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Items: 28

1.

Kras/ADAM17-dependent Jag1-ICD reverse signalling sustains colorectal cancer progression and chemoresistance.

Pelullo M, Nardozza F, Zema S, Quaranta R, Nicoletti C, Besharat ZM, Felli MP, Cerbelli B, d'Amati G, Palermo R, Capalbo C, Talora C, Di Marcotullio L, Giannini G, Checquolo S, Screpanti I, Bellavia D.

Cancer Res. 2019 Sep 10. pii: canres.0145.2019. doi: 10.1158/0008-5472.CAN-19-0145. [Epub ahead of print]

PMID:
31506332
2.

Notch Signaling Activation as a Hallmark for Triple-Negative Breast Cancer Subtype.

Giuli MV, Giuliani E, Screpanti I, Bellavia D, Checquolo S.

J Oncol. 2019 Jul 11;2019:8707053. doi: 10.1155/2019/8707053. eCollection 2019. Review.

3.

Histone Modifications Drive Aberrant Notch3 Expression/Activity and Growth in T-ALL.

Tottone L, Zhdanovskaya N, Carmona Pestaña Á, Zampieri M, Simeoni F, Lazzari S, Ruocco V, Pelullo M, Caiafa P, Felli MP, Checquolo S, Bellavia D, Talora C, Screpanti I, Palermo R.

Front Oncol. 2019 Apr 3;9:198. doi: 10.3389/fonc.2019.00198. eCollection 2019.

4.

Notch3 Targeting: A Novel Weapon against Ovarian Cancer Stem Cells.

Ceccarelli S, Megiorni F, Bellavia D, Marchese C, Screpanti I, Checquolo S.

Stem Cells Int. 2019 Jan 6;2019:6264931. doi: 10.1155/2019/6264931. eCollection 2019. Review.

5.

Mitogen-activated kinase kinase kinase 1 inhibits hedgehog signaling and medulloblastoma growth through GLI1 phosphorylation.

Antonucci L, Di Magno L, D'Amico D, Manni S, Serrao SM, Di Pastena F, Bordone R, Yurtsever ZN, Caimano M, Petroni M, Giorgi A, Schininà ME, Yates Iii JR, Di Marcotullio L, De Smaele E, Checquolo S, Capalbo C, Agostinelli E, Maroder M, Coni S, Canettieri G.

Int J Oncol. 2019 Feb;54(2):505-514. doi: 10.3892/ijo.2018.4638. Epub 2018 Nov 19.

6.

The Notch3 Receptor and Its Intracellular Signaling-Dependent Oncogenic Mechanisms.

Bellavia D, Checquolo S, Palermo R, Screpanti I.

Adv Exp Med Biol. 2018;1066:205-222. doi: 10.1007/978-3-319-89512-3_10. Review.

PMID:
30030828
7.

NOTCH3 inactivation increases triple negative breast cancer sensitivity to gefitinib by promoting EGFR tyrosine dephosphorylation and its intracellular arrest.

Diluvio G, Del Gaudio F, Giuli MV, Franciosa G, Giuliani E, Palermo R, Besharat ZM, Pignataro MG, Vacca A, d'Amati G, Maroder M, Talora C, Capalbo C, Bellavia D, Checquolo S.

Oncogenesis. 2018 May 25;7(5):42. doi: 10.1038/s41389-018-0051-9.

8.

Notch signaling as a therapeutic target for acute lymphoblastic leukemia.

Bellavia D, Palermo R, Felli MP, Screpanti I, Checquolo S.

Expert Opin Ther Targets. 2018 Apr;22(4):331-342. doi: 10.1080/14728222.2018.1451840. Epub 2018 Mar 21. Review.

PMID:
29527929
9.

Maml1 acts cooperatively with Gli proteins to regulate sonic hedgehog signaling pathway.

Quaranta R, Pelullo M, Zema S, Nardozza F, Checquolo S, Lauer DM, Bufalieri F, Palermo R, Felli MP, Vacca A, Talora C, Di Marcotullio L, Screpanti I, Bellavia D.

Cell Death Dis. 2017 Jul 20;8(7):e2942. doi: 10.1038/cddis.2017.326.

10.

RET mutation and increased angiogenesis in medullary thyroid carcinomas.

Verrienti A, Tallini G, Colato C, Boichard A, Checquolo S, Pecce V, Sponziello M, Rosignolo F, de Biase D, Rhoden K, Casadei GP, Russo D, Visani M, Acquaviva G, Ferdeghini M, Filetti S, Durante C.

Endocr Relat Cancer. 2016 Aug;23(8):665-76. doi: 10.1530/ERC-16-0132. Epub 2016 Jul 8.

PMID:
27402614
11.

Prolyl-isomerase Pin1 controls Notch3 protein expression and regulates T-ALL progression.

Franciosa G, Diluvio G, Gaudio FD, Giuli MV, Palermo R, Grazioli P, Campese AF, Talora C, Bellavia D, D'Amati G, Besharat ZM, Nicoletti C, Siebel CW, Choy L, Rustighi A, Sal GD, Screpanti I, Checquolo S.

Oncogene. 2016 Sep 8;35(36):4741-51. doi: 10.1038/onc.2016.5. Epub 2016 Feb 15.

12.

The deregulated expression of miR-125b in acute myeloid leukemia is dependent on the transcription factor C/EBPα.

Vargas Romero P, Cialfi S, Palermo R, De Blasio C, Checquolo S, Bellavia D, Chiaretti S, Foà R, Amadori A, Gulino A, Zardo G, Talora C, Screpanti I.

Leukemia. 2015 Dec;29(12):2442-5. doi: 10.1038/leu.2015.117. Epub 2015 May 18. No abstract available.

13.

Notch3/Jagged1 circuitry reinforces notch signaling and sustains T-ALL.

Pelullo M, Quaranta R, Talora C, Checquolo S, Cialfi S, Felli MP, te Kronnie G, Borga C, Besharat ZM, Palermo R, Di Marcotullio L, Capobianco AJ, Gulino A, Screpanti I, Bellavia D.

Neoplasia. 2014 Dec;16(12):1007-17. doi: 10.1016/j.neo.2014.10.004.

14.

Numb-dependent integration of pre-TCR and p53 function in T-cell precursor development.

Martin-Blanco NM, Checquolo S, Del Gaudio F, Palermo R, Franciosa G, Di Marcotullio L, Gulino A, Canelles M, Screpanti I.

Cell Death Dis. 2014 Oct 16;5:e1472. doi: 10.1038/cddis.2014.438.

15.

Loss of Notch1-dependent p21(Waf1/Cip1) expression influences the Notch1 outcome in tumorigenesis.

Cialfi S, Palermo R, Manca S, De Blasio C, Vargas Romero P, Checquolo S, Bellavia D, Uccelletti D, Saliola M, D'Alessandro A, Zolla L, Gulino A, Screpanti I, Talora C.

Cell Cycle. 2014;13(13):2046-55. doi: 10.4161/cc.29079. Epub 2014 May 6.

16.

Notch and NF-kB signaling pathways regulate miR-223/FBXW7 axis in T-cell acute lymphoblastic leukemia.

Kumar V, Palermo R, Talora C, Campese AF, Checquolo S, Bellavia D, Tottone L, Testa G, Miele E, Indraccolo S, Amadori A, Ferretti E, Gulino A, Vacca A, Screpanti I.

Leukemia. 2014 Dec;28(12):2324-35. doi: 10.1038/leu.2014.133. Epub 2014 Apr 14.

PMID:
24727676
17.

The molecular basis of notch signaling regulation: a complex simplicity.

Palermo R, Checquolo S, Bellavia D, Talora C, Screpanti I.

Curr Mol Med. 2014 Jan;14(1):34-44. Review.

PMID:
24236458
18.

Glucocorticoid sensitivity of T-cell lymphoblastic leukemia/lymphoma is associated with glucocorticoid receptor-mediated inhibition of Notch1 expression.

Cialfi S, Palermo R, Manca S, Checquolo S, Bellavia D, Pelullo M, Quaranta R, Dominici C, Gulino A, Screpanti I, Talora C.

Leukemia. 2013 Feb;27(2):485-8. doi: 10.1038/leu.2012.192. Epub 2012 Jul 13. No abstract available.

PMID:
22846929
19.

Loss of CBL E3-ligase activity in B-lineage childhood acute lymphoblastic leukaemia.

Martinelli S, Checquolo S, Consoli F, Stellacci E, Rossi C, Silvano M, Franciosa G, Flex E, Cossu C, De Luca A, Foà R, Cazzaniga G, Biondi A, Screpanti I, Tartaglia M.

Br J Haematol. 2012 Oct;159(1):115-9. doi: 10.1111/j.1365-2141.2012.09245.x. Epub 2012 Jul 27. No abstract available.

PMID:
22834886
20.

Acetylation controls Notch3 stability and function in T-cell leukemia.

Palermo R, Checquolo S, Giovenco A, Grazioli P, Kumar V, Campese AF, Giorgi A, Napolitano M, Canettieri G, Ferrara G, Schininà ME, Maroder M, Frati L, Gulino A, Vacca A, Screpanti I.

Oncogene. 2012 Aug 16;31(33):3807-17. doi: 10.1038/onc.2011.533. Epub 2011 Nov 28.

PMID:
22120716
21.

Heterozygous germline mutations in the CBL tumor-suppressor gene cause a Noonan syndrome-like phenotype.

Martinelli S, De Luca A, Stellacci E, Rossi C, Checquolo S, Lepri F, Caputo V, Silvano M, Buscherini F, Consoli F, Ferrara G, Digilio MC, Cavaliere ML, van Hagen JM, Zampino G, van der Burgt I, Ferrero GB, Mazzanti L, Screpanti I, Yntema HG, Nillesen WM, Savarirayan R, Zenker M, Dallapiccola B, Gelb BD, Tartaglia M.

Am J Hum Genet. 2010 Aug 13;87(2):250-7. doi: 10.1016/j.ajhg.2010.06.015. Epub 2010 Jul 8.

22.

Differential subcellular localization regulates c-Cbl E3 ligase activity upon Notch3 protein in T-cell leukemia.

Checquolo S, Palermo R, Cialfi S, Ferrara G, Oliviero C, Talora C, Bellavia D, Giovenco A, Grazioli P, Frati L, Gulino A, Screpanti I.

Oncogene. 2010 Mar 11;29(10):1463-74. doi: 10.1038/onc.2009.446. Epub 2009 Dec 7.

PMID:
19966856
23.

Notch3 and pTalpha/pre-TCR sustain the in vivo function of naturally occurring regulatory T cells.

Campese AF, Grazioli P, Colantoni S, Anastasi E, Mecarozzi M, Checquolo S, De Luca G, Bellavia D, Frati L, Gulino A, Screpanti I.

Int Immunol. 2009 Jun;21(6):727-43. doi: 10.1093/intimm/dxp042. Epub 2009 May 21.

PMID:
19461123
24.

Notch3: from subtle structural differences to functional diversity.

Bellavia D, Checquolo S, Campese AF, Felli MP, Gulino A, Screpanti I.

Oncogene. 2008 Sep 1;27(38):5092-8. doi: 10.1038/onc.2008.230. Review.

PMID:
18758477
25.

PKC theta mediates pre-TCR signaling and contributes to Notch3-induced T-cell leukemia.

Felli MP, Vacca A, Calce A, Bellavia D, Campese AF, Grillo R, Di Giovine M, Checquolo S, Talora C, Palermo R, Di Mario G, Frati L, Gulino A, Screpanti I.

Oncogene. 2005 Feb 3;24(6):992-1000.

PMID:
15592506
26.

Expression of activated Notch3 in transgenic mice enhances generation of T regulatory cells and protects against experimental autoimmune diabetes.

Anastasi E, Campese AF, Bellavia D, Bulotta A, Balestri A, Pascucci M, Checquolo S, Gradini R, Lendahl U, Frati L, Gulino A, Di Mario U, Screpanti I.

J Immunol. 2003 Nov 1;171(9):4504-11.

27.

Pre-TCR-triggered ERK signalling-dependent downregulation of E2A activity in Notch3-induced T-cell lymphoma.

Talora C, Campese AF, Bellavia D, Pascucci M, Checquolo S, Groppioni M, Frati L, von Boehmer H, Gulino A, Screpanti I.

EMBO Rep. 2003 Nov;4(11):1067-72. Epub 2003 Oct 17.

28.

Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis.

Bellavia D, Campese AF, Checquolo S, Balestri A, Biondi A, Cazzaniga G, Lendahl U, Fehling HJ, Hayday AC, Frati L, von Boehmer H, Gulino A, Screpanti I.

Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3788-93. Epub 2002 Mar 12.

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