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Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors.

Oberlick EM, Rees MG, Seashore-Ludlow B, Vazquez F, Nelson GM, Dharia NV, Weir BA, Tsherniak A, Ghandi M, Krill-Burger JM, Meyers RM, Wang X, Montgomery P, Root DE, Bieber JM, Radko S, Cheah JH, Hon CS, Shamji AF, Clemons PA, Park PJ, Dyer MA, Golub TR, Stegmaier K, Hahn WC, Stewart EA, Schreiber SL, Roberts CWM.

Cell Rep. 2019 Aug 27;28(9):2331-2344.e8. doi: 10.1016/j.celrep.2019.07.021.


Management of hepatitis B and C infections in rheumatologic disease.

Cheah JT, Faragon JJ, Marks KM.

Best Pract Res Clin Rheumatol. 2018 Dec;32(6):848-868. doi: 10.1016/j.berh.2019.04.001. Review.


Total Synthesis and Anti-Cancer Activity of All Known Communesin Alkaloids and Related Derivatives.

Pompeo MM, Cheah JH, Movassaghi M.

J Am Chem Soc. 2019 Sep 11;141(36):14411-14420. doi: 10.1021/jacs.9b07397. Epub 2019 Aug 30.


An expanded proteome of cardiac t-tubules.

Cheah JX, Nieuwenhuis TO, Halushka MK.

Cardiovasc Pathol. 2019 Sep - Oct;42:15-20. doi: 10.1016/j.carpath.2019.05.001. Epub 2019 May 24.


A novel germline SAMD9L mutation in a family with ataxia-pancytopenia syndrome and pediatric acute lymphoblastic leukemia.

Cheah JJC, Brown AL, Schreiber AW, Feng J, Babic M, Moore S, Young CC, Fine M, Phillips K, Guandalini M, Wilson P, Poplawski N, Hahn CN, Scott HS.

Haematologica. 2019 Jul;104(7):e318-e321. doi: 10.3324/haematol.2018.207316. Epub 2019 Mar 28. No abstract available.


Peroneus longus tendon rupture: A case report.

Koh D, Liow L, Cheah J, Koo K.

World J Orthop. 2019 Jan 18;10(1):45-53. doi: 10.5312/wjo.v10.i1.45. eCollection 2019 Jan 18.


Effect of the flavonoid hesperidin on glucose and fructose transport, sucrase activity and glycaemic response to orange juice in a crossover trial on healthy volunteers.

Kerimi A, Gauer JS, Crabbe S, Cheah JW, Lau J, Walsh R, Cancalon PF, Williamson G.

Br J Nutr. 2019 Apr;121(7):782-792. doi: 10.1017/S0007114519000084. Epub 2019 Jan 23.


Improving Benefit-harm Assessment of Therapies from the Patient Perspective: OMERACT Premeeting Toward Consensus on Core Sets for Randomized Controlled Trials.

Andersen KM, Cheah JTL, March L, Bartlett SJ, Beaton D, Bingham CO 3rd, Brooks PM, Christensen R, Conaghan PG, D'Agostino MA, de Wit M, Dueck AC, Goodman SM, Grosskleg S, Hill CL, Howell M, Mackie SL, Richards B, Shea B, Singh JA, Strand V, Tugwell P, Wells GA, Simon LS.

J Rheumatol. 2019 Aug;46(8):1053-1058. doi: 10.3899/jrheum.181123. Epub 2019 Jan 15.


Toward a Core Domain Set for Glucocorticoid Impact in Inflammatory Rheumatic Diseases: The OMERACT 2018 Glucocorticoid Impact Working Group.

Cheah JTL, Black RJ, Robson JC, Navarro-Millán IY, Young SR, Richards P, Beard S, Simon LS, Goodman SM, Mackie SL, Hill CL.

J Rheumatol. 2019 Sep;46(9):1179-1182. doi: 10.3899/jrheum.181082. Epub 2019 Jan 15.


Clavicle Fracture Malunion Treated with an Osteotomy Guided by a Three-Dimensional-Printed Model: A Case Report.

Cheah JW, Goodman JZ, Dang AC.

JBJS Case Connect. 2018 Oct-Dec;8(4):e98. doi: 10.2106/JBJS.CC.17.00304.


Slow-twitch skeletal muscle defects accompany cardiac dysfunction in transgenic mice with a mutation in the myosin regulatory light chain.

Kazmierczak K, Liang J, Yuan CC, Yadav S, Sitbon YH, Walz K, Ma W, Irving TC, Cheah JX, Gomes AV, Szczesna-Cordary D.

FASEB J. 2019 Mar;33(3):3152-3166. doi: 10.1096/fj.201801402R. Epub 2018 Oct 26.


Transferrin receptors-targeting nanocarriers for efficient targeted delivery and transcytosis of drugs into the brain tumors: a review of recent advancements and emerging trends.

Choudhury H, Pandey M, Chin PX, Phang YL, Cheah JY, Ooi SC, Mak KK, Pichika MR, Kesharwani P, Hussain Z, Gorain B.

Drug Deliv Transl Res. 2018 Oct;8(5):1545-1563. doi: 10.1007/s13346-018-0552-2. Review.


A High-Throughput Assay for Collagen Secretion Suggests an Unanticipated Role for Hsp90 in Collagen Production.

Wong MY, Doan ND, DiChiara AS, Papa LJ 3rd, Cheah JH, Soule CK, Watson N, Hulleman JD, Shoulders MD.

Biochemistry. 2018 May 15;57(19):2814-2827. doi: 10.1021/acs.biochem.8b00378. Epub 2018 May 3.


Persistent wrist monarthritis: down to the bone.

Cheah JTL, Fields TR.

BMJ Case Rep. 2018 Feb 27;2018. pii: bcr-2017-222939. doi: 10.1136/bcr-2017-222939.


Does Intrathecal Morphine in Spinal Anesthesia Have a Role in Modern Multimodal Analgesia for Primary Total Joint Arthroplasty?

Cheah JW, Sing DC, Hansen EN, Aleshi P, Vail TP.

J Arthroplasty. 2018 Jun;33(6):1693-1698. doi: 10.1016/j.arth.2018.01.016. Epub 2018 Jan 31.


Multimodal analgesia decreases opioid consumption after shoulder arthroplasty: a prospective cohort study.

McLaughlin DC, Cheah JW, Aleshi P, Zhang AL, Ma CB, Feeley BT.

J Shoulder Elbow Surg. 2018 Apr;27(4):686-691. doi: 10.1016/j.jse.2017.11.015. Epub 2018 Jan 3.


A simple elution strategy for biotinylated proteins bound to streptavidin conjugated beads using excess biotin and heat.

Cheah JS, Yamada S.

Biochem Biophys Res Commun. 2017 Dec 2;493(4):1522-1527. doi: 10.1016/j.bbrc.2017.09.168. Epub 2017 Oct 3.


The perioperative effects of chronic preoperative opioid use on shoulder arthroplasty outcomes.

Cheah JW, Sing DC, McLaughlin D, Feeley BT, Ma CB, Zhang AL.

J Shoulder Elbow Surg. 2017 Nov;26(11):1908-1914. doi: 10.1016/j.jse.2017.05.016. Epub 2017 Jul 20.


Myeloid neoplasms with germline DDX41 mutation.

Cheah JJC, Hahn CN, Hiwase DK, Scott HS, Brown AL.

Int J Hematol. 2017 Aug;106(2):163-174. doi: 10.1007/s12185-017-2260-y. Epub 2017 May 25. Review.


A comparative study on electromagnetic interference shielding behaviors of chemically reduced and thermally reduced graphene aerogels.

Bi S, Zhang L, Mu C, Lee HY, Cheah JW, Chua EK, See KY, Liu M, Hu X.

J Colloid Interface Sci. 2017 Apr 15;492:112-118. doi: 10.1016/j.jcis.2016.12.060. Epub 2016 Dec 28.


Long-Acting Opioid Use Independently Predicts Perioperative Complication in Total Joint Arthroplasty.

Sing DC, Barry JJ, Cheah JW, Vail TP, Hansen EN.

J Arthroplasty. 2016 Sep;31(9 Suppl):170-174.e1. doi: 10.1016/j.arth.2016.02.068. Epub 2016 Mar 16.


Intraoperative Use of Neuromonitoring in Multilevel Thoracolumbar Spine Instrumentation and the Effects on Postoperative Neurological Injuries.

Cheah J, Zhang AL, Tay B.

Clin Spine Surg. 2017 Aug;30(7):321-327. doi: 10.1097/BSD.0000000000000420.


Integrated genetic and pharmacologic interrogation of rare cancers.

Hong AL, Tseng YY, Cowley GS, Jonas O, Cheah JH, Kynnap BD, Doshi MB, Oh C, Meyer SC, Church AJ, Gill S, Bielski CM, Keskula P, Imamovic A, Howell S, Kryukov GV, Clemons PA, Tsherniak A, Vazquez F, Crompton BD, Shamji AF, Rodriguez-Galindo C, Janeway KA, Roberts CW, Stegmaier K, van Hummelen P, Cima MJ, Langer RS, Garraway LA, Schreiber SL, Root DE, Hahn WC, Boehm JS.

Nat Commun. 2016 Jun 22;7:11987. doi: 10.1038/ncomms11987.


Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects.

Wagner FF, Bishop JA, Gale JP, Shi X, Walk M, Ketterman J, Patnaik D, Barker D, Walpita D, Campbell AJ, Nguyen S, Lewis M, Ross L, Weïwer M, An WF, Germain AR, Nag PP, Metkar S, Kaya T, Dandapani S, Olson DE, Barbe AL, Lazzaro F, Sacher JR, Cheah JH, Fei D, Perez J, Munoz B, Palmer M, Stegmaier K, Schreiber SL, Scolnick E, Zhang YL, Haggarty SJ, Holson EB, Pan JQ.

ACS Chem Biol. 2016 Jul 15;11(7):1952-63. doi: 10.1021/acschembio.6b00306. Epub 2016 May 13.


A complex behavioural change intervention to reduce the risk of diabetes and prediabetes in the pre-conception period in Malaysia: study protocol for a randomised controlled trial.

Skau JK, Nordin AB, Cheah JC, Ali R, Zainal R, Aris T, Ali ZM, Matzen P, Biesma R, Aagaard-Hansen J, Hanson MA, Norris SA.

Trials. 2016 Apr 27;17(1):215. doi: 10.1186/s13063-016-1345-x.


A genetic basis for the variation in the vulnerability of cancer to DNA damage.

Yard BD, Adams DJ, Chie EK, Tamayo P, Battaglia JS, Gopal P, Rogacki K, Pearson BE, Phillips J, Raymond DP, Pennell NA, Almeida F, Cheah JH, Clemons PA, Shamji A, Peacock CD, Schreiber SL, Hammerman PS, Abazeed ME.

Nat Commun. 2016 Apr 25;7:11428. doi: 10.1038/ncomms11428.


Proteomic analysis of physiological versus pathological cardiac remodeling in animal models expressing mutations in myosin essential light chains.

Gomes AV, Kazmierczak K, Cheah JX, Gilda JE, Yuan CC, Zhou Z, Szczesna-Cordary D.

J Muscle Res Cell Motil. 2015 Dec;36(6):447-61. doi: 10.1007/s10974-015-9434-0. Epub 2015 Dec 14.


Correlating chemical sensitivity and basal gene expression reveals mechanism of action.

Rees MG, Seashore-Ludlow B, Cheah JH, Adams DJ, Price EV, Gill S, Javaid S, Coletti ME, Jones VL, Bodycombe NE, Soule CK, Alexander B, Li A, Montgomery P, Kotz JD, Hon CS, Munoz B, Liefeld T, Dančík V, Haber DA, Clish CB, Bittker JA, Palmer M, Wagner BK, Clemons PA, Shamji AF, Schreiber SL.

Nat Chem Biol. 2016 Feb;12(2):109-16. doi: 10.1038/nchembio.1986. Epub 2015 Dec 14.


Sensitivity, specificity and diagnostic accuracy of novices integrating lung ultrasound into the care of breathless older patients.

Baker K, Soong L, Harding T, Wain A, Cheah J, Mitchell G, Brierley S.

Australas J Ultrasound Med. 2015 Nov;18(4):143-145. doi: 10.1002/j.2205-0140.2015.tb00221.x. Epub 2015 Dec 31.


Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset.

Seashore-Ludlow B, Rees MG, Cheah JH, Cokol M, Price EV, Coletti ME, Jones V, Bodycombe NE, Soule CK, Gould J, Alexander B, Li A, Montgomery P, Wawer MJ, Kuru N, Kotz JD, Hon CS, Munoz B, Liefeld T, Dančík V, Bittker JA, Palmer M, Bradner JE, Shamji AF, Clemons PA, Schreiber SL.

Cancer Discov. 2015 Nov;5(11):1210-23. doi: 10.1158/2159-8290.CD-15-0235. Epub 2015 Oct 19.


Concise Total Synthesis of (+)-Luteoalbusins A and B.

Adams TC, Payette JN, Cheah JH, Movassaghi M.

Org Lett. 2015 Sep 4;17(17):4268-71. doi: 10.1021/acs.orglett.5b02059. Epub 2015 Aug 25.


Western Blotting Inaccuracies with Unverified Antibodies: Need for a Western Blotting Minimal Reporting Standard (WBMRS).

Gilda JE, Ghosh R, Cheah JX, West TM, Bodine SC, Gomes AV.

PLoS One. 2015 Aug 19;10(8):e0135392. doi: 10.1371/journal.pone.0135392. eCollection 2015.


No hospital is an island - emerging new roles of the acute general hospital in the Singapore healthcare ecosystem.

Koh A, Cheah J.

Future Hosp J. 2015 Jun;2(2):121-124. doi: 10.7861/futurehosp.2-2-121.


Discovery of a Small-Molecule Probe for V-ATPase Function.

Aldrich LN, Kuo SY, Castoreno AB, Goel G, Kuballa P, Rees MG, Seashore-Ludlow BA, Cheah JH, Latorre IJ, Schreiber SL, Shamji AF, Xavier RJ.

J Am Chem Soc. 2015 Apr 29;137(16):5563-8. doi: 10.1021/jacs.5b02150. Epub 2015 Apr 20.


Attempting to prevent persistent postamputation phantom limb and stump pain.

Cheah J, Yap E, Naidu R.

A A Case Rep. 2014 Aug 1;3(3):35-7. doi: 10.1213/XAA.0000000000000038.


Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map.

Martins MM, Zhou AY, Corella A, Horiuchi D, Yau C, Rakhshandehroo T, Gordan JD, Levin RS, Johnson J, Jascur J, Shales M, Sorrentino A, Cheah J, Clemons PA, Shamji AF, Schreiber SL, Krogan NJ, Shokat KM, McCormick F, Goga A, Bandyopadhyay S.

Cancer Discov. 2015 Feb;5(2):154-67. doi: 10.1158/2159-8290.CD-14-0552. Epub 2014 Dec 12. Erratum in: Cancer Discov. 2018 Aug;8(8):1045. Rakshandehroo, Taha [corrected to Rakhshandehroo, Taha].


The life and health challenges of young Malaysian couples: results from a stakeholder consensus and engagement study to support non-communicable disease prevention.

Norris SA, Anuar H, Matzen P, Cheah JC, Jensen BB, Hanson M.

BMC Public Health. 2014;14 Suppl 2:S6. doi: 10.1186/1471-2458-14-S2-S6. Epub 2014 Jun 20.


NAMPT is the cellular target of STF-31-like small-molecule probes.

Adams DJ, Ito D, Rees MG, Seashore-Ludlow B, Puyang X, Ramos AH, Cheah JH, Clemons PA, Warmuth M, Zhu P, Shamji AF, Schreiber SL.

ACS Chem Biol. 2014 Oct 17;9(10):2247-54. doi: 10.1021/cb500347p. Epub 2014 Aug 7.


Effectiveness of a national transitional care program in reducing acute care use.

Wee SL, Loke CK, Liang C, Ganesan G, Wong LM, Cheah J.

J Am Geriatr Soc. 2014 Apr;62(4):747-53. doi: 10.1111/jgs.12750. Epub 2014 Mar 17.


Regulation of ferroptotic cancer cell death by GPX4.

Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, Cheah JH, Clemons PA, Shamji AF, Clish CB, Brown LM, Girotti AW, Cornish VW, Schreiber SL, Stockwell BR.

Cell. 2014 Jan 16;156(1-2):317-331. doi: 10.1016/j.cell.2013.12.010.


Validity of self-measured waist and hip circumferences: results from a community study in Malaysia.

Reidpath DD, Cheah JC, Lam FC, Yasin S, Soyiri I, Allotey P.

Nutr J. 2013 Oct 5;12:135. doi: 10.1186/1475-2891-12-135.


PKA modulates iron trafficking in the striatum via small GTPase, Rhes.

Choi BR, Bang S, Chen Y, Cheah JH, Kim SF.

Neuroscience. 2013 Dec 3;253:214-20. doi: 10.1016/j.neuroscience.2013.08.043. Epub 2013 Aug 30.


An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules.

Basu A, Bodycombe NE, Cheah JH, Price EV, Liu K, Schaefer GI, Ebright RY, Stewart ML, Ito D, Wang S, Bracha AL, Liefeld T, Wawer M, Gilbert JC, Wilson AJ, Stransky N, Kryukov GV, Dancik V, Barretina J, Garraway LA, Hon CS, Munoz B, Bittker JA, Stockwell BR, Khabele D, Stern AM, Clemons PA, Shamji AF, Schreiber SL.

Cell. 2013 Aug 29;154(5):1151-1161. doi: 10.1016/j.cell.2013.08.003.


Integrating mental health: the last frontier?

Chong R, Tan WM, Wong LM, Cheah J.

Int J Integr Care. 2012 Sep 28;12:e198. Print 2012 Jul-Sep. No abstract available.


Extremely high (>20 %) glycated haemoglobin A1c in patients with normal haemoglobin and erythrocyte parameters.

Loh TP, Zhang HL, Cheah JS.

Endocrine. 2013 Oct;44(2):542-3. doi: 10.1007/s12020-013-9920-3. Epub 2013 Mar 14. No abstract available.


Prenatal nutritional influence on skeletal development.

Curtis E, Cheah J, Harvey NC.

World Rev Nutr Diet. 2013;106:46-51. doi: 10.1159/000342605. Epub 2013 Feb 11. Review.


Dexras1, a small GTPase, is required for glutamate-NMDA neurotoxicity.

Chen Y, Khan RS, Cwanger A, Song Y, Steenstra C, Bang S, Cheah JH, Dunaief J, Shindler KS, Snyder SH, Kim SF.

J Neurosci. 2013 Feb 20;33(8):3582-7. doi: 10.1523/JNEUROSCI.1497-12.2013.


No longer lost in transition.

Chia B, Abraham M, Seong LP, Cheah JT.

Ann Acad Med Singapore. 2012 Nov;41(11):479-82. No abstract available.


Demographic and lifestyle characteristics associated with non-willingness to participate in health promotion programmes among adults of a lower socioeconomic status in Singapore.

Ng CW, Heng BH, Molina JA, Wong LY, George PP, Cheah J.

Glob Health Promot. 2012 Dec;19(4):9-19. doi: 10.1177/1757975912453184.


Financing universal coverage in Malaysia: a case study.

Chua HT, Cheah JC.

BMC Public Health. 2012;12 Suppl 1:S7. doi: 10.1186/1471-2458-12-S1-S7. Epub 2012 Jun 22.

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