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Genome Editing: Insights from Chemical Biology to Support Safe and Transformative Therapeutic Applications.

Wegrzyn RD, Lee AH, Jenkins AL, Stoddard CD, Cheever AE.

ACS Chem Biol. 2018 Feb 16;13(2):333-342. doi: 10.1021/acschembio.7b00689. Epub 2017 Oct 18.


Combinatorial targeting of TSLP, IL-25, and IL-33 in type 2 cytokine-driven inflammation and fibrosis.

Vannella KM, Ramalingam TR, Borthwick LA, Barron L, Hart KM, Thompson RW, Kindrachuk KN, Cheever AW, White S, Budelsky AL, Comeau MR, Smith DE, Wynn TA.

Sci Transl Med. 2016 May 4;8(337):337ra65. doi: 10.1126/scitranslmed.aaf1938.


Enhanced protection from fibrosis and inflammation in the combined absence of IL-13 and IFN-γ.

Ramalingam TR, Gieseck RL, Acciani TH, M Hart K, Cheever AW, Mentink-Kane MM, Vannella KM, Wynn TA.

J Pathol. 2016 Jul;239(3):344-54. doi: 10.1002/path.4733. Epub 2016 Jun 10.


Acidic chitinase primes the protective immune response to gastrointestinal nematodes.

Vannella KM, Ramalingam TR, Hart KM, de Queiroz Prado R, Sciurba J, Barron L, Borthwick LA, Smith AD, Mentink-Kane M, White S, Thompson RW, Cheever AW, Bock K, Moore I, Fitz LJ, Urban JF Jr, Wynn TA.

Nat Immunol. 2016 May;17(5):538-44. doi: 10.1038/ni.3417. Epub 2016 Apr 4.


Macrophages are critical to the maintenance of IL-13-dependent lung inflammation and fibrosis.

Borthwick LA, Barron L, Hart KM, Vannella KM, Thompson RW, Oland S, Cheever A, Sciurba J, Ramalingam TR, Fisher AJ, Wynn TA.

Mucosal Immunol. 2016 Jan;9(1):38-55. doi: 10.1038/mi.2015.34. Epub 2015 Apr 29.


Incomplete deletion of IL-4Rα by LysM(Cre) reveals distinct subsets of M2 macrophages controlling inflammation and fibrosis in chronic schistosomiasis.

Vannella KM, Barron L, Borthwick LA, Kindrachuk KN, Narasimhan PB, Hart KM, Thompson RW, White S, Cheever AW, Ramalingam TR, Wynn TA.

PLoS Pathog. 2014 Sep 11;10(9):e1004372. doi: 10.1371/journal.ppat.1004372. eCollection 2014 Sep.


Velocity response curves demonstrate the complexity of modeling entrainable clocks.

Taylor SR, Cheever A, Harmon SM.

J Theor Biol. 2014 Dec 21;363:307-17. doi: 10.1016/j.jtbi.2014.08.044. Epub 2014 Sep 3.


Role of arginase 1 from myeloid cells in th2-dominated lung inflammation.

Barron L, Smith AM, El Kasmi KC, Qualls JE, Huang X, Cheever A, Borthwick LA, Wilson MS, Murray PJ, Wynn TA.

PLoS One. 2013 Apr 24;8(4):e61961. doi: 10.1371/journal.pone.0061961. Print 2013.


Mannose-binding lectin regulates host resistance and pathology during experimental infection with Trypanosoma cruzi.

Rothfuchs AG, Roffê E, Gibson A, Cheever AW, Ezekowitz RA, Takahashi K, Steindel M, Sher A, Báfica A.

PLoS One. 2012;7(11):e47835. doi: 10.1371/journal.pone.0047835. Epub 2012 Nov 6.


Accelerated and progressive and lethal liver fibrosis in mice that lack interleukin (IL)-10, IL-12p40, and IL-13Rα2.

Mentink-Kane MM, Cheever AW, Wilson MS, Madala SK, Beers LM, Ramalingam TR, Wynn TA.

Gastroenterology. 2011 Dec;141(6):2200-9. doi: 10.1053/j.gastro.2011.08.008. Epub 2011 Aug 22.


IL-10 blocks the development of resistance to re-infection with Schistosoma mansoni.

Wilson MS, Cheever AW, White SD, Thompson RW, Wynn TA.

PLoS Pathog. 2011 Aug;7(8):e1002171. doi: 10.1371/journal.ppat.1002171. Epub 2011 Aug 4.


Quantitative assessment of macrophage functions in repair and fibrosis.

Wynn TA, Barron L, Thompson RW, Madala SK, Wilson MS, Cheever AW, Ramalingam T.

Curr Protoc Immunol. 2011 Apr;Chapter 14:Unit14.22. doi: 10.1002/0471142735.im1422s93.


Colitis and intestinal inflammation in IL10-/- mice results from IL-13Rα2-mediated attenuation of IL-13 activity.

Wilson MS, Ramalingam TR, Rivollier A, Shenderov K, Mentink-Kane MM, Madala SK, Cheever AW, Artis D, Kelsall BL, Wynn TA.

Gastroenterology. 2011 Jan;140(1):254-64. doi: 10.1053/j.gastro.2010.09.047. Epub 2010 Oct 14.


Fragile X protein family member FXR1P is regulated by microRNAs.

Cheever A, Blackwell E, Ceman S.

RNA. 2010 Aug;16(8):1530-9. doi: 10.1261/rna.2022210. Epub 2010 Jun 2.


Intranasal Poly-IC treatment exacerbates tuberculosis in mice through the pulmonary recruitment of a pathogen-permissive monocyte/macrophage population.

Antonelli LR, Gigliotti Rothfuchs A, Gonçalves R, Roffê E, Cheever AW, Bafica A, Salazar AM, Feng CG, Sher A.

J Clin Invest. 2010 May;120(5):1674-82. doi: 10.1172/JCI40817. Epub 2010 Apr 12.


Redundant and pathogenic roles for IL-22 in mycobacterial, protozoan, and helminth infections.

Wilson MS, Feng CG, Barber DL, Yarovinsky F, Cheever AW, Sher A, Grigg M, Collins M, Fouser L, Wynn TA.

J Immunol. 2010 Apr 15;184(8):4378-90. doi: 10.4049/jimmunol.0903416. Epub 2010 Mar 10.


Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo.

Mayer-Barber KD, Barber DL, Shenderov K, White SD, Wilson MS, Cheever A, Kugler D, Hieny S, Caspar P, Núñez G, Schlueter D, Flavell RA, Sutterwala FS, Sher A.

J Immunol. 2010 Apr 1;184(7):3326-30. doi: 10.4049/jimmunol.0904189. Epub 2010 Mar 3.


Matrix metalloproteinase 12-deficiency augments extracellular matrix degrading metalloproteinases and attenuates IL-13-dependent fibrosis.

Madala SK, Pesce JT, Ramalingam TR, Wilson MS, Minnicozzi S, Cheever AW, Thompson RW, Mentink-Kane MM, Wynn TA.

J Immunol. 2010 Apr 1;184(7):3955-63. doi: 10.4049/jimmunol.0903008. Epub 2010 Feb 24.


Bleomycin and IL-1beta-mediated pulmonary fibrosis is IL-17A dependent.

Wilson MS, Madala SK, Ramalingam TR, Gochuico BR, Rosas IO, Cheever AW, Wynn TA.

J Exp Med. 2010 Mar 15;207(3):535-52. doi: 10.1084/jem.20092121. Epub 2010 Feb 22.


Regulation of helminth-induced Th2 responses by thymic stromal lymphopoietin.

Ramalingam TR, Pesce JT, Mentink-Kane MM, Madala S, Cheever AW, Comeau MR, Ziegler SF, Wynn TA.

J Immunol. 2009 May 15;182(10):6452-9. doi: 10.4049/jimmunol.0900181.


Retnla (relmalpha/fizz1) suppresses helminth-induced Th2-type immunity.

Pesce JT, Ramalingam TR, Wilson MS, Mentink-Kane MM, Thompson RW, Cheever AW, Urban JF Jr, Wynn TA.

PLoS Pathog. 2009 Apr;5(4):e1000393. doi: 10.1371/journal.ppat.1000393. Epub 2009 Apr 17.


Arginase-1-expressing macrophages suppress Th2 cytokine-driven inflammation and fibrosis.

Pesce JT, Ramalingam TR, Mentink-Kane MM, Wilson MS, El Kasmi KC, Smith AM, Thompson RW, Cheever AW, Murray PJ, Wynn TA.

PLoS Pathog. 2009 Apr;5(4):e1000371. doi: 10.1371/journal.ppat.1000371. Epub 2009 Apr 10.


Translation regulation of mRNAs by the fragile X family of proteins through the microRNA pathway.

Cheever A, Ceman S.

RNA Biol. 2009 Apr-Jun;6(2):175-8. Epub 2009 Apr 17. Review.


Phosphorylation of FMRP inhibits association with Dicer.

Cheever A, Ceman S.

RNA. 2009 Mar;15(3):362-6. doi: 10.1261/rna.1500809. Epub 2009 Jan 20.


Suppression of murine allergic airway disease by IL-2:anti-IL-2 monoclonal antibody-induced regulatory T cells.

Wilson MS, Pesce JT, Ramalingam TR, Thompson RW, Cheever A, Wynn TA.

J Immunol. 2008 Nov 15;181(10):6942-54.


Cationic amino acid transporter-2 regulates immunity by modulating arginase activity.

Thompson RW, Pesce JT, Ramalingam T, Wilson MS, White S, Cheever AW, Ricklefs SM, Porcella SF, Li L, Ellies LG, Wynn TA.

PLoS Pathog. 2008 Mar 14;4(3):e1000023. doi: 10.1371/journal.ppat.1000023.


Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor alpha1 chain.

Ramalingam TR, Pesce JT, Sheikh F, Cheever AW, Mentink-Kane MM, Wilson MS, Stevens S, Valenzuela DM, Murphy AJ, Yancopoulos GD, Urban JF Jr, Donnelly RP, Wynn TA.

Nat Immunol. 2008 Jan;9(1):25-33. Epub 2007 Dec 9.


The IFN-inducible GTPase LRG47 (Irgm1) negatively regulates TLR4-triggered proinflammatory cytokine production and prevents endotoxemia.

Bafica A, Feng CG, Santiago HC, Aliberti J, Cheever A, Thomas KE, Taylor GA, Vogel SN, Sher A.

J Immunol. 2007 Oct 15;179(8):5514-22.


IL-13Ralpha2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in mice.

Wilson MS, Elnekave E, Mentink-Kane MM, Hodges MG, Pesce JT, Ramalingam TR, Thompson RW, Kamanaka M, Flavell RA, Keane-Myers A, Cheever AW, Wynn TA.

J Clin Invest. 2007 Oct;117(10):2941-51.


NK cell-derived IFN-gamma differentially regulates innate resistance and neutrophil response in T cell-deficient hosts infected with Mycobacterium tuberculosis.

Feng CG, Kaviratne M, Rothfuchs AG, Cheever A, Hieny S, Young HA, Wynn TA, Sher A.

J Immunol. 2006 Nov 15;177(10):7086-93.


IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis.

Kullberg MC, Jankovic D, Feng CG, Hue S, Gorelick PL, McKenzie BS, Cua DJ, Powrie F, Cheever AW, Maloy KJ, Sher A.

J Exp Med. 2006 Oct 30;203(11):2485-94. Epub 2006 Oct 9.


The IL-21 receptor augments Th2 effector function and alternative macrophage activation.

Pesce J, Kaviratne M, Ramalingam TR, Thompson RW, Urban JF Jr, Cheever AW, Young DA, Collins M, Grusby MJ, Wynn TA.

J Clin Invest. 2006 Jul;116(7):2044-55. Epub 2006 Jun 15.


Schistosoma mansoni infection in eosinophil lineage-ablated mice.

Swartz JM, Dyer KD, Cheever AW, Ramalingam T, Pesnicak L, Domachowske JB, Lee JJ, Lee NA, Foster PS, Wynn TA, Rosenberg HF.

Blood. 2006 Oct 1;108(7):2420-7. Epub 2006 Jun 13.


SAP regulates T cell-mediated help for humoral immunity by a mechanism distinct from cytokine regulation.

Cannons JL, Yu LJ, Jankovic D, Crotty S, Horai R, Kirby M, Anderson S, Cheever AW, Sher A, Schwartzberg PL.

J Exp Med. 2006 Jun 12;203(6):1551-65. Epub 2006 Jun 5.


Interleukin-5 (IL-5) augments the progression of liver fibrosis by regulating IL-13 activity.

Reiman RM, Thompson RW, Feng CG, Hari D, Knight R, Cheever AW, Rosenberg HF, Wynn TA.

Infect Immun. 2006 Mar;74(3):1471-9.


TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis.

Bafica A, Scanga CA, Feng CG, Leifer C, Cheever A, Sher A.

J Exp Med. 2005 Dec 19;202(12):1715-24.


Mice deficient in LRG-47 display enhanced susceptibility to Trypanosoma cruzi infection associated with defective hemopoiesis and intracellular control of parasite growth.

Santiago HC, Feng CG, Bafica A, Roffe E, Arantes RM, Cheever A, Taylor G, Vieira LQ, Aliberti J, Gazzinelli RT, Sher A.

J Immunol. 2005 Dec 15;175(12):8165-72. Erratum in: J Immunol. 2006 Mar 15;176(6):3840. Vierira, Leda Q [corrected to Vieira, Leda Q].


Identification and characterization of the methyl arginines in the fragile X mental retardation protein Fmrp.

Stetler A, Winograd C, Sayegh J, Cheever A, Patton E, Zhang X, Clarke S, Ceman S.

Hum Mol Genet. 2006 Jan 1;15(1):87-96. Epub 2005 Nov 30.


TGF-beta1 production by CD4+ CD25+ regulatory T cells is not essential for suppression of intestinal inflammation.

Kullberg MC, Hay V, Cheever AW, Mamura M, Sher A, Letterio JJ, Shevach EM, Piccirillo CA.

Eur J Immunol. 2005 Oct;35(10):2886-95.


Maintenance of pulmonary Th1 effector function in chronic tuberculosis requires persistent IL-12 production.

Feng CG, Jankovic D, Kullberg M, Cheever A, Scanga CA, Hieny S, Caspar P, Yap GS, Sher A.

J Immunol. 2005 Apr 1;174(7):4185-92.


Immunopathogenesis of schistosomiasis.

Wynn TA, Thompson RW, Cheever AW, Mentink-Kane MM.

Immunol Rev. 2004 Oct;201:156-67. Review.


IL-13 activates a mechanism of tissue fibrosis that is completely TGF-beta independent.

Kaviratne M, Hesse M, Leusink M, Cheever AW, Davies SJ, McKerrow JH, Wakefield LM, Letterio JJ, Wynn TA.

J Immunol. 2004 Sep 15;173(6):4020-9.


Simultaneous deficiency in CD28 and STAT6 results in chronic ectoparasite-induced inflammatory skin disease.

Liu Q, Arseculeratne C, Liu Z, Whitmire J, Grusby MJ, Finkelman FD, Darling TN, Cheever AW, Swearengen J, Urban JF, Gause WC.

Infect Immun. 2004 Jul;72(7):3706-15.


P-selectin suppresses hepatic inflammation and fibrosis in mice by regulating interferon gamma and the IL-13 decoy receptor.

Wynn TA, Hesse M, Sandler NG, Kaviratne M, Hoffmann KF, Chiaramonte MG, Reiman R, Cheever AW, Sypek JP, Mentink-Kane MM.

Hepatology. 2004 Mar;39(3):676-87.


The pathogenesis of schistosomiasis is controlled by cooperating IL-10-producing innate effector and regulatory T cells.

Hesse M, Piccirillo CA, Belkaid Y, Prufer J, Mentink-Kane M, Leusink M, Cheever AW, Shevach EM, Wynn TA.

J Immunol. 2004 Mar 1;172(5):3157-66.


IL-13 receptor alpha 2 down-modulates granulomatous inflammation and prolongs host survival in schistosomiasis.

Mentink-Kane MM, Cheever AW, Thompson RW, Hari DM, Kabatereine NB, Vennervald BJ, Ouma JH, Mwatha JK, Jones FM, Donaldson DD, Grusby MJ, Dunne DW, Wynn TA.

Proc Natl Acad Sci U S A. 2004 Jan 13;101(2):586-90. Epub 2003 Dec 29.


Induction of colitis by a CD4+ T cell clone specific for a bacterial epitope.

Kullberg MC, Andersen JF, Gorelick PL, Caspar P, Suerbaum S, Fox JG, Cheever AW, Jankovic D, Sher A.

Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15830-5. Epub 2003 Dec 12.


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