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Determinants of dihydroartemisinin-piperaquine treatment failure in Plasmodium falciparum malaria in Cambodia, Thailand, and Vietnam: a prospective clinical, pharmacological, and genetic study.

van der Pluijm RW, Imwong M, Chau NH, Hoa NT, Thuy-Nhien NT, Thanh NV, Jittamala P, Hanboonkunupakarn B, Chutasmit K, Saelow C, Runjarern R, Kaewmok W, Tripura R, Peto TJ, Yok S, Suon S, Sreng S, Mao S, Oun S, Yen S, Amaratunga C, Lek D, Huy R, Dhorda M, Chotivanich K, Ashley EA, Mukaka M, Waithira N, Cheah PY, Maude RJ, Amato R, Pearson RD, Gonçalves S, Jacob CG, Hamilton WL, Fairhurst RM, Tarning J, Winterberg M, Kwiatkowski DP, Pukrittayakamee S, Hien TT, Day NP, Miotto O, White NJ, Dondorp AM.

Lancet Infect Dis. 2019 Sep;19(9):952-961. doi: 10.1016/S1473-3099(19)30391-3. Epub 2019 Jul 22.


Short-course primaquine for the radical cure of Plasmodium vivax malaria: a multicentre, randomised, placebo-controlled non-inferiority trial.

Taylor WRJ, Thriemer K, von Seidlein L, Yuentrakul P, Assawariyathipat T, Assefa A, Auburn S, Chand K, Chau NH, Cheah PY, Dong LT, Dhorda M, Degaga TS, Devine A, Ekawati LL, Fahmi F, Hailu A, Hasanzai MA, Hien TT, Khu H, Ley B, Lubell Y, Marfurt J, Mohammad H, Moore KA, Naddim MN, Pasaribu AP, Pasaribu S, Promnarate C, Rahim AG, Sirithiranont P, Solomon H, Sudoyo H, Sutanto I, Thanh NV, Tuyet-Trinh NT, Waithira N, Woyessa A, Yamin FY, Dondorp A, Simpson JA, Baird JK, White NJ, Day NP, Price RN.

Lancet. 2019 Jul 18. pii: S0140-6736(19)31285-1. doi: 10.1016/S0140-6736(19)31285-1. [Epub ahead of print]


Evaluation of the Pint of Science festival in Thailand.

Adhikari B, Hlaing PH, Robinson MT, Ruecker A, Tan NH, Jatupornpimol N, Chanviriyavuth R, Cheah PY.

PLoS One. 2019 Jul 18;14(7):e0219983. doi: 10.1371/journal.pone.0219983. eCollection 2019.


Prospects and strategies for malaria elimination in the Greater Mekong Sub-region: a qualitative study.

Kaehler N, Adhikari B, Cheah PY, von Seidlein L, Day NPJ, Paris DH, Tanner M, Pell C.

Malar J. 2019 Jun 20;18(1):203. doi: 10.1186/s12936-019-2835-6.


A new social sciences network for infectious threats.

Giles-Vernick T, Kutalek R, Napier D, Kaawa-Mafigiri D, Dückers M, Paget J, Ahmed SM, Cheah PY, Desclaux A, De Vries D, Hardon A, MacGregor H, Pell C, Rashid SF, Rodyna R, Schultsz C, Sow K, Wilkinson A.

Lancet Infect Dis. 2019 May;19(5):461-463. doi: 10.1016/S1473-3099(19)30159-8. No abstract available.


Treatment-seeking behaviour for febrile illnesses and its implications for malaria control and elimination in Savannakhet Province, Lao PDR (Laos): a mixed method study.

Adhikari B, Phommasone K, Pongvongsa T, Koummarasy P, Soundala X, Henriques G, Sirithiranont P, Parker DM, von Seidlein L, White NJ, Day NPJ, Dondorp AM, Newton PN, Cheah PY, Pell C, Mayxay M.

BMC Health Serv Res. 2019 Apr 24;19(1):252. doi: 10.1186/s12913-019-4070-9.


Data management and sharing policy: the first step towards promoting data sharing.

Waithira N, Mutinda B, Cheah PY.

BMC Med. 2019 Apr 17;17(1):80. doi: 10.1186/s12916-019-1315-8.


Community engagement, social context and coverage of mass anti-malarial administration: Comparative findings from multi-site research in the Greater Mekong sub-Region.

Pell CL, Adhikari B, Myo Thwin M, Kajeechiwa L, Nosten S, Nosten FH, Sahan KM, Smithuis FM, Nguyen TN, Hien TT, Tripura R, Peto TJ, Sanann N, Nguon C, Pongvongsa T, Phommasone K, Mayxay M, Mukaka M, Peerawaranun P, Kaehler N, Cheah PY, Day NPJ, White NJ, Dondorp AM, von Seidlein L.

PLoS One. 2019 Mar 25;14(3):e0214280. doi: 10.1371/journal.pone.0214280. eCollection 2019.


"Nine Dimensions": A multidisciplinary approach for community engagement in a complex postwar border region as part of the targeted malaria elimination in Karen/Kayin State, Myanmar.

Tangseefa D, Monthathip K, Tuenpakdee N, König A, Kajeechiwa L, Thwin MM, Nosten S, Tun SW, Ma K, Hashmi A, Lwin KM, Cheah PY, von Seidlein L, Nosten F.

Version 2. Wellcome Open Res. 2019 Feb 21 [revised 2019 Jan 1];3:116. doi: 10.12688/wellcomeopenres.14698.2. eCollection 2018.


The impact of targeted malaria elimination with mass drug administrations on falciparum malaria in Southeast Asia: A cluster randomised trial.

von Seidlein L, Peto TJ, Landier J, Nguyen TN, Tripura R, Phommasone K, Pongvongsa T, Lwin KM, Keereecharoen L, Kajeechiwa L, Thwin MM, Parker DM, Wiladphaingern J, Nosten S, Proux S, Corbel V, Tuong-Vy N, Phuc-Nhi TL, Son DH, Huong-Thu PN, Tuyen NTK, Tien NT, Dong LT, Hue DV, Quang HH, Nguon C, Davoeung C, Rekol H, Adhikari B, Henriques G, Phongmany P, Suangkanarat P, Jeeyapant A, Vihokhern B, van der Pluijm RW, Lubell Y, White LJ, Aguas R, Promnarate C, Sirithiranont P, Malleret B, Rénia L, Onsjö C, Chan XH, Chalk J, Miotto O, Patumrat K, Chotivanich K, Hanboonkunupakarn B, Jittmala P, Kaehler N, Cheah PY, Pell C, Dhorda M, Imwong M, Snounou G, Mukaka M, Peerawaranun P, Lee SJ, Simpson JA, Pukrittayakamee S, Singhasivanon P, Grobusch MP, Cobelens F, Smithuis F, Newton PN, Thwaites GE, Day NPJ, Mayxay M, Hien TT, Nosten FH, Dondorp AM, White NJ.

PLoS Med. 2019 Feb 15;16(2):e1002745. doi: 10.1371/journal.pmed.1002745. eCollection 2019 Feb.


Institutions must state policy on data sharing.

Cheah PY.

Nature. 2019 Jan;565(7739):294. doi: 10.1038/d41586-019-00118-9. No abstract available.


Perceptions of asymptomatic malaria infection and their implications for malaria control and elimination in Laos.

Adhikari B, Phommasone K, Pongvongsa T, Soundala X, Koummarasy P, Henriques G, Peto TJ, Seidlein LV, White NJ, Day NPJ, Dondorp AM, Newton PN, Cheah PY, Mayxay M, Pell C.

PLoS One. 2018 Dec 11;13(12):e0208912. doi: 10.1371/journal.pone.0208912. eCollection 2018.


Challenges arising when seeking broad consent for health research data sharing: a qualitative study of perspectives in Thailand.

Cheah PY, Jatupornpimol N, Hanboonkunupakarn B, Khirikoekkong N, Jittamala P, Pukrittayakamee S, Day NPJ, Parker M, Bull S.

BMC Med Ethics. 2018 Nov 7;19(1):86. doi: 10.1186/s12910-018-0326-x.


The promise, problems and pitfalls of mass drug administration for malaria elimination: a qualitative study with scientists and policymakers.

Kaehler N, Adhikari B, Cheah PY, Day NPJ, Paris DH, Tanner M, Pell C.

Int Health. 2019 May 1;11(3):166-176. doi: 10.1093/inthealth/ihy079.


The First Pint of Science Festival in Asia.

Robinson MT, Jatupornpimol N, Sachaphimukh S, Lönnkvist M, Ruecker A, Cheah PY.

Sci Commun. 2017 Dec;39(6):810-820. doi: 10.1177/1075547017739907. Epub 2017 Nov 3.


Smartphones for community health in rural Cambodia: A feasibility study.

Ngor P, White LJ, Chalk J, Lubell Y, Favede C, Cheah PY, Nguon C, Ly P, Maude RJ, Sovannaroth S, Day NP, Dunachie S.

Wellcome Open Res. 2018 Jun 12;3:69. doi: 10.12688/wellcomeopenres.13751.1. eCollection 2018.


Effectiveness and safety of 3 and 5 day courses of artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in an area of emerging artemisinin resistance in Myanmar.

Tun KM, Jeeyapant A, Myint AH, Kyaw ZT, Dhorda M, Mukaka M, Cheah PY, Imwong M, Hlaing T, Kyaw TH, Ashley EA, Dondorp A, White NJ, Day NPJ, Smithuis F.

Malar J. 2018 Jul 11;17(1):258. doi: 10.1186/s12936-018-2404-4.


The feasibility and acceptability of mass drug administration for malaria in Cambodia: a mixed-methods study.

Peto TJ, Tripura R, Sanann N, Adhikari B, Callery J, Droogleever M, Heng C, Cheah PY, Davoeung C, Nguon C, von Seidlein L, Dondorp AM, Pell C.

Trans R Soc Trop Med Hyg. 2018 Jun 1;112(6):264-271. doi: 10.1093/trstmh/try053.


Comparison of the Cumulative Efficacy and Safety of Chloroquine, Artesunate, and Chloroquine-Primaquine in Plasmodium vivax Malaria.

Chu CS, Phyo AP, Lwin KM, Win HH, San T, Aung AA, Raksapraidee R, Carrara VI, Bancone G, Watson J, Moore KA, Wiladphaingern J, Proux S, Sriprawat K, Winterberg M, Cheah PY, Chue AL, Tarning J, Imwong M, Nosten F, White NJ.

Clin Infect Dis. 2018 Oct 30;67(10):1543-1549. doi: 10.1093/cid/ciy319.


Human colorectal cancer initiation is bidirectional, and cell growth, metabolic genes and transporter genes are early drivers of tumorigenesis.

Hong Y, Liew SC, Thean LF, Tang CL, Cheah PY.

Cancer Lett. 2018 Sep 1;431:213-218. doi: 10.1016/j.canlet.2018.06.005. Epub 2018 Jun 6.


The ethics of using placebo in randomised controlled trials: a case study of a Plasmodium vivax antirelapse trial.

Cheah PY, Steinkamp N, von Seidlein L, Price RN.

BMC Med Ethics. 2018 Mar 6;19(1):19. doi: 10.1186/s12910-018-0259-4.


Community participation during two mass anti-malarial administrations in Cambodia: lessons from a joint workshop.

Peto TJ, Debackere M, Etienne W, Vernaeve L, Tripura R, Falq G, Davoeung C, Nguon C, Rekol H, von Seidlein L, Dondorp AM, Sanann N, Cheah PY, De Smet M, Pell C, Kindermans JM.

Malar J. 2018 Jan 27;17(1):53. doi: 10.1186/s12936-018-2202-z.


Sharing Individual-Level Health Research Data: Experiences, Challenges and a Research Agenda.

Cheah PY, Day NPJ, Parker M, Bull S.

Asian Bioeth Rev. 2017;9(4):393-400. doi: 10.1007/s41649-017-0029-5. Epub 2017 Nov 28.


Why do people participate in mass anti-malarial administration? Findings from a qualitative study in Nong District, Savannakhet Province, Lao PDR (Laos).

Adhikari B, Phommasone K, Kommarasy P, Soundala X, Souvanthong P, Pongvongsa T, Henriques G, Newton PN, White NJ, Day NPJ, Dondorp AM, von Seidlein L, Mayxay M, Cheah PY, Pell C.

Malar J. 2018 Jan 9;17(1):15. doi: 10.1186/s12936-017-2158-4.


Ethics, regulation, and beyond: the landscape of research with pregnant women.

Saenz C, Cheah PY, van der Graaf R, Henry LM, Mastroianni AC.

Reprod Health. 2017 Dec 14;14(Suppl 3):173. doi: 10.1186/s12978-017-0421-3.


Art and theatre for health in rural Cambodia.

Nguon C, Dysoley L, Davoeung C, Sovann Y, Sanann N, Sareth M, Kunthea P, Vuth S, Sovann K, Kol K, Heng C, Sary R, Peto TJ, Tripura R, Lim R, Cheah PY.

Glob Bioeth. 2017 Dec 7;29(1):16-21. doi: 10.1080/11287462.2017.1411762. eCollection 2018.


Reflections on a Community Engagement Strategy for Mass Antimalarial Drug Administration in Cambodia.

Peto TJ, Tripura R, Davoeung C, Nguon C, Nou S, Heng C, Kunthea P, Adhikari B, Lim R, James N, Pell C, Cheah PY.

Am J Trop Med Hyg. 2018 Jan;98(1):100-104. doi: 10.4269/ajtmh.17-0428.


Data sharing: experience from a tropical medicine research unit.

Cheah PY, Day NPJ.

Lancet. 2017 Oct 7;390(10103):1642. doi: 10.1016/S0140-6736(17)31951-7. Epub 2017 Oct 5. No abstract available.


GREM1 Defect Unlikely to be Disease Causing and Hence Not Useful for Screening and Surveillance in Singapore Mixed Polyposis Families.

Cheah PY, Lo M, Tang CL.

Gastroenterology. 2017 Dec;153(6):1692. doi: 10.1053/j.gastro.2017.04.057. Epub 2017 Nov 3. No abstract available.


Genome-wide association study identified copy number variants associated with sporadic colorectal cancer risk.

Thean LF, Low YS, Lo M, Teo YY, Koh WP, Yuan JM, Chew MH, Tang CL, Cheah PY.

J Med Genet. 2018 Mar;55(3):181-188. doi: 10.1136/jmedgenet-2017-104913. Epub 2017 Oct 27.


Drama as a community engagement strategy for malaria in rural Cambodia.

Lim R, Tripura R, J Peto T, Sareth M, Sanann N, Davoeung C, Nguon C, Cheah PY.

Wellcome Open Res. 2017 Sep 29;2:95. doi: 10.12688/wellcomeopenres.12594.2. eCollection 2017.


Factors associated with population coverage of targeted malaria elimination (TME) in southern Savannakhet Province, Lao PDR.

Adhikari B, Phommasone K, Pongvongsa T, Kommarasy P, Soundala X, Henriques G, White NJ, Day NPJ, Dondorp AM, von Seidlein L, Cheah PY, Pell C, Mayxay M.

Malar J. 2017 Oct 23;16(1):424. doi: 10.1186/s12936-017-2070-y.


Elements of effective community engagement: lessons from a targeted malaria elimination study in Lao PDR (Laos).

Adhikari B, Pell C, Phommasone K, Soundala X, Kommarasy P, Pongvongsa T, Henriques G, Day NPJ, Mayxay M, Cheah PY.

Glob Health Action. 2017;10(1):1366136. doi: 10.1080/16549716.2017.1366136.


Community engagement for the rapid elimination of malaria: the case of Kayin State, Myanmar.

Kajeechiwa L, Thwin MM, Nosten S, Tun SW, Parker D, von Seidlein L, Tangseefa D, Nosten F, Cheah PY.

Wellcome Open Res. 2017 Jul 28;2:59. doi: 10.12688/wellcomeopenres.12051.1. eCollection 2017.


"Know your audience": A hospital community engagement programme in a non-profit paediatric hospital in Cambodia.

Pol S, Fox-Lewis S, Cheah PY, Turner C.

PLoS One. 2017 Aug 3;12(8):e0182573. doi: 10.1371/journal.pone.0182573. eCollection 2017.


A formalin-fixed paraffin-embedded (FFPE)-based prognostic signature to predict metastasis in clinically low risk stage I/II microsatellite stable colorectal cancer.

Low YS, Blöcker C, McPherson JR, Tang SA, Cheng YY, Wong JYS, Chua C, Lim TKH, Tang CL, Chew MH, Tan P, Tan IB, Rozen SG, Cheah PY.

Cancer Lett. 2017 Sep 10;403:13-20. doi: 10.1016/j.canlet.2017.05.031. Epub 2017 Jun 15.


Chromosome 19q13 disruption alters expressions of CYP2A7, MIA and MIA-RAB4B lncRNA and contributes to FAP-like phenotype in APC mutation-negative familial colorectal cancer patients.

Thean LF, Wong YH, Lo M, Loi C, Chew MH, Tang CL, Cheah PY.

PLoS One. 2017 Mar 17;12(3):e0173772. doi: 10.1371/journal.pone.0173772. eCollection 2017.


Community engagement and the social context of targeted malaria treatment: a qualitative study in Kayin (Karen) State, Myanmar.

Sahan K, Pell C, Smithuis F, Phyo AK, Maung SM, Indrasuta C, Dondorp AM, White NJ, Day NP, von Seidlein L, Cheah PY.

Malar J. 2017 Feb 14;16(1):75. doi: 10.1186/s12936-017-1718-y.


Community perceptions of targeted anti-malarial mass drug administrations in two provinces in Vietnam: a quantitative survey.

Nguyen TN, Thu PN, Hung NT, Son DH, Tien NT, Van Dung N, Quang HH, Seidlein LV, Cheah PY, Dondorp AM, Day NP, White NJ, Hien TT.

Malar J. 2017 Jan 6;16(1):17. doi: 10.1186/s12936-016-1662-2.


Village Drama Against Malaria.

Lim R, Peto TJ, Tripura R, Cheah PY.

Lancet. 2016 Dec 17;388(10063):2990. doi: 10.1016/S0140-6736(16)32519-3. No abstract available.


Community engagement and population coverage in mass anti-malarial administrations: a systematic literature review.

Adhikari B, James N, Newby G, von Seidlein L, White NJ, Day NP, Dondorp AM, Pell C, Cheah PY.

Malar J. 2016 Nov 2;15(1):523. Review.


The first Science Café in Laos.

Cheah PY, Newton PN, Mayxay M.

Lancet. 2016 Oct 1;388(10052):1376. doi: 10.1016/S0140-6736(16)31742-1. No abstract available.


Development of drugs for severe malaria in children.

Cheah PY, Parker M, Dondorp AM.

Int Health. 2016 Sep;8(5):313-6. doi: 10.1093/inthealth/ihw038. Epub 2016 Sep 12.


Antimalarial mass drug administration: ethical considerations.

Cheah PY, White NJ.

Int Health. 2016 Jul;8(4):235-8. doi: 10.1093/inthealth/ihw027. Epub 2016 Aug 1. Review.


Ethical challenges in designing and conducting medicine quality surveys.

Tabernero P, Parker M, Ravinetto R, Phanouvong S, Yeung S, Kitutu FE, Cheah PY, Mayxay M, Guerin PJ, Newton PN.

Trop Med Int Health. 2016 Jun;21(6):799-806. doi: 10.1111/tmi.12707. Epub 2016 May 20.


Cost-effectiveness analysis of parenteral antimicrobials for acute melioidosis in Thailand.

Hantrakun V, Chierakul W, Chetchotisakd P, Anunnatsiri S, Currie BJ, Peacock SJ, Day NP, Cheah PY, Limmathurotsakul D, Lubell Y.

Trans R Soc Trop Med Hyg. 2015 Dec;109(12):803. doi: 10.1093/trstmh/trv093. No abstract available.


Prevalence of KRAS, BRAF, PI3K and EGFR mutations among Asian patients with metastatic colorectal cancer.

Phua LC, Ng HW, Yeo AH, Chen E, Lo MS, Cheah PY, Chan EC, Koh PK, Ho HK.

Oncol Lett. 2015 Oct;10(4):2519-2526. Epub 2015 Aug 3.


Crowdfunding not fit for clinical trials.

Cheah PY.

Nature. 2015 Nov 26;527(7579):446. doi: 10.1038/527446e. No abstract available.


Amino-terminal p53 mutations lead to expression of apoptosis proficient p47 and prognosticate better survival, but predispose to tumorigenesis.

Phang BH, Othman R, Bougeard G, Chia RH, Frebourg T, Tang CL, Cheah PY, Sabapathy K.

Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):E6349-58. doi: 10.1073/pnas.1510043112. Epub 2015 Nov 2.


Genomics of Hereditary Colorectal Cancer: Lessons Learnt from 25 Years of the Singapore Polyposis Registry.

Chew MH, Tan WS, Liu Y, Cheah PY, Loi CT, Tang CL.

Ann Acad Med Singapore. 2015 Aug;44(8):290-6. Review.

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