resch-Marat Y, Chen KW, Hofer G, Fauland K, Keller W, Hemmer W, Vrtala S, Focke-Tejkl M, Valenta R.

Allergy. 2018 Aug;73(8):1653-1661. doi: 10.1111/all.13398. Epub 2018 Feb 21.


Note: A simple multi-channel optical system for modulation spectroscopies.

Solís-Macías J, Sánchez-López JD, Castro-García R, Flores-Camacho JM, Flores-Rangel G, Ciou JJ, Chen KW, Chen CH, Lastras-Martínez LF, Balderas-Navarro RE.

Rev Sci Instrum. 2017 Dec;88(12):126107. doi: 10.1063/1.4998596.


Phase diagram of URu2-x Fe x Si2 in high magnetic fields.

Ran S, Jeon I, Pouse N, Breindel AJ, Kanchanavatee N, Huang K, Gallagher A, Chen KW, Graf D, Baumbach RE, Singleton J, Maple MB.

Proc Natl Acad Sci U S A. 2017 Sep 12;114(37):9826-9831. doi: 10.1073/pnas.1710192114. Epub 2017 Aug 28.


Psychometric properties of three measures assessing advanced theory of mind: Evidence from people with schizophrenia.

Chen KW, Lee SC, Chiang HY, Syu YC, Yu XX, Hsieh CL.

Psychiatry Res. 2017 Nov;257:490-496. doi: 10.1016/j.psychres.2017.08.026. Epub 2017 Aug 17.


Electronic Structure and Properties of Berkelium Iodates.

Silver MA, Cary SK, Garza AJ, Baumbach RE, Arico AA, Galmin GA, Chen KW, Johnson JA, Wang JC, Clark RJ, Chemey A, Eaton TM, Marsh ML, Seidler K, Galley SS, van de Burgt L, Gray AL, Hobart DE, Hanson K, Van Cleve SM, Gendron F, Autschbach J, Scuseria GE, Maron L, Speldrich M, Kögerler P, Celis-Barros C, Páez-Hernández D, Arratia-Pérez R, Ruf M, Albrecht-Schmitt TE.

J Am Chem Soc. 2017 Sep 27;139(38):13361-13375. doi: 10.1021/jacs.7b05569. Epub 2017 Sep 14.


The role of thiazolidinediones in hepatocellular carcinoma risk reduction: a population-based cohort study in Taiwan.

Huang MY, Chung CH, Chang WK, Lin CS, Chen KW, Hsieh TY, Chien WC, Lin HH.

Am J Cancer Res. 2017 Jul 1;7(7):1606-1616. eCollection 2017.


Chronic hepatitis B, nonalcoholic steatohepatitis and physical fitness of military males: CHIEF study.

Chen YJ, Chen KW, Shih YL, Su FY, Lin YP, Meng FC, Lin F, Yu YS, Han CL, Wang CH, Lin JW, Hsieh TY, Li YH, Lin GM.

World J Gastroenterol. 2017 Jul 7;23(25):4587-4594. doi: 10.3748/wjg.v23.i25.4587.


XIAP Loss Triggers RIPK3- and Caspase-8-Driven IL-1β Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation.

Lawlor KE, Feltham R, Yabal M, Conos SA, Chen KW, Ziehe S, Graß C, Zhan Y, Nguyen TA, Hall C, Vince AJ, Chatfield SM, D'Silva DB, Pang KC, Schroder K, Silke J, Vaux DL, Jost PJ, Vince JE.

Cell Rep. 2017 Jul 18;20(3):668-682. doi: 10.1016/j.celrep.2017.06.073.


Comparison cisplatin with cisplatin plus 5FU in head and neck cancer patients received postoperative chemoradiotherapy.

Chen CC, Lin JC, Chen KW.

Oral Oncol. 2017 Jun;69:11-14. doi: 10.1016/j.oraloncology.2017.03.017. Epub 2017 Apr 3.


The kinetics in mathematical models on segmentation clock genes in zebrafish.

Chen KW, Liao KL, Shih CW.

J Math Biol. 2018 Jan;76(1-2):97-150. doi: 10.1007/s00285-017-1138-1. Epub 2017 May 25.


Protein disulfide isomerase a4 acts as a novel regulator of cancer growth through the procaspase pathway.

Kuo TF, Chen TY, Jiang ST, Chen KW, Chiang YM, Hsu YJ, Liu YJ, Chen HM, Yokoyama KK, Tsai KC, Yeh HH, Chen YR, Yang MT, Yang CY, Yang WC.

Oncogene. 2017 Sep 28;36(39):5484-5496. doi: 10.1038/onc.2017.156. Epub 2017 May 22.


Frailty as a Predictor of Future Fracture in Older Adults: A Systematic Review and Meta-Analysis.

Chen KW, Chang SF, Lin PL.

Worldviews Evid Based Nurs. 2017 Aug;14(4):282-293. doi: 10.1111/wvn.12222. Epub 2017 Apr 27.


Multi-Förster Resonance Energy Transfer-Based Fluorescent Probe for Spatiotemporal Matrix Metalloproteinase-2 and Caspase-3 Imaging.

Cheng H, Li SY, Zheng HR, Li CX, Xie BR, Chen KW, Li B, Zhang XZ.

Anal Chem. 2017 Apr 18;89(8):4349-4354. doi: 10.1021/acs.analchem.7b00277. Epub 2017 Apr 5.


Epigenetic Regulation of BDNF Gene during Development and Diseases.

Chen KW, Chen L.

Int J Mol Sci. 2017 Mar 6;18(3). pii: E571. doi: 10.3390/ijms18030571. Review.


Clinical validation of a house dust mite environmental challenge chamber model.

Zieglmayer P, Lemell P, Chen KW, Schmutz R, Zieglmayer R, Pfaar O, Horak F, Vrtala S.

J Allergy Clin Immunol. 2017 Jul;140(1):266-268.e5. doi: 10.1016/j.jaci.2016.12.986. Epub 2017 Feb 24. No abstract available.


Reliable mite-specific IgE testing in nasal secretions by means of allergen microarray.

Berings M, Arasi S, De Ruyck N, Perna S, Resch Y, Lupinek C, Chen KW, Vrtala S, Pajno GB, Bachert C, Lambrecht BN, Dullaers M, Valenta R, Matricardi PM, Gevaert P.

J Allergy Clin Immunol. 2017 Jul;140(1):301-303.e8. doi: 10.1016/j.jaci.2016.11.047. Epub 2017 Feb 21. No abstract available.


Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner.

Conos SA, Chen KW, De Nardo D, Hara H, Whitehead L, Núñez G, Masters SL, Murphy JM, Schroder K, Vaux DL, Lawlor KE, Lindqvist LM, Vince JE.

Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E961-E969. doi: 10.1073/pnas.1613305114. Epub 2017 Jan 17. Erratum in: Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5762-E5763.


SH2B1 modulates chromatin state and MyoD occupancy to enhance expressions of myogenic genes.

Chen KW, Chang YJ, Yeh CM, Lian YL, Chan MW, Kao CF, Chen L.

Biochim Biophys Acta Gene Regul Mech. 2017 Feb;1860(2):270-281. doi: 10.1016/j.bbagrm.2016.12.007. Epub 2016 Dec 27.


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