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Guarana supplementation attenuated obesity, insulin resistance, and adipokines dysregulation induced by a standardized human Western diet via brown adipose tissue activation.

Bortolin RC, Vargas AR, Ramos VM, Gasparotto J, Chaves PR, Schnorr CE, da Boit Martinello K, Silveira AK, Gomes HM, Rabelo TK, Grunwald MS, Ligabue-Braun R, Gelain DP, Moreira JCF.

Phytother Res. 2019 Mar 13. doi: 10.1002/ptr.6330. [Epub ahead of print]


Deep Friction Massage and the Minimum Skin Pressure Required to Promote a Macroscopic Deformation of the Patellar Tendon.

Chaves P, Simões D, Paço M, Pinho F, Duarte JA, Ribeiro F.

J Chiropr Med. 2018 Dec;17(4):226-230. doi: 10.1016/j.jcm.2018.04.007. Epub 2019 Feb 25.


Discrepancy in Frailty Identification: Move beyond Predictive Validity.

Xue QL, Tian J, Walston JD, Chaves PHM, Newman AB, Bandeen-Roche K.

J Gerontol A Biol Sci Med Sci. 2019 Feb 21. pii: glz052. doi: 10.1093/gerona/glz052. [Epub ahead of print]


NT-pro-BNP correlates with disease severity and predicts outcome in cerebral haemorrhage patients: Cohort study.

Gregorio T, Albuquerque I, Neves V, Reinas R, Pipa S, Azevedo L, Chaves PC.

J Neurol Sci. 2019 Feb 8;399:51-56. doi: 10.1016/j.jns.2019.02.014. [Epub ahead of print]


Single Cell Gene Expression to Understand the Dynamic Architecture of the Heart.

Massaia A, Chaves P, Samari S, Miragaia RJ, Meyer K, Teichmann SA, Noseda M.

Front Cardiovasc Med. 2018 Nov 21;5:167. doi: 10.3389/fcvm.2018.00167. eCollection 2018. Review.


Is tartrazine really safe? In silico and ex vivo toxicological studies in human leukocytes: a question of dose.

Floriano JM, da Rosa E, do Amaral QDF, Zuravski L, Chaves PEE, Machado MM, de Oliveira LFS.

Toxicol Res (Camb). 2018 Jul 20;7(6):1128-1134. doi: 10.1039/c8tx00034d. eCollection 2018 Nov 1.


Prognostic models for intracerebral hemorrhage: systematic review and meta-analysis.

Gregório T, Pipa S, Cavaleiro P, Atanásio G, Albuquerque I, Chaves PC, Azevedo L.

BMC Med Res Methodol. 2018 Nov 20;18(1):145. doi: 10.1186/s12874-018-0613-8.


Assessment and Comparison of the Four Most Extensively Validated Prognostic Scales for Intracerebral Hemorrhage: Systematic Review with Meta-analysis.

Gregório T, Pipa S, Cavaleiro P, Atanásio G, Albuquerque I, Chaves PC, Azevedo L.

Neurocrit Care. 2019 Apr;30(2):449-466. doi: 10.1007/s12028-018-0633-6.


Loss of Canonical Notch Signaling Affects Multiple Steps in NK Cell Development in Mice.

Chaves P, Zriwil A, Wittmann L, Boukarabila H, Peitzsch C, Jacobsen SEW, Sitnicka E.

J Immunol. 2018 Dec 1;201(11):3307-3319. doi: 10.4049/jimmunol.1701675. Epub 2018 Oct 26.


Serial circulating omega 3 polyunsaturated fatty acids and healthy ageing among older adults in the Cardiovascular Health Study: prospective cohort study.

Lai HT, de Oliveira Otto MC, Lemaitre RN, McKnight B, Song X, King IB, Chaves PH, Odden MC, Newman AB, Siscovick DS, Mozaffarian D.

BMJ. 2018 Oct 17;363:k4067. doi: 10.1136/bmj.k4067. Erratum in: BMJ. 2018 Oct 23;363:k4445.


Buried Barrett's Esophagus with High-Grade Dysplasia after Radiofrequency Ablation.

Castela J, Serrano M, Ferro SM, Pereira DV, Chaves P, Pereira AD.

Clin Endosc. 2018 Oct 5. doi: 10.5946/ce.2018.124. [Epub ahead of print]


Obese rats are more vulnerable to inflammation, genotoxicity and oxidative stress induced by coal dust inhalation than non-obese rats.

Gasparotto J, Chaves PR, da Boit Martinello K, da Rosa-Siva HT, Bortolin RC, Silva LFO, Rabelo TK, da Silva J, da Silva FR, Nordin AP, Soares K, Borges MS, Gelain DP, Moreira JCF.

Ecotoxicol Environ Saf. 2018 Dec 15;165:44-51. doi: 10.1016/j.ecoenv.2018.08.097. Epub 2018 Sep 1.


Effects of the consumption of polyunsaturated fatty acids on the oxidative status of adult dogs.

Pacheco GFE, Bortolin RC, Chaves PR, Moreira JCF, Kessler AM, Trevizan L.

J Anim Sci. 2018 Nov 21;96(11):4590-4598. doi: 10.1093/jas/sky313.


Reforming the Portuguese mental health system: an incentive-based approach.

Perelman J, Chaves P, de Almeida JMC, Matias MA.

Int J Ment Health Syst. 2018 May 30;12:25. doi: 10.1186/s13033-018-0204-4. eCollection 2018.


Clinical Impact of KRAS and GNAS Analysis Added to CEA and Cytology in Pancreatic Cystic Fluid Obtained by EUS-FNA.

Faias S, Duarte M, Albuquerque C, da Silva JP, Fonseca R, Roque R, Dias Pereira A, Chaves P, Cravo M.

Dig Dis Sci. 2018 Sep;63(9):2351-2361. doi: 10.1007/s10620-018-5128-y. Epub 2018 May 24.


Centrosome amplification arises before neoplasia and increases upon p53 loss in tumorigenesis.

Lopes CAM, Mesquita M, Cunha AI, Cardoso J, Carapeta S, Laranjeira C, Pinto AE, Pereira-Leal JB, Dias-Pereira A, Bettencourt-Dias M, Chaves P.

J Cell Biol. 2018 Jul 2;217(7):2353-2363. doi: 10.1083/jcb.201711191. Epub 2018 May 8.


Social Network Trajectories in Myocardial Infarction Versus Ischemic Stroke.

Dhand A, Longstreth WT Jr, Chaves PHM, Dhamoon MS.

J Am Heart Assoc. 2018 Apr 13;7(8). pii: e008029. doi: 10.1161/JAHA.117.008029.


Common symptoms of temporomandibular disorders do not mean same treatment plans: A case series.

Paço M, Chaves P, Pinho F, Lemos C, Costa R, Duarte JA, Pinho T.

Int Orthod. 2018 Mar;16(1):174-214. doi: 10.1016/j.ortho.2018.01.029. Epub 2018 Mar 11.


Une même symptomatologie articulaire temporomandibulaire n’implique pas nécessairement la même thérapeutique : une série de cas cliniques.

Paço M, Chaves P, Pinho F, Lemos C, Costa R, Duarte JA, Pinho T.

Int Orthod. 2018 Mar;16(1):174-214. doi: 10.1016/j.ortho.2018.01.030. Epub 2018 Mar 11. French. No abstract available.


Mucoadhesive Properties of Eudragit®RS100, Eudragit®S100, and Poly(ε-caprolactone) Nanocapsules: Influence of the Vehicle and the Mucosal Surface.

Chaves PDS, Frank LA, Frank AG, Pohlmann AR, Guterres SS, Beck RCR.

AAPS PharmSciTech. 2018 May;19(4):1637-1646. doi: 10.1208/s12249-018-0968-5. Epub 2018 Mar 2.


Applications of Polymeric Nanoparticles in Oral Diseases: A Review of Recent Findings.

Chaves P, Oliveira J, Haas A, Beck RCR.

Curr Pharm Des. 2018;24(13):1377-1394. doi: 10.2174/1381612824666180209110635.


Late-Life Depressive Symptoms as Partial Mediators in the Associations between Subclinical Cardiovascular Disease with Onset of Mild Cognitive Impairment and Dementia.

Armstrong NM, Carlson MC, Schrack J, Xue QL, Carnethon MR, Rosano C, Chaves PHM, Gross AL.

Am J Geriatr Psychiatry. 2018 May;26(5):559-568. doi: 10.1016/j.jagp.2017.11.004. Epub 2017 Nov 20.


Role of Late-Life Depression in the Association of Subclinical Cardiovascular Disease With All-Cause Mortality: Cardiovascular Health Study.

Armstrong NM, Carlson MC, Xue QL, Schrack J, Carnethon MR, Chaves PHM, Gross AL.

J Aging Health. 2019 Apr;31(4):652-666. doi: 10.1177/0898264317744921. Epub 2017 Nov 28.



Chaves PJ, de Oliveira FEM, Damázio LCM.

Acta Ortop Bras. 2017 Jul-Aug;25(4):162-164. doi: 10.1590/1413-785220172504171249.


Cyriax's deep friction massage application parameters: Evidence from a cross-sectional study with physiotherapists.

Chaves P, Simões D, Paço M, Pinho F, Duarte JA, Ribeiro F.

Musculoskelet Sci Pract. 2017 Dec;32:92-97. doi: 10.1016/j.msksp.2017.09.005. Epub 2017 Sep 14.


A new animal diet based on human Western diet is a robust diet-induced obesity model: comparison to high-fat and cafeteria diets in term of metabolic and gut microbiota disruption.

Bortolin RC, Vargas AR, Gasparotto J, Chaves PR, Schnorr CE, Martinello KB, Silveira AK, Rabelo TK, Gelain DP, Moreira JCF.

Int J Obes (Lond). 2018 Mar;42(3):525-534. doi: 10.1038/ijo.2017.225. Epub 2017 Sep 12.


Term amniotic fluid: an unexploited reserve of mesenchymal stromal cells for reprogramming and potential cell therapy applications.

Moraghebi R, Kirkeby A, Chaves P, Rönn RE, Sitnicka E, Parmar M, Larsson M, Herbst A, Woods NB.

Stem Cell Res Ther. 2017 Aug 25;8(1):190. doi: 10.1186/s13287-017-0582-6.


Ontogenetic development of the inner ear saccule and utricle in the Lusitanian toadfish: Potential implications for auditory sensitivity.

Chaves PP, Valdoria CMC, Amorim MCP, Vasconcelos RO.

Hear Res. 2017 Sep;353:112-121. doi: 10.1016/j.heares.2017.06.008. Epub 2017 Jun 15.


3D printed tablets loaded with polymeric nanocapsules: An innovative approach to produce customized drug delivery systems.

Beck RCR, Chaves PS, Goyanes A, Vukosavljevic B, Buanz A, Windbergs M, Basit AW, Gaisford S.

Int J Pharm. 2017 Aug 7;528(1-2):268-279. doi: 10.1016/j.ijpharm.2017.05.074. Epub 2017 Jun 3.


Ciprofloxacin-loaded lipid-core nanocapsules as mucus penetrating drug delivery system intended for the treatment of bacterial infections in cystic fibrosis.

Torge A, Wagner S, Chaves PS, Oliveira EG, Guterres SS, Pohlmann AR, Titz A, Schneider M, Beck RCR.

Int J Pharm. 2017 Jul 15;527(1-2):92-102. doi: 10.1016/j.ijpharm.2017.05.013. Epub 2017 May 10.


Bone Mineral Density and Risk of Heart Failure in Older Adults: The Cardiovascular Health Study.

Fohtung RB, Brown DL, Koh WJ, Bartz TM, Carbone LD, Civitelli R, Stein PK, Chaves PH, Kestenbaum BR, Kizer JR.

J Am Heart Assoc. 2017 Mar 13;6(3). pii: e004344. doi: 10.1161/JAHA.116.004344.


Discovering the Neural Nature of Moral Cognition? Empirical, Theoretical, and Practical Challenges in Bioethical Research with Electroencephalography (EEG).

Wagner NF, Chaves P, Wolff A.

J Bioeth Inq. 2017 Jun;14(2):299-313. doi: 10.1007/s11673-017-9780-2. Epub 2017 Feb 28.


The use of chitosan as cationic coating or gel vehicle for polymeric nanocapsules: Increasing penetration and adhesion of imiquimod in vaginal tissue.

Frank LA, Chaves PS, D'Amore CM, Contri RV, Frank AG, Beck RC, Pohlmann AR, Buffon A, Guterres SS.

Eur J Pharm Biopharm. 2017 May;114:202-212. doi: 10.1016/j.ejpb.2017.01.021. Epub 2017 Feb 1.


Carvedilol-loaded nanocapsules: Mucoadhesive properties and permeability across the sublingual mucosa.

Chaves PD, Ourique AF, Frank LA, Pohlmann AR, Guterres SS, Beck RC.

Eur J Pharm Biopharm. 2017 May;114:88-95. doi: 10.1016/j.ejpb.2017.01.007. Epub 2017 Jan 22.


The Association of Vitamin D Deficiency and Incident Frailty in Older Women: The Role of Cardiometabolic Diseases.

Buta B, Choudhury PP, Xue QL, Chaves P, Bandeen-Roche K, Shardell M, Semba RD, Walston J, Michos ED, Appel LJ, McAdams-DeMarco M, Gross A, Yasar S, Ferrucci L, Fried LP, Kalyani RR.

J Am Geriatr Soc. 2017 Mar;65(3):619-624. doi: 10.1111/jgs.14677. Epub 2016 Dec 23.


Dynamics of SOX2 and CDX2 Expression in Barrett's Mucosa.

Barros R, Pereira D, Callé C, Camilo V, Cunha AI, David L, Almeida R, Dias-Pereira A, Chaves P.

Dis Markers. 2016;2016:1532791. Epub 2016 Sep 27.


Can a Healthy Lifestyle Compress the Disabled Period in Older Adults?

Jacob ME, Yee LM, Diehr PH, Arnold AM, Thielke SM, Chaves PH, Gobbo LD, Hirsch C, Siscovick D, Newman AB.

J Am Geriatr Soc. 2016 Oct;64(10):1952-1961. doi: 10.1111/jgs.14314. Epub 2016 Sep 7.


LPIN1 deficiency: A novel mutation associated with different phenotypes in the same family.

Nunes D, Nogueira C, Lopes A, Chaves P, Rodrigues E, Cardoso T, Leão Teles E, Vilarinho L.

Mol Genet Metab Rep. 2016 Oct 2;9:29-30. eCollection 2016 Dec. No abstract available.


Mid-Esophagus Columnar Metaplasia: What Is the Biopathogenic Pathway?

Rolim I, Rodrigues RV, Bettencourt A, Barros R, Camilo V, Dias Pereira A, Almeida R, Chaves P.

Int J Surg Pathol. 2017 May;25(3):262-265. doi: 10.1177/1066896916672332. Epub 2016 Oct 5.


Effects of Freeze-Thaw and Storage on Enzymatic Activities, Protein Oxidative Damage, and Immunocontent of the Blood, Liver, and Brain of Rats.

Bortolin RC, Gasparotto J, Vargas AR, da Silva Morrone M, Kunzler A, Henkin BS, Chaves PR, Roncato S, Gelain DP, Moreira JCF.

Biopreserv Biobank. 2017 Jun;15(3):182-190. doi: 10.1089/bio.2016.0023. Epub 2016 Sep 23.


CYR61 and TAZ Upregulation and Focal Epithelial to Mesenchymal Transition May Be Early Predictors of Barrett's Esophagus Malignant Progression.

Cardoso J, Mesquita M, Dias Pereira A, Bettencourt-Dias M, Chaves P, Pereira-Leal JB.

PLoS One. 2016 Sep 1;11(9):e0161967. doi: 10.1371/journal.pone.0161967. eCollection 2016.


Serrated polyposis associated with a family history of colorectal cancer and/or polyps: The preferential location of polyps in the colon and rectum defines two molecular entities.

Silva P, Albuquerque C, Lage P, Fontes V, Fonseca R, Vitoriano I, Filipe B, Rodrigues P, Moita S, Ferreira S, Sousa R, Claro I, Nobre Leitão C, Chaves P, Dias Pereira A.

Int J Mol Med. 2016 Sep;38(3):687-702. doi: 10.3892/ijmm.2016.2666. Epub 2016 Jul 5.


ω-3 Polyunsaturated Fatty Acid Biomarkers and Coronary Heart Disease: Pooling Project of 19 Cohort Studies.

Del Gobbo LC, Imamura F, Aslibekyan S, Marklund M, Virtanen JK, Wennberg M, Yakoob MY, Chiuve SE, Dela Cruz L, Frazier-Wood AC, Fretts AM, Guallar E, Matsumoto C, Prem K, Tanaka T, Wu JH, Zhou X, Helmer C, Ingelsson E, Yuan JM, Barberger-Gateau P, Campos H, Chaves PH, Djoussé L, Giles GG, Gómez-Aracena J, Hodge AM, Hu FB, Jansson JH, Johansson I, Khaw KT, Koh WP, Lemaitre RN, Lind L, Luben RN, Rimm EB, Risérus U, Samieri C, Franks PW, Siscovick DS, Stampfer M, Steffen LM, Steffen BT, Tsai MY, van Dam RM, Voutilainen S, Willett WC, Woodward M, Mozaffarian D; Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Fatty Acids and Outcomes Research Consortium (FORCe).

JAMA Intern Med. 2016 Aug 1;176(8):1155-66. doi: 10.1001/jamainternmed.2016.2925. Erratum in: JAMA Intern Med. 2016 Nov 1;176(11):1727-1728. JAMA Intern Med. 2016 Nov 1;176(11):1728.


Vitamin D and Risk of Neuroimaging Abnormalities.

Littlejohns TJ, Kos K, Henley WE, Lang IA, Annweiler C, Beauchet O, Chaves PH, Kestenbaum BR, Kuller LH, Langa KM, Lopez OL, Llewellyn DJ.

PLoS One. 2016 May 11;11(5):e0154896. doi: 10.1371/journal.pone.0154896. eCollection 2016.


Prevention of falls in older people living in the community.

Vieira ER, Palmer RC, Chaves PH.

BMJ. 2016 Apr 28;353:i1419. doi: 10.1136/bmj.i1419. Review. No abstract available.


Sporadic colorectal cancer: Studying ways to an end.

Rosa I, Fidalgo P, Filipe B, Albuquerque C, Fonseca R, Chaves P, Pereira AD.

United European Gastroenterol J. 2016 Apr;4(2):288-96. doi: 10.1177/2050640615599329. Epub 2015 Aug 6.


Vitamin D and Memory Decline: Two Population-Based Prospective Studies.

Kuźma E, Soni M, Littlejohns TJ, Ranson JM, van Schoor NM, Deeg DJ, Comijs H, Chaves PH, Kestenbaum BR, Kuller LH, Lopez OL, Becker JT, Langa KM, Henley WE, Lang IA, Ukoumunne OC, Llewellyn DJ.

J Alzheimers Dis. 2016;50(4):1099-108. doi: 10.3233/JAD-150811. Review.


The family role in children׳s sleep disturbances: Results from a cross-sectional study in a Portuguese Urban pediatric population.

Martins AL, Chaves P, Papoila AL, Loureiro HC.

Sleep Sci. 2015 Nov;8(3):108-14. doi: 10.1016/j.slsci.2015.09.003. Epub 2015 Oct 9.

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