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Neutralizing Mutations Significantly Inhibit Amyloid Formation by Human Prion Protein and Decrease Its Cytotoxicity.

Huang JJ, Li XN, Liu WL, Yuan HY, Gao Y, Wang K, Tang B, Pang DW, Chen J, Liang Y.

J Mol Biol. 2019 Dec 7. pii: S0022-2836(19)30697-7. doi: 10.1016/j.jmb.2019.11.020. [Epub ahead of print]


Highly Enantioselective Construction of Strained Spiro[2,3]hexanes via Michael-Ring Expansion-Cyclization Cascade Strategy.

Zhao CG, Feng ZT, Xu GQ, Gao A, Chen JW, Wang ZY, Xu PF.

Angew Chem Int Ed Engl. 2019 Dec 10. doi: 10.1002/anie.201912834. [Epub ahead of print]


Blended learning in basic medical laboratory courses improves medical students' abilities in self-learning, understanding, and problem solving.

Chen J, Zhou J, Wang Y, Qi G, Xia C, Mo G, Zhang Z.

Adv Physiol Educ. 2020 Mar 1;44(1):9-14. doi: 10.1152/advan.00076.2019.


Discovery of a covalent inhibitor of KRASG12C (AMG 510) for the treatment of solid tumors.

Lanman BA, Allen JR, Allen JG, Amegadzie AK, Ashton KS, Booker SK, Chen JJ, Chen N, Frohn MJ, Goodman G, Kopecky DJ, Liu L, Lopez P, Low JD, Ma V, Minatti AE, Nguyen TT, Nishimura N, Pickrell AJ, Reed AB, Shin Y, Siegmund A, Tamayo NA, Tegley CM, Walton MC, Wang HL, Wurz RP, Xue M, Yang KC, Achanta P, Bartberger MD, Canon J, Hollis LS, McCarter JD, Mohr C, Rex K, Saiki AY, San Miguel T, Volak L, Wang KH, Whittington DA, Zech SG, Lipford JR, Cee VJ.

J Med Chem. 2019 Dec 10. doi: 10.1021/acs.jmedchem.9b01180. [Epub ahead of print]


Diastereo- and Enantioselective Synthesis of Quaternary α-Amino Acid Precursors by Copper-Catalyzed Propargylation.

Zhu Q, Meng B, Gu C, Xu Y, Chen J, Lei C, Wu X.

Org Lett. 2019 Dec 10. doi: 10.1021/acs.orglett.9b03894. [Epub ahead of print]


Selectfluor-Mediated Stereoselective [1 + 1 + 4 + 4] Dimerization of Styrylnaphthols.

Yang H, Sun HR, Xue RD, Wu ZB, Gou BB, Lei Y, Chen J, Zhou L.

Org Lett. 2019 Dec 10. doi: 10.1021/acs.orglett.9b03587. [Epub ahead of print]


Microstructural analysis of skeletal muscle force generation during aging.

Zhang Y, Chen JS, He Q, He X, Basava RR, Hodgson J, Sinha U, Sinha S.

Int J Numer Method Biomed Eng. 2019 Dec 9:e3295. doi: 10.1002/cnm.3295. [Epub ahead of print]


Sertraline/ICG-Loaded liposome for dual-modality imaging and effective chemo-photothermal combination therapy against Metastatic clear cell renal cell carcinoma.

Lei Y, Zeng L, Xie S, Fan K, Yu Y, Chen J, Zhang S, Wang Z, Zhong L.

Chem Biol Drug Des. 2019 Dec 9. doi: 10.1111/cbdd.13652. [Epub ahead of print]


Identification and characterization of microRNAs in phloem and xylem from ramie (Boehmeria nivea).

Liu F, Tang Y, Guo Q, Chen J.

Mol Biol Rep. 2019 Dec 9. doi: 10.1007/s11033-019-05193-9. [Epub ahead of print]


A nomogram for predicting 5-year incidence of type 2 diabetes in a Chinese population.

Lin Z, Guo D, Chen J, Zheng B.

Endocrine. 2019 Dec 9. doi: 10.1007/s12020-019-02154-x. [Epub ahead of print]


Proanthocyanidin-crosslinked collagen/konjac glucomannan hydrogel with improved mechanical properties and MRI trackable biodegradation for potential tissue engineering scaffolds.

Chen J, Cai Z, Wei Q, Wang D, Wu J, Tan Y, Lu J, Ai H.

J Mater Chem B. 2019 Dec 10. doi: 10.1039/c9tb02053e. [Epub ahead of print]


Retrospective Analysis Of Comparative Outcomes In Recurrent Platinum-Sensitive Ovarian Cancer Treated With Pegylated Liposomal Doxorubicin (Lipo-Dox) And Carboplatin Versus Paclitaxel And Carboplatin.

Weng CS, Wu CC, Chen TC, Chen JR, Huang CY, Chang CL.

Cancer Manag Res. 2019 Nov 21;11:9899-9905. doi: 10.2147/CMAR.S217329. eCollection 2019.


miR-509-5p Downregulation Is Associated With Male Infertility And Acts As A Suppressor In Testicular Germ Cell Tumor Cells Through Targeting MDM2.

Sun J, Niu L, Gao S, Yi X, Chen J.

Onco Targets Ther. 2019 Dec 2;12:10515-10522. doi: 10.2147/OTT.S215998. eCollection 2019.


Prevalence of DLL3, CTLA-4 and MSTN Expression in Patients with Small Cell Lung Cancer.

Regzedmaa O, Li Y, Li Y, Zhang H, Wang J, Gong H, Yuan Y, Li W, Liu H, Chen J.

Onco Targets Ther. 2019 Nov 21;12:10043-10055. doi: 10.2147/OTT.S216362. eCollection 2019.


The γ-tubulin complex protein GCP6 is crucial for spindle morphogenesis but not essential for microtubule reorganization in Arabidopsis.

Miao H, Guo R, Chen J, Wang Q, Lee YJ, Liu B.

Proc Natl Acad Sci U S A. 2019 Dec 9. pii: 201912240. doi: 10.1073/pnas.1912240116. [Epub ahead of print]


A study on a 210Pbex accumulation-decay model for dating moraine soils to trace glacier retreat time.

Chen J, Zhang X, Navas A, Wen A, Wang X, Zhang R.

J Environ Radioact. 2019 Dec 3;212:106124. doi: 10.1016/j.jenvrad.2019.106124. [Epub ahead of print]


Toxicological responses in human airway epithelial cells (BEAS-2B) exposed to particulate matter emissions from gasoline fuels with varying aromatic and ethanol levels.

Ahmed CMS, Yang J, Chen JY, Jiang H, Cullen C, Karavalakis G, Lin YH.

Sci Total Environ. 2019 Nov 24:135732. doi: 10.1016/j.scitotenv.2019.135732. [Epub ahead of print]


Minimally invasive surfactant therapy versus intubation for surfactant administration in very low birth weight infants with respiratory distress syndrome.

Wang XA, Chen LJ, Chen SM, Su PH, Chen JY.

Pediatr Neonatol. 2019 Nov 13. pii: S1875-9572(19)30542-X. doi: 10.1016/j.pedneo.2019.11.002. [Epub ahead of print]


Surface mineralized biphasic calcium phosphate ceramics loaded with urine-derived stem cells are effective in bone regeneration.

Xing F, Li L, Sun J, Liu G, Duan X, Chen J, Liu M, Long Y, Xiang Z.

J Orthop Surg Res. 2019 Dec 9;14(1):419. doi: 10.1186/s13018-019-1500-7.


Survival analysis of local excision vs total mesorectal excision for middle and low rectal cancer in pT1/pT2 stage and intermediate pathological risk.

Lai IL, You JF, Chern YJ, Tsai WS, Chiang JM, Hsieh PS, Hung HY, Yeh CY, Chiang SF, Lai CC, Tang RP, Chen JS, Hsu YJ.

World J Surg Oncol. 2019 Dec 9;17(1):212. doi: 10.1186/s12957-019-1763-9.


Pathogenic Leishmania spp. detected in lizards from Northwest China using molecular methods.

Zhang JR, Guo XG, Chen H, Liu JL, Gong X, Chen DL, Chen JP.

BMC Vet Res. 2019 Dec 9;15(1):446. doi: 10.1186/s12917-019-2174-4.


Influence of microcystins-LR (MC-LR) on autophagy in human neuroblastoma SK-N-SH cells.

Yang Y, Wen C, Zheng S, Liu W, Chen J, Feng X, Wang X, Yang F, Ding Z.

J Toxicol Environ Health A. 2019 Dec 9:1-8. doi: 10.1080/15287394.2019.1699732. [Epub ahead of print]


Effects of microcystins-LR on genotoxic responses in human intestinal epithelial cells (NCM460).

Wen C, Zheng S, Yang Y, Li X, Chen J, Wang X, Feng X, Yang F.

J Toxicol Environ Health A. 2019 Dec 9:1-7. doi: 10.1080/15287394.2019.1698498. [Epub ahead of print]


Neutrophils, as "Trojan horses", participate in the delivery of therapeutical PLGA nanoparticles into a tumor based on the chemotactic effect.

Hao J, Chen J, Wang M, Zhao J, Wang J, Wang X, Li Y, Tang H.

Drug Deliv. 2020 Dec;27(1):1-14. doi: 10.1080/10717544.2019.1701141.


GRK2 Mediated Abnormal Transduction of PGE2-EP4-cAMP-CREB Signaling Induces the Imbalance of Macrophages Polarization in Collagen-Induced Arthritis Mice.

Yang X, Li S, Zhao Y, Li S, Zhao T, Tai Y, Zhang B, Wang X, Wang C, Chen J, Wang Q, Zhang L, Xu D, Chang Y, Wei W.

Cells. 2019 Dec 8;8(12). pii: E1596. doi: 10.3390/cells8121596.


Quantitative Proteomic Analysis Uncovers the Mediation of Endoplasmic Reticulum Stress-Induced Autophagy in DHAV-1-Infected DEF Cells.

Lan J, Zhang R, Yu H, Wang J, Xue W, Chen J, Lin S, Wang Y, Xie Z, Jiang S.

Int J Mol Sci. 2019 Dec 6;20(24). pii: E6160. doi: 10.3390/ijms20246160.


Extended Target Echo Detection Based on KLD and Wigner Matrices.

Xie D, Wang F, Chen J.

Sensors (Basel). 2019 Dec 6;19(24). pii: E5385. doi: 10.3390/s19245385.


Frying Oil Evaluation by a Portable Sensor Based on Dielectric Constant Measurement.

Liu M, Qin X, Chen Z, Tang L, Borom B, Cao N, Barnes D, Cheng K, Chen J, Wang T, Rao J.

Sensors (Basel). 2019 Dec 5;19(24). pii: E5375. doi: 10.3390/s19245375.


Fluorescence Polarization Immunoassay for Determination of Enrofloxacin in Pork Liver and Chicken.

Shen X, Chen J, Lv S, Sun X, Dzantiev BB, Eremin SA, Zherdev AV, Xu J, Sun Y, Lei H.

Molecules. 2019 Dec 5;24(24). pii: E4462. doi: 10.3390/molecules24244462.


Improving the Wear Life of a-C:H Film in High Vacuum by Self-Assembled Reduced Graphene Oxide Layers.

Song H, Chen G, Chen J, Li H, Ji L, Jiang N.

Nanomaterials (Basel). 2019 Dec 5;9(12). pii: E1733. doi: 10.3390/nano9121733.


Genomic Survey, Transcriptome, and Metabolome Analysis of Apocynum venetum and Apocynum hendersonii to Reveal Major Flavonoid Biosynthesis Pathways.

Gao G, Chen P, Chen J, Chen K, Wang X, Abubakar AS, Liu N, Yu C, Zhu A.

Metabolites. 2019 Dec 5;9(12). pii: E296. doi: 10.3390/metabo9120296.


The Relationship between the Number of Daily Health-Related Behavioral Risk Factors and Sleep Health of the Elderly in China.

Liu X, Chen J, Zhou J, Liu J, Lertpitakpong C, Tan A, Wu S, Mao Z.

Int J Environ Res Public Health. 2019 Dec 4;16(24). pii: E4905. doi: 10.3390/ijerph16244905.


Towards the Exploitation of Physical Compliance in Segmented and Electrically Actuated Robotic Legs: A Review Focused on Elastic Mechanisms.

Chen J, Liang Z, Zhu Y, Liu C, Zhang L, Hao L, Zhao J.

Sensors (Basel). 2019 Dec 4;19(24). pii: E5351. doi: 10.3390/s19245351. Review.


Combination of area controllable sensing surface and bipolar electrode-electrochemiluminescence approach for the detection of tetracycline.

Jin L, Qiao J, Chen J, Xu N, Wu M.

Talanta. 2020 Feb 1;208:120404. doi: 10.1016/j.talanta.2019.120404. Epub 2019 Sep 28.


Changes in vitellogenin and estrogen receptor expression and 17β-estradiol concentration in male juvenile tilapia can be used to evaluate endocrine-disrupting chemicals.

Chen JR, Wu SM, Tsai SC, Hsien FC, Huang CT.

Comp Biochem Physiol C Toxicol Pharmacol. 2019 Dec 6:108682. doi: 10.1016/j.cbpc.2019.108682. [Epub ahead of print]


Clinical Decision Support for Ovarian Carcinoma Subtype Classification: A Pilot Observer Study With Pathology Trainees.

Gavrielides MA, Miller M, Hagemann IS, Abdelal H, Alipour Z, Chen JF, Salari B, Sun L, Zhou H, Seidman JD.

Arch Pathol Lab Med. 2019 Dec 9. doi: 10.5858/arpa.2019-0390-OA. [Epub ahead of print]


Low COMT and Stress Potentiate Functional Pain and Depressive Behavior, Especially in Female Mice.

Zhang X, Kanter K, Chen J, Kim S, Wang Y, Adeyemi C, O'Buckley SC, Nackley AG.

Pain. 2019 Dec 6. doi: 10.1097/j.pain.0000000000001734. [Epub ahead of print]


Cp*RhIII-Catalyzed Sulfonamide-Directed Ortho Arene C-H Carbenoid Functionalization with Pyridotriazoles.

Dong Y, Chen J, Cui Y, Bao L, Xu H.

Org Lett. 2019 Dec 9. doi: 10.1021/acs.orglett.9b03904. [Epub ahead of print]


Exploring the Activation Mechanism of a Metabotropic Glutamate Receptor Homodimer via Molecular Dynamics Simulation.

Lei T, Hu Z, Ding R, Chen J, Li S, Zhang F, Pu X, Zhao N.

ACS Chem Neurosci. 2019 Dec 9. doi: 10.1021/acschemneuro.9b00425. [Epub ahead of print]


MicroRNA-429 inhibits cancer cell proliferation and migration by targeting AKT1 in renal cell carcinoma.

Su Z, Jiang G, Chen J, Liu X, Zhao H, Fang Z, He Y, Jiang X, Xu G.

Mol Clin Oncol. 2020 Jan;12(1):75-80. doi: 10.3892/mco.2019.1940. Epub 2019 Oct 25.


Fibroblast growth factor 10 protects against particulate matter-induced airway inflammatory response through regulating inflammatory signaling and apoptosis.

Liu L, Xia Z, Li J, Hu Y, Wang Q, Chen J, Fan S, Wu J, Dong N, Chen C.

Am J Transl Res. 2019 Nov 15;11(11):6977-6988. eCollection 2019.


Intra-articular injection of etoricoxib-loaded PLGA-PEG-PLGA triblock copolymeric nanoparticles attenuates osteoarthritis progression.

Liu P, Gu L, Ren L, Chen J, Li T, Wang X, Yang J, Chen C, Sun L.

Am J Transl Res. 2019 Nov 15;11(11):6775-6789. eCollection 2019.


Combination of contrast-enhanced ultrasound and strain elastography to assess cytologically non-diagnostic thyroid nodules.

Lin ZM, Wen Q, Yan CX, Pan MQ, Mo GQ, Chen JF, Huang PT.

Oncol Lett. 2019 Dec;18(6):6845-6851. doi: 10.3892/ol.2019.11058. Epub 2019 Nov 5.


Prx1-Expressing Progenitor Primary Cilia Mediate Bone Formation in response to Mechanical Loading in Mice.

Moore ER, Chen JC, Jacobs CR.

Stem Cells Int. 2019 Nov 11;2019:3094154. doi: 10.1155/2019/3094154. eCollection 2019.


Radiologic Complete Response In Lung Adenocarcinoma With Symptomatic Brain Metastasis After Systematic Therapy: A Case Study.

Chen J, Wang J, Zheng Q, Weng M, Wu X.

Onco Targets Ther. 2019 Nov 11;12:9551-9557. doi: 10.2147/OTT.S226735. eCollection 2019.


Texture analysis on gadoxetic acid enhanced-MRI for predicting Ki-67 status in hepatocellular carcinoma: A prospective study.

Ye Z, Jiang H, Chen J, Liu X, Wei Y, Xia C, Duan T, Cao L, Zhang Z, Song B.

Chin J Cancer Res. 2019 Oct;31(5):806-817. doi: 10.21147/j.issn.1000-9604.2019.05.10.


Technical Modification of the Terminal Ureter During Total Transperitoneal Laparoscopic Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma.

Fu C, Zhang Y, Wang X, Zhu S, Hou H, Liu S, Pang C, Song X, Chen J, Wang J, Liu M.

J Vis Exp. 2019 Nov 22;(153). doi: 10.3791/60662.


Microwave ablation of hepatic malignant tumors using 1.5T MRI guidance and monitoring: feasibility and preliminary clinical experience.

Lin Z, Chen J, Yan Y, Chen J, Li Y.

Int J Hyperthermia. 2019;36(1):1216-1222. doi: 10.1080/02656736.2019.1690166.


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