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Items: 1 to 50 of 56

1.

Toxin B Variants from Clostridium difficile Strains VPI 10463 and NAP1/027 Share Similar Substrate Profile and Cellular Intoxication Kinetics but Use Different Host Cell Entry Factors.

López-Ureña D, Orozco-Aguilar J, Chaves-Madrigal Y, Ramírez-Mata A, Villalobos-Jimenez A, Ost S, Quesada-Gómez C, Rodríguez C, Papatheodorou P, Chaves-Olarte E.

Toxins (Basel). 2019 Jun 17;11(6). pii: E348. doi: 10.3390/toxins11060348.

2.

Neutrophils as Trojan Horse Vehicles for Brucella abortus Macrophage Infection.

Gutiérrez-Jiménez C, Mora-Cartín R, Altamirano-Silva P, Chacón-Díaz C, Chaves-Olarte E, Moreno E, Barquero-Calvo E.

Front Immunol. 2019 May 7;10:1012. doi: 10.3389/fimmu.2019.01012. eCollection 2019.

3.

Neutrophils Dampen Adaptive Immunity in Brucellosis.

Mora-Cartín R, Gutiérrez-Jiménez C, Alfaro-Alarcón A, Chaves-Olarte E, Chacón-Díaz C, Barquero-Calvo E, Moreno E.

Infect Immun. 2019 Apr 23;87(5). pii: e00118-19. doi: 10.1128/IAI.00118-19. Print 2019 Mar.

4.

Cytotoxicity of Clostridium difficile toxins A and B requires an active and functional SREBP-2 pathway.

Papatheodorou P, Song S, López-Ureña D, Witte A, Marques F, Ost GS, Schorch B, Chaves-Olarte E, Aktories K.

FASEB J. 2019 Apr;33(4):4883-4892. doi: 10.1096/fj.201801440R. Epub 2018 Dec 28.

PMID:
30592645
5.

Novel Clade C-I Clostridium difficile strains escape diagnostic tests, differ in pathogenicity potential and carry toxins on extrachromosomal elements.

Ramírez-Vargas G, López-Ureña D, Badilla A, Orozco-Aguilar J, Murillo T, Rojas P, Riedel T, Overmann J, González G, Chaves-Olarte E, Quesada-Gómez C, Rodríguez C.

Sci Rep. 2018 Sep 17;8(1):13951. doi: 10.1038/s41598-018-32390-6.

6.

Depletion of Complement Enhances the Clearance of Brucella abortus in Mice.

González-Espinoza G, Barquero-Calvo E, Lizano-González E, Alfaro-Alarcón A, Arias-Gómez B, Chaves-Olarte E, Lomonte B, Moreno E, Chacón-Díaz C.

Infect Immun. 2018 Sep 21;86(10). pii: e00567-18. doi: 10.1128/IAI.00567-18. Print 2018 Oct.

7.

Two Groups of Cocirculating, Epidemic Clostridiodes difficile Strains Microdiversify through Different Mechanisms.

Murillo T, Ramírez-Vargas G, Riedel T, Overmann J, Andersen JM, Guzmán-Verri C, Chaves-Olarte E, Rodríguez C.

Genome Biol Evol. 2018 Mar 1;10(3):982-998. doi: 10.1093/gbe/evy059.

8.

Brucella abortus Senses the Intracellular Environment through the BvrR/BvrS Two-Component System, Which Allows B. abortus To Adapt to Its Replicative Niche.

Altamirano-Silva P, Meza-Torres J, Castillo-Zeledón A, Ruiz-Villalobos N, Zuñiga-Pereira AM, Chacón-Díaz C, Moreno E, Guzmán-Verri C, Chaves-Olarte E.

Infect Immun. 2018 Mar 22;86(4). pii: e00713-17. doi: 10.1128/IAI.00713-17. Print 2018 Apr.

9.

Brucellosis caused by the wood rat pathogen Brucella neotomae: two case reports.

Villalobos-Vindas JM, Amuy E, Barquero-Calvo E, Rojas N, Chacón-Díaz C, Chaves-Olarte E, Guzman-Verri C, Moreno E.

J Med Case Rep. 2017 Dec 19;11(1):352. doi: 10.1186/s13256-017-1496-8.

10.

Brucella Genetic Variability in Wildlife Marine Mammals Populations Relates to Host Preference and Ocean Distribution.

Suárez-Esquivel M, Baker KS, Ruiz-Villalobos N, Hernández-Mora G, Barquero-Calvo E, González-Barrientos R, Castillo-Zeledón A, Jiménez-Rojas C, Chacón-Díaz C, Cloeckaert A, Chaves-Olarte E, Thomson NR, Moreno E, Guzmán-Verri C.

Genome Biol Evol. 2017 Jul 1;9(7):1901-1912. doi: 10.1093/gbe/evx137.

11.

Epidemiology of bovine brucellosis in Costa Rica: Lessons learned from failures in the control of the disease.

Hernández-Mora G, Ruiz-Villalobos N, Bonilla-Montoya R, Romero-Zúniga JJ, Jiménez-Arias J, González-Barrientos R, Barquero-Calvo E, Chacón-Díaz C, Rojas N, Chaves-Olarte E, Guzmán-Verri C, Moreno E.

PLoS One. 2017 Aug 10;12(8):e0182380. doi: 10.1371/journal.pone.0182380. eCollection 2017.

12.

Brucellosis in mammals of Costa Rica: An epidemiological survey.

Hernández-Mora G, Bonilla-Montoya R, Barrantes-Granados O, Esquivel-Suárez A, Montero-Caballero D, González-Barrientos R, Fallas-Monge Z, Palacios-Alfaro JD, Baldi M, Campos E, Chanto G, Barquero-Calvo E, Chacón-Díaz C, Chaves-Olarte E, Guzmán Verri C, Romero-Zúñiga JJ, Moreno E.

PLoS One. 2017 Aug 9;12(8):e0182644. doi: 10.1371/journal.pone.0182644. eCollection 2017.

13.

Brucella neotomae Infection in Humans, Costa Rica.

Suárez-Esquivel M, Ruiz-Villalobos N, Jiménez-Rojas C, Barquero-Calvo E, Chacón-Díaz C, Víquez-Ruiz E, Rojas-Campos N, Baker KS, Oviedo-Sánchez G, Amuy E, Chaves-Olarte E, Thomson NR, Moreno E, Guzmán-Verri C.

Emerg Infect Dis. 2017 Jun;23(6):997-1000. doi: 10.3201/eid2306.162018. Erratum in: Emerg Infect Dis. 2017 Aug;23(8):1435.

14.

A Clostridium difficile Lineage Endemic to Costa Rican Hospitals Is Multidrug Resistant by Acquisition of Chromosomal Mutations and Novel Mobile Genetic Elements.

Ramírez-Vargas G, Quesada-Gómez C, Acuña-Amador L, López-Ureña D, Murillo T, Del Mar Gamboa-Coronado M, Chaves-Olarte E, Thomson N, Rodríguez-Cavallini E, Rodríguez C.

Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02054-16. doi: 10.1128/AAC.02054-16. Print 2017 Apr.

15.

Brucella abortus Strain 2308 Wisconsin Genome: Importance of the Definition of Reference Strains.

Suárez-Esquivel M, Ruiz-Villalobos N, Castillo-Zeledón A, Jiménez-Rojas C, Roop Ii RM, Comerci DJ, Barquero-Calvo E, Chacón-Díaz C, Caswell CC, Baker KS, Chaves-Olarte E, Thomson NR, Moreno E, Letesson JJ, De Bolle X, Guzmán-Verri C.

Front Microbiol. 2016 Sep 29;7:1557. eCollection 2016.

16.

Clostridium difficile Infection.

Shin JH, Chaves-Olarte E, Warren CA.

Microbiol Spectr. 2016 Jun;4(3). doi: 10.1128/microbiolspec.EI10-0007-2015. Review.

PMID:
27337475
17.

A MLST Clade 2 Clostridium difficile strain with a variant TcdB induces severe inflammatory and oxidative response associated with mucosal disruption.

Costa CL, López-Ureña D, de Oliveira Assis T, Ribeiro RA, Silva RO, Rupnik M, Wilcox MH, de Carvalho AF, do Carmo AO, Dias AA, de Carvalho CB, Chaves-Olarte E, Rodríguez C, Quesada-Gómez C, de Castro Brito GA.

Anaerobe. 2016 Aug;40:76-84. doi: 10.1016/j.anaerobe.2016.06.005. Epub 2016 Jun 14.

18.

N-Formyl-Perosamine Surface Homopolysaccharides Hinder the Recognition of Brucella abortus by Mouse Neutrophils.

Mora-Cartín R, Chacón-Díaz C, Gutiérrez-Jiménez C, Gurdián-Murillo S, Lomonte B, Chaves-Olarte E, Barquero-Calvo E, Moreno E.

Infect Immun. 2016 May 24;84(6):1712-21. doi: 10.1128/IAI.00137-16. Print 2016 Jun.

19.

Analysis of TcdB Proteins within the Hypervirulent Clade 2 Reveals an Impact of RhoA Glucosylation on Clostridium difficile Proinflammatory Activities.

Quesada-Gómez C, López-Ureña D, Chumbler N, Kroh HK, Castro-Peña C, Rodríguez C, Orozco-Aguilar J, González-Camacho S, Rucavado A, Guzmán-Verri C, Lawley TD, Lacy DB, Chaves-Olarte E.

Infect Immun. 2016 Jan 11;84(3):856-65. doi: 10.1128/IAI.01291-15.

20.

Brucella canis is an intracellular pathogen that induces a lower proinflammatory response than smooth zoonotic counterparts.

Chacón-Díaz C, Altamirano-Silva P, González-Espinoza G, Medina MC, Alfaro-Alarcón A, Bouza-Mora L, Jiménez-Rojas C, Wong M, Barquero-Calvo E, Rojas N, Guzmán-Verri C, Moreno E, Chaves-Olarte E.

Infect Immun. 2015 Dec;83(12):4861-70. doi: 10.1128/IAI.00995-15. Epub 2015 Oct 5.

21.

Brucella abortus Induces the Premature Death of Human Neutrophils through the Action of Its Lipopolysaccharide.

Barquero-Calvo E, Mora-Cartín R, Arce-Gorvel V, de Diego JL, Chacón-Díaz C, Chaves-Olarte E, Guzmán-Verri C, Buret AG, Gorvel JP, Moreno E.

PLoS Pathog. 2015 May 6;11(5):e1004853. doi: 10.1371/journal.ppat.1004853. eCollection 2015 May.

22.

Emergence of an outbreak-associated Clostridium difficile variant with increased virulence.

Quesada-Gómez C, López-Ureña D, Acuña-Amador L, Villalobos-Zúñiga M, Du T, Freire R, Guzmán-Verri C, del Mar Gamboa-Coronado M, Lawley TD, Moreno E, Mulvey MR, de Castro Brito GA, Rodríguez-Cavallini E, Rodríguez C, Chaves-Olarte E.

J Clin Microbiol. 2015 Apr;53(4):1216-26. doi: 10.1128/JCM.03058-14. Epub 2015 Feb 4.

23.

Brucella ceti infection in dolphins from the Western Mediterranean sea.

Isidoro-Ayza M, Ruiz-Villalobos N, Pérez L, Guzmán-Verri C, Muñoz PM, Alegre F, Barberán M, Chacón-Díaz C, Chaves-Olarte E, González-Barrientos R, Moreno E, Blasco JM, Domingo M.

BMC Vet Res. 2014 Sep 17;10:206. doi: 10.1186/s12917-014-0206-7.

24.

Purification of intracellular bacteria: isolation of viable Brucella abortus from host cells.

Chaves-Olarte E, Altamirano-Silva P, Guzmán-Verri C, Moreno E.

Methods Mol Biol. 2014;1197:245-60. doi: 10.1007/978-1-4939-1261-2_14.

PMID:
25172285
25.

Brucella ceti and brucellosis in cetaceans.

Guzmán-Verri C, González-Barrientos R, Hernández-Mora G, Morales JA, Baquero-Calvo E, Chaves-Olarte E, Moreno E.

Front Cell Infect Microbiol. 2012 Feb 6;2:3. doi: 10.3389/fcimb.2012.00003. eCollection 2012. Review.

26.

The lipopolysaccharide core of Brucella abortus acts as a shield against innate immunity recognition.

Conde-Álvarez R, Arce-Gorvel V, Iriarte M, Manček-Keber M, Barquero-Calvo E, Palacios-Chaves L, Chacón-Díaz C, Chaves-Olarte E, Martirosyan A, von Bargen K, Grilló MJ, Jerala R, Brandenburg K, Llobet E, Bengoechea JA, Moreno E, Moriyón I, Gorvel JP.

PLoS Pathog. 2012;8(5):e1002675. doi: 10.1371/journal.ppat.1002675. Epub 2012 May 10.

27.

The struggle of neglected scientific groups: ten years of NeTropica efforts to promote research in tropical diseases in Central America.

Moreno E, Gutiérrez JM, Chaves-Olarte E.

PLoS Negl Trop Dis. 2011 Jul;5(7):e1055. doi: 10.1371/journal.pntd.0001055. Epub 2011 Jul 26. No abstract available.

28.

Thioredoxin 80-activated-monocytes (TAMs) inhibit the replication of intracellular pathogens.

Cortes-Bratti X, Bassères E, Herrera-Rodriguez F, Botero-Kleiven S, Coppotelli G, Andersen JB, Masucci MG, Holmgren A, Chaves-Olarte E, Frisan T, Avila-Cariño J.

PLoS One. 2011 Feb 18;6(2):e16960. doi: 10.1371/journal.pone.0016960.

29.

Brucella abortus ornithine lipids are dispensable outer membrane components devoid of a marked pathogen-associated molecular pattern.

Palacios-Chaves L, Conde-Álvarez R, Gil-Ramírez Y, Zúñiga-Ripa A, Barquero-Calvo E, Chacón-Díaz C, Chaves-Olarte E, Arce-Gorvel V, Gorvel JP, Moreno E, de Miguel MJ, Grilló MJ, Moriyón I, Iriarte M.

PLoS One. 2011 Jan 7;6(1):e16030. doi: 10.1371/journal.pone.0016030.

30.

The use of green fluorescent protein as a marker for Brucella vaccines.

Chacón-Díaz C, Muñoz-Rodríguez M, Barquero-Calvo E, Guzmán-Verri C, Chaves-Olarte E, Grilló MJ, Moreno E.

Vaccine. 2011 Jan 10;29(3):577-82. doi: 10.1016/j.vaccine.2010.09.109. Epub 2010 Nov 4.

PMID:
21056079
31.

The two-component system BvrR/BvrS regulates the expression of the type IV secretion system VirB in Brucella abortus.

Martínez-Núñez C, Altamirano-Silva P, Alvarado-Guillén F, Moreno E, Guzmán-Verri C, Chaves-Olarte E.

J Bacteriol. 2010 Nov;192(21):5603-8. doi: 10.1128/JB.00567-10. Epub 2010 Sep 10.

32.

Pathology of striped dolphins (Stenella coeruleoalba) infected with Brucella ceti.

González-Barrientos R, Morales JA, Hernández-Mora G, Barquero-Calvo E, Guzmán-Verri C, Chaves-Olarte E, Moreno E.

J Comp Pathol. 2010 May;142(4):347-52. doi: 10.1016/j.jcpa.2009.10.017. Epub 2009 Dec 2.

PMID:
19954790
33.

The differential interaction of Brucella and ochrobactrum with innate immunity reveals traits related to the evolution of stealthy pathogens.

Barquero-Calvo E, Conde-Alvarez R, Chacón-Díaz C, Quesada-Lobo L, Martirosyan A, Guzmán-Verri C, Iriarte M, Mancek-Keber M, Jerala R, Gorvel JP, Moriyón I, Moreno E, Chaves-Olarte E.

PLoS One. 2009 Jun 16;4(6):e5893. doi: 10.1371/journal.pone.0005893.

34.

Serological diagnosis of Brucella infections in odontocetes.

Hernández-Mora G, Manire CA, González-Barrientos R, Barquero-Calvo E, Guzmán-Verri C, Staggs L, Thompson R, Chaves-Olarte E, Moreno E.

Clin Vaccine Immunol. 2009 Jun;16(6):906-15. doi: 10.1128/CVI.00413-08. Epub 2009 Apr 22.

35.

Intracellular adaptation of Brucella abortus.

Lamontagne J, Forest A, Marazzo E, Denis F, Butler H, Michaud JF, Boucher L, Pedro I, Villeneuve A, Sitnikov D, Trudel K, Nassif N, Boudjelti D, Tomaki F, Chaves-Olarte E, Guzmán-Verri C, Brunet S, Côté-Martin A, Hunter J, Moreno E, Paramithiotis E.

J Proteome Res. 2009 Mar;8(3):1594-609. doi: 10.1021/pr800978p.

36.

Neurobrucellosis in stranded dolphins, Costa Rica.

Hernández-Mora G, González-Barrientos R, Morales JA, Chaves-Olarte E, Guzmán-Verri C, Barquero-Calvo E, De-Miguel MJ, Marín CM, Blasco JM, Moreno E.

Emerg Infect Dis. 2008 Sep;14(9):1430-3. doi: 10.3201/eid1409.071056. Erratum in: Emerg Infect Dis. 2008 Nov;14(11):1825. Baquero-Calvo, Elías [corrected to Barquero-Calvo, Elías].

37.

Clostridium difficile in adult patients with nosocomial diarrhea in a Costa Rican hospital.

Zumbado-Salas R, Gamboa-Coronado Mdel M, Rodríguez-Cavallini E, Chaves-Olarte E.

Am J Trop Med Hyg. 2008 Aug;79(2):164-5.

PMID:
18689617
38.

BvrR/BvrS-controlled outer membrane proteins Omp3a and Omp3b are not essential for Brucella abortus virulence.

Manterola L, Guzmán-Verri C, Chaves-Olarte E, Barquero-Calvo E, de Miguel MJ, Moriyón I, Grilló MJ, López-Goñi I, Moreno E.

Infect Immun. 2007 Oct;75(10):4867-74. Epub 2007 Jul 30.

39.

Brucella abortus uses a stealthy strategy to avoid activation of the innate immune system during the onset of infection.

Barquero-Calvo E, Chaves-Olarte E, Weiss DS, Guzmán-Verri C, Chacón-Díaz C, Rucavado A, Moriyón I, Moreno E.

PLoS One. 2007 Jul 18;2(7):e631.

40.
41.

Extensive cell envelope modulation is associated with virulence in Brucella abortus.

Lamontagne J, Butler H, Chaves-Olarte E, Hunter J, Schirm M, Paquet C, Tian M, Kearney P, Hamaidi L, Chelsky D, Moriyón I, Moreno E, Paramithiotis E.

J Proteome Res. 2007 Apr;6(4):1519-29. Epub 2007 Mar 8.

PMID:
17343405
42.

Inhibition of hippocampal synaptic transmission by impairment of Ral function.

Owe-Larsson B, Chaves-Olarte E, Chauhan A, Kjaerulff O, Brask J, Thelestam M, Brodin L, Löw P.

Neuroreport. 2005 Nov 7;16(16):1805-8.

PMID:
16237331
43.

The Haemophilus ducreyi cytolethal distending toxin induces DNA double-strand breaks and promotes ATM-dependent activation of RhoA.

Frisan T, Cortes-Bratti X, Chaves-Olarte E, Stenerlöw B, Thelestam M.

Cell Microbiol. 2003 Oct;5(10):695-707.

PMID:
12969375
44.

R-Ras glucosylation and transient RhoA activation determine the cytopathic effect produced by toxin B variants from toxin A-negative strains of Clostridium difficile.

Chaves-Olarte E, Freer E, Parra A, Guzmán-Verri C, Moreno E, Thelestam M.

J Biol Chem. 2003 Mar 7;278(10):7956-63. Epub 2002 Dec 19.

45.

Activation of Rho and Rab GTPases dissociates Brucella abortus internalization from intracellular trafficking.

Chaves-Olarte E, Guzmán-Verri C, Méresse S, Desjardins M, Pizarro-Cerdá J, Badilla J, Gorvel JP, Moreno E.

Cell Microbiol. 2002 Oct;4(10):663-76.

PMID:
12366403
46.

The Haemophilus ducreyi cytolethal distending toxin activates sensors of DNA damage and repair complexes in proliferating and non-proliferating cells.

Li L, Sharipo A, Chaves-Olarte E, Masucci MG, Levitsky V, Thelestam M, Frisan T.

Cell Microbiol. 2002 Feb;4(2):87-99.

PMID:
11896765
47.

GTPases of the Rho subfamily are required for Brucella abortus internalization in nonprofessional phagocytes: direct activation of Cdc42.

Guzmán-Verri C, Chaves-Olarte E, von Eichel-Streiber C, López-Goñi I, Thelestam M, Arvidson S, Gorvel JP, Moreno E.

J Biol Chem. 2001 Nov 30;276(48):44435-43. Epub 2001 Sep 28.

48.

In vivo proteolytic degradation of the Escherichia coli acyltransferase HlyC.

Guzman-Verri C, Chaves-Olarte E, García F, Arvidson S, Moreno E.

J Biol Chem. 2001 May 18;276(20):16660-6. Epub 2001 Feb 15.

49.

Cellular internalization of cytolethal distending toxin from Haemophilus ducreyi.

Cortes-Bratti X, Chaves-Olarte E, Lagergård T, Thelestam M.

Infect Immun. 2000 Dec;68(12):6903-11.

50.

Cytotoxic effects of the Clostridium difficile toxins.

Thelestam M, Chaves-Olarte E.

Curr Top Microbiol Immunol. 2000;250:85-96. Review. No abstract available.

PMID:
10981358

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