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Agomelatine versus fluoxetine in glycemic control and treating depressive and anxiety symptoms in type 2 diabetes mellitus subjects: a single-blind randomized controlled trial.

Che T, Teng X, Huang Q, Mu Y, Tang X, Mu X, Wei Y.

Neuropsychiatr Dis Treat. 2018 Jun 13;14:1527-1533. doi: 10.2147/NDT.S167608. eCollection 2018.


FSH receptor binding inhibitor impacts K-Ras and c-Myc of ovarian cancer and signal pathway.

Wei S, Shen X, Lai L, Liang H, Deng Y, Gong Z, Che T.

Oncotarget. 2018 Apr 27;9(32):22498-22508. doi: 10.18632/oncotarget.25139. eCollection 2018 Apr 27.


Measuring Drug-Induced Changes in Metabolite Populations of Live Bacteria: Real Time Analysis by Raman Spectroscopy.

Carey PR, Whitmer GR, Yoon MJ, Lombardo MN, Pusztai-Carey M, Heidari-Torkabadi H, Che T.

J Phys Chem B. 2018 Jun 21;122(24):6377-6385. doi: 10.1021/acs.jpcb.8b03279. Epub 2018 Jun 7.


Discovery of Novel Schizocommunin Derivatives as Telomeric G-Quadruplex Ligands That Trigger Telomere Dysfunction and the Deoxyribonucleic Acid (DNA) Damage Response.

Che T, Chen SB, Tu JL, Wang B, Wang YQ, Zhang Y, Wang J, Wang ZQ, Zhang ZP, Ou TM, Zhao Y, Tan JH, Huang ZS.

J Med Chem. 2018 Apr 26;61(8):3436-3453. doi: 10.1021/acs.jmedchem.7b01615. Epub 2018 Apr 11.


Long non-coding RNAs and mRNAs profiling during spleen development in pig.

Che T, Li D, Jin L, Fu Y, Liu Y, Liu P, Wang Y, Tang Q, Ma J, Wang X, Jiang A, Li X, Li M.

PLoS One. 2018 Mar 14;13(3):e0193552. doi: 10.1371/journal.pone.0193552. eCollection 2018.


Transcriptome differences in frontal cortex between wild boar and domesticated pig.

Long K, Mao K, Che T, Zhang J, Qiu W, Wang Y, Tang Q, Ma J, Li M, Li X.

Anim Sci J. 2018 Jun;89(6):848-857. doi: 10.1111/asj.12999. Epub 2018 Mar 13.


Natural Alkaloids and Heterocycles as G-Quadruplex Ligands and Potential Anticancer Agents.

Che T, Wang YQ, Huang ZL, Tan JH, Huang ZS, Chen SB.

Molecules. 2018 Feb 23;23(2). pii: E493. doi: 10.3390/molecules23020493. Review.


Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone.

Wang S, Che T, Levit A, Shoichet BK, Wacker D, Roth BL.

Nature. 2018 Mar 8;555(7695):269-273. doi: 10.1038/nature25758. Epub 2018 Jan 24.


5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.

Peng Y, McCorvy JD, Harpsøe K, Lansu K, Yuan S, Popov P, Qu L, Pu M, Che T, Nikolajsen LF, Huang XP, Wu Y, Shen L, Bjørn-Yoshimoto WE, Ding K, Wacker D, Han GW, Cheng J, Katritch V, Jensen AA, Hanson MA, Zhao S, Gloriam DE, Roth BL, Stevens RC, Liu ZJ.

Cell. 2018 Feb 8;172(4):719-730.e14. doi: 10.1016/j.cell.2018.01.001. Epub 2018 Feb 1.


Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor.

Che T, Majumdar S, Zaidi SA, Ondachi P, McCorvy JD, Wang S, Mosier PD, Uprety R, Vardy E, Krumm BE, Han GW, Lee MY, Pardon E, Steyaert J, Huang XP, Strachan RT, Tribo AR, Pasternak GW, Carroll FI, Stevens RC, Cherezov V, Katritch V, Wacker D, Roth BL.

Cell. 2018 Jan 11;172(1-2):55-67.e15. doi: 10.1016/j.cell.2017.12.011. Epub 2018 Jan 4.


The role of aryl hydrocarbon receptor in bone remodeling.

Yu H, Jiang L, Wan B, Zhang W, Yao L, Che T, Gan C, Su N, He J, Huang J, Zhang K, Zhang Y.

Prog Biophys Mol Biol. 2018 May;134:44-49. doi: 10.1016/j.pbiomolbio.2017.12.005. Epub 2017 Dec 24. Review.


Genetic diversity and natural selection in wild fruit flies revealed by whole-genome resequencing.

Lian T, Li D, Tan X, Che T, Xu Z, Fan X, Wu N, Zhang L, Gaur U, Sun B, Yang M.

Genomics. 2018 Sep;110(5):304-309. doi: 10.1016/j.ygeno.2017.12.002. Epub 2017 Dec 13.


Fentanyl-related designer drugs W-18 and W-15 lack appreciable opioid activity in vitro and in vivo.

Huang XP, Che T, Mangano TJ, Le Rouzic V, Pan YX, Majumdar S, Cameron MD, Baumann MH, Pasternak GW, Roth BL.

JCI Insight. 2017 Nov 16;2(22). pii: 97222. doi: 10.1172/jci.insight.97222. [Epub ahead of print]


Genome-wide profiling of gene expression and DNA methylation provides insight into low-altitude acclimation in Tibetan pigs.

Jin L, Mao K, Li J, Huang W, Che T, Fu Y, Tang Q, Liu P, Song Y, Liu R, Lin X, Shang D, Liu Y, Liu Y, Ma J, Gu Y, Li X, Li M.

Gene. 2018 Feb 5;642:522-532. doi: 10.1016/j.gene.2017.11.074. Epub 2017 Nov 29.


Comparative transcriptomics of 5 high-altitude vertebrates and their low-altitude relatives.

Tang Q, Gu Y, Zhou X, Jin L, Guan J, Liu R, Li J, Long K, Tian S, Che T, Hu S, Liang Y, Yang X, Tao X, Zhong Z, Wang G, Chen X, Li D, Ma J, Wang X, Mai M, Jiang A, Luo X, Lv X, Gladyshev VN, Li X, Li M.

Gigascience. 2017 Dec 1;6(12):1-9. doi: 10.1093/gigascience/gix105.


D4 dopamine receptor high-resolution structures enable the discovery of selective agonists.

Wang S, Wacker D, Levit A, Che T, Betz RM, McCorvy JD, Venkatakrishnan AJ, Huang XP, Dror RO, Shoichet BK, Roth BL.

Science. 2017 Oct 20;358(6361):381-386. doi: 10.1126/science.aan5468.


A multiscale dataset for understanding complex eco-hydrological processes in a heterogeneous oasis system.

Li X, Liu S, Xiao Q, Ma M, Jin R, Che T, Wang W, Hu X, Xu Z, Wen J, Wang L.

Sci Data. 2017 Jun 27;4:170083. doi: 10.1038/sdata.2017.83.


Genomic data for 78 chickens from 14 populations.

Li D, Che T, Chen B, Tian S, Zhou X, Zhang G, Li M, Gaur U, Li Y, Luo M, Zhang L, Xu Z, Zhao X, Yin H, Wang Y, Jin L, Tang Q, Xu H, Yang M, Zhou R, Li R, Zhu Q, Li M.

Gigascience. 2017 Jun 1;6(6):1-5. doi: 10.1093/gigascience/gix026.


In silico design of novel probes for the atypical opioid receptor MRGPRX2.

Lansu K, Karpiak J, Liu J, Huang XP, McCorvy JD, Kroeze WK, Che T, Nagase H, Carroll FI, Jin J, Shoichet BK, Roth BL.

Nat Chem Biol. 2017 May;13(5):529-536. doi: 10.1038/nchembio.2334. Epub 2017 Mar 13.


mRNA N6-methyladenosine methylation of postnatal liver development in pig.

He S, Wang H, Liu R, He M, Che T, Jin L, Deng L, Tian S, Li Y, Lu H, Li X, Jiang Z, Li D, Li M.

PLoS One. 2017 Mar 7;12(3):e0173421. doi: 10.1371/journal.pone.0173421. eCollection 2017.


Crystal Structure of an LSD-Bound Human Serotonin Receptor.

Wacker D, Wang S, McCorvy JD, Betz RM, Venkatakrishnan AJ, Levit A, Lansu K, Schools ZL, Che T, Nichols DE, Shoichet BK, Dror RO, Roth BL.

Cell. 2017 Jan 26;168(3):377-389.e12. doi: 10.1016/j.cell.2016.12.033.


Design, Synthesis, and Evaluation of Isaindigotone Derivatives To Downregulate c-myc Transcription via Disrupting the Interaction of NM23-H2 with G-Quadruplex.

Shan C, Yan JW, Wang YQ, Che T, Huang ZL, Chen AC, Yao PF, Tan JH, Li D, Ou TM, Gu LQ, Huang ZS.

J Med Chem. 2017 Feb 23;60(4):1292-1308. doi: 10.1021/acs.jmedchem.6b01218. Epub 2017 Feb 13.


Identification of the First Marine-Derived Opioid Receptor "Balanced" Agonist with a Signaling Profile That Resembles the Endorphins.

Johnson TA, Milan-Lobo L, Che T, Ferwerda M, Lambu E, McIntosh NL, Li F, He L, Lorig-Roach N, Crews P, Whistler JL.

ACS Chem Neurosci. 2017 Mar 15;8(3):473-485. doi: 10.1021/acschemneuro.6b00167. Epub 2016 Nov 22.


Uncovering synthetic lethal interactions for therapeutic targets and predictive markers in lung adenocarcinoma.

Chang JG, Chen CC, Wu YY, Che TF, Huang YS, Yeh KT, Shieh GS, Yang PC.

Oncotarget. 2016 Nov 8;7(45):73664-73680. doi: 10.18632/oncotarget.12046.


Comprehensive variation discovery and recovery of missing sequence in the pig genome using multiple de novo assemblies.

Li M, Chen L, Tian S, Lin Y, Tang Q, Zhou X, Li D, Yeung CKL, Che T, Jin L, Fu Y, Ma J, Wang X, Jiang A, Lan J, Pan Q, Liu Y, Luo Z, Guo Z, Liu H, Zhu L, Shuai S, Tang G, Zhao J, Jiang Y, Bai L, Zhang S, Mai M, Li C, Wang D, Gu Y, Wang G, Lu H, Li Y, Zhu H, Li Z, Li M, Gladyshev VN, Jiang Z, Zhao S, Wang J, Li R, Li X.

Genome Res. 2017 May;27(5):865-874. doi: 10.1101/gr.207456.116. Epub 2016 Sep 19.


A structural and stochastic optimal model for projections of LNG imports and exports in Asia-Pacific.

Kompas T, Che TN.

Heliyon. 2016 Jun 2;2(6):e00108. doi: 10.1016/j.heliyon.2016.e00108. eCollection 2016 Jun.


A de novo silencer causes elimination of MITF-M expression and profound hearing loss in pigs.

Chen L, Guo W, Ren L, Yang M, Zhao Y, Guo Z, Yi H, Li M, Hu Y, Long X, Sun B, Li J, Zhai S, Zhang T, Tian S, Meng Q, Yu N, Zhu D, Tang G, Tang Q, Ren L, Liu K, Zhang S, Che T, Yu Z, Wu N, Jing L, Zhang R, Cong T, Chen S, Zhao Y, Zhang Y, Bai X, Guo Y, Zhao L, Zhang F, Zhao H, Zhang L, Hou Z, Zhao J, Li J, Zhang L, Sun W, Zou X, Wang T, Ge L, Liu Z, Hu X, Wang J, Yang S, Li N.

BMC Biol. 2016 Jun 27;14:52. doi: 10.1186/s12915-016-0273-2.


Developmental methylation pattern regulates porcine GPR120 expression.

Wang HM, Ma JD, Jin L, Liu YH, Che TD, Li MZ, Li XW.

Genet Mol Res. 2016 Feb 5;15(1). doi: 10.4238/gmr.15014240.


Effect of an EDA-A1 gene mutant on the proliferation and cell cycle distribution of cultured human umbilical vein endothelial cells.

Lei KE, Wang L, Ma B, Shi P, Li L, Che T, He X.

Exp Ther Med. 2016 Feb;11(2):535-539. Epub 2015 Dec 18.


Mitochondrial translocation of EGFR regulates mitochondria dynamics and promotes metastasis in NSCLC.

Che TF, Lin CW, Wu YY, Chen YJ, Han CL, Chang YL, Wu CT, Hsiao TH, Hong TM, Yang PC.

Oncotarget. 2015 Nov 10;6(35):37349-66. doi: 10.18632/oncotarget.5736.


Interaction network analysis of differentially expressed genes and screening of cancer marker in the urine of patients with invasive bladder cancer.

Guo B, Che T, Shi B, Guo L, Zhang Z, Li L, Cai C, Chen Y.

Int J Clin Exp Med. 2015 Mar 15;8(3):3619-28. eCollection 2015.


Transcriptomic analysis provides insight into high-altitude acclimation in domestic goats.

Tang Q, Huang W, Guan J, Jin L, Che T, Fu Y, Hu Y, Tian S, Wang D, Jiang Z, Li X, Li M.

Gene. 2015 Aug 10;567(2):208-16. doi: 10.1016/j.gene.2015.05.007. Epub 2015 May 7.


Puerarin enhances proliferation and osteoblastic differentiation of human bone marrow stromal cells via a nitric oxide/cyclic guanosine monophosphate signaling pathway.

Lv H, Che T, Tang X, Liu L, Cheng J.

Mol Med Rep. 2015 Aug;12(2):2283-90. doi: 10.3892/mmr.2015.3647. Epub 2015 Apr 20.


Measuring propargyl-linked drug populations inside bacterial cells, and their interaction with a dihydrofolate reductase target, by Raman microscopy.

Heidari-Torkabadi H, Che T, Lombardo MN, Wright DL, Anderson AC, Carey PR.

Biochemistry. 2015 May 5;54(17):2719-26. doi: 10.1021/acs.biochem.5b00202. Epub 2015 Apr 22.


Estimation of the growth curve and heritability of the growth rate for giant panda (Ailuropoda melanoleuca) cubs.

Che TD, Wang CD, Jin L, Wei M, Wu K, Zhang YH, Zhang HM, Li DS.

Genet Mol Res. 2015 Mar 27;14(1):2322-30. doi: 10.4238/2015.March.27.17.


Effectiveness of microsatellite and single nucleotide polymorphism markers for parentage analysis in European domestic pigs.

Yu GC, Tang QZ, Long KR, Che TD, Li MZ, Shuai SR.

Genet Mol Res. 2015 Feb 13;14(1):1362-70. doi: 10.4238/2015.February.13.15.


Spray-dried plasma attenuates inflammation and improves pregnancy rate of mated female mice.

Song M, Liu Y, Lee JJ, Che TM, Soares-Almeida JA, Chun JL, Campbell JM, Polo J, Crenshaw JD, Seo SW, Pettigrew JE.

J Anim Sci. 2015 Jan;93(1):298-305. doi: 10.2527/jas.2014-7259.


Detecting a quasi-stable imine species on the reaction pathway of SHV-1 β-lactamase and 6β-(hydroxymethyl)penicillanic acid sulfone.

Che T, Rodkey EA, Bethel CR, Shanmugam S, Ding Z, Pusztai-Carey M, Nottingham M, Chai W, Buynak JD, Bonomo RA, van den Akker F, Carey PR.

Biochemistry. 2015 Jan 27;54(3):734-43. doi: 10.1021/bi501197t. Epub 2015 Jan 8.


Snapshot of structural variations in the Tibetan wild boar genome at single-nucleotide resolution.

Chen L, Jin L, Li M, Tian S, Che T, Tang Q, Lan J, Jiang Z, Li R, Gu Y, Li X, Wang J.

J Genet Genomics. 2014 Dec 20;41(12):653-7. doi: 10.1016/j.jgg.2014.10.001. Epub 2014 Oct 22. No abstract available.


[Analysis of the infection status of saliva Helicobacter pylori in Lanzhou].

Guo R, Che T, Ju J, Yang S, He X, Zhang Y.

Hua Xi Kou Qiang Yi Xue Za Zhi. 2014 Aug;32(4):358-62. Chinese.


Lethal protein in mass consumption edible mushroom Agrocybe aegerita linked to strong hepatic toxicity.

Jin Y, Che T, Yin Y, Yu G, Yang Q, Liu W, Ye X, Yu W, Alok S, Chen Y, Wong BH, Cheng P, Sun H.

Toxicon. 2014 Nov;90:273-85. doi: 10.1016/j.toxicon.2014.08.066. Epub 2014 Aug 28.


Effects of capsicum oleoresin, garlic botanical, and turmeric oleoresin on gene expression profile of ileal mucosa in weaned pigs.

Liu Y, Song M, Che TM, Bravo D, Maddox CW, Pettigrew JE.

J Anim Sci. 2014 Aug;92(8):3426-40. doi: 10.2527/jas.2013-6496. Epub 2014 Jun 19.


[Characteristics of newly diagnosed diabetes patients with young onset in the West China Hospital of Sichuan University].

Gong Y, Che TT, Liu SF, Ren Y.

Sichuan Da Xue Xue Bao Yi Xue Ban. 2014 May;45(3):524-8. Chinese.


Dietary plant extracts modulate gene expression profiles in ileal mucosa of weaned pigs after an Escherichia coli infection.

Liu Y, Song M, Che TM, Lee JJ, Bravo D, Maddox CW, Pettigrew JE.

J Anim Sci. 2014 May;92(5):2050-62. doi: 10.2527/jas.2013-6422. Epub 2014 Mar 18.


Analysis of carotenoid isomerase activity in a prototypical carotenoid cleavage enzyme, apocarotenoid oxygenase (ACO).

Sui X, Kiser PD, Che T, Carey PR, Golczak M, Shi W, von Lintig J, Palczewski K.

J Biol Chem. 2014 May 2;289(18):12286-99. doi: 10.1074/jbc.M114.552836. Epub 2014 Mar 19.


The different inhibition mechanisms of OXA-1 and OXA-24 β-lactamases are determined by the stability of active site carboxylated lysine.

Che T, Bethel CR, Pusztai-Carey M, Bonomo RA, Carey PR.

J Biol Chem. 2014 Feb 28;289(9):6152-64. doi: 10.1074/jbc.M113.533562. Epub 2014 Jan 17.


H2 S modulates duodenal motility in male rats via activating TRPV1 and K(ATP) channels.

Lu W, Li J, Gong L, Xu X, Han T, Ye Y, Che T, Luo Y, Li J, Zhan R, Yao W, Liu K, Cui S, Liu C.

Br J Pharmacol. 2014 Mar;171(6):1534-50. doi: 10.1111/bph.12562.


β-Lactamase inhibition by 7-alkylidenecephalosporin sulfones: allylic transposition and formation of an unprecedented stabilized acyl-enzyme.

Rodkey EA, McLeod DC, Bethel CR, Smith KM, Xu Y, Chai W, Che T, Carey PR, Bonomo RA, van den Akker F, Buynak JD.

J Am Chem Soc. 2013 Dec 11;135(49):18358-69. doi: 10.1021/ja403598g. Epub 2013 Dec 3.


Dietary plant extracts improve immune responses and growth efficiency of pigs experimentally infected with porcine reproductive and respiratory syndrome virus.

Liu Y, Che TM, Song M, Lee JJ, Almeida JA, Bravo D, Van Alstine WG, Pettigrew JE.

J Anim Sci. 2013 Dec;91(12):5668-79. doi: 10.2527/jas.2013-6495. Epub 2013 Oct 14.


Dietary plant extracts alleviate diarrhea and alter immune responses of weaned pigs experimentally infected with a pathogenic Escherichia coli.

Liu Y, Song M, Che TM, Almeida JA, Lee JJ, Bravo D, Maddox CW, Pettigrew JE.

J Anim Sci. 2013 Nov;91(11):5294-306. doi: 10.2527/jas.2012-6194. Epub 2013 Sep 17.


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