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Serial circulating omega 3 polyunsaturated fatty acids and healthy ageing among older adults in the Cardiovascular Health Study: prospective cohort study.

Lai HT, de Oliveira Otto MC, Lemaitre RN, McKnight B, Song X, King IB, Chaves PH, Odden MC, Newman AB, Siscovick DS, Mozaffarian D.

BMJ. 2018 Oct 17;363:k4067. doi: 10.1136/bmj.k4067. Erratum in: BMJ. 2018 Oct 23;363:k4445.


Social Network Trajectories in Myocardial Infarction Versus Ischemic Stroke.

Dhand A, Longstreth WT Jr, Chaves PHM, Dhamoon MS.

J Am Heart Assoc. 2018 Apr 13;7(8). pii: e008029. doi: 10.1161/JAHA.117.008029.


Late-Life Depressive Symptoms as Partial Mediators in the Associations between Subclinical Cardiovascular Disease with Onset of Mild Cognitive Impairment and Dementia.

Armstrong NM, Carlson MC, Schrack J, Xue QL, Carnethon MR, Rosano C, Chaves PHM, Gross AL.

Am J Geriatr Psychiatry. 2018 May;26(5):559-568. doi: 10.1016/j.jagp.2017.11.004. Epub 2017 Nov 20.


Role of Late-Life Depression in the Association of Subclinical Cardiovascular Disease With All-Cause Mortality: Cardiovascular Health Study.

Armstrong NM, Carlson MC, Xue QL, Schrack J, Carnethon MR, Chaves PHM, Gross AL.

J Aging Health. 2017 Nov 1:898264317744921. doi: 10.1177/0898264317744921. [Epub ahead of print]


Bone Mineral Density and Risk of Heart Failure in Older Adults: The Cardiovascular Health Study.

Fohtung RB, Brown DL, Koh WJ, Bartz TM, Carbone LD, Civitelli R, Stein PK, Chaves PH, Kestenbaum BR, Kizer JR.

J Am Heart Assoc. 2017 Mar 13;6(3). pii: e004344. doi: 10.1161/JAHA.116.004344.


Can a Healthy Lifestyle Compress the Disabled Period in Older Adults?

Jacob ME, Yee LM, Diehr PH, Arnold AM, Thielke SM, Chaves PH, Gobbo LD, Hirsch C, Siscovick D, Newman AB.

J Am Geriatr Soc. 2016 Oct;64(10):1952-1961. doi: 10.1111/jgs.14314. Epub 2016 Sep 7.


ω-3 Polyunsaturated Fatty Acid Biomarkers and Coronary Heart Disease: Pooling Project of 19 Cohort Studies.

Del Gobbo LC, Imamura F, Aslibekyan S, Marklund M, Virtanen JK, Wennberg M, Yakoob MY, Chiuve SE, Dela Cruz L, Frazier-Wood AC, Fretts AM, Guallar E, Matsumoto C, Prem K, Tanaka T, Wu JH, Zhou X, Helmer C, Ingelsson E, Yuan JM, Barberger-Gateau P, Campos H, Chaves PH, Djoussé L, Giles GG, Gómez-Aracena J, Hodge AM, Hu FB, Jansson JH, Johansson I, Khaw KT, Koh WP, Lemaitre RN, Lind L, Luben RN, Rimm EB, Risérus U, Samieri C, Franks PW, Siscovick DS, Stampfer M, Steffen LM, Steffen BT, Tsai MY, van Dam RM, Voutilainen S, Willett WC, Woodward M, Mozaffarian D; Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Fatty Acids and Outcomes Research Consortium (FORCe).

JAMA Intern Med. 2016 Aug 1;176(8):1155-66. doi: 10.1001/jamainternmed.2016.2925. Erratum in: JAMA Intern Med. 2016 Nov 1;176(11):1727-1728. JAMA Intern Med. 2016 Nov 1;176(11):1728.


Vitamin D and Risk of Neuroimaging Abnormalities.

Littlejohns TJ, Kos K, Henley WE, Lang IA, Annweiler C, Beauchet O, Chaves PH, Kestenbaum BR, Kuller LH, Langa KM, Lopez OL, Llewellyn DJ.

PLoS One. 2016 May 11;11(5):e0154896. doi: 10.1371/journal.pone.0154896. eCollection 2016.


Prevention of falls in older people living in the community.

Vieira ER, Palmer RC, Chaves PH.

BMJ. 2016 Apr 28;353:i1419. doi: 10.1136/bmj.i1419. Review. No abstract available.


Vitamin D and Memory Decline: Two Population-Based Prospective Studies.

Kuźma E, Soni M, Littlejohns TJ, Ranson JM, van Schoor NM, Deeg DJ, Comijs H, Chaves PH, Kestenbaum BR, Kuller LH, Lopez OL, Becker JT, Langa KM, Henley WE, Lang IA, Ukoumunne OC, Llewellyn DJ.

J Alzheimers Dis. 2016;50(4):1099-108. doi: 10.3233/JAD-150811. Review.


Cardiovascular and Mortality Outcomes in the Elderly With Impaired Cardiac and Pulmonary Function: The Cardiovascular Health Study (CHS).

Waheed S, Chaves PH, Gardin JM, Cao JJ.

J Am Heart Assoc. 2015 Dec 8;4(12). pii: e002308. doi: 10.1161/JAHA.115.002308.


Microvascular and Macrovascular Abnormalities and Cognitive and Physical Function in Older Adults: Cardiovascular Health Study.

Kim DH, Grodstein F, Newman AB, Chaves PH, Odden MC, Klein R, Sarnak MJ, Lipsitz LA.

J Am Geriatr Soc. 2015 Sep;63(9):1886-93. doi: 10.1111/jgs.13594. Epub 2015 Sep 4.


One-Year Change in the Japanese Version of the Montreal Cognitive Assessment Performance and Related Predictors in Community-Dwelling Older Adults.

Suzuki H, Kawai H, Hirano H, Yoshida H, Ihara K, Kim H, Chaves PH, Minami U, Yasunaga M, Obuchi S, Fujiwara Y.

J Am Geriatr Soc. 2015 Sep;63(9):1874-9. doi: 10.1111/jgs.13595. Epub 2015 Aug 27.


Urinary uromodulin, kidney function, and cardiovascular disease in elderly adults.

Garimella PS, Biggs ML, Katz R, Ix JH, Bennett MR, Devarajan P, Kestenbaum BR, Siscovick DS, Jensen MK, Shlipak MG, Chaves PH, Sarnak MJ.

Kidney Int. 2015 Nov;88(5):1126-34. doi: 10.1038/ki.2015.192. Epub 2015 Jul 8.


Association of mitochondrial DNA levels with frailty and all-cause mortality.

Ashar FN, Moes A, Moore AZ, Grove ML, Chaves PHM, Coresh J, Newman AB, Matteini AM, Bandeen-Roche K, Boerwinkle E, Walston JD, Arking DE.

J Mol Med (Berl). 2015 Feb;93(2):177-186. doi: 10.1007/s00109-014-1233-3. Epub 2014 Dec 4.


Monitoring 6-month trajectory of grip strength improves the prediction of long-term change in grip strength in disabled older women.

Xue QL, Guralnik JM, Beamer BA, Fried LP, Chaves PH.

J Gerontol A Biol Sci Med Sci. 2015 Mar;70(3):367-73. doi: 10.1093/gerona/glu149. Epub 2014 Aug 28.


Vitamin D and the risk of dementia and Alzheimer disease.

Littlejohns TJ, Henley WE, Lang IA, Annweiler C, Beauchet O, Chaves PH, Fried L, Kestenbaum BR, Kuller LH, Langa KM, Lopez OL, Kos K, Soni M, Llewellyn DJ.

Neurology. 2014 Sep 2;83(10):920-8. doi: 10.1212/WNL.0000000000000755. Epub 2014 Aug 6.


Prognostic implications of microvascular and macrovascular abnormalities in older adults: cardiovascular health study.

Kim DH, Grodstein F, Newman AB, Chaves PH, Odden MC, Klein R, Sarnak MJ, Patel KV, Lipsitz LA.

J Gerontol A Biol Sci Med Sci. 2014 Dec;69(12):1495-502. doi: 10.1093/gerona/glu074. Epub 2014 May 26.


Soluble CD14: genomewide association analysis and relationship to cardiovascular risk and mortality in older adults.

Reiner AP, Lange EM, Jenny NS, Chaves PH, Ellis J, Li J, Walston J, Lange LA, Cushman M, Tracy RP.

Arterioscler Thromb Vasc Biol. 2013 Jan;33(1):158-64. doi: 10.1161/ATVBAHA.112.300421. Epub 2012 Nov 15.


The role of energetic cost in the age-related slowing of gait speed.

Schrack JA, Simonsick EM, Chaves PH, Ferrucci L.

J Am Geriatr Soc. 2012 Oct;60(10):1811-6. doi: 10.1111/j.1532-5415.2012.04153.x. Epub 2012 Oct 4.


Patterns of 12-year change in physical activity levels in community-dwelling older women: can modest levels of physical activity help older women live longer?

Xue QL, Bandeen-Roche K, Mielenz TJ, Seplaki CL, Szanton SL, Thorpe RJ, Kalyani RR, Chaves PH, Dam TT, Ornstein K, RoyChoudhury A, Varadhan R, Yao W, Fried LP.

Am J Epidemiol. 2012 Sep 15;176(6):534-43. Epub 2012 Aug 30.


Modification of the association between ambient air pollution and lung function by frailty status among older adults in the Cardiovascular Health Study.

Eckel SP, Louis TA, Chaves PH, Fried LP, Margolis AH.

Am J Epidemiol. 2012 Aug 1;176(3):214-23. doi: 10.1093/aje/kws001. Epub 2012 Jul 18.


Long-term assessment of inflammation and healthy aging in late life: the Cardiovascular Health Study All Stars.

Jenny NS, French B, Arnold AM, Strotmeyer ES, Cushman M, Chaves PH, Ding J, Fried LP, Kritchevsky SB, Rifkin DE, Sarnak MJ, Newman AB.

J Gerontol A Biol Sci Med Sci. 2012 Sep;67(9):970-6. doi: 10.1093/gerona/glr261. Epub 2012 Feb 24.


Serum 25-hydroxyvitamin D and physical function in older adults: the Cardiovascular Health Study All Stars.

Houston DK, Tooze JA, Davis CC, Chaves PH, Hirsch CH, Robbins JA, Arnold AM, Newman AB, Kritchevsky SB.

J Am Geriatr Soc. 2011 Oct;59(10):1793-801. doi: 10.1111/j.1532-5415.2011.03601.x. Epub 2011 Sep 21.


Retinal microvascular signs and disability in the Cardiovascular Health Study.

Kim DH, Chaves PH, Newman AB, Klein R, Sarnak MJ, Newton E, Strotmeyer ES, Burke GL, Lipsitz LA.

Arch Ophthalmol. 2012 Mar;130(3):350-6. doi: 10.1001/archophthalmol.2011.360. Epub 2011 Nov 14.


Surrogate screening models for the low physical activity criterion of frailty.

Eckel SP, Bandeen-Roche K, Chaves PH, Fried LP, Louis TA.

Aging Clin Exp Res. 2011 Jun;23(3):209-16.


Longitudinal changes in adiponectin and inflammatory markers and relation to survival in the oldest old: the Cardiovascular Health Study All Stars study.

Kizer JR, Arnold AM, Jenny NS, Cushman M, Strotmeyer ES, Ives DG, Ding J, Kritchevsky SB, Chaves PH, Hirsch CH, Newman AB.

J Gerontol A Biol Sci Med Sci. 2011 Oct;66(10):1100-7. doi: 10.1093/gerona/glr098. Epub 2011 Jun 9.


Hypertension, white matter hyperintensities, and concurrent impairments in mobility, cognition, and mood: the Cardiovascular Health Study.

Hajjar I, Quach L, Yang F, Chaves PH, Newman AB, Mukamal K, Longstreth W Jr, Inzitari M, Lipsitz LA.

Circulation. 2011 Mar 1;123(8):858-65. doi: 10.1161/CIRCULATIONAHA.110.978114. Epub 2011 Feb 14.


Patterns and predictors of recovery from exhaustion in older adults: the cardiovascular health study.

Whitson HE, Thielke S, Diehr P, O'Hare AM, Chaves PH, Zakai NA, Arnold A, Chaudhry S, Ives D, Newman AB.

J Am Geriatr Soc. 2011 Feb;59(2):207-13. doi: 10.1111/j.1532-5415.2010.03238.x. Epub 2011 Feb 2.


Severe osteopenia and osteoporosis, sarcopenia, and frailty status in community-dwelling older women: results from the Women's Health and Aging Study (WHAS) II.

Frisoli A Jr, Chaves PH, Ingham SJ, Fried LP.

Bone. 2011 Apr 1;48(4):952-7. doi: 10.1016/j.bone.2010.12.025. Epub 2010 Dec 30.


Associations of visceral and liver fat with the metabolic syndrome across the spectrum of obesity: the AGES-Reykjavik study.

Kim LJ, Nalls MA, Eiriksdottir G, Sigurdsson S, Launer LJ, Koster A, Chaves PH, Jonsdottir B, Garcia M, Gudnason V, Harris TB; AGES-Reykjavik Study Investigators.

Obesity (Silver Spring). 2011 Jun;19(6):1265-71. doi: 10.1038/oby.2010.291. Epub 2010 Dec 23.


Heterogeneity in rate of decline in grip, hip, and knee strength and the risk of all-cause mortality: the Women's Health and Aging Study II.

Xue QL, Beamer BA, Chaves PH, Guralnik JM, Fried LP.

J Am Geriatr Soc. 2010 Nov;58(11):2076-84. doi: 10.1111/j.1532-5415.2010.03154.x.


Oral intake of Lactobacillus pentosus strain b240 accelerates salivary immunoglobulin A secretion in the elderly: A randomized, placebo-controlled, double-blind trial.

Kotani Y, Shinkai S, Okamatsu H, Toba M, Ogawa K, Yoshida H, Fukaya T, Fujiwara Y, Chaves PH, Kakumoto K, Kohda N.

Immun Ageing. 2010 Aug 26;7:11. doi: 10.1186/1742-4933-7-11.


Change in circulating adiponectin in advanced old age: determinants and impact on physical function and mortality. The Cardiovascular Health Study All Stars Study.

Kizer JR, Arnold AM, Strotmeyer ES, Ives DG, Cushman M, Ding J, Kritchevsky SB, Chaves PH, Hirsch CH, Newman AB.

J Gerontol A Biol Sci Med Sci. 2010 Nov;65(11):1208-14. doi: 10.1093/gerona/glq122. Epub 2010 Jul 8.


Concurrent change in dehydroepiandrosterone sulfate and functional performance in the oldest old: results from the Cardiovascular Health Study All Stars study.

Sanders JL, Cappola AR, Arnold AM, Boudreau RM, Chaves PH, Robbins J, Cushman M, Newman AB.

J Gerontol A Biol Sci Med Sci. 2010 Sep;65(9):976-81. doi: 10.1093/gerona/glq072. Epub 2010 May 13.


Red cell distribution width and mortality in older adults: a meta-analysis.

Patel KV, Semba RD, Ferrucci L, Newman AB, Fried LP, Wallace RB, Bandinelli S, Phillips CS, Yu B, Connelly S, Shlipak MG, Chaves PH, Launer LJ, Ershler WB, Harris TB, Longo DL, Guralnik JM.

J Gerontol A Biol Sci Med Sci. 2010 Mar;65(3):258-65. doi: 10.1093/gerona/glp163. Epub 2009 Oct 30. Review.


Anemia and 9-year domain-specific cognitive decline in community-dwelling older women: The Women's Health and Aging Study II.

Deal JA, Carlson MC, Xue QL, Fried LP, Chaves PH.

J Am Geriatr Soc. 2009 Sep;57(9):1604-11. doi: 10.1111/j.1532-5415.2009.02400.x. Epub 2009 Aug 13.


Frailty and impaired cardiac autonomic control: new insights from principal components aggregation of traditional heart rate variability indices.

Varadhan R, Chaves PH, Lipsitz LA, Stein PK, Tian J, Windham BG, Berger RD, Fried LP.

J Gerontol A Biol Sci Med Sci. 2009 Jun;64(6):682-7. doi: 10.1093/gerona/glp013. Epub 2009 Feb 17.


Long-term function in an older cohort--the cardiovascular health study all stars study.

Newman AB, Arnold AM, Sachs MC, Ives DG, Cushman M, Strotmeyer ES, Ding J, Kritchevsky SB, Chaves PH, Fried LP, Robbins J.

J Am Geriatr Soc. 2009 Mar;57(3):432-40. doi: 10.1111/j.1532-5415.2008.02152.x. Epub 2009 Jan 29.


Physiological complexity underlying heart rate dynamics and frailty status in community-dwelling older women.

Chaves PH, Varadhan R, Lipsitz LA, Stein PK, Windham BG, Tian J, Fleisher LA, Guralnik JM, Fried LP.

J Am Geriatr Soc. 2008 Sep;56(9):1698-703. doi: 10.1111/j.1532-5415.2008.01858.x.


Heart rate variability and its changes over 5 years in older adults.

Stein PK, Barzilay JI, Chaves PH, Domitrovich PP, Gottdiener JS.

Age Ageing. 2009 Mar;38(2):212-8. doi: 10.1093/ageing/afn292. Epub 2009 Jan 15.


Intellectual activity and likelihood of subsequently improving or maintaining instrumental activities of daily living functioning in community-dwelling older Japanese: a longitudinal study.

Fujiwara Y, Chaves PH, Yoshida H, Amano H, Fukaya T, Watanabe N, Nishi M, Lee S, Uchida H, Shinkai S.

Int J Geriatr Psychiatry. 2009 Jun;24(6):547-55. doi: 10.1002/gps.2148.


Functional outcomes of anemia in older adults.

Chaves PH.

Semin Hematol. 2008 Oct;45(4):255-60. doi: 10.1053/j.seminhematol.2008.06.005.


Novel measures of heart rate variability predict cardiovascular mortality in older adults independent of traditional cardiovascular risk factors: the Cardiovascular Health Study (CHS).

Stein PK, Barzilay JI, Chaves PH, Mistretta SQ, Domitrovich PP, Gottdiener JS, Rich MW, Kleiger RE.

J Cardiovasc Electrophysiol. 2008 Nov;19(11):1169-74. doi: 10.1111/j.1540-8167.2008.01232.x.


Baseline serum cholesterol is selectively associated with motor speed and not rates of cognitive decline: the Women's Health and Aging Study II.

Mielke MM, Xue QL, Zhou J, Chaves PH, Fried LP, Carlson MC.

J Gerontol A Biol Sci Med Sci. 2008 Jun;63(6):619-24.


Beta2-microglobulin for risk stratification of total mortality in the elderly population: comparison with cystatin C and C-reactive protein.

Shinkai S, Chaves PH, Fujiwara Y, Watanabe S, Shibata H, Yoshida H, Suzuki T.

Arch Intern Med. 2008 Jan 28;168(2):200-6. doi: 10.1001/archinternmed.2007.64.


Higher levels of inflammation factors and greater insulin resistance are independently associated with higher heart rate and lower heart rate variability in normoglycemic older individuals: the Cardiovascular Health Study.

Stein PK, Barzilay JI, Chaves PH, Traber J, Domitrovich PP, Heckbert SR, Gottdiener JS.

J Am Geriatr Soc. 2008 Feb;56(2):315-21. doi: 10.1111/j.1532-5415.2007.01564.x. Epub 2008 Jan 4.


Life-space constriction, development of frailty, and the competing risk of mortality: the Women's Health And Aging Study I.

Xue QL, Fried LP, Glass TA, Laffan A, Chaves PH.

Am J Epidemiol. 2008 Jan 15;167(2):240-8. Epub 2007 Sep 28.


Association between reduced heart rate variability and cognitive impairment in older disabled women in the community: Women's Health and Aging Study I.

Kim DH, Lipsitz LA, Ferrucci L, Varadhan R, Guralnik JM, Carlson MC, Fleisher LA, Fried LP, Chaves PH.

J Am Geriatr Soc. 2006 Nov;54(11):1751-7.

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