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Evolutionary loss of foot muscle during development with characteristics of atrophy and no evidence of cell death.

Tran MP, Tsutsumi R, Erberich JM, Chen KD, Flores MD, Cooper KL.

Elife. 2019 Oct 15;8. pii: e50645. doi: 10.7554/eLife.50645. [Epub ahead of print]


Process optimization for the rapid production of Enterovirus 71.

Wu XX, Chen KD, Chen DZ, Xiao LL, Huang KZ, Zhang YJ, Li LJ.

Cytotechnology. 2019 Sep 26. doi: 10.1007/s10616-019-00340-3. [Epub ahead of print]


Decreased DNA methyltransferases expression is associated with coronary artery lesion formation in Kawasaki disease.

Huang YH, Chen KD, Lo MH, Cai XY, Chang LS, Kuo YH, Huang WD, Kuo HC.

Int J Med Sci. 2019 Apr 25;16(4):576-582. doi: 10.7150/ijms.32773. eCollection 2019.


Decreased Steroid Hormone Receptor NR4A2 Expression in Kawasaki Disease Before IVIG Treatment.

Huang YH, Chen KD, Lo MH, Cai XY, Kuo HC.

Front Pediatr. 2019 Feb 4;7:7. doi: 10.3389/fped.2019.00007. eCollection 2019.


Decreased PEDF Expression Promotes Adipogenic Differentiation through the Up-Regulation of CD36.

Huang KT, Hsu LW, Chen KD, Kung CP, Goto S, Chen CL.

Int J Mol Sci. 2018 Dec 11;19(12). pii: E3992. doi: 10.3390/ijms19123992.


Patients with chronic hepatitis C receiving sofosbuvir and ribavirin-based treatment, with or without interferon in Zhejiang, China: An observational study.

Xu XW, Wu XX, Chen KD, Chen DZ, Ou HL, Su JW, Yu HY, Yao HP, Li LJ.

Medicine (Baltimore). 2018 Sep;97(38):e12403. doi: 10.1097/MD.0000000000012403.


Comparing medical, dental, and nursing students' preparedness to address lesbian, gay, bisexual, transgender, and queer health.

Greene MZ, France K, Kreider EF, Wolfe-Roubatis E, Chen KD, Wu A, Yehia BR.

PLoS One. 2018 Sep 20;13(9):e0204104. doi: 10.1371/journal.pone.0204104. eCollection 2018.


Tumor microenvironment mediated by suppression of autophagic flux drives liver malignancy.

Chen KD, Lin CC, Tsai MC, Huang KT, Chiu KW.

Biomed J. 2018 Jun;41(3):163-168. doi: 10.1016/ Epub 2018 Jun 29. Review.


The human blood DNA methylome identifies crucial role of β-catenin in the pathogenesis of Kawasaki disease.

Chen KD, Huang YH, Ming-Huey Guo M, Lin TY, Weng WT, Yang HJ, Yang KD, Kuo HC.

Oncotarget. 2018 Jun 19;9(47):28337-28350. doi: 10.18632/oncotarget.25305. eCollection 2018 Jun 19.


Pigment epithelium-derived factor in lipid metabolic disorders.

Huang KT, Lin CC, Tsai MC, Chen KD, Chiu KW.

Biomed J. 2018 Apr;41(2):102-108. doi: 10.1016/ Review.


Process optimization for the rapid production of adenoviral vectors for clinical trials in a disposable bioreactor system.

Chen KD, Wu XX, Yu DS, Ou HL, Li YH, Zhou YQ, Li LJ.

Appl Microbiol Biotechnol. 2018 Aug;102(15):6469-6477. doi: 10.1007/s00253-018-9091-5. Epub 2018 Jun 2.


Association between Subclinical Low Serum 25(OH)D in Donors and Fatty Liver Disease in Recipients after Living Donor Liver Transplantation.

Chiu KW, Nakano T, Hu TH, Chen KD, Hsu LW, Eng HL, Cheng YF, Goto S, Chen CL.

Biomed Res Int. 2018 Mar 19;2018:4508085. doi: 10.1155/2018/4508085. eCollection 2018.


Identification of IL-28B Genotype Modification in Hepatocytes after Living Donor Liver Transplantation by Laser Capture Microdissection and Pyrosequencing Analysis.

Chiu KW, Nakano T, Chen KD, Hu TH, Lin CC, Hsu LW, Chen CL, Goto S.

Biomed Res Int. 2018 Mar 4;2018:1826140. doi: 10.1155/2018/1826140. eCollection 2018.


Factor VII-Induced MicroRNA-135a Inhibits Autophagy and Is Associated with Poor Prognosis in Hepatocellular Carcinoma.

Huang KT, Kuo IY, Tsai MC, Wu CH, Hsu LW, Chen LY, Kung CP, Cheng YF, Goto S, Chou YW, Chen CL, Lin CC, Chen KD.

Mol Ther Nucleic Acids. 2017 Dec 15;9:274-283. doi: 10.1016/j.omtn.2017.10.002. Epub 2017 Oct 7.


Whole genome gene expression changes and hematological effects of rikkunshito in patients with advanced non-small cell lung cancer receiving first line chemotherapy.

Chen YC, Lin AS, Hung YC, Chen KD, Wu CY, Lie CH, Hsiao CC, Chen CJ, Liu SF, Fang WF, Chang JC, Wang TY, Wang YH, Chung YH, Chao TY, Leung SY, Su MC, Lin MC.

Exp Ther Med. 2017 Sep;14(3):2040-2052. doi: 10.3892/etm.2017.4773. Epub 2017 Jul 11.


Genome-wide gene expression array identifies novel genes related to disease severity and excessive daytime sleepiness in patients with obstructive sleep apnea.

Chen YC, Chen KD, Su MC, Chin CH, Chen CJ, Liou CW, Chen TW, Chang YC, Huang KT, Wang CC, Wang TY, Chang JC, Lin YY, Zheng YX, Lin MC, Hsiao CC.

PLoS One. 2017 May 17;12(5):e0176575. doi: 10.1371/journal.pone.0176575. eCollection 2017.


Increased S100A15 expression and decreased DNA methylation of its gene promoter are involved in high metastasis potential and poor outcome of lung adenocarcinoma.

Chen YC, Lin MC, Hsiao CC, Zheng YX, Chen KD, Sung MT, Chen CJ, Wang TY, Lin YY, Chang HC, Chen YM, Chang JC.

Oncotarget. 2017 Jul 11;8(28):45710-45724. doi: 10.18632/oncotarget.17391.


DHL-HisZn, a novel antioxidant, enhances adipogenic differentiation and antioxidative response in adipose-derived stem cells.

Chen CC, Hsu LW, Nakano T, Huang KT, Chen KD, Lai CY, Goto S, Chen CL.

Biomed Pharmacother. 2016 Dec;84:1601-1609. doi: 10.1016/j.biopha.2016.10.066. Epub 2016 Nov 5.


Association of IL28B SNPs rs12979860 and rs8099917 on Hepatitis C Virus-RNA Status in Donors/Recipients of Living Donor Liver Transplantation.

Chiu KW, Nakano T, Chen KD, Lin CC, Hu TH, Goto S, Chen CL.

PLoS One. 2016 Jun 8;11(6):e0156846. doi: 10.1371/journal.pone.0156846. eCollection 2016.


Coagulation factor VII and malignant progression of hepatocellular carcinoma.

Chen KD, Huang KT, Tsai MC, Wu CH, Kuo IY, Chen LY, Hu TH, Chen CL, Lin CC.

Cell Death Dis. 2016 Feb 25;7:e2110. doi: 10.1038/cddis.2015.395. No abstract available.


Whole Genome DNA Methylation Analysis of Obstructive Sleep Apnea: IL1R2, NPR2, AR, SP140 Methylation and Clinical Phenotype.

Chen YC, Chen TW, Su MC, Chen CJ, Chen KD, Liou CW, Tang P, Wang TY, Chang JC, Wang CC, Lin HC, Chin CH, Huang KT, Lin MC, Hsiao CC.

Sleep. 2016 Apr 1;39(4):743-55. doi: 10.5665/sleep.5620.


MicroRNA-27b Enhances the Hepatic Regenerative Properties of Adipose-Derived Mesenchymal Stem Cells.

Chen KD, Huang KT, Lin CC, Weng WT, Hsu LW, Goto S, Nakano T, Lai CY, Kung CP, Chiu KW, Wang CC, Cheng YF, Ma YY, Chen CL.

Mol Ther Nucleic Acids. 2016 Feb 2;5:e285. doi: 10.1038/mtna.2015.55.


Repeated-measures implication of hepatocellular carcinoma biomarkers in living donor liver transplantation.

Chiu KW, Nakano T, Chen KD, Hsu LW, Lai CY, Huang CY, Cheng YF, Goto S, Chen CL.

PLoS One. 2015 May 15;10(5):e0124943. doi: 10.1371/journal.pone.0124943. eCollection 2015.


Cytochrome P450 in living donor liver transplantation.

Chiu KW, Nakano T, Chen KD, Hsu LW, Lai CY, Huang CY, Cheng YF, Goto S, Chen CL.

J Biomed Sci. 2015 May 15;22:32. doi: 10.1186/s12929-015-0140-4. Review.


Genetic stability of a recombinant adenovirus vaccine vector seed library expressing human papillomavirus type 16 E6 and E7 proteins.

Wu J, Chen KD, Gao M, Chen G, Jin SF, Zhuang FC, Wu XH, Jiang YS, Li JB.

Exp Ther Med. 2015 Apr;9(4):1161-1165. Epub 2015 Feb 5.


The preoperative evaluation prevent the postoperative complications of thyroidectomy.

Huang CF, Jeng Y, Chen KD, Yu JK, Shih CM, Huang SM, Lee CH, Chou FF, Shih ML, Jeng KC, Chang TM.

Ann Med Surg (Lond). 2014 Dec 18;4(1):5-10. doi: 10.1016/j.amsu.2014.11.005. eCollection 2015 Mar.


Factor VII promotes hepatocellular carcinoma progression through ERK-TSC signaling.

Tsai MC, Chen KD, Wang CC, Huang KT, Wu CH, Kuo IY, Chen LY, Hu TH, Goto S, Nakano T, Dorling A, McVey JH, Chen CL, Lin CC.

Cell Death Discov. 2015 Nov 30;1:15051. doi: 10.1038/cddiscovery.2015.51. eCollection 2015.


Prolonged survival by combined treatment with granulocyte colony-stimulating factor and dipeptidyl peptidase IV inhibitor in a rat small-for-size liver transplantation model.

Hsu LW, Nakano T, Huang KT, Chen CC, Chen KD, Lai CY, Yang SM, Lin CC, Wang CC, Cheng YF, Chiu KW, Kuo YR, Goto S, Chen CL.

Hepatol Res. 2015 Jul;45(7):804-13. doi: 10.1111/hepr.12413. Epub 2014 Oct 23.


Interconnections between autophagy and the coagulation cascade in hepatocellular carcinoma.

Chen KD, Wang CC, Tsai MC, Wu CH, Yang HJ, Chen LY, Nakano T, Goto S, Huang KT, Hu TH, Chen CL, Lin CC.

Cell Death Dis. 2014 May 22;5:e1244. doi: 10.1038/cddis.2014.212.


Regulation of heme oxygenase 1 expression by miR-27b with stem cell therapy for liver regeneration in rats.

Chen KD, Hsu LW, Goto S, Huang KT, Nakano T, Weng WT, Lai CY, Kuo YR, Chiu KW, Wang CC, Cheng YF, Lin CC, Ma YY, Chen CL.

Transplant Proc. 2014 May;46(4):1198-200. doi: 10.1016/j.transproceed.2013.12.013.


Induction of antinuclear antibodies by de novo autoimmune hepatitis regulates alloimmune responses in rat liver transplantation.

Nakano T, Goto S, Lai CY, Hsu LW, Tseng HP, Chen KD, Chiu KW, Wang CC, Cheng YF, Chen CL.

Clin Dev Immunol. 2013;2013:413928. doi: 10.1155/2013/413928. Epub 2013 Dec 23.


Homogeneous phenomenon of the graft when using different genotype characteristic of recipients/donors in living donor liver transplantation.

Chiu KW, Nakano T, Chen KD, Hsu LW, Lai CY, Chiu HC, Huang CY, Cheng YF, Goto S, Chen CL.

World J Hepatol. 2013 Nov 27;5(11):642-8. doi: 10.4254/wjh.v5.i11.642.


Erosive esophagitis associated with metabolic syndrome, impaired liver function, and dyslipidemia.

Loke SS, Yang KD, Chen KD, Chen JF.

World J Gastroenterol. 2013 Sep 21;19(35):5883-8. doi: 10.3748/wjg.v19.i35.5883.


Pyrosequencing to identify homogeneous phenomenon when using recipients/donors with different CYP3A5*3 genotypes in living donor liver transplantation.

Chiu KW, Nakano T, Chen KD, Lai CY, Hsu LW, Chiu HC, Huang CY, Cheng YF, Goto S, Chen CL.

PLoS One. 2013 Aug 8;8(8):e71314. doi: 10.1371/journal.pone.0071314. eCollection 2013.


Biological interactions of CYP2C19 genotypes with CYP3A4*18, CYP3A5*3, and MDR1-3435 in living donor liver transplantation recipients.

Chiu KW, Hu TH, Nakano T, Chen KD, Lai CY, Hsu LW, Tseng HP, Chiu HC, Cheng YF, Goto S, Chen CL.

Transplant Res. 2013 Apr 23;2(1):6. doi: 10.1186/2047-1440-2-6.


Identification of miR-27b as a novel signature from the mRNA profiles of adipose-derived mesenchymal stem cells involved in the tolerogenic response.

Chen KD, Goto S, Hsu LW, Lin TY, Nakano T, Lai CY, Chang YC, Weng WT, Kuo YR, Wang CC, Cheng YF, Ma YY, Lin CC, Chen CL.

PLoS One. 2013 Apr 16;8(4):e60492. doi: 10.1371/journal.pone.0060492. Print 2013.


Peripheral immune cell gene expression changes in advanced non-small cell lung cancer patients treated with first line combination chemotherapy.

Chen YC, Hsiao CC, Chen KD, Hung YC, Wu CY, Lie CH, Liu SF, Sung MT, Chen CJ, Wang TY, Chang JC, Tang P, Fang WF, Wang YH, Chung YH, Chao TY, Leung SY, Su MC, Wang CC, Lin MC.

PLoS One. 2013;8(2):e57053. doi: 10.1371/journal.pone.0057053. Epub 2013 Feb 25.


Immunological and regenerative aspects of hepatic mast cells in liver allograft rejection and tolerance.

Nakano T, Lai CY, Goto S, Hsu LW, Kawamoto S, Ono K, Chen KD, Lin CC, Chiu KW, Wang CC, Cheng YF, Chen CL.

PLoS One. 2012;7(5):e37202. doi: 10.1371/journal.pone.0037202. Epub 2012 May 15.


The effect of exogenous histone H1 on rat adipose-derived stem cell proliferation, migration, and osteogenic differentiation in vitro.

Hsu LW, Goto S, Nakano T, Chen KD, Wang CC, Lai CY, Hou CH, Chang YC, Cheng YF, Chiu KW, Chen CC, Chen SH, Chen CL.

J Cell Physiol. 2012 Oct;227(10):3417-25. doi: 10.1002/jcp.24042.


Low-dose LBH589 increases the sensitivity of cisplatin to cisplatin-resistant ovarian cancer cells.

Ma YY, Lin H, Moh JS, Chen KD, Wang IW, Ou YC, You YS, Lung CC.

Taiwan J Obstet Gynecol. 2011 Jun;50(2):165-71. doi: 10.1016/j.tjog.2011.01.022.


Gene expression profiling of peripheral blood leukocytes identifies and validates ABCB1 as a novel biomarker for Alzheimer's disease.

Chen KD, Chang PT, Ping YH, Lee HC, Yeh CW, Wang PN.

Neurobiol Dis. 2011 Sep;43(3):698-705. doi: 10.1016/j.nbd.2011.05.023. Epub 2011 Jun 6.


Adaptor protein Shc acts as an immune-regulator for the LPS-stimulated maturation of bone marrow-derived dendritic cells.

Chen KD, Hsu LW, Goto S, Yeh CW, Nakano T, Lai CY, Chang YC, Hou CH, Wang CC, Cheng YF, Chiu KW, Lin CC, Chen CL.

BMC Immunol. 2011 May 25;12:32. doi: 10.1186/1471-2172-12-32.


Impact of artificial sunlight therapy on the progress of non-alcoholic fatty liver disease in rats.

Nakano T, Cheng YF, Lai CY, Hsu LW, Chang YC, Deng JY, Huang YZ, Honda H, Chen KD, Wang CC, Chiu KW, Jawan B, Eng HL, Goto S, Chen CL.

J Hepatol. 2011 Aug;55(2):415-25. doi: 10.1016/j.jhep.2010.11.028. Epub 2010 Dec 22.


Anti-invasive effect of a rare mushroom, Ganoderma colossum , on human hepatoma cells.

Weng CJ, Fang PS, Chen DH, Chen KD, Yen GC.

J Agric Food Chem. 2010 Jul 14;58(13):7657-63. doi: 10.1021/jf101464h.


Inhibitory effects of ganoderma lucidum on tumorigenesis and metastasis of human hepatoma cells in cells and animal models.

Weng CJ, Chau CF, Yen GC, Liao JW, Chen DH, Chen KD.

J Agric Food Chem. 2009 Jun 10;57(11):5049-57. doi: 10.1021/jf900828k.


The anti-invasive effect of lucidenic acids isolated from a new Ganoderma lucidum strain.

Weng CJ, Chau CF, Chen KD, Chen DH, Yen GC.

Mol Nutr Food Res. 2007 Dec;51(12):1472-7.


MCP-1 Promoter Polymorphism at 2518 is associated with metastasis of nasopharyngeal carcinoma after treatment.

Tse KP, Tsang NM, Chen KD, Li HP, Liang Y, Hsueh C, Chang KP, Yu JS, Hao SP, Hsieh LL, Chang YS.

Clin Cancer Res. 2007 Nov 1;13(21):6320-6.


Functional network analysis of the transcriptomes of mesenchymal stem cells derived from amniotic fluid, amniotic membrane, cord blood, and bone marrow.

Tsai MS, Hwang SM, Chen KD, Lee YS, Hsu LW, Chang YJ, Wang CN, Peng HH, Chang YL, Chao AS, Chang SD, Lee KD, Wang TH, Wang HS, Soong YK.

Stem Cells. 2007 Oct;25(10):2511-23. Epub 2007 Jun 7.


Selective adapter recruitment and differential signaling networks by VEGF vs. shear stress.

Wang Y, Chang J, Chen KD, Li S, Li JY, Wu C, Chien S.

Proc Natl Acad Sci U S A. 2007 May 22;104(21):8875-9. Epub 2007 May 11.


Nucleophosmin acts as a novel AP2alpha-binding transcriptional corepressor during cell differentiation.

Liu H, Tan BC, Tseng KH, Chuang CP, Yeh CW, Chen KD, Lee SC, Yung BY.

EMBO Rep. 2007 Apr;8(4):394-400. Epub 2007 Feb 23.

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