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Chromosome Segregation: Evolving a Plastic Chromosome-Microtubule Interface.

Navarro AP, Cheeseman IM.

Curr Biol. 2020 Feb 24;30(4):R174-R177. doi: 10.1016/j.cub.2019.12.058.


Cohesin Removal Reprograms Gene Expression upon Mitotic Entry.

Perea-Resa C, Bury L, Cheeseman IM, Blower MD.

Mol Cell. 2020 Feb 3. pii: S1097-2765(20)30044-7. doi: 10.1016/j.molcel.2020.01.023. [Epub ahead of print]


Quiescent Cells Actively Replenish CENP-A Nucleosomes to Maintain Centromere Identity and Proliferative Potential.

Swartz SZ, McKay LS, Su KC, Bury L, Padeganeh A, Maddox PS, Knouse KA, Cheeseman IM.

Dev Cell. 2019 Oct 7;51(1):35-48.e7. doi: 10.1016/j.devcel.2019.07.016. Epub 2019 Aug 15.


The AAA + ATPase TorsinA polymerizes into hollow helical tubes with 8.5 subunits per turn.

Demircioglu FE, Zheng W, McQuown AJ, Maier NK, Watson N, Cheeseman IM, Denic V, Egelman EH, Schwartz TU.

Nat Commun. 2019 Jul 22;10(1):3262. doi: 10.1038/s41467-019-11194-w.


Ectopic Activation of the Spindle Assembly Checkpoint Signaling Cascade Reveals Its Biochemical Design.

Chen C, Whitney IP, Banerjee A, Sacristan C, Sekhri P, Kern DM, Fontan A, Kops GJPL, Tyson JJ, Cheeseman IM, Joglekar AP.

Curr Biol. 2019 Jan 7;29(1):104-119.e10. doi: 10.1016/j.cub.2018.11.054. Epub 2018 Dec 27.


Distinct Roles of RZZ and Bub1-KNL1 in Mitotic Checkpoint Signaling and Kinetochore Expansion.

Rodriguez-Rodriguez JA, Lewis C, McKinley KL, Sikirzhytski V, Corona J, Maciejowski J, Khodjakov A, Cheeseman IM, Jallepalli PV.

Curr Biol. 2018 Nov 5;28(21):3422-3429.e5. doi: 10.1016/j.cub.2018.10.006. Epub 2018 Oct 25.


Microcephaly Modeling of Kinetochore Mutation Reveals a Brain-Specific Phenotype.

Omer Javed A, Li Y, Muffat J, Su KC, Cohen MA, Lungjangwa T, Aubourg P, Cheeseman IM, Jaenisch R.

Cell Rep. 2018 Oct 9;25(2):368-382.e5. doi: 10.1016/j.celrep.2018.09.032.


Dynamic regulation of dynein localization revealed by small molecule inhibitors of ubiquitination enzymes.

Monda JK, Cheeseman IM.

Open Biol. 2018 Sep 26;8(9). pii: 180095. doi: 10.1098/rsob.180095.


The kinetochore-microtubule interface at a glance.

Monda JK, Cheeseman IM.

J Cell Sci. 2018 Aug 16;131(16). pii: jcs214577. doi: 10.1242/jcs.214577. Review.


CRISPR/Cas9-based gene targeting using synthetic guide RNAs enables robust cell biological analyses.

Su KC, Tsang MJ, Emans N, Cheeseman IM.

Mol Biol Cell. 2018 Oct 1;29(20):2370-2377. doi: 10.1091/mbc.E18-04-0214. Epub 2018 Aug 9.


Nde1 promotes diverse dynein functions through differential interactions and exhibits an isoform-specific proteasome association.

Monda JK, Cheeseman IM.

Mol Biol Cell. 2018 Sep 15;29(19):2336-2345. doi: 10.1091/mbc.E18-07-0418. Epub 2018 Jul 19.


Microtubule Tip Tracking by the Spindle and Kinetochore Protein Ska1 Requires Diverse Tubulin-Interacting Surfaces.

Monda JK, Whitney IP, Tarasovetc EV, Wilson-Kubalek E, Milligan RA, Grishchuk EL, Cheeseman IM.

Curr Biol. 2017 Dec 4;27(23):3666-3675.e6. doi: 10.1016/j.cub.2017.10.018. Epub 2017 Nov 16.


Astrin-SKAP complex reconstitution reveals its kinetochore interaction with microtubule-bound Ndc80.

Kern DM, Monda JK, Su KC, Wilson-Kubalek EM, Cheeseman IM.

Elife. 2017 Aug 25;6. pii: e26866. doi: 10.7554/eLife.26866.


Centromeres are maintained by fastening CENP-A to DNA and directing an arginine anchor-dependent nucleosome transition.

Guo LY, Allu PK, Zandarashvili L, McKinley KL, Sekulic N, Dawicki-McKenna JM, Fachinetti D, Logsdon GA, Jamiolkowski RM, Cleveland DW, Cheeseman IM, Black BE.

Nat Commun. 2017 Jun 9;8:15775. doi: 10.1038/ncomms15775.


Large-Scale Analysis of CRISPR/Cas9 Cell-Cycle Knockouts Reveals the Diversity of p53-Dependent Responses to Cell-Cycle Defects.

McKinley KL, Cheeseman IM.

Dev Cell. 2017 Feb 27;40(4):405-420.e2. doi: 10.1016/j.devcel.2017.01.012. Epub 2017 Feb 16.


A Regulatory Switch Alters Chromosome Motions at the Metaphase-to-Anaphase Transition.

Su KC, Barry Z, Schweizer N, Maiato H, Bathe M, Cheeseman IM.

Cell Rep. 2016 Nov 8;17(7):1728-1738. doi: 10.1016/j.celrep.2016.10.046.


A mitotic SKAP isoform regulates spindle positioning at astral microtubule plus ends.

Kern DM, Nicholls PK, Page DC, Cheeseman IM.

J Cell Biol. 2016 May 9;213(3):315-28. doi: 10.1083/jcb.201510117. Epub 2016 May 2.


Structural comparison of the Caenorhabditis elegans and human Ndc80 complexes bound to microtubules reveals distinct binding behavior.

Wilson-Kubalek EM, Cheeseman IM, Milligan RA.

Mol Biol Cell. 2016 Apr 15;27(8):1197-203. doi: 10.1091/mbc.E15-12-0858. Epub 2016 Mar 3.


The CENP-L-N Complex Forms a Critical Node in an Integrated Meshwork of Interactions at the Centromere-Kinetochore Interface.

McKinley KL, Sekulic N, Guo LY, Tsinman T, Black BE, Cheeseman IM.

Mol Cell. 2015 Dec 17;60(6):886-98. doi: 10.1016/j.molcel.2015.10.027. Epub 2015 Nov 19.


The molecular basis for centromere identity and function.

McKinley KL, Cheeseman IM.

Nat Rev Mol Cell Biol. 2016 Jan;17(1):16-29. doi: 10.1038/nrm.2015.5. Epub 2015 Nov 25. Review.


Chromosome Segregation: A Spatial Code to Correct Kinetochore-Microtubule Attachments.

Monda JK, Cheeseman IM.

Curr Biol. 2015 Jul 20;25(14):R601-3. doi: 10.1016/j.cub.2015.05.056.


Inferring transient particle transport dynamics in live cells.

Monnier N, Barry Z, Park HY, Su KC, Katz Z, English BP, Dey A, Pan K, Cheeseman IM, Singer RH, Bathe M.

Nat Methods. 2015 Sep;12(9):838-40. doi: 10.1038/nmeth.3483. Epub 2015 Jul 20.


Distinct organization and regulation of the outer kinetochore KMN network downstream of CENP-C and CENP-T.

Rago F, Gascoigne KE, Cheeseman IM.

Curr Biol. 2015 Mar 2;25(5):671-7. doi: 10.1016/j.cub.2015.01.059. Epub 2015 Feb 5.


The outer kinetochore protein KNL-1 contains a defined oligomerization domain in nematodes.

Kern DM, Kim T, Rigney M, Hattersley N, Desai A, Cheeseman IM.

Mol Biol Cell. 2015 Jan 15;26(2):229-37. doi: 10.1091/mbc.E14-06-1125. Epub 2014 Nov 19.


Polo-like kinase 1 licenses CENP-A deposition at centromeres.

McKinley KL, Cheeseman IM.

Cell. 2014 Jul 17;158(2):397-411. doi: 10.1016/j.cell.2014.06.016.


The kinetochore.

Cheeseman IM.

Cold Spring Harb Perspect Biol. 2014 Jul 1;6(7):a015826. doi: 10.1101/cshperspect.a015826. Review.


Kinetochore genes are coordinately up-regulated in human tumors as part of a FoxM1-related cell division program.

Thiru P, Kern DM, McKinley KL, Monda JK, Rago F, Su KC, Tsinman T, Yarar D, Bell GW, Cheeseman IM.

Mol Biol Cell. 2014 Jul 1;25(13):1983-94. doi: 10.1091/mbc.E14-03-0837. Epub 2014 May 14.


Spindle assembly checkpoint robustness requires Tpr-mediated regulation of Mad1/Mad2 proteostasis.

Schweizer N, Ferrás C, Kern DM, Logarinho E, Cheeseman IM, Maiato H.

J Cell Biol. 2013 Dec 23;203(6):883-93.


Cortical dynein and asymmetric membrane elongation coordinately position the spindle in anaphase.

Kiyomitsu T, Cheeseman IM.

Cell. 2013 Jul 18;154(2):391-402. doi: 10.1016/j.cell.2013.06.010. Erratum in: Cell. 2013 Sep 12;154(6):1401.


Induced dicentric chromosome formation promotes genomic rearrangements and tumorigenesis.

Gascoigne KE, Cheeseman IM.

Chromosome Res. 2013 Jul;21(4):407-18. doi: 10.1007/s10577-013-9368-6. Epub 2013 Jun 22.


Resonance assignments of the microtubule-binding domain of the C. elegans spindle and kinetochore-associated protein 1.

Boeszoermenyi A, Schmidt JC, Cheeseman IM, Oberer M, Wagner G, Arthanari H.

Biomol NMR Assign. 2014 Oct;8(2):275-8. doi: 10.1007/s12104-013-9499-x. Epub 2013 Jun 14.


Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant.

Earnshaw WC, Allshire RC, Black BE, Bloom K, Brinkley BR, Brown W, Cheeseman IM, Choo KH, Copenhaver GP, Deluca JG, Desai A, Diekmann S, Erhardt S, Fitzgerald-Hayes M, Foltz D, Fukagawa T, Gassmann R, Gerlich DW, Glover DM, Gorbsky GJ, Harrison SC, Heun P, Hirota T, Jansen LE, Karpen G, Kops GJ, Lampson MA, Lens SM, Losada A, Luger K, Maiato H, Maddox PS, Margolis RL, Masumoto H, McAinsh AD, Mellone BG, Meraldi P, Musacchio A, Oegema K, O'Neill RJ, Salmon ED, Scott KC, Straight AF, Stukenberg PT, Sullivan BA, Sullivan KF, Sunkel CE, Swedlow JR, Walczak CE, Warburton PE, Westermann S, Willard HF, Wordeman L, Yanagida M, Yen TJ, Yoda K, Cleveland DW.

Chromosome Res. 2013 Apr;21(2):101-6. doi: 10.1007/s10577-013-9347-y. Epub 2013 Apr 12.


CDK-dependent phosphorylation and nuclear exclusion coordinately control kinetochore assembly state.

Gascoigne KE, Cheeseman IM.

J Cell Biol. 2013 Apr 1;201(1):23-32. doi: 10.1083/jcb.201301006. Epub 2013 Mar 25.


Review series: The functions and consequences of force at kinetochores.

Rago F, Cheeseman IM.

J Cell Biol. 2013 Mar 4;200(5):557-65. doi: 10.1083/jcb.201211113. Review.


CENP-T provides a structural platform for outer kinetochore assembly.

Nishino T, Rago F, Hori T, Tomii K, Cheeseman IM, Fukagawa T.

EMBO J. 2013 Feb 6;32(3):424-36. doi: 10.1038/emboj.2012.348. Epub 2013 Jan 18.


The microtubule-binding protein Cep170 promotes the targeting of the kinesin-13 depolymerase Kif2b to the mitotic spindle.

Welburn JP, Cheeseman IM.

Mol Biol Cell. 2012 Dec;23(24):4786-95. doi: 10.1091/mbc.E12-03-0214. Epub 2012 Oct 19.


The kinetochore-bound Ska1 complex tracks depolymerizing microtubules and binds to curved protofilaments.

Schmidt JC, Arthanari H, Boeszoermenyi A, Dashkevich NM, Wilson-Kubalek EM, Monnier N, Markus M, Oberer M, Milligan RA, Bathe M, Wagner G, Grishchuk EL, Cheeseman IM.

Dev Cell. 2012 Nov 13;23(5):968-80. doi: 10.1016/j.devcel.2012.09.012. Epub 2012 Oct 18. Erratum in: Dev Cell. 2012 Nov 13;23(5):1081.


Kinetochore structure: pulling answers from yeast.

Kern DM, Cheeseman IM.

Curr Biol. 2012 Oct 9;22(19):R842-4. doi: 10.1016/j.cub.2012.08.001.


Cdk1 and Plk1 mediate a CLASP2 phospho-switch that stabilizes kinetochore-microtubule attachments.

Maia AR, Garcia Z, Kabeche L, Barisic M, Maffini S, Macedo-Ribeiro S, Cheeseman IM, Compton DA, Kaverina I, Maiato H.

J Cell Biol. 2012 Oct 15;199(2):285-301. doi: 10.1083/jcb.201203091. Epub 2012 Oct 8.


Targeted proteomic dissection of Toxoplasma cytoskeleton sub-compartments using MORN1.

Lorestani A, Ivey FD, Thirugnanam S, Busby MA, Marth GT, Cheeseman IM, Gubbels MJ.

Cytoskeleton (Hoboken). 2012 Dec;69(12):1069-85. doi: 10.1002/cm.21077. Epub 2012 Oct 11.


LAB-1 targets PP1 and restricts Aurora B kinase upon entrance into meiosis to promote sister chromatid cohesion.

Tzur YB, Egydio de Carvalho C, Nadarajan S, Van Bostelen I, Gu Y, Chu DS, Cheeseman IM, Colaiácovo MP.

PLoS Biol. 2012;10(8):e1001378. doi: 10.1371/journal.pbio.1001378. Epub 2012 Aug 21.


T time for point centromeres.

Gascoigne KE, Cheeseman IM.

Nat Cell Biol. 2012 May 30;14(6):559-61. doi: 10.1038/ncb2509.


CSAP localizes to polyglutamylated microtubules and promotes proper cilia function and zebrafish development.

Backer CB, Gutzman JH, Pearson CG, Cheeseman IM.

Mol Biol Cell. 2012 Jun;23(11):2122-30. doi: 10.1091/mbc.E11-11-0931. Epub 2012 Apr 4.


Chromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and orientation.

Kiyomitsu T, Cheeseman IM.

Nat Cell Biol. 2012 Feb 12;14(3):311-7. doi: 10.1038/ncb2440.


CENP-T-W-S-X forms a unique centromeric chromatin structure with a histone-like fold.

Nishino T, Takeuchi K, Gascoigne KE, Suzuki A, Hori T, Oyama T, Morikawa K, Cheeseman IM, Fukagawa T.

Cell. 2012 Feb 3;148(3):487-501. doi: 10.1016/j.cell.2011.11.061.


Induced ectopic kinetochore assembly bypasses the requirement for CENP-A nucleosomes.

Gascoigne KE, Takeuchi K, Suzuki A, Hori T, Fukagawa T, Cheeseman IM.

Cell. 2011 Apr 29;145(3):410-22. doi: 10.1016/j.cell.2011.03.031.


Chromosome segregation: keeping kinetochores in the loop.

Schmidt JC, Cheeseman IM.

Curr Biol. 2011 Feb 8;21(3):R110-2. doi: 10.1016/j.cub.2010.12.030.


Sensing centromere tension: Aurora B and the regulation of kinetochore function.

Lampson MA, Cheeseman IM.

Trends Cell Biol. 2011 Mar;21(3):133-40. doi: 10.1016/j.tcb.2010.10.007. Epub 2010 Nov 22. Review.


Aurora B kinase controls the targeting of the Astrin-SKAP complex to bioriented kinetochores.

Schmidt JC, Kiyomitsu T, Hori T, Backer CB, Fukagawa T, Cheeseman IM.

J Cell Biol. 2010 Oct 18;191(2):269-80. doi: 10.1083/jcb.201006129. Epub 2010 Oct 11.


Tension at EMBO's Aneuploidy Workshop.

De Wulf P, Cheeseman IM.

EMBO Rep. 2010 Oct;11(10):727-9. doi: 10.1038/embor.2010.146. Epub 2010 Sep 24.

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