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Items: 1 to 50 of 85

1.

Redox-dependent control of i-Motif DNA structure using copper cations.

Abdelhamid MA, Fábián L, MacDonald CJ, Cheesman MR, Gates AJ, Waller ZA.

Nucleic Acids Res. 2018 Jul 6;46(12):5886-5893. doi: 10.1093/nar/gky390.

2.

Sensing iron availability via the fragile [4Fe-4S] cluster of the bacterial transcriptional repressor RirA.

Pellicer Martinez MT, Martinez AB, Crack JC, Holmes JD, Svistunenko DA, Johnston AWB, Cheesman MR, Todd JD, Le Brun NE.

Chem Sci. 2017 Dec 1;8(12):8451-8463. doi: 10.1039/c7sc02801f. Epub 2017 Oct 23.

3.

Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1.

Chenge JT, Duyet LV, Swami S, McLean KJ, Kavanagh ME, Coyne AG, Rigby SE, Cheesman MR, Girvan HM, Levy CW, Rupp B, von Kries JP, Abell C, Leys D, Munro AW.

J Biol Chem. 2017 Jan 27;292(4):1310-1329. doi: 10.1074/jbc.M116.748822. Epub 2016 Dec 8.

4.

Analysis of Heme Iron Coordination in DGCR8: The Heme-Binding Component of the Microprocessor Complex.

Girvan HM, Bradley JM, Cheesman MR, Kincaid JR, Liu Y, Czarnecki K, Fisher K, Leys D, Rigby SE, Munro AW.

Biochemistry. 2016 Sep 13;55(36):5073-83. doi: 10.1021/acs.biochem.6b00204. Epub 2016 Sep 1.

PMID:
27546061
5.

Resolution of key roles for the distal pocket histidine in cytochrome C nitrite reductases.

Lockwood CW, Burlat B, Cheesman MR, Kern M, Simon J, Clarke TA, Richardson DJ, Butt JN.

J Am Chem Soc. 2015 Mar 4;137(8):3059-68. doi: 10.1021/ja512941j. Epub 2015 Feb 18.

6.

Contrasting catalytic profiles of multiheme nitrite reductases containing CxxCK heme-binding motifs.

Doyle RM, Marritt SJ, Gwyer JD, Lowe TG, Tikhonova TV, Popov VO, Cheesman MR, Butt JN.

J Biol Inorg Chem. 2013 Aug;18(6):655-67. doi: 10.1007/s00775-013-1011-7. Epub 2013 Jun 16.

PMID:
23771821
7.

Unexpected weak magnetic exchange coupling between haem and non-haem iron in the catalytic site of nitric oxide reductase (NorBC) from Paracoccus denitrificans1.

Van Wonderen JH, Oganesyan VS, Watmough NJ, Richardson DJ, Thomson AJ, Cheesman MR.

Biochem J. 2013 May 1;451(3):389-94. doi: 10.1042/BJ20121406.

PMID:
23421449
8.

Redox and chemical activities of the hemes in the sulfur oxidation pathway enzyme SoxAX.

Bradley JM, Marritt SJ, Kihlken MA, Haynes K, Hemmings AM, Berks BC, Cheesman MR, Butt JN.

J Biol Chem. 2012 Nov 23;287(48):40350-9. doi: 10.1074/jbc.M112.396192. Epub 2012 Oct 11.

9.

Unusual spectroscopic and ligand binding properties of the cytochrome P450-flavodoxin fusion enzyme XplA.

Bui SH, McLean KJ, Cheesman MR, Bradley JM, Rigby SE, Levy CW, Leys D, Munro AW.

J Biol Chem. 2012 Jun 1;287(23):19699-714. doi: 10.1074/jbc.M111.319202. Epub 2012 Apr 12.

10.

A functional description of CymA, an electron-transfer hub supporting anaerobic respiratory flexibility in Shewanella.

Marritt SJ, Lowe TG, Bye J, McMillan DG, Shi L, Fredrickson J, Zachara J, Richardson DJ, Cheesman MR, Jeuken LJ, Butt JN.

Biochem J. 2012 Jun 15;444(3):465-74. doi: 10.1042/BJ20120197.

PMID:
22458729
11.

Characterization of Cupriavidus metallidurans CYP116B1--a thiocarbamate herbicide oxygenating P450-phthalate dioxygenase reductase fusion protein.

Warman AJ, Robinson JW, Luciakova D, Lawrence AD, Marshall KR, Warren MJ, Cheesman MR, Rigby SE, Munro AW, McLean KJ.

FEBS J. 2012 May;279(9):1675-93. doi: 10.1111/j.1742-4658.2012.08543.x. Epub 2012 Mar 21.

12.

Probing a complex of cytochrome c and cardiolipin by magnetic circular dichroism spectroscopy: implications for the initial events in apoptosis.

Bradley JM, Silkstone G, Wilson MT, Cheesman MR, Butt JN.

J Am Chem Soc. 2011 Dec 14;133(49):19676-9. doi: 10.1021/ja209144h. Epub 2011 Nov 18.

PMID:
22081937
13.

Electrochemical titrations and reaction time courses monitored in situ by magnetic circular dichroism spectroscopy.

Bradley JM, Butt JN, Cheesman MR.

Anal Biochem. 2011 Dec 15;419(2):110-6. doi: 10.1016/j.ab.2011.07.030. Epub 2011 Jul 30.

PMID:
21864495
14.

Heme binding to the second, lower-affinity site of the global iron regulator Irr from Rhizobium leguminosarum promotes oligomerization.

White GF, Singleton C, Todd JD, Cheesman MR, Johnston AW, Le Brun NE.

FEBS J. 2011 Jun;278(12):2011-21. doi: 10.1111/j.1742-4658.2011.08117.x. Epub 2011 May 17.

15.

Kinetic and thermodynamic resolution of the interactions between sulfite and the pentahaem cytochrome NrfA from Escherichia coli.

Kemp GL, Clarke TA, Marritt SJ, Lockwood C, Poock SR, Hemmings AM, Richardson DJ, Cheesman MR, Butt JN.

Biochem J. 2010 Oct 1;431(1):73-80. doi: 10.1042/BJ20100866.

PMID:
20629638
16.

Expression and characterization of Mycobacterium tuberculosis CYP144: common themes and lessons learned in the M. tuberculosis P450 enzyme family.

Driscoll MD, McLean KJ, Cheesman MR, Jowitt TA, Howard M, Carroll P, Parish T, Munro AW.

Biochim Biophys Acta. 2011 Jan;1814(1):76-87. doi: 10.1016/j.bbapap.2010.05.015. Epub 2010 Jun 8.

PMID:
20621636
17.

Heme-responsive DNA binding by the global iron regulator Irr from Rhizobium leguminosarum.

Singleton C, White GF, Todd JD, Marritt SJ, Cheesman MR, Johnston AW, Le Brun NE.

J Biol Chem. 2010 May 21;285(21):16023-31. doi: 10.1074/jbc.M109.067215. Epub 2010 Mar 16.

18.

Glutamate-haem ester bond formation is disfavoured in flavocytochrome P450 BM3: characterization of glutamate substitution mutants at the haem site of P450 BM3.

Girvan HM, Levy CW, Williams P, Fisher K, Cheesman MR, Rigby SE, Leys D, Munro AW.

Biochem J. 2010 Apr 14;427(3):455-66. doi: 10.1042/BJ20091603.

PMID:
20180779
19.

The Structure of Mycobacterium tuberculosis CYP125: molecular basis for cholesterol binding in a P450 needed for host infection.

McLean KJ, Lafite P, Levy C, Cheesman MR, Mast N, Pikuleva IA, Leys D, Munro AW.

J Biol Chem. 2009 Dec 18;284(51):35524-33. doi: 10.1074/jbc.M109.032706.

20.

Opportunities for mesoporous nanocrystalline SnO2 electrodes in kinetic and catalytic analyses of redox proteins.

Kemp GL, Marritt SJ, Xiaoe L, Durrant JR, Cheesman MR, Butt JN.

Biochem Soc Trans. 2009 Apr;37(Pt 2):368-72. doi: 10.1042/BST0370368. Review.

PMID:
19290864
21.

The O2 sensitivity of the transcription factor FNR is controlled by Ser24 modulating the kinetics of [4Fe-4S] to [2Fe-2S] conversion.

Jervis AJ, Crack JC, White G, Artymiuk PJ, Cheesman MR, Thomson AJ, Le Brun NE, Green J.

Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4659-64. doi: 10.1073/pnas.0804943106. Epub 2009 Mar 4.

22.

Ferrocenium salts mediate para-tert-butylcalixarene synthesis.

Bew SP, Cheesman MR, Sharma SV.

Chem Commun (Camb). 2008 Nov 30;(44):5731-3. doi: 10.1039/b813789g. Epub 2008 Oct 1.

PMID:
19009063
23.

Characterization of active site structure in CYP121. A cytochrome P450 essential for viability of Mycobacterium tuberculosis H37Rv.

McLean KJ, Carroll P, Lewis DG, Dunford AJ, Seward HE, Neeli R, Cheesman MR, Marsollier L, Douglas P, Smith WE, Rosenkrands I, Cole ST, Leys D, Parish T, Munro AW.

J Biol Chem. 2008 Nov 28;283(48):33406-16. doi: 10.1074/jbc.M802115200. Epub 2008 Sep 24.

24.

Novel haem co-ordination variants of flavocytochrome P450BM3.

Girvan HM, Toogood HS, Littleford RE, Seward HE, Smith WE, Ekanem IS, Leys D, Cheesman MR, Munro AW.

Biochem J. 2009 Jan 1;417(1):65-76. doi: 10.1042/BJ20081133.

PMID:
18721129
25.

Spectroelectrochemical characterization of a pentaheme cytochrome in solution and as electrocatalytically active films on nanocrystalline metal-oxide electrodes.

Marritt SJ, Kemp GL, Xiaoe L, Durrant JR, Cheesman MR, Butt JN.

J Am Chem Soc. 2008 Jul 9;130(27):8588-9. doi: 10.1021/ja802641a. Epub 2008 Jun 13.

PMID:
18549208
26.

Escherichia coli cytochrome c nitrite reductase NrfA.

Clarke TA, Mills PC, Poock SR, Butt JN, Cheesman MR, Cole JA, Hinton JC, Hemmings AM, Kemp G, Söderberg CA, Spiro S, Van Wonderen J, Richardson DJ.

Methods Enzymol. 2008;437:63-77. doi: 10.1016/S0076-6879(07)37004-3. Review.

PMID:
18433623
27.

A kinetic, spectroscopic, and redox study of human tryptophan 2,3-dioxygenase.

Basran J, Rafice SA, Chauhan N, Efimov I, Cheesman MR, Ghamsari L, Raven EL.

Biochemistry. 2008 Apr 22;47(16):4752-60. doi: 10.1021/bi702393b. Epub 2008 Mar 28.

PMID:
18370401
28.

Role of a conserved glutamine residue in tuning the catalytic activity of Escherichia coli cytochrome c nitrite reductase.

Clarke TA, Kemp GL, Van Wonderen JH, Doyle RM, Cole JA, Tovell N, Cheesman MR, Butt JN, Richardson DJ, Hemmings AM.

Biochemistry. 2008 Mar 25;47(12):3789-99. doi: 10.1021/bi702175w. Epub 2008 Mar 1.

PMID:
18311941
29.

The nitric oxide reductase activity of cytochrome c nitrite reductase from Escherichia coli.

van Wonderen JH, Burlat B, Richardson DJ, Cheesman MR, Butt JN.

J Biol Chem. 2008 Apr 11;283(15):9587-94. doi: 10.1074/jbc.M709090200. Epub 2008 Feb 1.

30.

Influence of the environment on the [4Fe-4S]2+ to [2Fe-2S]2+ cluster switch in the transcriptional regulator FNR.

Crack JC, Gaskell AA, Green J, Cheesman MR, Le Brun NE, Thomson AJ.

J Am Chem Soc. 2008 Feb 6;130(5):1749-58. doi: 10.1021/ja077455+. Epub 2008 Jan 11.

PMID:
18186637
31.

Magnetic circular dichroism evidence for a weakly coupled heme-radical pair at the active site of cytochrome cd1, a nitrite reductase.

Oganesyan VS, Cheesman MR, Thomson AJ.

Inorg Chem. 2007 Dec 24;46(26):10950-2. Epub 2007 Nov 29.

PMID:
18044879
32.

Activation of the cytochrome cd1 nitrite reductase from Paracoccus pantotrophus. Reaction of oxidized enzyme with substrate drives a ligand switch at heme c.

van Wonderen JH, Knight C, Oganesyan VS, George SJ, Zumft WG, Cheesman MR.

J Biol Chem. 2007 Sep 21;282(38):28207-15. Epub 2007 Jul 10.

33.

Superoxide-mediated amplification of the oxygen-induced switch from [4Fe-4S] to [2Fe-2S] clusters in the transcriptional regulator FNR.

Crack JC, Green J, Cheesman MR, Le Brun NE, Thomson AJ.

Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2092-7. Epub 2007 Jan 31.

34.
35.

Magnetic circular dichroism of hemoproteins with in situ control of electrochemical potential: "MOTTLE".

Marritt SJ, van Wonderen JH, Cheesman MR, Butt JN.

Anal Biochem. 2006 Dec 1;359(1):79-83. Epub 2006 Aug 30.

PMID:
16996021
36.

Biophysical characterization of the sterol demethylase P450 from Mycobacterium tuberculosis, its cognate ferredoxin, and their interactions.

McLean KJ, Warman AJ, Seward HE, Marshall KR, Girvan HM, Cheesman MR, Waterman MR, Munro AW.

Biochemistry. 2006 Jul 11;45(27):8427-43.

PMID:
16819841
37.

Reductive activation of nitrate reductases.

Field SJ, Thornton NP, Anderson LJ, Gates AJ, Reilly A, Jepson BJ, Richardson DJ, George SJ, Cheesman MR, Butt JN.

Dalton Trans. 2005 Nov 7;(21):3580-6. Epub 2005 Sep 26.

PMID:
16234941
38.
39.

Cytochrome c nitrite reductase: from structural to physicochemical analysis.

Burlat B, Gwyer JD, Poock S, Clarke T, Cole JA, Hemmings AM, Cheesman MR, Butt JN, Richardson DJ.

Biochem Soc Trans. 2005 Feb;33(Pt 1):137-40.

PMID:
15667286
40.

Evidence that the Streptomyces developmental protein WhiD, a member of the WhiB family, binds a [4Fe-4S] cluster.

Jakimowicz P, Cheesman MR, Bishai WR, Chater KF, Thomson AJ, Buttner MJ.

J Biol Chem. 2005 Mar 4;280(9):8309-15. Epub 2004 Dec 21.

41.

Interaction of nitric oxide with cytochrome P450 BM3.

Quaroni LG, Seward HE, McLean KJ, Girvan HM, Ost TW, Noble MA, Kelly SM, Price NC, Cheesman MR, Smith WE, Munro AW.

Biochemistry. 2004 Dec 28;43(51):16416-31.

PMID:
15610036
42.

Thermodynamic and biophysical characterization of cytochrome P450 BioI from Bacillus subtilis.

Lawson RJ, Leys D, Sutcliffe MJ, Kemp CA, Cheesman MR, Smith SJ, Clarkson J, Smith WE, Haq I, Perkins JB, Munro AW.

Biochemistry. 2004 Oct 5;43(39):12410-26.

PMID:
15449931
43.

Expression, purification, and characterization of Bacillus subtilis cytochromes P450 CYP102A2 and CYP102A3: flavocytochrome homologues of P450 BM3 from Bacillus megaterium.

Gustafsson MC, Roitel O, Marshall KR, Noble MA, Chapman SK, Pessegueiro A, Fulco AJ, Cheesman MR, von Wachenfeldt C, Munro AW.

Biochemistry. 2004 May 11;43(18):5474-87.

PMID:
15122913
44.

The nature of the exchange coupling between high-spin Fe(III) heme o3 and CuBII in Escherichia coli quinol oxidase, cytochrome bo3: MCD and EPR studies.

Cheesman MR, Oganesyan VS, Watmough NJ, Butler CS, Thomson AJ.

J Am Chem Soc. 2004 Apr 7;126(13):4157-66.

PMID:
15053605
45.

Flavocytochrome P450 BM3 mutant A264E undergoes substrate-dependent formation of a novel heme iron ligand set.

Girvan HM, Marshall KR, Lawson RJ, Leys D, Joyce MG, Clarkson J, Smith WE, Cheesman MR, Munro AW.

J Biol Chem. 2004 May 28;279(22):23274-86. Epub 2004 Mar 12.

46.

Instantaneous, stoichiometric generation of powerfully reducing states of protein active sites using Eu(II) and polyaminocarboxylate ligands.

Vincent KA, Tilley GJ, Quammie NC, Streeter I, Burgess BK, Cheesman MR, Armstrong FA.

Chem Commun (Camb). 2003 Oct 21;(20):2590-1.

PMID:
14594295
47.

Expression, purification and characterisation of a Bacillus subtilis ferredoxin: a potential electron transfer donor to cytochrome P450 BioI.

Green AJ, Munro AW, Cheesman MR, Reid GA, von Wachenfeldt C, Chapman SK.

J Inorg Biochem. 2003 Jan 1;93(1-2):92-9.

PMID:
12538057
48.

Characterization of the redox centers in dimethyl sulfide dehydrogenase from Rhodovulum sulfidophilum.

McDevitt CA, Hanson GR, Noble CJ, Cheesman MR, McEwan AG.

Biochemistry. 2002 Dec 24;41(51):15234-44.

PMID:
12484761
49.

Structural basis for the oxidation of thiosulfate by a sulfur cycle enzyme.

Bamford VA, Bruno S, Rasmussen T, Appia-Ayme C, Cheesman MR, Berks BC, Hemmings AM.

EMBO J. 2002 Nov 1;21(21):5599-610.

50.

Expression, purification and spectroscopic characterization of the cytochrome P450 CYP121 from Mycobacterium tuberculosis.

McLean KJ, Cheesman MR, Rivers SL, Richmond A, Leys D, Chapman SK, Reid GA, Price NC, Kelly SM, Clarkson J, Smith WE, Munro AW.

J Inorg Biochem. 2002 Sep 20;91(4):527-41.

PMID:
12237220

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