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Items: 1 to 50 of 53

1.

Pharmacological analysis of CFTR variants of cystic fibrosis using stem cell-derived organoids.

Chen KG, Zhong P, Zheng W, Beekman JM.

Drug Discov Today. 2019 Jun 4. pii: S1359-6446(19)30137-0. doi: 10.1016/j.drudis.2019.05.029. [Epub ahead of print] Review.

PMID:
31173911
2.

LONGITUDINAL CHANGES IN EYES WITH HYDROXYCHLOROQUINE RETINAL TOXICITY.

Allahdina AM, Chen KG, Alvarez JA, Wong WT, Chew EY, Cukras CA.

Retina. 2019 Mar;39(3):473-484. doi: 10.1097/IAE.0000000000002437.

PMID:
30741731
3.

Induced pluripotent stem cells for neural drug discovery.

Farkhondeh A, Li R, Gorshkov K, Chen KG, Might M, Rodems S, Lo DC, Zheng W.

Drug Discov Today. 2019 Apr;24(4):992-999. doi: 10.1016/j.drudis.2019.01.007. Epub 2019 Jan 18. Review.

4.

Orbital Roof Reconstruction Using Nylon Foil Implants.

Grob SR, Chen KG, Tao JP.

Ophthalmic Plast Reconstr Surg. 2019 Jan 7. doi: 10.1097/IOP.0000000000001299. [Epub ahead of print]

PMID:
30624413
5.

10-YEAR FOLLOW-UP OF A SUBCLINICAL CHOROIDAL NEOVASCULAR MEMBRANE IN A PATIENT WITH AGE-RELATED MACULAR DEGENERATION.

Chen KG, Christakis PG, Chew EY.

Retin Cases Brief Rep. 2018 Oct 15. doi: 10.1097/ICB.0000000000000826. [Epub ahead of print]

PMID:
30325876
6.

Longitudinal Study of Dark Adaptation as a Functional Outcome Measure for Age-Related Macular Degeneration.

Chen KG, Alvarez JA, Yazdanie M, Papudesu C, Wong WT, Wiley HE, Keenan TD, Chew EY, Ferris FL 3rd, Cukras CA.

Ophthalmology. 2019 Jun;126(6):856-865. doi: 10.1016/j.ophtha.2018.09.039. Epub 2018 Sep 29.

PMID:
30278196
7.

Advancing precision medicine with personalized drug screening.

Gorshkov K, Chen CZ, Marshall RE, Mihatov N, Choi Y, Nguyen DT, Southall N, Chen KG, Park JK, Zheng W.

Drug Discov Today. 2019 Jan;24(1):272-278. doi: 10.1016/j.drudis.2018.08.010. Epub 2018 Aug 17. Review.

PMID:
30125678
8.

Pluripotent Stem Cell Platforms for Drug Discovery.

Chen KG, Mallon BS, Park K, Robey PG, McKay RDG, Gottesman MM, Zheng W.

Trends Mol Med. 2018 Sep;24(9):805-820. doi: 10.1016/j.molmed.2018.06.009. Epub 2018 Jul 11. Review.

9.

Cationic Polymeric Nanoparticle Delivering CCR2 siRNA to Inflammatory Monocytes for Tumor Microenvironment Modification and Cancer Therapy.

Shen S, Zhang Y, Chen KG, Luo YL, Wang J.

Mol Pharm. 2018 Sep 4;15(9):3642-3653. doi: 10.1021/acs.molpharmaceut.7b00997. Epub 2018 Jan 26.

PMID:
29337566
10.

Mouse Genetic Analysis of Bone Marrow Stem Cell Niches: Technological Pitfalls, Challenges, and Translational Considerations.

Chen KG, Johnson KR, Robey PG.

Stem Cell Reports. 2017 Nov 14;9(5):1343-1358. doi: 10.1016/j.stemcr.2017.09.014. Epub 2017 Oct 19. Review.

11.

Concise Review: Conceptualizing Paralogous Stem-Cell Niches and Unfolding Bone Marrow Progenitor Cell Identities.

Chen KG, Johnson KR, McKay RDG, Robey PG.

Stem Cells. 2018 Jan;36(1):11-21. doi: 10.1002/stem.2711. Epub 2017 Oct 12. Review.

12.

Spatial Targeting of Tumor-Associated Macrophages and Tumor Cells with a pH-Sensitive Cluster Nanocarrier for Cancer Chemoimmunotherapy.

Shen S, Li HJ, Chen KG, Wang YC, Yang XZ, Lian ZX, Du JZ, Wang J.

Nano Lett. 2017 Jun 14;17(6):3822-3829. doi: 10.1021/acs.nanolett.7b01193. Epub 2017 May 16.

PMID:
28488871
13.

The Age-Related Orientational Changes of Human Semicircular Canals.

Lyu HY, Chen KG, Yin DM, Hong J, Yang L, Zhang TY, Dai PD.

Clin Exp Otorhinolaryngol. 2016 Jun;9(2):109-15. doi: 10.21053/ceo.2014.02012. Epub 2016 Apr 19.

14.

Promoting tumor penetration of nanoparticles for cancer stem cell therapy by TGF-β signaling pathway inhibition.

Zuo ZQ, Chen KG, Yu XY, Zhao G, Shen S, Cao ZT, Luo YL, Wang YC, Wang J.

Biomaterials. 2016 Mar;82:48-59. doi: 10.1016/j.biomaterials.2015.12.014. Epub 2015 Dec 21.

PMID:
26751819
15.

Variations in Glycogen Synthesis in Human Pluripotent Stem Cells with Altered Pluripotent States.

Chen RJ, Zhang G, Garfield SH, Shi YJ, Chen KG, Robey PG, Leapman RD.

PLoS One. 2015 Nov 13;10(11):e0142554. doi: 10.1371/journal.pone.0142554. eCollection 2015.

16.

The age-related positional and orientational changes of the human cochlea.

Lyu HY, Chen KG, Yang L, Zhang TY, Dai PD.

Acta Otolaryngol. 2015 Mar;135(3):205-10. doi: 10.3109/00016489.2014.981286. Epub 2015 Jan 26.

PMID:
25622541
17.

Lost in Translation: Regulation of ABCG2 Expression in Human Embryonic Stem Cells.

Padmanabhan R, Chen KG, Gottesman MM.

J Stem Cell Res Ther. 2014 Mar 17;4. pii: 24230.

18.

Alternative cultures for human pluripotent stem cell production, maintenance, and genetic analysis.

Chen KG, Hamilton RS, Robey PG, Mallon BS.

J Vis Exp. 2014 Jul 24;(89). doi: 10.3791/51519.

19.

Directed differentiation of human induced pluripotent stem cells toward bone and cartilage: in vitro versus in vivo assays.

Phillips MD, Kuznetsov SA, Cherman N, Park K, Chen KG, McClendon BN, Hamilton RS, McKay RD, Chenoweth JG, Mallon BS, Robey PG.

Stem Cells Transl Med. 2014 Jul;3(7):867-78. doi: 10.5966/sctm.2013-0154. Epub 2014 May 22.

20.

Developmental insights from early mammalian embryos and core signaling pathways that influence human pluripotent cell growth and differentiation.

Chen KG, Mallon BS, Johnson KR, Hamilton RS, McKay RD, Robey PG.

Stem Cell Res. 2014 May;12(3):610-21. doi: 10.1016/j.scr.2014.02.002. Epub 2014 Feb 19. Review.

21.

Human pluripotent stem cell culture: considerations for maintenance, expansion, and therapeutics.

Chen KG, Mallon BS, McKay RD, Robey PG.

Cell Stem Cell. 2014 Jan 2;14(1):13-26. doi: 10.1016/j.stem.2013.12.005. Review.

22.

Elimination of self-reactive T cells in the thymus: a timeline for negative selection.

Dzhagalov IL, Chen KG, Herzmark P, Robey EA.

PLoS Biol. 2013;11(5):e1001566. doi: 10.1371/journal.pbio.1001566. Epub 2013 May 21.

23.

StemCellDB: the human pluripotent stem cell database at the National Institutes of Health.

Mallon BS, Chenoweth JG, Johnson KR, Hamilton RS, Tesar PJ, Yavatkar AS, Tyson LJ, Park K, Chen KG, Fann YC, McKay RD.

Stem Cell Res. 2013 Jan;10(1):57-66. doi: 10.1016/j.scr.2012.09.002. Epub 2012 Sep 26.

24.

Non-colony type monolayer culture of human embryonic stem cells.

Chen KG, Mallon BS, Hamilton RS, Kozhich OA, Park K, Hoeppner DJ, Robey PG, McKay RD.

Stem Cell Res. 2012 Nov;9(3):237-48. doi: 10.1016/j.scr.2012.06.003. Epub 2012 Jun 28.

25.

Regulation and expression of the ATP-binding cassette transporter ABCG2 in human embryonic stem cells.

Padmanabhan R, Chen KG, Gillet JP, Handley M, Mallon BS, Hamilton RS, Park K, Varma S, Mehaffey MG, Robey PG, McKay RD, Gottesman MM.

Stem Cells. 2012 Oct;30(10):2175-87. doi: 10.1002/stem.1195.

26.

Molecular pathways: regulation and therapeutic implications of multidrug resistance.

Chen KG, Sikic BI.

Clin Cancer Res. 2012 Apr 1;18(7):1863-9. doi: 10.1158/1078-0432.CCR-11-1590. Epub 2012 Feb 16. Review.

27.

Involvement of ABC transporters in melanogenesis and the development of multidrug resistance of melanoma.

Chen KG, Valencia JC, Gillet JP, Hearing VJ, Gottesman MM.

Pigment Cell Melanoma Res. 2009 Dec;22(6):740-9. doi: 10.1111/j.1755-148X.2009.00630.x. Epub 2009 Aug 29. Review.

28.

Influence of melanosome dynamics on melanoma drug sensitivity.

Chen KG, Leapman RD, Zhang G, Lai B, Valencia JC, Cardarelli CO, Vieira WD, Hearing VJ, Gottesman MM.

J Natl Cancer Inst. 2009 Sep 16;101(18):1259-71. doi: 10.1093/jnci/djp259. Epub 2009 Aug 24.

29.

Characterization of human embryonic stem cell lines by the International Stem Cell Initiative.

International Stem Cell Initiative, Adewumi O, Aflatoonian B, Ahrlund-Richter L, Amit M, Andrews PW, Beighton G, Bello PA, Benvenisty N, Berry LS, Bevan S, Blum B, Brooking J, Chen KG, Choo AB, Churchill GA, Corbel M, Damjanov I, Draper JS, Dvorak P, Emanuelsson K, Fleck RA, Ford A, Gertow K, Gertsenstein M, Gokhale PJ, Hamilton RS, Hampl A, Healy LE, Hovatta O, Hyllner J, Imreh MP, Itskovitz-Eldor J, Jackson J, Johnson JL, Jones M, Kee K, King BL, Knowles BB, Lako M, Lebrin F, Mallon BS, Manning D, Mayshar Y, McKay RD, Michalska AE, Mikkola M, Mileikovsky M, Minger SL, Moore HD, Mummery CL, Nagy A, Nakatsuji N, O'Brien CM, Oh SK, Olsson C, Otonkoski T, Park KY, Passier R, Patel H, Patel M, Pedersen R, Pera MF, Piekarczyk MS, Pera RA, Reubinoff BE, Robins AJ, Rossant J, Rugg-Gunn P, Schulz TC, Semb H, Sherrer ES, Siemen H, Stacey GN, Stojkovic M, Suemori H, Szatkiewicz J, Turetsky T, Tuuri T, van den Brink S, Vintersten K, Vuoristo S, Ward D, Weaver TA, Young LA, Zhang W.

Nat Biotechnol. 2007 Jul;25(7):803-16. Epub 2007 Jun 17.

PMID:
17572666
30.

Sialylated core 1 O-glycans influence the sorting of Pmel17/gp100 and determine its capacity to form fibrils.

Valencia JC, Rouzaud F, Julien S, Chen KG, Passeron T, Yamaguchi Y, Abu-Asab M, Tsokos M, Costin GE, Yamaguchi H, Jenkins LM, Nagashima K, Appella E, Hearing VJ.

J Biol Chem. 2007 Apr 13;282(15):11266-80. Epub 2007 Feb 15.

31.

Regulation of constitutive and UVR-induced skin pigmentation by melanocortin 1 receptor isoforms.

Rouzaud F, Costin GE, Yamaguchi Y, Valencia JC, Berens WF, Chen KG, Hoashi T, Böhm M, Abdel-Malek ZA, Hearing VJ.

FASEB J. 2006 Sep;20(11):1927-9. Epub 2006 Jul 28.

PMID:
16877522
32.

Melanosomal sequestration of cytotoxic drugs contributes to the intractability of malignant melanomas.

Chen KG, Valencia JC, Lai B, Zhang G, Paterson JK, Rouzaud F, Berens W, Wincovitch SM, Garfield SH, Leapman RD, Hearing VJ, Gottesman MM.

Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9903-7. Epub 2006 Jun 15.

33.

[Stomach perforation due to infection of Gnathostoma doloresi].

Yang QS, Chen KG, Lu XS.

Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2005 Dec 30;23(6):427. Chinese. No abstract available.

PMID:
16566212
34.

Sorting of Pmel17 to melanosomes through the plasma membrane by AP1 and AP2: evidence for the polarized nature of melanocytes.

Valencia JC, Watabe H, Chi A, Rouzaud F, Chen KG, Vieira WD, Takahashi K, Yamaguchi Y, Berens W, Nagashima K, Shabanowitz J, Hunt DF, Appella E, Hearing VJ.

J Cell Sci. 2006 Mar 15;119(Pt 6):1080-91. Epub 2006 Feb 21.

35.

Toward xeno-free culture of human embryonic stem cells.

Mallon BS, Park KY, Chen KG, Hamilton RS, McKay RD.

Int J Biochem Cell Biol. 2006;38(7):1063-75. Epub 2006 Jan 23. Review.

36.

Regional activation of chromosomal arm 7q with and without gene amplification in taxane-selected human ovarian cancer cell lines.

Wang YC, Juric D, Francisco B, Yu RX, Duran GE, Chen KG, Chen X, Sikic BI.

Genes Chromosomes Cancer. 2006 Apr;45(4):365-74.

PMID:
16382445
37.

Genetic and epigenetic modeling of the origins of multidrug-resistant cells in a human sarcoma cell line.

Chen KG, Wang YC, Schaner ME, Francisco B, Durán GE, Juric D, Huff LM, Padilla-Nash H, Ried T, Fojo T, Sikic BI.

Cancer Res. 2005 Oct 15;65(20):9388-97.

38.

Principal expression of two mRNA isoforms (ABCB 5alpha and ABCB 5beta ) of the ATP-binding cassette transporter gene ABCB 5 in melanoma cells and melanocytes.

Chen KG, Szakács G, Annereau JP, Rouzaud F, Liang XJ, Valencia JC, Nagineni CN, Hooks JJ, Hearing VJ, Gottesman MM.

Pigment Cell Res. 2005 Apr;18(2):102-12.

39.

Useful tool to generate unidirectional deletion vectors by utilizing the star activity of BamHI in an NcoI-BamHI-XhoI cassette.

Chen KG, Gottesman MM.

Biotechniques. 2005 Feb;38(2):198, 200, 202, 204. No abstract available.

40.

Resistance to microtubule-targeted cytotoxins in a K562 leukemia cell variant associated with altered tubulin expression and polymerization.

Dumontet C, Jaffrezou JP, Tsuchiya E, Duran GE, Chen KG, Derry WB, Wilson L, Jordan MA, Sikic BI.

Bull Cancer. 2004 May;91(5):E81-112.

41.

Trafficking and localization of platinum complexes in cisplatin-resistant cell lines monitored by fluorescence-labeled platinum.

Liang XJ, Shen DW, Chen KG, Wincovitch SM, Garfield SH, Gottesman MM.

J Cell Physiol. 2005 Mar;202(3):635-41.

PMID:
15546142
43.

The molecular mysteries underlying P-glycoprotein-mediated multidrug resistance.

Szakács G, Chen KG, Gottesman MM.

Cancer Biol Ther. 2004 Apr;3(4):382-4. doi: 10.4161/cbt.3.4.743. Epub 2004 Apr 29. No abstract available.

PMID:
14976423
44.

Preferential expression of a mutant allele of the amplified MDR1 (ABCB1) gene in drug-resistant variants of a human sarcoma.

Chen KG, Lacayo NJ, Durán GE, Wang Y, Bangs CD, Rea S, Kovacs M, Cherry AM, Brown JM, Sikic BI.

Genes Chromosomes Cancer. 2002 Aug;34(4):372-83.

PMID:
12112526
45.

Loss of cyclosporin and azidopine binding are associated with altered ATPase activity by a mutant P-glycoprotein with deleted phe(335).

Chen KG, Lacayo NJ, Durán GE, Cohen D, Sikic BI.

Mol Pharmacol. 2000 Apr;57(4):769-77.

PMID:
10727524
46.
47.

NMR spectroscopy studies of severe hypokalemia in isolated rat hearts.

Peterson EW, Chen KG, Elkins N, Hutchison RB, Shapiro JI.

Am J Physiol. 1995 Dec;269(6 Pt 2):H1981-7.

PMID:
8594907
48.

Decreased mutation rate for cellular resistance to doxorubicin and suppression of mdr1 gene activation by the cyclosporin PSC 833.

Beketic-Oreskovic L, Durán GE, Chen KG, Dumontet C, Sikic BI.

J Natl Cancer Inst. 1995 Nov 1;87(21):1593-602.

PMID:
7563202
49.

Inhibition of lysosomal acid sphingomyelinase by agents which reverse multidrug resistance.

Jaffrézou JP, Chen KG, Durán GE, Muller C, Bordier C, Laurent G, Sikic BI, Levade T.

Biochim Biophys Acta. 1995 Apr 6;1266(1):1-8.

50.

Novel mechanism of resistance to paclitaxel (Taxol) in human K562 leukemia cells by combined selection with PSC 833.

Jaffrézou JP, Dumontet C, Derry WB, Durán G, Chen KG, Tsuchiya E, Wilson L, Jordan MA, Sikic BI.

Oncol Res. 1995;7(10-11):517-27.

PMID:
8866664

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