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Randomized, Multicenter, Phase II Trial of Gemcitabine and Cisplatin With or Without Veliparib in Patients With Pancreas Adenocarcinoma and a Germline BRCA/PALB2 Mutation.

O'Reilly EM, Lee JW, Zalupski M, Capanu M, Park J, Golan T, Tahover E, Lowery MA, Chou JF, Sahai V, Brenner R, Kindler HL, Yu KH, Zervoudakis A, Vemuri S, Stadler ZK, Do RKG, Dhani N, Chen AP, Kelsen DP.

J Clin Oncol. 2020 Jan 24:JCO1902931. doi: 10.1200/JCO.19.02931. [Epub ahead of print]


Trametinib activity in patients with solid tumors and lymphomas harboring BRAF non-V600 mutations or fusions: results from NCI-MATCH (EAY131).

Johnson DB, Zhao F, Noel MS, Riely GJ, Mitchell EP, Wright JJ, Chen HX, Gray RJ, Li S, McShane LM, Rubinstein L, Patton D, Williams M, Hamilton SR, Conley BA, Arteaga CL, Harris LN, O'Dwyer PJ, Chen AP, Flaherty KT.

Clin Cancer Res. 2020 Jan 10. pii: clincanres.3443.2019. doi: 10.1158/1078-0432.CCR-19-3443. [Epub ahead of print]


Nanowrinkled Carbon Aerogels Embedded with FeN x Sites as Effective Oxygen Electrodes for Rechargeable Zinc-Air Battery.

He T, Lu B, Chen Y, Wang Y, Zhang Y, Davenport JL, Chen AP, Pao CW, Liu M, Sun Z, Stram A, Mordaunt A, Velasco J Jr, Ping Y, Zhang Y, Chen S.

Research (Wash D C). 2019 Dec 20;2019:6813585. doi: 10.34133/2019/6813585. eCollection 2019.


[Effect of GPX4 on proliferation and metastasis of renal clear cell carcinoma and its relationship with expression of IGF-1R and COX-2].

Su Y, Zhao A, Chen AP, Liu XZ, Tian YP, Jin JY.

Zhonghua Bing Li Xue Za Zhi. 2019 Dec 8;48(12):955-960. doi: 10.3760/cma.j.issn.0529-5807.2019.12.008. Chinese.


Nivolumab Is Effective in Mismatch Repair-Deficient Noncolorectal Cancers: Results From Arm Z1D-A Subprotocol of the NCI-MATCH (EAY131) Study.

Azad NS, Gray RJ, Overman MJ, Schoenfeld JD, Mitchell EP, Zwiebel JA, Sharon E, Streicher H, Li S, McShane LM, Rubinstein L, Patton DR, Williams PM, Coffey B, Hamilton SR, Bahary N, Suga JM, Hatoum H, Abrams JS, Conley BA, Arteaga CL, Harris L, O'Dwyer PJ, Chen AP, Flaherty KT.

J Clin Oncol. 2020 Jan 20;38(3):214-222. doi: 10.1200/JCO.19.00818. Epub 2019 Nov 25.


Clinical Evolution of Epithelial-Mesenchymal Transition in Human Carcinomas.

Navas T, Kinders RJ, Lawrence SM, Ferry-Galow KV, Borgel S, Hollingshead MG, Srivastava AK, Alcoser SY, Makhlouf HR, Chuaqui R, Wilsker DF, Konaté MM, Miller SB, Voth AR, Chen L, Vilimas T, Subramanian J, Rubinstein L, Kummar S, Chen AP, Bottaro DP, Doroshow JH, Parchment RE.

Cancer Res. 2020 Jan 15;80(2):304-318. doi: 10.1158/0008-5472.CAN-18-3539. Epub 2019 Nov 15.


Partial Fourier reconstruction for improved resolution in 3D hyperpolarized 13 C EPI.

Geraghty BJ, Lee CY, Chen AP, Perks WJ, Soliman H, Cunningham CH.

Magn Reson Med. 2019 Nov 13. doi: 10.1002/mrm.28079. [Epub ahead of print]


Using mind mapping technology for personal preparedness planning.

Chen AP, Chang AH, Hsu EB.

Am J Disaster Med. 2019 Spring;14(2):96-100. doi: 10.5055/ajdm.2019.0320.


Hyperpolarized MRI of Human Prostate Cancer Reveals Increased Lactate with Tumor Grade Driven by Monocarboxylate Transporter 1.

Granlund KL, Tee SS, Vargas HA, Lyashchenko SK, Reznik E, Fine S, Laudone V, Eastham JA, Touijer KA, Reuter VE, Gonen M, Sosa RE, Nicholson D, Guo YW, Chen AP, Tropp J, Robb F, Hricak H, Keshari KR.

Cell Metab. 2020 Jan 7;31(1):105-114.e3. doi: 10.1016/j.cmet.2019.08.024. Epub 2019 Sep 26.


Lactate topography of the human brain using hyperpolarized 13C-MRI.

Lee CY, Soliman H, Geraghty BJ, Chen AP, Connelly KA, Endre R, Perks WJ, Heyn C, Black SE, Cunningham CH.

Neuroimage. 2020 Jan 1;204:116202. doi: 10.1016/j.neuroimage.2019.116202. Epub 2019 Sep 23.


Genetic targeting of astrocytes to combat neurodegenerative disease.

Kery R, Chen APF, Kirschen GW.

Neural Regen Res. 2020 Feb;15(2):199-211. doi: 10.4103/1673-5374.265541.


Phase 1 study of veliparib (ABT-888), a poly (ADP-ribose) polymerase inhibitor, with carboplatin and paclitaxel in advanced solid malignancies.

Appleman LJ, Beumer JH, Jiang Y, Lin Y, Ding F, Puhalla S, Swartz L, Owonikoko TK, Donald Harvey R, Stoller R, Petro DP, Tawbi HA, Argiris A, Strychor S, Pouquet M, Kiesel B, Chen AP, Gandara D, Belani CP, Chu E, Ramalingam SS.

Cancer Chemother Pharmacol. 2019 Dec;84(6):1289-1301. doi: 10.1007/s00280-019-03960-w. Epub 2019 Sep 23.


Ado-trastuzumab emtansine (T-DM1) in patients with HER2-amplified tumors excluding breast and gastric/gastroesophageal junction (GEJ) adenocarcinomas: results from the NCI-MATCH trial (EAY131) subprotocol Q.

Jhaveri KL, Wang XV, Makker V, Luoh SW, Mitchell EP, Zwiebel JA, Sharon E, Gray RJ, Li S, McShane LM, Rubinstein LV, Patton D, Williams PM, Hamilton SR, Conley BA, Arteaga CL, Harris LN, O'Dwyer PJ, Chen AP, Flaherty KT.

Ann Oncol. 2019 Nov 1;30(11):1821-1830. doi: 10.1093/annonc/mdz291.


Cediranib phase-II study in children with metastatic alveolar soft-part sarcoma (ASPS).

Cohen JW, Widemann BC, Derdak J, Dombi E, Goodwin A, Dompierre J, Onukwubiri U, Steinberg SM, O'Sullivan Coyne G, Kummar S, Chen AP, Glod J.

Pediatr Blood Cancer. 2019 Dec;66(12):e27987. doi: 10.1002/pbc.27987. Epub 2019 Sep 10.


Imaging of glucose metabolism by 13C-MRI distinguishes pancreatic cancer subtypes in mice.

Kishimoto S, Brender JR, Crooks DR, Matsumoto S, Seki T, Oshima N, Merkle H, Lin P, Reed G, Chen AP, Ardenkjaer-Larsen JH, Munasinghe J, Saito K, Yamamoto K, Choyke PL, Mitchell J, Lane AN, Fan TW, Linehan WM, Krishna MC.

Elife. 2019 Aug 13;8. pii: e46312. doi: 10.7554/eLife.46312.


Differentiations in Gene Content and Expression Response to Virulence Induction Between Two Agrobacterium Strains.

Haryono M, Cho ST, Fang MJ, Chen AP, Chou SJ, Lai EM, Kuo CH.

Front Microbiol. 2019 Jul 9;10:1554. doi: 10.3389/fmicb.2019.01554. eCollection 2019.


National Cancer Institute Basket/Umbrella Clinical Trials: MATCH, LungMAP, and Beyond.

Chen AP, Eljanne M, Harris L, Malik S, Seibel NL.

Cancer J. 2019 Jul/Aug;25(4):272-281. doi: 10.1097/PPO.0000000000000389.


A phase I pharmacokinetic study of belinostat in patients with advanced cancers and varying degrees of liver dysfunction.

Takebe N, Beumer JH, Kummar S, Kiesel BF, Dowlati A, O'Sullivan Coyne G, Piekarz R, Rubinstein L, Fogli LK, Vaishampayan U, Goel S, O'Bryant CL, El-Rayes BF, Chung V, Lenz HJ, Kim R, Belani CP, Tuscano JM, Schelman W, Moore N, Doroshow JH, Chen AP.

Br J Clin Pharmacol. 2019 Nov;85(11):2499-2511. doi: 10.1111/bcp.14054. Epub 2019 Sep 4.


Effects of Luo Han Guo on throat complications associated with tracheal intubation: a randomized controlled trial.

Tan HL, Liang YK, Li YM, Qiu LY, Huang R, Guo L, Yang XH, Lu HX, Liang HM, Chen AP.

J Int Med Res. 2019 Jul;47(7):3203-3211. doi: 10.1177/0300060519853656. Epub 2019 Jun 12. No abstract available.


The use of research biopsies in oncology trials: challenges and controversies.

Ferry-Galow KV, Chen AP.

J Hosp Manag Health Policy. 2019 Apr;3. pii: 7. doi: 10.21037/jhmhp.2019.03.01. Epub 2019 Apr 1. No abstract available.


Vacancy-Induced Synaptic Behavior in 2D WS2 Nanosheet-Based Memristor for Low-Power Neuromorphic Computing.

Yan X, Zhao Q, Chen AP, Zhao J, Zhou Z, Wang J, Wang H, Zhang L, Li X, Xiao Z, Wang K, Qin C, Wang G, Pei Y, Li H, Ren D, Chen J, Liu Q.

Small. 2019 Jun;15(24):e1901423. doi: 10.1002/smll.201901423. Epub 2019 May 2.


Dynamic Imaging of Glucose and Lactate Metabolism by 13C-MRS without Hyperpolarization.

Brender JR, Kishimoto S, Merkle H, Reed G, Hurd RE, Chen AP, Ardenkjaer-Larsen JH, Munasinghe J, Saito K, Seki T, Oshima N, Yamamoto K, Choyke PL, Mitchell J, Krishna MC.

Sci Rep. 2019 Mar 4;9(1):3410. doi: 10.1038/s41598-019-38981-1.


What Can Be Done to Improve Research Biopsy Quality in Oncology Clinical Trials?

Ferry-Galow KV, Datta V, Makhlouf HR, Wright J, Wood BJ, Levy E, Pisano ED, Tam AL, Lee SI, Mahmood U, Rubinstein LV, Doroshow JH, Chen AP.

J Oncol Pract. 2018 Oct 4:JOP1800092. doi: 10.1200/JOP.18.00092. [Epub ahead of print]


A Phase I Study of Ganetespib and Ziv-Aflibercept in Patients with Advanced Carcinomas and Sarcomas.

Meehan R, Kummar S, Do K, O'Sullivan Coyne G, Juwara L, Zlott J, Rubinstein L, Doroshow JH, Chen AP.

Oncologist. 2018 Nov;23(11):1269-e125. doi: 10.1634/theoncologist.2018-0203. Epub 2018 May 31.


Metabolic Imaging of the Human Brain with Hyperpolarized 13C Pyruvate Demonstrates 13C Lactate Production in Brain Tumor Patients.

Miloushev VZ, Granlund KL, Boltyanskiy R, Lyashchenko SK, DeAngelis LM, Mellinghoff IK, Brennan CW, Tabar V, Yang TJ, Holodny AI, Sosa RE, Guo YW, Chen AP, Tropp J, Robb F, Keshari KR.

Cancer Res. 2018 Jul 15;78(14):3755-3760. doi: 10.1158/0008-5472.CAN-18-0221. Epub 2018 May 16.


In vivo hyperpolarization transfer in a clinical MRI scanner.

von Morze C, Reed GD, Larson PE, Mammoli D, Chen AP, Tropp J, Van Criekinge M, Ohliger MA, Kurhanewicz J, Vigneron DB, Merritt ME.

Magn Reson Med. 2018 Aug;80(2):480-487. doi: 10.1002/mrm.27154. Epub 2018 Feb 27.


Simultaneous multislice acquisition without trajectory modification for hyperpolarized 13 C experiments.

Lau AZ, Lau JYC, Chen AP, Cunningham CH.

Magn Reson Med. 2018 Oct;80(4):1588-1594. doi: 10.1002/mrm.27136. Epub 2018 Feb 9.


Improved tolerance to off-resonance in spectral-spatial EPI of hyperpolarized [1-13 C]pyruvate and metabolites.

Lau JYC, Geraghty BJ, Chen AP, Cunningham CH.

Magn Reson Med. 2018 Sep;80(3):925-934. doi: 10.1002/mrm.27086. Epub 2018 Jan 29. No abstract available.


Phase 1 trial evaluating cisplatin, gemcitabine, and veliparib in 2 patient cohorts: Germline BRCA mutation carriers and wild-type BRCA pancreatic ductal adenocarcinoma.

O'Reilly EM, Lee JW, Lowery MA, Capanu M, Stadler ZK, Moore MJ, Dhani N, Kindler HL, Estrella H, Maynard H, Golan T, Segal A, Salo-Mullen EE, Yu KH, Epstein AS, Segal M, Brenner R, Do RK, Chen AP, Tang LH, Kelsen DP.

Cancer. 2018 Apr 1;124(7):1374-1382. doi: 10.1002/cncr.31218. Epub 2018 Jan 16.


Magnetization Reversal Modes in Short Nanotubes with Chiral Vortex Domain Walls.

Chen AP, Gonzalez J, Guslienko K.

Materials (Basel). 2018 Jan 10;11(1). pii: E101. doi: 10.3390/ma11010101.


Phf8 histone demethylase deficiency causes cognitive impairments through the mTOR pathway.

Chen X, Wang S, Zhou Y, Han Y, Li S, Xu Q, Xu L, Zhu Z, Deng Y, Yu L, Song L, Chen AP, Song J, Takahashi E, He G, He L, Li W, Chen CD.

Nat Commun. 2018 Jan 9;9(1):114. doi: 10.1038/s41467-017-02531-y.


Clinical outcome and long-term survival of 150 consecutive patients with pancreatic neuroendocrine tumors: A comprehensive analysis by the World Health Organization 2010 grading classification.

Deng BY, Liu F, Yin SN, Chen AP, Xu L, Li B.

Clin Res Hepatol Gastroenterol. 2018 Jun;42(3):261-268. doi: 10.1016/j.clinre.2017.09.004. Epub 2018 Jan 5.


Phase II trial of veliparib in patients with previously treated BRCA-mutated pancreas ductal adenocarcinoma.

Lowery MA, Kelsen DP, Capanu M, Smith SC, Lee JW, Stadler ZK, Moore MJ, Kindler HL, Golan T, Segal A, Maynard H, Hollywood E, Moynahan M, Salo-Mullen EE, Do RKG, Chen AP, Yu KH, Tang LH, O'Reilly EM.

Eur J Cancer. 2018 Jan;89:19-26. doi: 10.1016/j.ejca.2017.11.004. Epub 2017 Dec 8.


Sensitivity enhancement for detection of hyperpolarized 13 C MRI probes with 1 H spin coupling introduced by enzymatic transformation in vivo.

von Morze C, Tropp J, Chen AP, Marco-Rius I, Van Criekinge M, Skloss TW, Mammoli D, Kurhanewicz J, Vigneron DB, Ohliger MA, Merritt ME.

Magn Reson Med. 2018 Jul;80(1):36-41. doi: 10.1002/mrm.27000. Epub 2017 Nov 28.


Hidradenitis Suppurativa-Like Lesions Associated with Pharmacologic Inhibition of Gamma-Secretase.

O'Sullivan Coyne G, Woodring TS, Lee CR, Chen AP, Kong HH.

J Invest Dermatol. 2018 Apr;138(4):979-981. doi: 10.1016/j.jid.2017.09.051. Epub 2017 Nov 11. No abstract available.


Probing the cardiac malate-aspartate shuttle non-invasively using hyperpolarized [1,2-13 C2 ]pyruvate.

Chen AP, Lau AZ, Gu YP, Schroeder MA, Barry J, Cunningham CH.

NMR Biomed. 2018 Jan;31(1). doi: 10.1002/nbm.3845. Epub 2017 Nov 6.


First-in-human study of the epichaperome inhibitor PU-H71: clinical results and metabolic profile.

Speranza G, Anderson L, Chen AP, Do K, Eugeni M, Weil M, Rubinstein L, Majerova E, Collins J, Horneffer Y, Juwara L, Zlott J, Bishop R, Conley BA, Streicher H, Tomaszewski J, Doroshow JH, Kummar S.

Invest New Drugs. 2018 Apr;36(2):230-239. doi: 10.1007/s10637-017-0495-3. Epub 2017 Aug 12.


Epitaxial thin films of pyrochlore iridate Bi2+xIr2-yO7-δ: structure, defects and transport properties.

Yang WC, Xie YT, Zhu WK, Park K, Chen AP, Losovyj Y, Li Z, Liu HM, Starr M, Acosta JA, Tao CG, Li N, Jia QX, Heremans JJ, Zhang SX.

Sci Rep. 2017 Aug 10;7(1):7740. doi: 10.1038/s41598-017-06785-w.


Highly Absorbent Antibacterial Hemostatic Dressing for Healing Severe Hemorrhagic Wounds.

Li TT, Lou CW, Chen AP, Lee MC, Ho TF, Chen YS, Lin JH.

Materials (Basel). 2016 Sep 21;9(9). pii: E793. doi: 10.3390/ma9090793.


T1 nuclear magnetic relaxation dispersion of hyperpolarized sodium and cesium hydrogencarbonate-13 C.

Martínez-Santiesteban FM, Dang TP, Lim H, Chen AP, Scholl TJ.

NMR Biomed. 2017 Sep;30(9). doi: 10.1002/nbm.3749. Epub 2017 Jun 27.


Black Tungsten Nitride as a Metallic Photocatalyst for Overall Water Splitting Operable at up to 765 nm.

Wang YL, Nie T, Li YH, Wang XL, Zheng LR, Chen AP, Gong XQ, Yang HG.

Angew Chem Int Ed Engl. 2017 Jun 19;56(26):7430-7434. doi: 10.1002/anie.201702943. Epub 2017 May 30.


Plasmon-enhanced Raman spectroscopic metrics for in situ quantitative and dynamic assays of cell apoptosis and necrosis.

Kang B, Li SS, Guan QY, Chen AP, Zhang PK, Zhang LB, Wei JW, Xu JJ, Chen HY.

Chem Sci. 2017 Feb 1;8(2):1243-1250. doi: 10.1039/c6sc02486f. Epub 2016 Oct 3.


Dual-Echo EPI sequence for integrated distortion correction in 3D time-resolved hyperpolarized 13 C MRI.

Geraghty BJ, Lau JYC, Chen AP, Cunningham CH.

Magn Reson Med. 2018 Feb;79(2):643-653. doi: 10.1002/mrm.26698. Epub 2017 Apr 10.


Defining precision: The precision medicine initiative trials NCI-MPACT and NCI-MATCH.

Coyne GO, Takebe N, Chen AP.

Curr Probl Cancer. 2017 May - Jun;41(3):182-193. doi: 10.1016/j.currproblcancer.2017.02.001. Epub 2017 Feb 11.


Subcellular-Scale Drug Transport via Ultrasound-Degradable Mesoporous Nanosilicon to Bypass Cancer Drug Resistance.

Kang B, Zheng MB, Song P, Chen AP, Wei JW, Xu JJ, Shi Y, Chen HY.

Small. 2017 May;13(20). doi: 10.1002/smll.201604228. Epub 2017 Mar 30.


Efficacy of the PARP Inhibitor Veliparib with Carboplatin or as a Single Agent in Patients with Germline BRCA1- or BRCA2-Associated Metastatic Breast Cancer: California Cancer Consortium Trial NCT01149083.

Somlo G, Frankel PH, Arun BK, Ma CX, Garcia AA, Cigler T, Cream LV, Harvey HA, Sparano JA, Nanda R, Chew HK, Moynihan TJ, Vahdat LT, Goetz MP, Beumer JH, Hurria A, Mortimer J, Piekarz R, Sand S, Herzog J, Van Tongeren LR, Ferry-Galow KV, Chen AP, Ruel C, Newman EM, Gandara DR, Weitzel JN.

Clin Cancer Res. 2017 Aug 1;23(15):4066-4076. doi: 10.1158/1078-0432.CCR-16-2714. Epub 2017 Mar 29.


Clinical Activity of the γ-Secretase Inhibitor PF-03084014 in Adults With Desmoid Tumors (Aggressive Fibromatosis).

Kummar S, O'Sullivan Coyne G, Do KT, Turkbey B, Meltzer PS, Polley E, Choyke PL, Meehan R, Vilimas R, Horneffer Y, Juwara L, Lih A, Choudhary A, Mitchell SA, Helman LJ, Doroshow JH, Chen AP.

J Clin Oncol. 2017 May 10;35(14):1561-1569. doi: 10.1200/JCO.2016.71.1994. Epub 2017 Mar 28.


Phosphorylated fraction of H2AX as a measurement for DNA damage in cancer cells and potential applications of a novel assay.

Ji J, Zhang Y, Redon CE, Reinhold WC, Chen AP, Fogli LK, Holbeck SL, Parchment RE, Hollingshead M, Tomaszewski JE, Dudon Q, Pommier Y, Doroshow JH, Bonner WM.

PLoS One. 2017 Feb 3;12(2):e0171582. doi: 10.1371/journal.pone.0171582. eCollection 2017.


Rhodium Dopants on Zn2 GeO4 Surfaces as Active Sites for Photocatalytic Water Splitting.

Wang YL, Li YH, Wang XL, Chen AP, Yang HG.

Chempluschem. 2017 Feb;82(2):199-203. doi: 10.1002/cplu.201600445. Epub 2016 Oct 12.


PARP Inhibitors in Reproductive System Cancers: Current Use and Developments.

O'Sullivan Coyne G, Chen AP, Meehan R, Doroshow JH.

Drugs. 2017 Feb;77(2):113-130. doi: 10.1007/s40265-016-0688-7. Review.

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