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Targeting Post-Translational Remodeling of Ryanodine Receptor: a New Track for Alzheimer's Disease Therapy?

Chami M, Checler F.

Curr Alzheimer Res. 2020 Feb 24. doi: 10.2174/1567205017666200225102941. [Epub ahead of print]


Palmitate Is Increased in the Cerebrospinal Fluid of Humans with Obesity and Induces Memory Impairment in Mice via Pro-inflammatory TNF-α.

Melo HM, Seixas da Silva GDS, Sant'Ana MR, Teixeira CVL, Clarke JR, Miya Coreixas VS, de Melo BC, Fortuna JTS, Forny-Germano L, Ledo JH, Oliveira MS, Figueiredo CP, Pardossi-Piquard R, Checler F, Delgado-García JM, Gruart A, Velloso LA, Balthazar MLF, Cintra DE, Ferreira ST, De Felice FG.

Cell Rep. 2020 Feb 18;30(7):2180-2194.e8. doi: 10.1016/j.celrep.2020.01.072.


Targeting γ-secretase triggers the selective enrichment of oligomeric APP-CTFs in brain extracellular vesicles from Alzheimer cell and mouse models.

Lauritzen I, Bécot A, Bourgeois A, Pardossi-Piquard R, Biferi MG, Barkats M, Checler F.

Transl Neurodegener. 2019 Dec 5;8:35. doi: 10.1186/s40035-019-0176-6. eCollection 2019.


Upregulation of the Sarco-Endoplasmic Reticulum Calcium ATPase 1 Truncated Isoform Plays a Pathogenic Role in Alzheimer's Disease.

Bussiere R, Oulès B, Mary A, Vaillant-Beuchot L, Martin C, El Manaa W, Vallée D, Duplan E, Paterlini-Bréchot P, Alves Da Costa C, Checler F, Chami M.

Cells. 2019 Nov 28;8(12). pii: E1539. doi: 10.3390/cells8121539.


Does Intraneuronal Accumulation of Carboxyl-terminal Fragments of the Amyloid Precursor Protein Trigger Early Neurotoxicity in Alzheimer's Disease?

Lauritzen I, Pardossi-Piquard R, Bourgeois A, Bécot A, Checler F.

Curr Alzheimer Res. 2019;16(5):453-457. doi: 10.2174/1567205016666190325092841.


The OncoAge Consortium: Linking Aging and Oncology from Bench to Bedside and Back Again.

Hofman P, Ayache N, Barbry P, Barlaud M, Bel A, Blancou P, Checler F, Chevillard S, Cristofari G, Demory M, Esnault V, Falandry C, Gilson E, Guérin O, Glaichenhaus N, Guigay J, Ilié M, Mari B, Marquette CH, Paquis-Flucklinger V, Prate F, Saintigny P, Seitz-Polsky B, Skhiri T, Van Obberghen-Schilling E, Van Obberghen E, Yvan-Charvet L.

Cancers (Basel). 2019 Feb 21;11(2). pii: E250. doi: 10.3390/cancers11020250.


The Transcription Factor Function of Parkin: Breaking the Dogma.

Alves da Costa C, Duplan E, Rouland L, Checler F.

Front Neurosci. 2019 Jan 15;12:965. doi: 10.3389/fnins.2018.00965. eCollection 2018. Review.


Chronic fornix deep brain stimulation in a transgenic Alzheimer's rat model reduces amyloid burden, inflammation, and neuronal loss.

Leplus A, Lauritzen I, Melon C, Kerkerian-Le Goff L, Fontaine D, Checler F.

Brain Struct Funct. 2019 Jan;224(1):363-372. doi: 10.1007/s00429-018-1779-x. Epub 2018 Oct 19.


Proamyloidogenic effects of membrane type 1 matrix metalloproteinase involve MMP-2 and BACE-1 activities, and the modulation of APP trafficking.

Paumier JM, Py NA, García-González L, Bernard A, Stephan D, Louis L, Checler F, Khrestchatisky M, Baranger K, Rivera S.

FASEB J. 2019 Feb;33(2):2910-2927. doi: 10.1096/fj.201801076R. Epub 2018 Oct 17.


Neurolysin: From Initial Detection to Latest Advances.

Checler F, Ferro ES.

Neurochem Res. 2018 Nov;43(11):2017-2024. doi: 10.1007/s11064-018-2624-6. Epub 2018 Aug 29. Review.


Are N- and C-terminally truncated Aβ species key pathological triggers in Alzheimer's disease?

Dunys J, Valverde A, Checler F.

J Biol Chem. 2018 Oct 5;293(40):15419-15428. doi: 10.1074/jbc.R118.003999. Epub 2018 Aug 24. Review.


Intraneuronal accumulation of C99 contributes to synaptic alterations, apathy-like behavior, and spatial learning deficits in 3×TgAD and 2×TgAD mice.

Bourgeois A, Lauritzen I, Lorivel T, Bauer C, Checler F, Pardossi-Piquard R.

Neurobiol Aging. 2018 Nov;71:21-31. doi: 10.1016/j.neurobiolaging.2018.06.038. Epub 2018 Jul 12.


Nuclear TP53: An unraveled function as transcriptional repressor of PINK1.

Checler F, Goiran T, Alves da Costa C.

Autophagy. 2018;14(6):1099-1101. doi: 10.1080/15548627.2018.1450022. Epub 2018 May 11.


Nuclear p53-mediated repression of autophagy involves PINK1 transcriptional down-regulation.

Goiran T, Duplan E, Rouland L, El Manaa W, Lauritzen I, Dunys J, You H, Checler F, Alves da Costa C.

Cell Death Differ. 2018 May;25(5):873-884. doi: 10.1038/s41418-017-0016-0. Epub 2018 Jan 19.


Presenilins at the crossroad of a functional interplay between PARK2/PARKIN and PINK1 to control mitophagy: Implication for neurodegenerative diseases.

Checler F, Goiran T, Alves da Costa C.

Autophagy. 2017;13(11):2004-2005. doi: 10.1080/15548627.2017.1363950. Epub 2017 Sep 21.


Post-translational remodeling of ryanodine receptor induces calcium leak leading to Alzheimer's disease-like pathologies and cognitive deficits.

Lacampagne A, Liu X, Reiken S, Bussiere R, Meli AC, Lauritzen I, Teich AF, Zalk R, Saint N, Arancio O, Bauer C, Duprat F, Briggs CA, Chakroborty S, Stutzmann GE, Shelanski ML, Checler F, Chami M, Marks AR.

Acta Neuropathol. 2017 Nov;134(5):749-767. doi: 10.1007/s00401-017-1733-7. Epub 2017 Jun 19.


β-Amyloid Precursor Protein Intracellular Domain Controls Mitochondrial Function by Modulating Phosphatase and Tensin Homolog-Induced Kinase 1 Transcription in Cells and in Alzheimer Mice Models.

Goiran T, Duplan E, Chami M, Bourgeois A, El Manaa W, Rouland L, Dunys J, Lauritzen I, You H, Stambolic V, Biféri MG, Barkats M, Pimplikar SW, Sergeant N, Colin M, Morais VA, Pardossi-Piquard R, Checler F, Alves da Costa C.

Biol Psychiatry. 2018 Mar 1;83(5):416-427. doi: 10.1016/j.biopsych.2017.04.011. Epub 2017 May 3.


Amyloid β production is regulated by β2-adrenergic signaling-mediated post-translational modifications of the ryanodine receptor.

Bussiere R, Lacampagne A, Reiken S, Liu X, Scheuerman V, Zalk R, Martin C, Checler F, Marks AR, Chami M.

J Biol Chem. 2017 Jun 16;292(24):10153-10168. doi: 10.1074/jbc.M116.743070. Epub 2017 May 5.


MT5-MMP Promotes Alzheimer's Pathogenesis in the Frontal Cortex of 5xFAD Mice and APP Trafficking in vitro.

Baranger K, Bonnet AE, Girard SD, Paumier JM, García-González L, Elmanaa W, Bernard A, Charrat E, Stephan D, Bauer C, Moschke K, Lichtenthaler SF, Roman FS, Checler F, Khrestchatisky M, Rivera S.

Front Mol Neurosci. 2017 Jan 10;9:163. doi: 10.3389/fnmol.2016.00163. eCollection 2016.


The Polyherbal Wattana Formula Displays Anti-Amyloidogenic Properties by Increasing α-Secretase Activities.

Htoo HH, Limsuvan S, Thamsermsang O, Hernandez JF, Checler F, Govitrapong P, Pakaprot N, Akarasereenont P, Vincent B.

PLoS One. 2017 Jan 20;12(1):e0170360. doi: 10.1371/journal.pone.0170360. eCollection 2017.


The transcription factor XBP1 in memory and cognition: Implications in Alzheimer disease.

Cissé M, Duplan E, Checler F.

Mol Med. 2017 Feb;22:905-917. doi: 10.2119/molmed.2016.00229. Epub 2017 Jan 4.


α-synuclein and p53 functional interplay in physiopathological contexts.

Alves da Costa C, Duplan E, Checler F.

Oncotarget. 2017 Feb 7;8(6):9001-9002. doi: 10.18632/oncotarget.14385. No abstract available.


Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism.

Chapuis J, Flaig A, Grenier-Boley B, Eysert F, Pottiez V, Deloison G, Vandeputte A, Ayral AM, Mendes T, Desai S, Goate AM, Kauwe JSK, Leroux F, Herledan A, Demiautte F, Bauer C, Checler F, Petersen RC, Blennow K, Zetterberg H, Minthon L, Van Deerlin VM, Lee VM, Shaw LM, Trojanowski JQ, Albert M, Moghekar A, O'Brien R, Peskind ER, Malmanche N, Schellenberg GD, Dourlen P, Song OR, Cruchaga C, Amouyel P, Deprez B, Brodin P, Lambert JC; ADGC, Alzheimer’s Disease Neuroimaging Initiative.

Acta Neuropathol. 2017 Jun;133(6):955-966. doi: 10.1007/s00401-016-1652-z. Epub 2016 Dec 8.


Localization and Processing of the Amyloid-β Protein Precursor in Mitochondria-Associated Membranes.

Del Prete D, Suski JM, Oulès B, Debayle D, Gay AS, Lacas-Gervais S, Bussiere R, Bauer C, Pinton P, Paterlini-Bréchot P, Wieckowski MR, Checler F, Chami M.

J Alzheimers Dis. 2017;55(4):1549-1570. doi: 10.3233/JAD-160953.


Aβ42 oligomers modulate β-secretase through an XBP-1s-dependent pathway involving HRD1.

Gerakis Y, Dunys J, Bauer C, Checler F.

Sci Rep. 2016 Nov 17;6:37436. doi: 10.1038/srep37436.


The transcription factor XBP1s restores hippocampal synaptic plasticity and memory by control of the Kalirin-7 pathway in Alzheimer model.

Cissé M, Duplan E, Lorivel T, Dunys J, Bauer C, Meckler X, Gerakis Y, Lauritzen I, Checler F.

Mol Psychiatry. 2017 Nov;22(11):1562-1575. doi: 10.1038/mp.2016.152. Epub 2016 Sep 20.


ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease.

Letronne F, Laumet G, Ayral AM, Chapuis J, Demiautte F, Laga M, Vandenberghe ME, Malmanche N, Leroux F, Eysert F, Sottejeau Y, Chami L, Flaig A, Bauer C, Dourlen P, Lesaffre M, Delay C, Huot L, Dumont J, Werkmeister E, Lafont F, Mendes T, Hansmannel F, Dermaut B, Deprez B, Hérard AS, Dhenain M, Souedet N, Pasquier F, Tulasne D, Berr C, Hauw JJ, Lemoine Y, Amouyel P, Mann D, Déprez R, Checler F, Hot D, Delzescaux T, Gevaert K, Lambert JC.

EBioMedicine. 2016 Jul;9:278-292. doi: 10.1016/j.ebiom.2016.06.002. Epub 2016 Jun 2.


Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology.

Lauritzen I, Pardossi-Piquard R, Bourgeois A, Pagnotta S, Biferi MG, Barkats M, Lacor P, Klein W, Bauer C, Checler F.

Acta Neuropathol. 2016 Aug;132(2):257-276. doi: 10.1007/s00401-016-1577-6. Epub 2016 Apr 30.


Presenilin 1 and Presenilin 2 Target γ-Secretase Complexes to Distinct Cellular Compartments.

Meckler X, Checler F.

J Biol Chem. 2016 Jun 10;291(24):12821-37. doi: 10.1074/jbc.M115.708297. Epub 2016 Apr 8.


Influence of Genetic Background on Apathy-Like Behavior in Triple Transgenic AD Mice.

Pardossi-Piquard R, Lauritzen I, Bauer C, Sacco G, Robert P, Checler F.

Curr Alzheimer Res. 2016;13(8):942-9.


Direct α-synuclein promoter transactivation by the tumor suppressor p53.

Duplan E, Giordano C, Checler F, Alves da Costa C.

Mol Neurodegener. 2016 Feb 2;11:13. doi: 10.1186/s13024-016-0079-2.


Nuclear factor-κB regulates βAPP and β- and γ-secretases differently at physiological and supraphysiological Aβ concentrations.

Chami L, Buggia-Prévot V, Duplan E, Del Prete D, Chami M, Peyron JF, Checler F.

J Biol Chem. 2015 Dec 11;290(50):29758. doi: 10.1074/jbc.A115.333054. No abstract available.


Sox2 functionally interacts with βAPP, the βAPP intracellular domain and ADAM10 at a transcriptional level in human cells.

Sarlak G, Htoo HH, Hernandez JF, Iizasa H, Checler F, Konietzko U, Song W, Vincent B.

Neuroscience. 2016 Jan 15;312:153-64. doi: 10.1016/j.neuroscience.2015.11.022. Epub 2015 Nov 17.


MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer's disease.

Baranger K, Marchalant Y, Bonnet AE, Crouzin N, Carrete A, Paumier JM, Py NA, Bernard A, Bauer C, Charrat E, Moschke K, Seiki M, Vignes M, Lichtenthaler SF, Checler F, Khrestchatisky M, Rivera S.

Cell Mol Life Sci. 2016 Jan;73(1):217-36. doi: 10.1007/s00018-015-1992-1. Epub 2015 Jul 23.


Melatonin stimulates the nonamyloidogenic processing of βAPP through the positive transcriptional regulation of ADAM10 and ADAM17.

Shukla M, Htoo HH, Wintachai P, Hernandez JF, Dubois C, Postina R, Xu H, Checler F, Smith DR, Govitrapong P, Vincent B.

J Pineal Res. 2015 Mar;58(2):151-65. doi: 10.1111/jpi.12200. Epub 2014 Dec 27.


Differential spatio-temporal regulation of MMPs in the 5xFAD mouse model of Alzheimer's disease: evidence for a pro-amyloidogenic role of MT1-MMP.

Py NA, Bonnet AE, Bernard A, Marchalant Y, Charrat E, Checler F, Khrestchatisky M, Baranger K, Rivera S.

Front Aging Neurosci. 2014 Sep 18;6:247. doi: 10.3389/fnagi.2014.00247. eCollection 2014.


The transcription factor X-box binding protein-1 in neurodegenerative diseases.

Dunys J, Duplan E, Checler F.

Mol Neurodegener. 2014 Sep 12;9:35. doi: 10.1186/1750-1326-9-35. Review.


Ryanodine receptors: dual contribution to Alzheimer disease?

Chami M, Checler F.

Channels (Austin). 2014;8(3):168. doi: 10.4161/chan.29000. No abstract available.


Eph receptors: new players in Alzheimer's disease pathogenesis.

Cissé M, Checler F.

Neurobiol Dis. 2015 Jan;73:137-49. doi: 10.1016/j.nbd.2014.08.028. Epub 2014 Sep 1. Review.


Ryanodine receptors: physiological function and deregulation in Alzheimer disease.

Del Prete D, Checler F, Chami M.

Mol Neurodegener. 2014 Jun 5;9:21. doi: 10.1186/1750-1326-9-21. Review.


Study on Aβ34 biology and detection in transgenic mice brains.

Caillava C, Ranaldi S, Lauritzen I, Bauer C, Fareh J, Abraham JD, Checler F.

Neurobiol Aging. 2014 Jul;35(7):1570-81. doi: 10.1016/j.neurobiolaging.2014.01.011. Epub 2014 Jan 11.


Visualization of specific γ-secretase complexes using bimolecular fluorescence complementation.

Meckler X, Checler F.

J Alzheimers Dis. 2014;40(1):161-76. doi: 10.3233/JAD-131268.


Experimental stroke: neurolysin back on stage.

Checler F.

J Neurochem. 2014 Apr;129(1):1-3. doi: 10.1111/jnc.12635. Epub 2014 Jan 5. No abstract available.


p53 in neurodegenerative diseases and brain cancers.

Checler F, Alves da Costa C.

Pharmacol Ther. 2014 Apr;142(1):99-113. doi: 10.1016/j.pharmthera.2013.11.009. Epub 2013 Nov 25. Review.


Alzheimer's and prion diseases: PDK1 at the crossroads.

Checler F.

Nat Med. 2013 Sep;19(9):1088-90. doi: 10.1038/nm.3332.


Interplay between parkin and p53 governs a physiological homeostasis that is disrupted in Parkinson's disease and cerebral cancer.

Checler F, Alves da Costa C.

Neurodegener Dis. 2014;13(2-3):118-21. doi: 10.1159/000354075. Epub 2013 Sep 4. Review.


Cerebrospinal Aβ11-x and 17-x levels as indicators of mild cognitive impairment and patients' stratification in Alzheimer's disease.

Abraham JD, Promé S, Salvetat N, Rubrecht L, Cobo S, du Paty E, Galéa P, Mathieu-Dupas E, Ranaldi S, Caillava C, Crémer GA, Rieunier F, Robert P, Molina F, Laune D, Checler F, Fareh J.

Transl Psychiatry. 2013 Jul 16;3:e281. doi: 10.1038/tp.2013.58.


Glioma tumor grade correlates with parkin depletion in mutant p53-linked tumors and results from loss of function of p53 transcriptional activity.

Viotti J, Duplan E, Caillava C, Condat J, Goiran T, Giordano C, Marie Y, Idbaih A, Delattre JY, Honnorat J, Checler F, Alves da Costa C.

Oncogene. 2014 Apr 3;33(14):1764-75. doi: 10.1038/onc.2013.124. Epub 2013 May 6.


ER-stress-associated functional link between Parkin and DJ-1 via a transcriptional cascade involving the tumor suppressor p53 and the spliced X-box binding protein XBP-1.

Duplan E, Giaime E, Viotti J, Sévalle J, Corti O, Brice A, Ariga H, Qi L, Checler F, Alves da Costa C.

J Cell Sci. 2013 May 1;126(Pt 9):2124-33. doi: 10.1242/jcs.127340. Epub 2013 Feb 27.


Parkin differently regulates presenilin-1 and presenilin-2 functions by direct control of their promoter transcription.

Duplan E, Sevalle J, Viotti J, Goiran T, Bauer C, Renbaum P, Levy-Lahad E, Gautier CA, Corti O, Leroudier N, Checler F, da Costa CA.

J Mol Cell Biol. 2013 Apr;5(2):132-42. doi: 10.1093/jmcb/mjt003. Epub 2013 Jan 28.


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