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Arachidonic Acid Kills Staphylococcus aureus through a Lipid Peroxidation Mechanism.

Beavers WN, Monteith AJ, Amarnath V, Mernaugh RL, Roberts LJ 2nd, Chazin WJ, Davies SS, Skaar EP.

MBio. 2019 Oct 1;10(5). pii: e01333-19. doi: 10.1128/mBio.01333-19.


Genetic Mosaicism in Calmodulinopathy.

Wren LM, Jiménez-Jáimez J, Al-Ghamdi S, Al-Aama JY, Bdeir A, Al-Hassnan ZN, Kuan JL, Foo RY, Potet F, Johnson CN, Aziz MC, Carvill GL, Kaski JP, Crotti L, Perin F, Monserrat L, Burridge PW, Schwartz PJ, Chazin WJ, Bhuiyan ZA, George AL Jr.

Circ Genom Precis Med. 2019 Sep;12(9):375-385. doi: 10.1161/CIRCGEN.119.002581. Epub 2019 Aug 27.


The anti-parasitic agent suramin and several of its analogues are inhibitors of the DNA binding protein Mcm10.

Paulson CN, John K, Baxley RM, Kurniawan F, Orellana K, Francis R, Sobeck A, Eichman BF, Chazin WJ, Aihara H, Georg GI, Hawkinson JE, Bielinsky AK.

Open Biol. 2019 Aug 30;9(8):190117. doi: 10.1098/rsob.190117. Epub 2019 Aug 14.


The novel interaction between Neisseria gonorrhoeae TdfJ and human S100A7 allows gonococci to subvert host zinc restriction.

Maurakis S, Keller K, Maxwell CN, Pereira K, Chazin WJ, Criss AK, Cornelissen CN.

PLoS Pathog. 2019 Aug 1;15(8):e1007937. doi: 10.1371/journal.ppat.1007937. eCollection 2019 Aug.


A new approach to discovery of S100 protein heterodimers.

Garcia V, Chazin WJ.

FEBS J. 2019 May;286(10):1838-1840. doi: 10.1111/febs.14851. Epub 2019 May 3.


The Innate Immune Protein S100A9 Protects from T-Helper Cell Type 2-mediated Allergic Airway Inflammation.

Palmer LD, Maloney KN, Boyd KL, Goleniewska AK, Toki S, Maxwell CN, Chazin WJ, Peebles RS Jr, Newcomb DC, Skaar EP.

Am J Respir Cell Mol Biol. 2019 Oct;61(4):459-468. doi: 10.1165/rcmb.2018-0217OC.


Multi-metal Restriction by Calprotectin Impacts De Novo Flavin Biosynthesis in Acinetobacter baumannii.

Wang J, Lonergan ZR, Gonzalez-Gutierrez G, Nairn BL, Maxwell CN, Zhang Y, Andreini C, Karty JA, Chazin WJ, Trinidad JC, Skaar EP, Giedroc DP.

Cell Chem Biol. 2019 May 16;26(5):745-755.e7. doi: 10.1016/j.chembiol.2019.02.011. Epub 2019 Mar 21.


An Acinetobacter baumannii, Zinc-Regulated Peptidase Maintains Cell Wall Integrity during Immune-Mediated Nutrient Sequestration.

Lonergan ZR, Nairn BL, Wang J, Hsu YP, Hesse LE, Beavers WN, Chazin WJ, Trinidad JC, VanNieuwenhze MS, Giedroc DP, Skaar EP.

Cell Rep. 2019 Feb 19;26(8):2009-2018.e6. doi: 10.1016/j.celrep.2019.01.089.


S100 Proteins in the Innate Immune Response to Pathogens.

Kozlyuk N, Monteith AJ, Garcia V, Damo SM, Skaar EP, Chazin WJ.

Methods Mol Biol. 2019;1929:275-290. doi: 10.1007/978-1-4939-9030-6_18.


Functional and structural similarity of human DNA primase [4Fe4S] cluster domain constructs.

Holt ME, Salay LE, O'Brien E, Barton JK, Chazin WJ.

PLoS One. 2018 Dec 18;13(12):e0209345. doi: 10.1371/journal.pone.0209345. eCollection 2018.


Yeast require redox switching in DNA primase.

O'Brien E, Salay LE, Epum EA, Friedman KL, Chazin WJ, Barton JK.

Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):13186-13191. doi: 10.1073/pnas.1810715115. Epub 2018 Dec 12.


Substrate Binding Regulates Redox Signaling in Human DNA Primase.

O'Brien E, Holt ME, Salay LE, Chazin WJ, Barton JK.

J Am Chem Soc. 2018 Dec 12;140(49):17153-17162. doi: 10.1021/jacs.8b09914. Epub 2018 Nov 29.


Characterization and development of SAPP as a specific peptidic inhibitor that targets Porphyromonas gingivalis.

Ho MH, Lamont RJ, Chazin WJ, Chen H, Young DF, Kumar P, Xie H.

Mol Oral Microbiol. 2018 Dec;33(6):430-439. doi: 10.1111/omi.12246. Epub 2018 Oct 30.


Disrupted structure and aberrant function of CHIP mediates the loss of motor and cognitive function in preclinical models of SCAR16.

Shi CH, Rubel C, Soss SE, Sanchez-Hodge R, Zhang S, Madrigal SC, Ravi S, McDonough H, Page RC, Chazin WJ, Patterson C, Mao CY, Willis MS, Luo HY, Li YS, Stevens DA, Tang MB, Du P, Wang YH, Hu ZW, Xu YM, Schisler JC.

PLoS Genet. 2018 Sep 17;14(9):e1007664. doi: 10.1371/journal.pgen.1007664. eCollection 2018 Sep.


Antimicrobial action of calprotectin that does not involve metal withholding.

Besold AN, Culbertson EM, Nam L, Hobbs RP, Boyko A, Maxwell CN, Chazin WJ, Marques AR, Culotta VC.

Metallomics. 2018 Dec 12;10(12):1728-1742. doi: 10.1039/c8mt00133b.


Calprotectin protects against experimental colonic inflammation in mice.

Aranda CJ, Ocón B, Arredondo-Amador M, Suárez MD, Zarzuelo A, Chazin WJ, Martínez-Augustin O, Sánchez de Medina F.

Br J Pharmacol. 2018 Oct;175(19):3797-3812. doi: 10.1111/bph.14449. Epub 2018 Sep 2.


A Mechanism of Calmodulin Modulation of the Human Cardiac Sodium Channel.

Johnson CN, Potet F, Thompson MK, Kroncke BM, Glazer AM, Voehler MW, Knollmann BC, George AL Jr, Chazin WJ.

Structure. 2018 May 1;26(5):683-694.e3. doi: 10.1016/j.str.2018.03.005. Epub 2018 Apr 5.


Identifying the substrate proteins of U-box E3s E4B and CHIP by orthogonal ubiquitin transfer.

Bhuripanyo K, Wang Y, Liu X, Zhou L, Liu R, Duong D, Zhao B, Bi Y, Zhou H, Chen G, Seyfried NT, Chazin WJ, Kiyokawa H, Yin J.

Sci Adv. 2018 Jan 3;4(1):e1701393. doi: 10.1126/sciadv.1701393. eCollection 2018 Jan.


Role of Calprotectin in Withholding Zinc and Copper from Candida albicans.

Besold AN, Gilston BA, Radin JN, Ramsoomair C, Culbertson EM, Li CX, Cormack BP, Chazin WJ, Kehl-Fie TE, Culotta VC.

Infect Immun. 2018 Jan 22;86(2). pii: e00779-17. doi: 10.1128/IAI.00779-17. Print 2018 Feb.


Ubiquitin turnover and endocytic trafficking in yeast are regulated by Ser57 phosphorylation of ubiquitin.

Lee S, Tumolo JM, Ehlinger AC, Jernigan KK, Qualls-Histed SJ, Hsu PC, McDonald WH, Chazin WJ, MacGurn JA.

Elife. 2017 Nov 13;6. pii: e29176. doi: 10.7554/eLife.29176.


Dietary Manganese Promotes Staphylococcal Infection of the Heart.

Juttukonda LJ, Berends ETM, Zackular JP, Moore JL, Stier MT, Zhang Y, Schmitz JE, Beavers WN, Wijers CD, Gilston BA, Kehl-Fie TE, Atkinson J, Washington MK, Peebles RS, Chazin WJ, Torres VJ, Caprioli RM, Skaar EP.

Cell Host Microbe. 2017 Oct 11;22(4):531-542.e8. doi: 10.1016/j.chom.2017.08.009. Epub 2017 Sep 21.


A Polymerase With Potential: The Fe-S Cluster in Human DNA Primase.

Holt ME, Salay LE, Chazin WJ.

Methods Enzymol. 2017;595:361-390. doi: 10.1016/bs.mie.2017.07.002. Epub 2017 Aug 18.


Analysis of DNA binding by human factor xeroderma pigmentosum complementation group A (XPA) provides insight into its interactions with nucleotide excision repair substrates.

Sugitani N, Voehler MW, Roh MS, Topolska-Woś AM, Chazin WJ.

J Biol Chem. 2017 Oct 13;292(41):16847-16857. doi: 10.1074/jbc.M117.800078. Epub 2017 Aug 31.


RADX Promotes Genome Stability and Modulates Chemosensitivity by Regulating RAD51 at Replication Forks.

Dungrawala H, Bhat KP, Le Meur R, Chazin WJ, Ding X, Sharan SK, Wessel SR, Sathe AA, Zhao R, Cortez D.

Mol Cell. 2017 Aug 3;67(3):374-386.e5. doi: 10.1016/j.molcel.2017.06.023. Epub 2017 Jul 20.


Response to Comments on "The [4Fe4S] cluster of human DNA primase functions as a redox switch using DNA charge transport".

O'Brien E, Holt ME, Thompson MK, Salay LE, Ehlinger AC, Chazin WJ, Barton JK.

Science. 2017 Jul 21;357(6348). pii: eaan2762. doi: 10.1126/science.aan2762.


Analysis of Functional Dynamics of Modular Multidomain Proteins by SAXS and NMR.

Thompson MK, Ehlinger AC, Chazin WJ.

Methods Enzymol. 2017;592:49-76. doi: 10.1016/bs.mie.2017.03.017. Epub 2017 Apr 17.


Calmodulin Mutants Linked to Catecholaminergic Polymorphic Ventricular Tachycardia Fail to Inhibit Human RyR2 Channels.

Walweel K, Gomez-Hurtado N, Oo YW, Beard NA, Dos Remedios C, Johnson CN, Chazin WJ, van Helden DF, Knollmann BC, Laver DR.

J Am Coll Cardiol. 2017 Jul 4;70(1):115-117. doi: 10.1016/j.jacc.2017.04.055. No abstract available.


Prp40 Homolog A Is a Novel Centrin Target.

Díaz Casas A, Chazin WJ, Pastrana-Ríos B.

Biophys J. 2017 Jun 20;112(12):2529-2539. doi: 10.1016/j.bpj.2017.03.042.


Molecular basis for PrimPol recruitment to replication forks by RPA.

Guilliam TA, Brissett NC, Ehlinger A, Keen BA, Kolesar P, Taylor EM, Bailey LJ, Lindsay HD, Chazin WJ, Doherty AJ.

Nat Commun. 2017 May 23;8:15222. doi: 10.1038/ncomms15222.


The [4Fe4S] cluster of human DNA primase functions as a redox switch using DNA charge transport.

O'Brien E, Holt ME, Thompson MK, Salay LE, Ehlinger AC, Chazin WJ, Barton JK.

Science. 2017 Feb 24;355(6327). pii: eaag1789. doi: 10.1126/science.aag1789.


Erratum: Dietary zinc alters the microbiota and decreases resistance to Clostridium difficile infection.

Zackular JP, Moore JL, Jordan AT, Juttukonda LJ, Noto MJ, Nicholson MR, Crews JD, Semler MW, Zhang Y, Ware LB, Washington MK, Chazin WJ, Caprioli RM, Skaar EP.

Nat Med. 2016 Dec 6;22(12):1502. doi: 10.1038/nm1216-1502d. No abstract available.


Dietary zinc alters the microbiota and decreases resistance to Clostridium difficile infection.

Zackular JP, Moore JL, Jordan AT, Juttukonda LJ, Noto MJ, Nicholson MR, Crews JD, Semler MW, Zhang Y, Ware LB, Washington MK, Chazin WJ, Caprioli RM, Skaar EP.

Nat Med. 2016 Nov;22(11):1330-1334. doi: 10.1038/nm.4174. Epub 2016 Sep 26. Erratum in: Nat Med. 2016 Dec 6;22(12 ):1502.


ETAA1 acts at stalled replication forks to maintain genome integrity.

Bass TE, Luzwick JW, Kavanaugh G, Carroll C, Dungrawala H, Glick GG, Feldkamp MD, Putney R, Chazin WJ, Cortez D.

Nat Cell Biol. 2016 Nov;18(11):1185-1195. doi: 10.1038/ncb3415. Epub 2016 Oct 10.


Acinetobacter baumannii Coordinates Urea Metabolism with Metal Import To Resist Host-Mediated Metal Limitation.

Juttukonda LJ, Chazin WJ, Skaar EP.

MBio. 2016 Sep 27;7(5). pii: e01475-16. doi: 10.1128/mBio.01475-16.


Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks.

Gomez-Hurtado N, Boczek NJ, Kryshtal DO, Johnson CN, Sun J, Nitu FR, Cornea RL, Chazin WJ, Calvert ML, Tester DJ, Ackerman MJ, Knollmann BC.

Circ Arrhythm Electrophysiol. 2016 Aug;9(8). pii: e004161. doi: 10.1161/CIRCEP.116.004161.


Binding of transition metals to S100 proteins.

Gilston BA, Skaar EP, Chazin WJ.

Sci China Life Sci. 2016 Aug;59(8):792-801. doi: 10.1007/s11427-016-5088-4. Epub 2016 Jul 19. Review.


Novel calmodulin mutations associated with congenital long QT syndrome affect calcium current in human cardiomyocytes.

Pipilas DC, Johnson CN, Webster G, Schlaepfer J, Fellmann F, Sekarski N, Wren LM, Ogorodnik KV, Chazin DM, Chazin WJ, Crotti L, Bhuiyan ZA, George AL Jr.

Heart Rhythm. 2016 Oct;13(10):2012-9. doi: 10.1016/j.hrthm.2016.06.038. Epub 2016 Jul 1.


The innate immune protein calprotectin promotes Pseudomonas aeruginosa and Staphylococcus aureus interaction.

Wakeman CA, Moore JL, Noto MJ, Zhang Y, Singleton MD, Prentice BM, Gilston BA, Doster RS, Gaddy JA, Chazin WJ, Caprioli RM, Skaar EP.

Nat Commun. 2016 Jun 15;7:11951. doi: 10.1038/ncomms11951.


The Response of Acinetobacter baumannii to Zinc Starvation.

Nairn BL, Lonergan ZR, Wang J, Braymer JJ, Zhang Y, Calcutt MW, Lisher JP, Gilston BA, Chazin WJ, de Crécy-Lagard V, Giedroc DP, Skaar EP.

Cell Host Microbe. 2016 Jun 8;19(6):826-36. doi: 10.1016/j.chom.2016.05.007.


Salmonella Mitigates Oxidative Stress and Thrives in the Inflamed Gut by Evading Calprotectin-Mediated Manganese Sequestration.

Diaz-Ochoa VE, Lam D, Lee CS, Klaus S, Behnsen J, Liu JZ, Chim N, Nuccio SP, Rathi SG, Mastroianni JR, Edwards RA, Jacobo CM, Cerasi M, Battistoni A, Ouellette AJ, Goulding CW, Chazin WJ, Skaar EP, Raffatellu M.

Cell Host Microbe. 2016 Jun 8;19(6):814-25. doi: 10.1016/j.chom.2016.05.005.


XPA: A key scaffold for human nucleotide excision repair.

Sugitani N, Sivley RM, Perry KE, Capra JA, Chazin WJ.

DNA Repair (Amst). 2016 Aug;44:123-135. doi: 10.1016/j.dnarep.2016.05.018. Epub 2016 May 20. Review.


Spectrum and Prevalence of CALM1-, CALM2-, and CALM3-Encoded Calmodulin Variants in Long QT Syndrome and Functional Characterization of a Novel Long QT Syndrome-Associated Calmodulin Missense Variant, E141G.

Boczek NJ, Gomez-Hurtado N, Ye D, Calvert ML, Tester DJ, Kryshtal D, Hwang HS, Johnson CN, Chazin WJ, Loporcaro CG, Shah M, Papez AL, Lau YR, Kanter R, Knollmann BC, Ackerman MJ.

Circ Cardiovasc Genet. 2016 Apr;9(2):136-146. doi: 10.1161/CIRCGENETICS.115.001323. Epub 2016 Mar 11.


Data publication with the structural biology data grid supports live analysis.

Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Fromme JC, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P.

Nat Commun. 2016 Mar 7;7:10882. doi: 10.1038/ncomms10882.


Molecular Basis for the Interaction Between AP4 β4 and its Accessory Protein, Tepsin.

Frazier MN, Davies AK, Voehler M, Kendall AK, Borner GH, Chazin WJ, Robinson MS, Jackson LP.

Traffic. 2016 Apr;17(4):400-15. doi: 10.1111/tra.12375. Epub 2016 Mar 4.


Identification and Optimization of Anthranilic Acid Based Inhibitors of Replication Protein A.

Patrone JD, Pelz NF, Bates BS, Souza-Fagundes EM, Vangamudi B, Camper DV, Kuznetsov AG, Browning CF, Feldkamp MD, Frank AO, Gilston BA, Olejniczak ET, Rossanese OW, Waterson AG, Chazin WJ, Fesik SW.

ChemMedChem. 2016 Apr 19;11(8):893-9. doi: 10.1002/cmdc.201500479. Epub 2016 Jan 8.


Helicobacter pylori Resists the Antimicrobial Activity of Calprotectin via Lipid A Modification and Associated Biofilm Formation.

Gaddy JA, Radin JN, Cullen TW, Chazin WJ, Skaar EP, Trent MS, Algood HM.

MBio. 2015 Dec 8;6(6):e01349-15. doi: 10.1128/mBio.01349-15.


Zinc and Manganese Chelation by Neutrophil S100A8/A9 (Calprotectin) Limits Extracellular Aspergillus fumigatus Hyphal Growth and Corneal Infection.

Clark HL, Jhingran A, Sun Y, Vareechon C, de Jesus Carrion S, Skaar EP, Chazin WJ, Calera JA, Hohl TM, Pearlman E.

J Immunol. 2016 Jan 1;196(1):336-44. doi: 10.4049/jimmunol.1502037. Epub 2015 Nov 18.


CacyBP/SIP--Structure and variety of functions.

Topolska-Woś AM, Chazin WJ, Filipek A.

Biochim Biophys Acta. 2016 Jan;1860(1 Pt A):79-85. doi: 10.1016/j.bbagen.2015.10.012. Epub 2015 Oct 19. Review.


Arrhythmogenic Calmodulin Mutations Affect the Activation and Termination of Cardiac Ryanodine Receptor-mediated Ca2+ Release.

Søndergaard MT, Tian X, Liu Y, Wang R, Chazin WJ, Chen SR, Overgaard MT.

J Biol Chem. 2015 Oct 23;290(43):26151-62. doi: 10.1074/jbc.M115.676627. Epub 2015 Aug 26.


Calprotectin Increases the Activity of the SaeRS Two Component System and Murine Mortality during Staphylococcus aureus Infections.

Cho H, Jeong DW, Liu Q, Yeo WS, Vogl T, Skaar EP, Chazin WJ, Bae T.

PLoS Pathog. 2015 Jul 6;11(7):e1005026. doi: 10.1371/journal.ppat.1005026. eCollection 2015 Jul.

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