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Fascin Controls Metastatic Colonization and Mitochondrial Oxidative Phosphorylation by Remodeling Mitochondrial Actin Filaments.

Lin S, Huang C, Gunda V, Sun J, Chellappan SP, Li Z, Izumi V, Fang B, Koomen J, Singh PK, Hao J, Yang S.

Cell Rep. 2019 Sep 10;28(11):2824-2836.e8. doi: 10.1016/j.celrep.2019.08.011.


HDAC Inhibition Enhances the In Vivo Efficacy of MEK Inhibitor Therapy in Uveal Melanoma.

Faião-Flores F, Emmons MF, Durante MA, Kinose F, Saha B, Fang B, Koomen JM, Chellappan SP, Maria-Engler SS, Rix U, Licht JD, Harbour JW, Smalley KSM.

Clin Cancer Res. 2019 Sep 15;25(18):5686-5701. doi: 10.1158/1078-0432.CCR-18-3382. Epub 2019 Jun 21.


Fendiline Enhances the Cytotoxic Effects of Therapeutic Agents on PDAC Cells by Inhibiting Tumor-Promoting Signaling Events: A Potential Strategy to Combat PDAC.

Alhothali M, Mathew M, Iyer G, Lawrence HR, Yang S, Chellappan S, Padmanabhan J.

Int J Mol Sci. 2019 May 16;20(10). pii: E2423. doi: 10.3390/ijms20102423.


Cationic lipoplexes for treatment of cancer stem cell-derived murine lung tumors.

Andey T, Bora-Singhal N, Chellappan SP, Singh M.

Nanomedicine. 2019 Jun;18:31-43. doi: 10.1016/j.nano.2019.02.007. Epub 2019 Mar 1.


Occurrence of zoonotic Cryptosporidium and Giardia duodenalis species/genotypes in urban rodents.

Tan TK, Low VL, Ng WH, Ibrahim J, Wang D, Tan CH, Chellappan S, Lim YAL.

Parasitol Int. 2019 Apr;69:110-113. doi: 10.1016/j.parint.2018.12.007. Epub 2018 Dec 24.


Regulation of Sox2 and stemness by nicotine and electronic-cigarettes in non-small cell lung cancer.

Schaal CM, Bora-Singhal N, Kumar DM, Chellappan SP.

Mol Cancer. 2018 Oct 15;17(1):149. doi: 10.1186/s12943-018-0901-2.


TussisWatch: A Smart-Phone System to Identify Cough Episodes as Early Symptoms of Chronic Obstructive Pulmonary Disease and Congestive Heart Failure.

Windmon A, Minakshi M, Bharti P, Chellappan S, Johansson M, Jenkins BA, Athilingam PR.

IEEE J Biomed Health Inform. 2019 Jul;23(4):1566-1573. doi: 10.1109/JBHI.2018.2872038. Epub 2018 Sep 24.


Methotrexate Free Chemotherapy and Limb Salvage Surgery for Paediatric Osteosarcoma in India.

Sukumaran RK, Rajeshwari B, Sugath S, Chellappan SG, Thankamony P, Parukuttyamma K.

Indian J Orthop. 2018 Jan-Feb;52(1):58-64. doi: 10.4103/ortho.IJOrtho_195_17.


Transesophageal Echocardiography in a Distal Aortopulmonary Window.

Chellappan S, Katewa A, Sathe YC.

J Cardiovasc Echogr. 2016 Oct-Dec;26(4):131-134. doi: 10.4103/2211-4122.192182.


Isolated Double-chambered Right Ventricle with Intact Interventricular Septum.

Chellappan S, Sahu B, Sathe YC.

J Cardiovasc Echogr. 2016 Oct-Dec;26(4):127-130. doi: 10.4103/2211-4122.192180.


Watch-Dog: Detecting Self-Harming Activities From Wrist Worn Accelerometers.

Bharti P, Panwar A, Gopalakrishna G, Chellappan S.

IEEE J Biomed Health Inform. 2018 May;22(3):686-696. doi: 10.1109/JBHI.2017.2692179. Epub 2017 Apr 7.


Intracardiac lipoma in a child, causing right ventricular outflow obstruction.

Chellappan S, Sahu B.

Asian Cardiovasc Thorac Ann. 2016 Oct;24(8):829-830. Epub 2016 Jun 28. No abstract available.


Nicotine-Mediated Regulation of Nicotinic Acetylcholine Receptors in Non-Small Cell Lung Adenocarcinoma by E2F1 and STAT1 Transcription Factors.

Schaal C, Chellappan S.

PLoS One. 2016 May 26;11(5):e0156451. doi: 10.1371/journal.pone.0156451. eCollection 2016.


Unusual variant of pulmonary venous atresia.

Chellappan S, Sathe YC, Sahu B.

Asian Cardiovasc Thorac Ann. 2017 Jul;25(6):474-475. doi: 10.1177/0218492316652993. Epub 2016 May 25. No abstract available.


Tank binding kinase 1 is a centrosome-associated kinase necessary for microtubule dynamics and mitosis.

Pillai S, Nguyen J, Johnson J, Haura E, Coppola D, Chellappan S.

Nat Commun. 2015 Dec 10;6:10072. doi: 10.1038/ncomms10072.


Fendiline inhibits proliferation and invasion of pancreatic cancer cells by interfering with ADAM10 activation and β-catenin signaling.

Woods N, Trevino J, Coppola D, Chellappan S, Yang S, Padmanabhan J.

Oncotarget. 2015 Nov 3;6(34):35931-48. doi: 10.18632/oncotarget.5933.


Gli1-Mediated Regulation of Sox2 Facilitates Self-Renewal of Stem-Like Cells and Confers Resistance to EGFR Inhibitors in Non-Small Cell Lung Cancer.

Bora-Singhal N, Perumal D, Nguyen J, Chellappan S.

Neoplasia. 2015 Jul;17(7):538-51. doi: 10.1016/j.neo.2015.07.001.


The Role of nAChR and Calcium Signaling in Pancreatic Cancer Initiation and Progression.

Schaal C, Padmanabhan J, Chellappan S.

Cancers (Basel). 2015 Jul 31;7(3):1447-71. doi: 10.3390/cancers7030845. Review.


ChIP on chip and ChIP-Seq assays: genome-wide analysis of transcription factor binding and histone modifications.

Pillai S, Chellappan SP.

Methods Mol Biol. 2015;1288:447-72. doi: 10.1007/978-1-4939-2474-5_26.


Chromatin immunoprecipitation assays: analyzing transcription factor binding and histone modifications in vivo.

Pillai S, Dasgupta P, Chellappan SP.

Methods Mol Biol. 2015;1288:429-46. doi: 10.1007/978-1-4939-2474-5_25.


In vitro replication assay with mammalian cell extracts.

Rizwani W, Chellappan SP.

Methods Mol Biol. 2015;1288:349-62. doi: 10.1007/978-1-4939-2474-5_20.


YAP1 Regulates OCT4 Activity and SOX2 Expression to Facilitate Self-Renewal and Vascular Mimicry of Stem-Like Cells.

Bora-Singhal N, Nguyen J, Schaal C, Perumal D, Singh S, Coppola D, Chellappan S.

Stem Cells. 2015 Jun;33(6):1705-18. doi: 10.1002/stem.1993.


β-arrestin-1 mediates nicotine-induced metastasis through E2F1 target genes that modulate epithelial-mesenchymal transition.

Pillai S, Trevino J, Rawal B, Singh S, Kovacs M, Li X, Schell M, Haura E, Bepler G, Chellappan S.

Cancer Res. 2015 Mar 15;75(6):1009-20. doi: 10.1158/0008-5472.CAN-14-0681. Epub 2015 Jan 19.


Nicotinic acetylcholine receptors induce c-Kit ligand/Stem Cell Factor and promote stemness in an ARRB1/ β-arrestin-1 dependent manner in NSCLC.

Perumal D, Pillai S, Nguyen J, Schaal C, Coppola D, Chellappan SP.

Oncotarget. 2014 Nov 15;5(21):10486-502.


Mammalian lysine histone demethylase KDM2A regulates E2F1-mediated gene transcription in breast cancer cells.

Rizwani W, Schaal C, Kunigal S, Coppola D, Chellappan S.

PLoS One. 2014 Jul 16;9(7):e100888. doi: 10.1371/journal.pone.0100888. eCollection 2014.


Nicotine-mediated invasion and migration of non-small cell lung carcinoma cells by modulating STMN3 and GSPT1 genes in an ID1-dependent manner.

Nair S, Bora-Singhal N, Perumal D, Chellappan S.

Mol Cancer. 2014 Jul 16;13:173. doi: 10.1186/1476-4598-13-173.


The Rb-E2F transcriptional regulatory pathway in tumor angiogenesis and metastasis.

Schaal C, Pillai S, Chellappan SP.

Adv Cancer Res. 2014;121:147-182. doi: 10.1016/B978-0-12-800249-0.00004-4. Review.


Cationic lipid guided short-hairpin RNA interference of annexin A2 attenuates tumor growth and metastasis in a mouse lung cancer stem cell model.

Andey T, Marepally S, Patel A, Jackson T, Sarkar S, O'Connell M, Reddy RC, Chellappan S, Singh P, Singh M.

J Control Release. 2014 Jun 28;184:67-78. doi: 10.1016/j.jconrel.2014.03.049. Epub 2014 Apr 12.


Nicotine-mediated cell proliferation and tumor progression in smoking-related cancers.

Schaal C, Chellappan SP.

Mol Cancer Res. 2014 Jan;12(1):14-23. doi: 10.1158/1541-7786.MCR-13-0541. Epub 2014 Jan 7. Review.


GATA3 transcription factor abrogates Smad4 transcription factor-mediated fascin overexpression, invadopodium formation, and breast cancer cell invasion.

Sun J, He H, Pillai S, Xiong Y, Challa S, Xu L, Chellappan S, Yang S.

J Biol Chem. 2013 Dec 27;288(52):36971-82. doi: 10.1074/jbc.M113.506535. Epub 2013 Nov 14.


Can symptom relief be provided in the home to palliative care cancer patients by the primary caregivers? An Indian study.

Chellappan S, Ezhilarasu P, Gnanadurai A, George R, Christopher S.

Cancer Nurs. 2014 Sep-Oct;37(5):E40-7. doi: 10.1097/NCC.0000000000000098.


Selective disruption of rb-raf-1 kinase interaction inhibits pancreatic adenocarcinoma growth irrespective of gemcitabine sensitivity.

Treviño JG, Verma M, Singh S, Pillai S, Zhang D, Pernazza D, Sebti SM, Lawrence NJ, Centeno BA, Chellappan SP.

Mol Cancer Ther. 2013 Dec;12(12):2722-34. doi: 10.1158/1535-7163.MCT-12-0719. Epub 2013 Oct 9.


Lung cancer stem cells: Molecular features and therapeutic targets.

Singh S, Chellappan S.

Mol Aspects Med. 2014 Oct;39:50-60. doi: 10.1016/j.mam.2013.08.003. Epub 2013 Sep 7. Review.


βArrestin-1 and Mcl-1 modulate self-renewal growth of cancer stem-like side-population cells in non-small cell lung cancer.

Singh S, Bora-Singhal N, Kroeger J, Laklai H, Chellappan SP.

PLoS One. 2013;8(2):e55982. doi: 10.1371/journal.pone.0055982. Epub 2013 Feb 13.


Nicotine induces inhibitor of differentiation-1 in a Src-dependent pathway promoting metastasis and chemoresistance in pancreatic adenocarcinoma.

Treviño JG, Pillai S, Kunigal S, Singh S, Fulp WJ, Centeno BA, Chellappan SP.

Neoplasia. 2012 Dec;14(12):1102-14.


Regulation of interlocking gene regulatory network subcircuits by a small molecule inhibitor of retinoblastoma protein (RB) phosphorylation: cancer cell expression of HLA-DR.

Pillai S, Szekeres K, Lawrence NJ, Chellappan SP, Blanck G.

Gene. 2013 Jan 10;512(2):403-7. doi: 10.1016/j.gene.2012.09.092. Epub 2012 Oct 3.


EGFR/Src/Akt signaling modulates Sox2 expression and self-renewal of stem-like side-population cells in non-small cell lung cancer.

Singh S, Trevino J, Bora-Singhal N, Coppola D, Haura E, Altiok S, Chellappan SP.

Mol Cancer. 2012 Sep 25;11:73. doi: 10.1186/1476-4598-11-73.


A novel five gene signature derived from stem-like side population cells predicts overall and recurrence-free survival in NSCLC.

Perumal D, Singh S, Yoder SJ, Bloom GC, Chellappan SP.

PLoS One. 2012;7(8):e43589. doi: 10.1371/journal.pone.0043589. Epub 2012 Aug 29.


Genetic and biochemical alterations in non-small cell lung cancer.

Johnson JL, Pillai S, Chellappan SP.

Biochem Res Int. 2012;2012:940405. doi: 10.1155/2012/940405. Epub 2012 Aug 15.


Nicotine/cigarette smoke promotes metastasis of pancreatic cancer through α7nAChR-mediated MUC4 upregulation.

Momi N, Ponnusamy MP, Kaur S, Rachagani S, Kunigal SS, Chellappan S, Ouellette MM, Batra SK.

Oncogene. 2013 Mar 14;32(11):1384-95. doi: 10.1038/onc.2012.163. Epub 2012 May 21.


IKBKE is induced by STAT3 and tobacco carcinogen and determines chemosensitivity in non-small cell lung cancer.

Guo J, Kim D, Gao J, Kurtyka C, Chen H, Yu C, Wu D, Mittal A, Beg AA, Chellappan SP, Haura EB, Cheng JQ.

Oncogene. 2013 Jan 10;32(2):151-9. doi: 10.1038/onc.2012.39. Epub 2012 Feb 13.


α7 nicotinic acetylcholine receptor subunit in angiogenesis and epithelial to mesenchymal transition.

Pillai S, Chellappan S.

Curr Drug Targets. 2012 May;13(5):671-9. Review.


Nicotine-mediated induction of E-selectin in aortic endothelial cells requires Src kinase and E2F1 transcriptional activity.

Alamanda V, Singh S, Lawrence NJ, Chellappan SP.

Biochem Biophys Res Commun. 2012 Feb 3;418(1):56-61. doi: 10.1016/j.bbrc.2011.12.127. Epub 2012 Jan 3.


TNF-α-mediated proliferation of vascular smooth muscle cells involves Raf-1-mediated inactivation of Rb and transcription of E2F1-regulated genes.

Davis R, Pillai S, Lawrence N, Sebti S, Chellappan SP.

Cell Cycle. 2012 Jan 1;11(1):109-18. doi: 10.4161/cc.11.1.18473. Epub 2012 Jan 1.


The Jab1-E2F1 interaction: a matter of life and death.

Chellappan SP.

Cell Cycle. 2011 Dec 1;10(23):3996-7. doi: 10.4161/cc.10.23.18355. Epub 2011 Dec 1. No abstract available.


Regulation of matrix metalloproteinase genes by E2F transcription factors: Rb-Raf-1 interaction as a novel target for metastatic disease.

Johnson JL, Pillai S, Pernazza D, Sebti SM, Lawrence NJ, Chellappan SP.

Cancer Res. 2012 Jan 15;72(2):516-26. doi: 10.1158/0008-5472.CAN-11-2647. Epub 2011 Nov 15. Erratum in: Cancer Res. 2012 Mar 1;72(5):1317.


TNF-α response of vascular endothelial and vascular smooth muscle cells involve differential utilization of ASK1 kinase and p73.

Rastogi S, Rizwani W, Joshi B, Kunigal S, Chellappan SP.

Cell Death Differ. 2012 Feb;19(2):274-83. doi: 10.1038/cdd.2011.93. Epub 2011 Jul 8.


Protease inhibitor from Moringa oleifera with potential for use as therapeutic drug and as seafood preservative.

Bijina B, Chellappan S, Krishna JG, Basheer SM, Elyas KK, Bahkali AH, Chandrasekaran M.

Saudi J Biol Sci. 2011 Jul;18(3):273-81. doi: 10.1016/j.sjbs.2011.04.002. Epub 2011 Apr 18.


ID1 facilitates the growth and metastasis of non-small cell lung cancer in response to nicotinic acetylcholine receptor and epidermal growth factor receptor signaling.

Pillai S, Rizwani W, Li X, Rawal B, Nair S, Schell MJ, Bepler G, Haura E, Coppola D, Chellappan S.

Mol Cell Biol. 2011 Jul;31(14):3052-67. doi: 10.1128/MCB.01311-10. Epub 2011 May 23.

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