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Application of N-Dodecyl l-Peptide to Enhance Serum Stability while Maintaining Inhibitory Effects on Myometrial Contractions Ex Vivo.

Poupart J, Hou X, Chemtob S, Lubell WD.

Molecules. 2019 Nov 15;24(22). pii: E4141. doi: 10.3390/molecules24224141.


Propranolol Attenuates Proangiogenic Activity of Mononuclear Phagocytes: Implication in Choroidal Neovascularization.

Omri S, Tahiri H, Pierre WC, Desjarlais M, Lahaie I, Loiselle SE, Rezende F, Lodygensky G, Hebert TE, Ong H, Chemtob S.

Invest Ophthalmol Vis Sci. 2019 Nov 1;60(14):4632-4642. doi: 10.1167/iovs.18-25502.


Immunometabolic modulation of retinal inflammation by CD36 ligand.

Mellal K, Omri S, Mulumba M, Tahiri H, Fortin C, Dorion MF, Pham H, Garcia Ramos Y, Zhang J, Pundir S, Joyal JS, Bouchard JF, Sennlaub F, Febbraio M, Hardy P, Gravel SP, Marleau S, Lubell WD, Chemtob S, Ong H.

Sci Rep. 2019 Sep 9;9(1):12903. doi: 10.1038/s41598-019-49472-8.


The Inability of the Choroid to Revascularize in Oxygen-Induced Retinopathy Results from Increased p53/miR-Let-7b Activity.

Zhou TE, Zhu T, Rivera JC, Omri S, Tahiri H, Lahaie I, Rouget R, Wirth M, Nattel S, Lodygensky G, Ferbeyre G, Nezhady M, Desjarlais M, Hamel P, Chemtob S.

Am J Pathol. 2019 Nov;189(11):2340-2356. doi: 10.1016/j.ajpath.2019.07.009. Epub 2019 Aug 17.


Assessing therapeutic response non-invasively in a neonatal rat model of acute inflammatory white matter injury using high-field MRI.

Pierre WC, Akakpo L, Londono I, Pouliot P, Chemtob S, Lesage F, Lodygensky GA.

Brain Behav Immun. 2019 Oct;81:348-360. doi: 10.1016/j.bbi.2019.06.032. Epub 2019 Jun 24.


Müller Cell-Localized G-Protein-Coupled Receptor 81 (Hydroxycarboxylic Acid Receptor 1) Regulates Inner Retinal Vasculature via Norrin/Wnt Pathways.

Madaan A, Chaudhari P, Nadeau-Vallée M, Hamel D, Zhu T, Mitchell G, Samuels M, Pundir S, Dabouz R, Howe Cheng CW, Mohammad Nezhady MA, Joyal JS, Rivera JC, Chemtob S.

Am J Pathol. 2019 Sep;189(9):1878-1896. doi: 10.1016/j.ajpath.2019.05.016. Epub 2019 Jun 18.


MicroRNA expression profile in retina and choroid in oxygen-induced retinopathy model.

Desjarlais M, Rivera JC, Lahaie I, Cagnone G, Wirt M, Omri S, Chemtob S.

PLoS One. 2019 Jun 12;14(6):e0218282. doi: 10.1371/journal.pone.0218282. eCollection 2019.


Induced and spontaneous colitis mouse models reveal complex interactions between IL-10 and IL-12/IL-23 pathways.

Hurtubise R, Audiger C, Dominguez-Punaro MC, Chabot-Roy G, Chognard G, Raymond-Marchand L, Coderre L, Chemtob S, Michnick SW, Rioux JD, Lesage S.

Cytokine. 2019 Sep;121:154738. doi: 10.1016/j.cyto.2019.154738. Epub 2019 May 31.


Paired Utility of Aza-Amino Acyl Proline and Indolizidinone Amino Acid Residues for Peptide Mimicry: Conception of Prostaglandin F2α Receptor Allosteric Modulators That Delay Preterm Birth.

Mir FM, Atmuri NDP, Bourguet CB, Fores JR, Hou X, Chemtob S, Lubell WD.

J Med Chem. 2019 May 9;62(9):4500-4525. doi: 10.1021/acs.jmedchem.9b00056. Epub 2019 Apr 23.


Probing Anti-inflammatory Properties Independent of NF-κB Through Conformational Constraint of Peptide-Based Interleukin-1 Receptor Biased Ligands.

Geranurimi A, Cheng CWH, Quiniou C, Zhu T, Hou X, Rivera JC, St-Cyr DJ, Beauregard K, Bernard-Gauthier V, Chemtob S, Lubell WD.

Front Chem. 2019 Feb 13;7:23. doi: 10.3389/fchem.2019.00023. eCollection 2019.


Cooperative effects of sequential PGF2α and IL-1β on IL-6 and COX-2 expression in human myometrial cells†.

Leimert KB, Verstraeten BSE, Messer A, Nemati R, Blackadar K, Fang X, Robertson SA, Chemtob S, Olson DM.

Biol Reprod. 2019 May 1;100(5):1370-1385. doi: 10.1093/biolre/ioz029.


Multifactorial contributions to WINROP to enhance prediction of severe retinopathy of prematurity.

Wirth M, Desjarlais M, Chemtob S, Hascoët JM.

Acta Paediatr. 2019 Jun;108(6):1170. doi: 10.1111/apa.14736. Epub 2019 Feb 17. No abstract available.


Maternal and fetal intrauterine tissue crosstalk promotes proinflammatory amplification and uterine transition†.

Leimert KB, Messer A, Gray T, Fang X, Chemtob S, Olson DM.

Biol Reprod. 2019 Mar 1;100(3):783-797. doi: 10.1093/biolre/ioy232.


Evaluating the neuroprotective effect of 17β-estradiol in rodent models of oxidative retinopathies.

Chaychi S, Polosa A, Chemtob S, Lachapelle P.

Doc Ophthalmol. 2018 Dec;137(3):151-168. doi: 10.1007/s10633-018-9658-6. Epub 2018 Oct 27.


Azasulfurylpeptide Modulation of CD36-Mediated Inflammation Without Effect on Neovascularization.

Turcotte S, Mellal K, Chingle R, Mulumba M, Omri S, Dif-Yaiche L, Chemtob S, Ong H, Lubell WD.

Biomedicines. 2018 Oct 22;6(4). pii: E98. doi: 10.3390/biomedicines6040098.


Antitumor activity of cell-penetrant kinin B1 receptor antagonists in human triple-negative breast cancer cells.

Dubuc C, Savard M, Bovenzi V, Lessard A, Côté J, Neugebauer W, Geha S, Chemtob S, Gobeil F Jr.

J Cell Physiol. 2019 Mar;234(3):2851-2865. doi: 10.1002/jcp.27103. Epub 2018 Aug 21.


Antenatal IL-1-dependent inflammation persists postnatally and causes retinal and sub-retinal vasculopathy in progeny.

Beaudry-Richard A, Nadeau-Vallée M, Prairie É, Maurice N, Heckel É, Nezhady M, Pundir S, Madaan A, Boudreault A, Hou X, Quiniou C, Sierra EM, Beaulac A, Lodygensky G, Robertson SA, Keelan J, Adams-Waldorf K, Olson DM, Rivera JC, Lubell WD, Joyal JS, Bouchard JF, Chemtob S.

Sci Rep. 2018 Aug 8;8(1):11875. doi: 10.1038/s41598-018-30087-4.


Receptors of intermediates of carbohydrate metabolism, GPR91 and GPR99, mediate axon growth.

Cherif H, Duhamel F, Cécyre B, Bouchard A, Quintal A, Chemtob S, Bouchard JF.

PLoS Biol. 2018 May 17;16(5):e2003619. doi: 10.1371/journal.pbio.2003619. eCollection 2018 May.


Targeting intracellular B2 receptors using novel cell-penetrating antagonists to arrest growth and induce apoptosis in human triple-negative breast cancer.

Dubuc C, Savard M, Bovenzi V, Lessard A, Fortier A, Côté J, Neugebauer W, Rizzolio F, Geha S, Giordano A, Chemtob S, Gobeil F.

Oncotarget. 2018 Jan 5;9(11):9885-9906. doi: 10.18632/oncotarget.24009. eCollection 2018 Feb 9.


Ischemic Retinopathies: Oxidative Stress and Inflammation.

Rivera JC, Dabouz R, Noueihed B, Omri S, Tahiri H, Chemtob S.

Oxid Med Cell Longev. 2017;2017:3940241. doi: 10.1155/2017/3940241. Epub 2017 Dec 19. Review.


miR-126-5p promotes retinal endothelial cell survival through SetD5 regulation in neurons.

Villain G, Poissonnier L, Noueihed B, Bonfils G, Rivera JC, Chemtob S, Soncin F, Mattot V.

Development. 2018 Jan 8;145(1). pii: dev156232. doi: 10.1242/dev.156232.


Influences of Histidine-1 and Azaphenylalanine-4 on the Affinity, Anti-inflammatory, and Antiangiogenic Activities of Azapeptide Cluster of Differentiation 36 Receptor Modulators.

Chignen Possi K, Mulumba M, Omri S, Garcia-Ramos Y, Tahiri H, Chemtob S, Ong H, Lubell WD.

J Med Chem. 2017 Nov 22;60(22):9263-9274. doi: 10.1021/acs.jmedchem.7b01209. Epub 2017 Nov 1.


Tetrahydrobiopterin (BH4) deficiency is associated with augmented inflammation and microvascular degeneration in the retina.

Rivera JC, Noueihed B, Madaan A, Lahaie I, Pan J, Belik J, Chemtob S.

J Neuroinflammation. 2017 Sep 6;14(1):181. doi: 10.1186/s12974-017-0955-x.


Preterm Birth and Neonatal Injuries: Importance of Interleukin-1 and Potential of Interleukin-1 Receptor Antagonists.

Nadeau-Vallee M, Obari D, Beaudry-Richard A, Sierra EM, Beaulac A, Maurice N, Olson DM, Chemtob S.

Curr Pharm Des. 2017;23(40):6132-6141. doi: 10.2174/1381612823666170825145114. Review.


Retinopathy of prematurity: inflammation, choroidal degeneration, and novel promising therapeutic strategies.

Rivera JC, Holm M, Austeng D, Morken TS, Zhou TE, Beaudry-Richard A, Sierra EM, Dammann O, Chemtob S.

J Neuroinflammation. 2017 Aug 22;14(1):165. doi: 10.1186/s12974-017-0943-1. Review.


Antenatal Suppression of IL-1 Protects against Inflammation-Induced Fetal Injury and Improves Neonatal and Developmental Outcomes in Mice.

Nadeau-Vallée M, Chin PY, Belarbi L, Brien MÈ, Pundir S, Berryer MH, Beaudry-Richard A, Madaan A, Sharkey DJ, Lupien-Meilleur A, Hou X, Quiniou C, Beaulac A, Boufaied I, Boudreault A, Carbonaro A, Doan ND, Joyal JS, Lubell WD, Olson DM, Robertson SA, Girard S, Chemtob S.

J Immunol. 2017 Mar 1;198(5):2047-2062. doi: 10.4049/jimmunol.1601600. Epub 2017 Feb 1.


Cone Genesis Tracing by the Chrnb4-EGFP Mouse Line: Evidences of Cellular Material Fusion after Cone Precursor Transplantation.

Decembrini S, Martin C, Sennlaub F, Chemtob S, Biel M, Samardzija M, Moulin A, Behar-Cohen F, Arsenijevic Y.

Mol Ther. 2017 Mar 1;25(3):634-653. doi: 10.1016/j.ymthe.2016.12.015. Epub 2017 Jan 28.


New insights into mechanisms of nuclear translocation of G-protein coupled receptors.

Bhosle VK, Rivera JC, Chemtob S.

Small GTPases. 2019 Jul;10(4):254-263. doi: 10.1080/21541248.2017.1282402. Epub 2017 Feb 10.


Preventing Corneal Calcification Associated With Xylazine for Longitudinal Optical Coherence Tomography in Young Rodents.

Zhou TE, Sayah DN, Noueihed B, Mazzaferri J, Costantino S, Brunette I, Chemtob S.

Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):461-469. doi: 10.1167/iovs.16-20526.


Lymphocytic Microparticles Modulate Angiogenic Properties of Macrophages in Laser-induced Choroidal Neovascularization.

Tahiri H, Omri S, Yang C, Duhamel F, Samarani S, Ahmad A, Vezina M, Bussières M, Vaucher E, Sapieha P, Hickson G, Hammamji K, Lapointe R, Rodier F, Tremblay S, Royal I, Cailhier JF, Chemtob S, Hardy P.

Sci Rep. 2016 Nov 22;6:37391. doi: 10.1038/srep37391.


Sterile inflammation and pregnancy complications: a review.

Nadeau-Vallée M, Obari D, Palacios J, Brien MÈ, Duval C, Chemtob S, Girard S.

Reproduction. 2016 Dec;152(6):R277-R292. Epub 2016 Sep 27. Review.


Choroidal Involution Is Associated with a Progressive Degeneration of the Outer Retinal Function in a Model of Retinopathy of Prematurity: Early Role for IL-1β.

Zhou TE, Rivera JC, Bhosle VK, Lahaie I, Shao Z, Tahiri H, Zhu T, Polosa A, Dorfman A, Beaudry-Richard A, Costantino S, Lodygensky GA, Lachapelle P, Chemtob S.

Am J Pathol. 2016 Dec;186(12):3100-3116. doi: 10.1016/j.ajpath.2016.08.004. Epub 2016 Oct 18.


Erratum: Nuclear localization of platelet-activating factor receptor controls retinal neovascularization.

Bhosle VK, Rivera JC, Zhou TE, Omri S, Sanchez M, Hamel D, Zhu T, Rouget R, Rabea AA, Hou X, Lahaie I, Ribeiro-da-Silva A, Chemtob S.

Cell Discov. 2016 Sep 20;2:16034. doi: 10.1038/celldisc.2016.34. eCollection 2016.


Review of the mechanisms and therapeutic avenues for retinal and choroidal vascular dysfunctions in retinopathy of prematurity.

Rivera JC, Madaan A, Zhou TE, Chemtob S.

Acta Paediatr. 2016 Dec;105(12):1421-1433. doi: 10.1111/apa.13586. Epub 2016 Sep 28. Review.


Lactate produced during labor modulates uterine inflammation via GPR81 (HCA1).

Madaan A, Nadeau-Vallée M, Rivera JC, Obari D, Hou X, Sierra EM, Girard S, Olson DM, Chemtob S.

Am J Obstet Gynecol. 2017 Jan;216(1):60.e1-60.e17. doi: 10.1016/j.ajog.2016.09.072. Epub 2016 Sep 9.


Neonatal microglia: The cornerstone of brain fate.

Pierre WC, Smith PLP, Londono I, Chemtob S, Mallard C, Lodygensky GA.

Brain Behav Immun. 2017 Jan;59:333-345. doi: 10.1016/j.bbi.2016.08.018. Epub 2016 Sep 3. Review.


Uterotonic Neuromedin U Receptor 2 and Its Ligands Are Upregulated by Inflammation in Mice and Humans, and Elicit Preterm Birth.

Nadeau-Vallée M, Boudreault A, Leimert K, Hou X, Obari D, Madaan A, Rouget R, Zhu T, Belarbi L, Brien MÈ, Beaudry-Richard A, Olson DM, Girard S, Chemtob S.

Biol Reprod. 2016 Sep;95(3):72. Epub 2016 Aug 10.


Nuclear localization of platelet-activating factor receptor controls retinal neovascularization.

Bhosle VK, Rivera JC, Zhou TE, Omri S, Sanchez M, Hamel D, Zhu T, Rouget R, Rabea AA, Hou X, Lahaie I, Ribeiro-da-Silva A, Chemtob S.

Cell Discov. 2016 Jul 12;2:16017. doi: 10.1038/celldisc.2016.17. eCollection 2016. Erratum in: Cell Discov. 2016;2:16034.


Hydrogen Sulfide Delays LPS-Induced Preterm Birth in Mice via Anti-Inflammatory Pathways.

Liu W, Xu C, You X, Olson DM, Chemtob S, Gao L, Ni X.

PLoS One. 2016 Apr 1;11(4):e0152838. doi: 10.1371/journal.pone.0152838. eCollection 2016.


ECL1i, d(LGTFLKC), a novel, small peptide that specifically inhibits CCL2-dependent migration.

Auvynet C, Baudesson de Chanville C, Hermand P, Dorgham K, Piesse C, Pouchy C, Carlier L, Poupel L, Barthélémy S, Felouzis V, Lacombe C, Sagan S, Chemtob S, Quiniou C, Salomon B, Deterre P, Sennlaub F, Combadière C.

FASEB J. 2016 Jun;30(6):2370-81. doi: 10.1096/fj.201500116. Epub 2016 Mar 15. Erratum in: FASEB J. 2017 Feb;31(2):852.


IL23R (Interleukin 23 Receptor) Variants Protective against Inflammatory Bowel Diseases (IBD) Display Loss of Function due to Impaired Protein Stability and Intracellular Trafficking.

Sivanesan D, Beauchamp C, Quinou C, Lee J, Lesage S, Chemtob S, Rioux JD, Michnick SW.

J Biol Chem. 2016 Apr 15;291(16):8673-85. doi: 10.1074/jbc.M116.715870. Epub 2016 Feb 17.


Tailoring Myopic CNV Treatment Based on Preexisting Ophthalmic Condition.

Zhou TE, Bhosle VK, Chemtob S.

Invest Ophthalmol Vis Sci. 2015 Dec;56(13):8362-3. doi: 10.1167/iovs.15-18314. No abstract available.


A critical role of interleukin-1 in preterm labor.

Nadeau-Vallée M, Obari D, Quiniou C, Lubell WD, Olson DM, Girard S, Chemtob S.

Cytokine Growth Factor Rev. 2016 Apr;28:37-51. doi: 10.1016/j.cytogfr.2015.11.001. Epub 2015 Nov 30. Review.


BIBF1120 (Vargatef) Inhibits Preretinal Neovascularization and Enhances Normal Vascularization in a Model of Vasoproliferative Retinopathy.

Rivera JC, Noueihed B, Omri S, Barrueco J, Hilberg F, Chemtob S.

Invest Ophthalmol Vis Sci. 2015 Dec;56(13):7897-907. doi: 10.1167/iovs.15-17146.


Novel Noncompetitive IL-1 Receptor-Biased Ligand Prevents Infection- and Inflammation-Induced Preterm Birth.

Nadeau-Vallée M, Quiniou C, Palacios J, Hou X, Erfani A, Madaan A, Sanchez M, Leimert K, Boudreault A, Duhamel F, Rivera JC, Zhu T, Noueihed B, Robertson SA, Ni X, Olson DM, Lubell W, Girard S, Chemtob S.

J Immunol. 2015 Oct 1;195(7):3402-15. doi: 10.4049/jimmunol.1500758. Epub 2015 Aug 24.


Investigation of the active turn geometry for the labour delaying activity of indolizidinone and azapeptide modulators of the prostaglandin F2α receptor.

Boukanoun MK, Hou X, Nikolajev L, Ratni S, Olson D, Claing A, Laporte SA, Chemtob S, Lubell WD.

Org Biomol Chem. 2015 Jul 28;13(28):7750-61. doi: 10.1039/c5ob00962f. Epub 2015 Jun 19.


Subcellular G-protein coupled receptor signaling hints at greater therapeutic selectivity.

Joyal JS, Bhosle VK, Chemtob S.

Expert Opin Ther Targets. 2015 Jun;19(6):717-21. doi: 10.1517/14728222.2015.1042365.


[New insights to prevent preterm labor].

Nadeau-Vallée M, Palacios J, Boudreault A, Chemtob S.

Med Sci (Paris). 2015 Apr;31(4):374-6. doi: 10.1051/medsci/20153104010. Epub 2015 May 8. French. No abstract available.


Retinal neurons curb inflammation and enhance revascularization in ischemic retinopathies via proteinase-activated receptor-2.

Sitaras N, Rivera JC, Noueihed B, Bien-Aimé M, Zaniolo K, Omri S, Hamel D, Zhu T, Hardy P, Sapieha P, Joyal JS, Chemtob S.

Am J Pathol. 2015 Feb;185(2):581-95. doi: 10.1016/j.ajpath.2014.10.020. Epub 2014 Dec 3.


Specific targeting of the IL-23 receptor, using a novel small peptide noncompetitive antagonist, decreases the inflammatory response.

Quiniou C, Domínguez-Punaro M, Cloutier F, Erfani A, Ennaciri J, Sivanesan D, Sanchez M, Chognard G, Hou X, Rivera JC, Beauchamp C, Charron G, Vilquin M, Kuchroo V, Michnick S, Rioux JD, Lesage S, Chemtob S.

Am J Physiol Regul Integr Comp Physiol. 2014 Nov 15;307(10):R1216-30. doi: 10.1152/ajpregu.00540.2013. Epub 2014 Aug 20.

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