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Items: 1 to 50 of 70

1.

Redirecting Pore Assembly of Staphylococcal α-Hemolysin by Protein Engineering.

Koo S, Cheley S, Bayley H.

ACS Cent Sci. 2019 Apr 24;5(4):629-639. doi: 10.1021/acscentsci.8b00910. Epub 2019 Mar 25.

2.

Semisynthetic Nanoreactor for Reversible Single-Molecule Covalent Chemistry.

Lee J, Boersma AJ, Boudreau MA, Cheley S, Daltrop O, Li J, Tamagaki H, Bayley H.

ACS Nano. 2016 Sep 27;10(9):8843-50. doi: 10.1021/acsnano.6b04663. Epub 2016 Aug 30.

3.

A Glycine-Insulin Autocrine Feedback Loop Enhances Insulin Secretion From Human β-Cells and Is Impaired in Type 2 Diabetes.

Yan-Do R, Duong E, Manning Fox JE, Dai X, Suzuki K, Khan S, Bautista A, Ferdaoussi M, Lyon J, Wu X, Cheley S, MacDonald PE, Braun M.

Diabetes. 2016 Aug;65(8):2311-21. doi: 10.2337/db15-1272. Epub 2016 May 3.

4.

Autocrine activation of P2Y1 receptors couples Ca (2+) influx to Ca (2+) release in human pancreatic beta cells.

Khan S, Yan-Do R, Duong E, Wu X, Bautista A, Cheley S, MacDonald PE, Braun M.

Diabetologia. 2014 Dec;57(12):2535-45. doi: 10.1007/s00125-014-3368-8. Epub 2014 Sep 11.

PMID:
25208758
5.

Stochastic detection of Pim protein kinases reveals electrostatically enhanced association of a peptide substrate.

Harrington L, Cheley S, Alexander LT, Knapp S, Bayley H.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):E4417-26. doi: 10.1073/pnas.1312739110. Epub 2013 Nov 5.

6.

Single-molecule interrogation of a bacterial sugar transporter allows the discovery of an extracellular inhibitor.

Kong L, Harrington L, Li Q, Cheley S, Davis BG, Bayley H.

Nat Chem. 2013 Aug;5(8):651-9. doi: 10.1038/nchem.1695. Epub 2013 Jun 30.

PMID:
23881495
7.

An engineered dimeric protein pore that spans adjacent lipid bilayers.

Mantri S, Sapra KT, Cheley S, Sharp TH, Bayley H.

Nat Commun. 2013;4:1725. doi: 10.1038/ncomms2726.

8.

SSTR2 is the functionally dominant somatostatin receptor in human pancreatic β- and α-cells.

Kailey B, van de Bunt M, Cheley S, Johnson PR, MacDonald PE, Gloyn AL, Rorsman P, Braun M.

Am J Physiol Endocrinol Metab. 2012 Nov 1;303(9):E1107-16. doi: 10.1152/ajpendo.00207.2012. Epub 2012 Aug 28.

9.

An engineered ClyA nanopore detects folded target proteins by selective external association and pore entry.

Soskine M, Biesemans A, Moeyaert B, Cheley S, Bayley H, Maglia G.

Nano Lett. 2012 Sep 12;12(9):4895-900. doi: 10.1021/nl3024438. Epub 2012 Aug 6.

10.

Permeation of styryl dyes through nanometer-scale pores in membranes.

Wu Y, Ma L, Cheley S, Bayley H, Cui Q, Chapman ER.

Biochemistry. 2011 Sep 6;50(35):7493-502. doi: 10.1021/bi2006288. Epub 2011 Aug 16.

11.

Molecular bases of cyclodextrin adapter interactions with engineered protein nanopores.

Banerjee A, Mikhailova E, Cheley S, Gu LQ, Montoya M, Nagaoka Y, Gouaux E, Bayley H.

Proc Natl Acad Sci U S A. 2010 May 4;107(18):8165-70. doi: 10.1073/pnas.0914229107. Epub 2010 Apr 16.

12.

Wrestling with native chemical ligation.

Bayley H, Cheley S, Harrington L, Syeda R.

ACS Chem Biol. 2009 Dec 18;4(12):983-5. doi: 10.1021/cb900304p.

PMID:
20017575
13.

DNA strands from denatured duplexes are translocated through engineered protein nanopores at alkaline pH.

Maglia G, Henricus M, Wyss R, Li Q, Cheley S, Bayley H.

Nano Lett. 2009 Nov;9(11):3831-6. doi: 10.1021/nl9020232.

PMID:
19645477
14.

Droplet networks with incorporated protein diodes show collective properties.

Maglia G, Heron AJ, Hwang WL, Holden MA, Mikhailova E, Li Q, Cheley S, Bayley H.

Nat Nanotechnol. 2009 Jul;4(7):437-40. doi: 10.1038/nnano.2009.121. Epub 2009 Jun 7.

PMID:
19581896
15.

Catalyzing the translocation of polypeptides through attractive interactions.

Wolfe AJ, Mohammad MM, Cheley S, Bayley H, Movileanu L.

J Am Chem Soc. 2007 Nov 14;129(45):14034-41. Epub 2007 Oct 19.

PMID:
17949000
16.

Membrane protein stoichiometry determined from the step-wise photobleaching of dye-labelled subunits.

Das SK, Darshi M, Cheley S, Wallace MI, Bayley H.

Chembiochem. 2007 Jun 18;8(9):994-9. No abstract available.

PMID:
17503420
17.

A storable encapsulated bilayer chip containing a single protein nanopore.

Kang XF, Cheley S, Rice-Ficht AC, Bayley H.

J Am Chem Soc. 2007 Apr 18;129(15):4701-5. Epub 2007 Mar 22.

PMID:
17375923
18.

A genetically encoded pore for the stochastic detection of a protein kinase.

Cheley S, Xie H, Bayley H.

Chembiochem. 2006 Dec;7(12):1923-7.

PMID:
17068836
19.

Stochastic detection of enantiomers.

Kang XF, Cheley S, Guan X, Bayley H.

J Am Chem Soc. 2006 Aug 23;128(33):10684-5.

PMID:
16910655
20.

Stochastic sensing of TNT with a genetically engineered pore.

Guan X, Gu LQ, Cheley S, Braha O, Bayley H.

Chembiochem. 2005 Oct;6(10):1875-81.

PMID:
16118820
21.
22.

Single protein pores containing molecular adapters at high temperatures.

Kang XF, Gu LQ, Cheley S, Bayley H.

Angew Chem Int Ed Engl. 2005 Feb 25;44(10):1495-9. No abstract available.

PMID:
15678432
23.
24.

Single DNA rotaxanes of a transmembrane pore protein.

Sánchez-Quesada J, Saghatelian A, Cheley S, Bayley H, Ghadiri MR.

Angew Chem Int Ed Engl. 2004 Jun 7;43(23):3063-7. No abstract available.

25.

Electroosmotic enhancement of the binding of a neutral molecule to a transmembrane pore.

Gu LQ, Cheley S, Bayley H.

Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15498-503. Epub 2003 Dec 15.

26.

Partitioning of individual flexible polymers into a nanoscopic protein pore.

Movileanu L, Cheley S, Bayley H.

Biophys J. 2003 Aug;85(2):897-910.

27.

Measurement of trehalose loading of mammalian cells porated with a metal-actuated switchable pore.

Acker JP, Lu XM, Young V, Cheley S, Bayley H, Fowler A, Toner M.

Biotechnol Bioeng. 2003 Jun 5;82(5):525-32.

PMID:
12652476
28.

Kinetics of a reversible covalent-bond-forming reaction observed at the single-molecule level.

Shin SH, Luchian T, Cheley S, Braha O, Bayley H.

Angew Chem Int Ed Engl. 2002 Oct 4;41(19):3707-9; 3523. No abstract available.

PMID:
12370938
29.
30.

Catalytic subunit of protein kinase A caged at the activating phosphothreonine.

Zou K, Cheley S, Givens RS, Bayley H.

J Am Chem Soc. 2002 Jul 17;124(28):8220-9.

PMID:
12105899
31.

Properties of Bacillus cereus hemolysin II: a heptameric transmembrane pore.

Miles G, Bayley H, Cheley S.

Protein Sci. 2002 Jul;11(7):1813-24.

32.

Beneficial effect of intracellular trehalose on the membrane integrity of dried mammalian cells.

Chen T, Acker JP, Eroglu A, Cheley S, Bayley H, Fowler A, Toner M.

Cryobiology. 2001 Sep;43(2):168-81.

PMID:
11846471
34.

The staphylococcal leukocidin bicomponent toxin forms large ionic channels.

Miles G, Cheley S, Braha O, Bayley H.

Biochemistry. 2001 Jul 24;40(29):8514-22.

PMID:
11456489
35.

Sequence-specific detection of individual DNA strands using engineered nanopores.

Howorka S, Cheley S, Bayley H.

Nat Biotechnol. 2001 Jul;19(7):636-9.

PMID:
11433274
36.

Location of a constriction in the lumen of a transmembrane pore by targeted covalent attachment of polymer molecules.

Movileanu L, Cheley S, Howorka S, Braha O, Bayley H.

J Gen Physiol. 2001 Mar;117(3):239-52.

37.

Capture of a single molecule in a nanocavity.

Gu LQ, Cheley S, Bayley H.

Science. 2001 Jan 26;291(5504):636-40.

38.

Biochemical and biophysical characterization of OmpG: A monomeric porin.

Conlan S, Zhang Y, Cheley S, Bayley H.

Biochemistry. 2000 Oct 3;39(39):11845-54.

PMID:
11009596
39.

Simultaneous stochastic sensing of divalent metal ions.

Braha O, Gu LQ, Zhou L, Lu X, Cheley S, Bayley H.

Nat Biotechnol. 2000 Sep;18(9):1005-7.

PMID:
10973225
40.

Reversal of charge selectivity in transmembrane protein pores by using noncovalent molecular adapters.

Gu LQ, Dalla Serra M, Vincent JB, Vigh G, Cheley S, Braha O, Bayley H.

Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):3959-64.

41.

Intracellular trehalose improves the survival of cryopreserved mammalian cells.

Eroglu A, Russo MJ, Bieganski R, Fowler A, Cheley S, Bayley H, Toner M.

Nat Biotechnol. 2000 Feb;18(2):163-7.

PMID:
10657121
42.

A functional protein pore with a "retro" transmembrane domain.

Cheley S, Braha O, Lu X, Conlan S, Bayley H.

Protein Sci. 1999 Jun;8(6):1257-67.

43.

Stochastic sensing of organic analytes by a pore-forming protein containing a molecular adapter.

Gu LQ, Braha O, Conlan S, Cheley S, Bayley H.

Nature. 1999 Apr 22;398(6729):686-90.

PMID:
10227291
44.

Heptameric structures of two alpha-hemolysin mutants imaged with in situ atomic force microscopy.

Malghani MS, Fang Y, Cheley S, Bayley H, Yang J.

Microsc Res Tech. 1999 Mar 1;44(5):353-6.

PMID:
10090210
45.

Genetically engineered metal ion binding sites on the outside of a Channel's transmembrane beta-barrel.

Kasianowicz JJ, Burden DL, Han LC, Cheley S, Bayley H.

Biophys J. 1999 Feb;76(2):837-45.

46.

Spontaneous oligomerization of a staphylococcal alpha-hemolysin conformationally constrained by removal of residues that form the transmembrane beta-barrel.

Cheley S, Malghani MS, Song L, Hobaugh M, Gouaux JE, Yang J, Bayley H.

Protein Eng. 1997 Dec;10(12):1433-43.

PMID:
9543005
47.

Purification and characterization of recombinant spider silk expressed in Escherichia coli.

Arcidiacono S, Mello C, Kaplan D, Cheley S, Bayley H.

Appl Microbiol Biotechnol. 1998 Jan;49(1):31-8.

PMID:
9487707
48.

The heptameric prepore of a staphylococcal alpha-hemolysin mutant in lipid bilayers imaged by atomic force microscopy.

Fang Y, Cheley S, Bayley H, Yang J.

Biochemistry. 1997 Aug 5;36(31):9518-22.

PMID:
9235997
49.

Designed protein pores as components for biosensors.

Braha O, Walker B, Cheley S, Kasianowicz JJ, Song L, Gouaux JE, Bayley H.

Chem Biol. 1997 Jul;4(7):497-505.

50.

Structure of staphylococcal alpha-hemolysin, a heptameric transmembrane pore.

Song L, Hobaugh MR, Shustak C, Cheley S, Bayley H, Gouaux JE.

Science. 1996 Dec 13;274(5294):1859-66.

PMID:
8943190

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