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Items: 1 to 50 of 209

1.

Hematopoietic progenitor cells as integrative hubs for adaptation to and fine-tuning of inflammation.

Chavakis T, Mitroulis I, Hajishengallis G.

Nat Immunol. 2019 Jul;20(7):802-811. doi: 10.1038/s41590-019-0402-5. Epub 2019 Jun 18. Review.

PMID:
31213716
2.

Endothelial-Specific Deficiency of ATG5 (Autophagy Protein 5) Attenuates Ischemia-Related Angiogenesis.

Sprott D, Poitz DM, Korovina I, Ziogas A, Phieler J, Chatzigeorgiou A, Mitroulis I, Deussen A, Chavakis T, Klotzsche-von Ameln A.

Arterioscler Thromb Vasc Biol. 2019 Jun;39(6):1137-1148. doi: 10.1161/ATVBAHA.119.309973.

PMID:
31070476
3.

Increased proteinase 3 and neutrophil elastase plasma concentrations are associated with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes.

Mirea AM, Toonen EJM, van den Munckhof I, Munsterman ID, Tjwa ETTL, Jaeger M, Oosting M, Schraa K, Rutten JHW, van der Graaf M, Riksen NP, de Graaf J, Netea MG, Tack CJ, Chavakis T, Joosten LAB.

Mol Med. 2019 May 2;25(1):16. doi: 10.1186/s10020-019-0084-3.

4.

DEL-1-Regulated Immune Plasticity and Inflammatory Disorders.

Hajishengallis G, Chavakis T.

Trends Mol Med. 2019 May;25(5):444-459. doi: 10.1016/j.molmed.2019.02.010. Epub 2019 Mar 15. Review.

PMID:
30885428
5.

Nerve Growth Factor modulates LPS - induced microglial glycolysis and inflammatory responses.

Fodelianaki G, Lansing F, Bhattarai P, Troullinaki M, Zeballos MA, Charalampopoulos I, Gravanis A, Mirtschink P, Chavakis T, Alexaki VI.

Exp Cell Res. 2019 Apr 15;377(1-2):10-16. doi: 10.1016/j.yexcr.2019.02.023. Epub 2019 Feb 25.

6.

Hypoxia Pathway Proteins in Normal and Malignant Hematopoiesis.

Wielockx B, Grinenko T, Mirtschink P, Chavakis T.

Cells. 2019 Feb 13;8(2). pii: E155. doi: 10.3390/cells8020155. Review.

7.

Comprehensive and quantitative analysis of white and brown adipose tissue by shotgun lipidomics.

Grzybek M, Palladini A, Alexaki VI, Surma MA, Simons K, Chavakis T, Klose C, Coskun Ü.

Mol Metab. 2019 Apr;22:12-20. doi: 10.1016/j.molmet.2019.01.009. Epub 2019 Jan 30.

8.

Macrophage β2-Integrins Regulate IL-22 by ILC3s and Protect from Lethal Citrobacter rodentium-Induced Colitis.

Wang B, Lim JH, Kajikawa T, Li X, Vallance BA, Moutsopoulos NM, Chavakis T, Hajishengallis G.

Cell Rep. 2019 Feb 5;26(6):1614-1626.e5. doi: 10.1016/j.celrep.2019.01.054.

9.

Nerve growth factor regulates endothelial cell survival and pathological retinal angiogenesis.

Troullinaki M, Alexaki VI, Mitroulis I, Witt A, Klotzsche-von Ameln A, Chung KJ, Chavakis T, Economopoulou M.

J Cell Mol Med. 2019 Apr;23(4):2362-2371. doi: 10.1111/jcmm.14002. Epub 2019 Jan 24.

10.

53BP1 Deficiency Promotes Pathological Neovascularization in Proliferative Retinopathy.

Troullinaki M, Garcia-Martin R, Sprott D, Klotzsche-von Ameln A, Grossklaus S, Mitroulis I, Chavakis T, Economopoulou M.

Thromb Haemost. 2019 Mar;119(3):439-448. doi: 10.1055/s-0038-1676966. Epub 2019 Jan 8.

PMID:
30620991
11.

Immunometabolic Crosstalk: An Ancestral Principle of Trained Immunity?

Penkov S, Mitroulis I, Hajishengallis G, Chavakis T.

Trends Immunol. 2019 Jan;40(1):1-11. doi: 10.1016/j.it.2018.11.002. Epub 2018 Nov 29. Review.

PMID:
30503793
12.

DEL-1 promotes macrophage efferocytosis and clearance of inflammation.

Kourtzelis I, Li X, Mitroulis I, Grosser D, Kajikawa T, Wang B, Grzybek M, von Renesse J, Czogalla A, Troullinaki M, Ferreira A, Doreth C, Ruppova K, Chen LS, Hosur K, Lim JH, Chung KJ, Grossklaus S, Tausche AK, Joosten LAB, Moutsopoulos NM, Wielockx B, Castrillo A, Korostoff JM, Coskun Ü, Hajishengallis G, Chavakis T.

Nat Immunol. 2019 Jan;20(1):40-49. doi: 10.1038/s41590-018-0249-1. Epub 2018 Nov 19.

13.

Lymph Node Cellular Dynamics in Cancer and HIV: What Can We Learn for the Follicular CD4 (Tfh) Cells?

Poultsidi A, Dimopoulos Y, He TF, Chavakis T, Saloustros E, Lee PP, Petrovas C.

Front Immunol. 2018 Sep 27;9:2233. doi: 10.3389/fimmu.2018.02233. eCollection 2018. Review.

14.

Stabilin-1-Mediated Efferocytosis Protects against Vascular Leakage in Sepsis: A Novel Therapeutic Approach?

Mirtschink P, Chavakis T.

Thromb Haemost. 2018 Nov;118(11):1852-1853. doi: 10.1055/s-0038-1673688. Epub 2018 Oct 12.

PMID:
30312979
15.

Hematopoietic hypoxia-inducible factor 2α deficiency ameliorates pathological retinal neovascularization via modulation of endothelial cell apoptosis.

Korovina I, Neuwirth A, Sprott D, Weber S, Sardar Pasha SPB, Gercken B, Breier G, El-Armouche A, Deussen A, Karl MO, Wielockx B, Chavakis T, Klotzsche-von Ameln A.

FASEB J. 2019 Feb;33(2):1758-1770. doi: 10.1096/fj.201800430R. Epub 2018 Aug 29.

PMID:
30156910
16.

The Coagulation Factors Fibrinogen, Thrombin, and Factor XII in Inflammatory Disorders-A Systematic Review.

Göbel K, Eichler S, Wiendl H, Chavakis T, Kleinschnitz C, Meuth SG.

Front Immunol. 2018 Jul 26;9:1731. doi: 10.3389/fimmu.2018.01731. eCollection 2018.

17.

Innate immune cells in the adipose tissue.

Chung KJ, Nati M, Chavakis T, Chatzigeorgiou A.

Rev Endocr Metab Disord. 2018 Dec;19(4):283-292. doi: 10.1007/s11154-018-9451-6. Review.

PMID:
29922964
18.

Myelopoiesis in the Context of Innate Immunity.

Mitroulis I, Kalafati L, Hajishengallis G, Chavakis T.

J Innate Immun. 2018;10(5-6):365-372. doi: 10.1159/000489406. Epub 2018 Jun 6. Review.

19.

Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice.

Grinenko T, Eugster A, Thielecke L, Ramasz B, Krüger A, Dietz S, Glauche I, Gerbaulet A, von Bonin M, Basak O, Clevers H, Chavakis T, Wielockx B.

Nat Commun. 2018 May 15;9(1):1898. doi: 10.1038/s41467-018-04188-7.

20.

Hematopoietic Stem Cells but Not Multipotent Progenitors Drive Erythropoiesis during Chronic Erythroid Stress in EPO Transgenic Mice.

Singh RP, Grinenko T, Ramasz B, Franke K, Lesche M, Dahl A, Gassmann M, Chavakis T, Henry I, Wielockx B.

Stem Cell Reports. 2018 Jun 5;10(6):1908-1919. doi: 10.1016/j.stemcr.2018.04.012. Epub 2018 May 10.

21.

IL-1 Family Cytokine Pathways Underlying NAFLD: Towards New Treatment Strategies.

Mirea AM, Tack CJ, Chavakis T, Joosten LAB, Toonen EJM.

Trends Mol Med. 2018 May;24(5):458-471. doi: 10.1016/j.molmed.2018.03.005. Epub 2018 Apr 14. Review.

22.

The Missed Notch to Bring Down Diabetes.

Mirtschink P, Chavakis T.

Trends Endocrinol Metab. 2018 Jul;29(7):448-450. doi: 10.1016/j.tem.2018.03.011. Epub 2018 Mar 29.

PMID:
29606343
23.

CD8+ T cells in beige adipogenesis and energy homeostasis.

Moysidou M, Karaliota S, Kodela E, Salagianni M, Koutmani Y, Katsouda A, Kodella K, Tsakanikas P, Ourailidou S, Andreakos E, Kostomitsopoulos N, Skokos D, Chatzigeorgiou A, Chung KJ, Bornstein S, Sleeman MW, Chavakis T, Karalis KP.

JCI Insight. 2018 Mar 8;3(5). pii: 95456. doi: 10.1172/jci.insight.95456.

24.

Endothelial Cell-Specific Overexpression of Del-1 Drives Expansion of Haematopoietic Progenitor Cells in the Bone Marrow.

Chen LS, Kourtzelis I, Singh RP, Grossklaus S, Wielockx B, Hajishengallis G, Chavakis T, Mitroulis I.

Thromb Haemost. 2018 Feb 7. doi: 10.1055/s-0038-1624582. [Epub ahead of print] No abstract available.

PMID:
29415284
25.

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity.

Mitroulis I, Ruppova K, Wang B, Chen LS, Grzybek M, Grinenko T, Eugster A, Troullinaki M, Palladini A, Kourtzelis I, Chatzigeorgiou A, Schlitzer A, Beyer M, Joosten LAB, Isermann B, Lesche M, Petzold A, Simons K, Henry I, Dahl A, Schultze JL, Wielockx B, Zamboni N, Mirtschink P, Coskun Ü, Hajishengallis G, Netea MG, Chavakis T.

Cell. 2018 Jan 11;172(1-2):147-161.e12. doi: 10.1016/j.cell.2017.11.034.

26.

Metabolic Induction of Trained Immunity through the Mevalonate Pathway.

Bekkering S, Arts RJW, Novakovic B, Kourtzelis I, van der Heijden CDCC, Li Y, Popa CD, Ter Horst R, van Tuijl J, Netea-Maier RT, van de Veerdonk FL, Chavakis T, Joosten LAB, van der Meer JWM, Stunnenberg H, Riksen NP, Netea MG.

Cell. 2018 Jan 11;172(1-2):135-146.e9. doi: 10.1016/j.cell.2017.11.025.

27.

DHEA inhibits acute microglia-mediated inflammation through activation of the TrkA-Akt1/2-CREB-Jmjd3 pathway.

Alexaki VI, Fodelianaki G, Neuwirth A, Mund C, Kourgiantaki A, Ieronimaki E, Lyroni K, Troullinaki M, Fujii C, Kanczkowski W, Ziogas A, Peitzsch M, Grossklaus S, Sönnichsen B, Gravanis A, Bornstein SR, Charalampopoulos I, Tsatsanis C, Chavakis T.

Mol Psychiatry. 2018 Jun;23(6):1410-1420. doi: 10.1038/mp.2017.167. Epub 2017 Sep 12.

PMID:
28894299
28.

Secreted protein Del-1 regulates myelopoiesis in the hematopoietic stem cell niche.

Mitroulis I, Chen LS, Singh RP, Kourtzelis I, Economopoulou M, Kajikawa T, Troullinaki M, Ziogas A, Ruppova K, Hosur K, Maekawa T, Wang B, Subramanian P, Tonn T, Verginis P, von Bonin M, Wobus M, Bornhäuser M, Grinenko T, Di Scala M, Hidalgo A, Wielockx B, Hajishengallis G, Chavakis T.

J Clin Invest. 2017 Oct 2;127(10):3624-3639. doi: 10.1172/JCI92571. Epub 2017 Aug 28.

29.

Endothelial cell-specific overexpression of developmental endothelial locus-1 does not influence atherosclerosis development in ApoE-/- mice.

Subramanian P, Prucnal M, Gercken B, Economopoulou M, Hajishengallis G, Chavakis T.

Thromb Haemost. 2017 Oct 5;117(10):2003-2005. doi: 10.1160/TH17-03-0160. Epub 2017 Aug 10. No abstract available.

30.

Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function.

Madhusudhan T, Wang H, Ghosh S, Dong W, Kumar V, Al-Dabet MM, Manoharan J, Nazir S, Elwakiel A, Bock F, Kohli S, Marquardt A, Sögüt I, Shahzad K, Müller AJ, Esmon CT, Nawroth PP, Reiser J, Chavakis T, Ruf W, Isermann B.

Blood. 2017 Sep 21;130(12):1445-1455. doi: 10.1182/blood-2017-02-767921. Epub 2017 Jul 7.

31.

Angiogenesis in metabolic-vascular disease.

Breier G, Chavakis T, Hirsch E.

Thromb Haemost. 2017 Jun 27;117(7):1289-1295. doi: 10.1160/TH17-05-0325. Epub 2017 Jun 8. Review.

PMID:
28594427
32.

Tregs restrain dendritic cell autophagy to ameliorate autoimmunity.

Alissafi T, Banos A, Boon L, Sparwasser T, Ghigo A, Wing K, Vassilopoulos D, Boumpas D, Chavakis T, Cadwell K, Verginis P.

J Clin Invest. 2017 Jun 30;127(7):2789-2804. doi: 10.1172/JCI92079. Epub 2017 Jun 5.

33.

Bone marrow niche-mimetics modulate HSPC function via integrin signaling.

Kräter M, Jacobi A, Otto O, Tietze S, Müller K, Poitz DM, Palm S, Zinna VM, Biehain U, Wobus M, Chavakis T, Werner C, Guck J, Bornhauser M.

Sci Rep. 2017 May 31;7(1):2549. doi: 10.1038/s41598-017-02352-5.

34.

Endogenous developmental endothelial locus-1 limits ischaemia-related angiogenesis by blocking inflammation.

Klotzsche-von Ameln A, Cremer S, Hoffmann J, Schuster P, Khedr S, Korovina I, Troullinaki M, Neuwirth A, Sprott D, Chatzigeorgiou A, Economopoulou M, Orlandi A, Hain A, Zeiher AM, Deussen A, Hajishengallis G, Dimmeler S, Chavakis T, Chavakis E.

Thromb Haemost. 2017 Jun 2;117(6):1150-1163. doi: 10.1160/TH16-05-0354. Epub 2017 Apr 27.

35.

A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity.

Chung KJ, Chatzigeorgiou A, Economopoulou M, Garcia-Martin R, Alexaki VI, Mitroulis I, Nati M, Gebler J, Ziemssen T, Goelz SE, Phieler J, Lim JH, Karalis KP, Papayannopoulou T, Blüher M, Hajishengallis G, Chavakis T.

Nat Immunol. 2017 Jun;18(6):654-664. doi: 10.1038/ni.3728. Epub 2017 Apr 17.

36.

From leukocyte recruitment to resolution of inflammation: the cardinal role of integrins.

Kourtzelis I, Mitroulis I, von Renesse J, Hajishengallis G, Chavakis T.

J Leukoc Biol. 2017 Sep;102(3):677-683. doi: 10.1189/jlb.3MR0117-024R. Epub 2017 Mar 14. Review.

37.

A BMP4-angiomiR connection in angiogenesis.

Sprott D, Chavakis T.

Thromb Haemost. 2017 Apr 3;117(4):650. doi: 10.1160/TH17-03-0148. Epub 2017 Mar 9. No abstract available.

PMID:
28276565
38.

Milk fat globule epidermal growth factor 8 inhibits periodontitis in non-human primates and its gingival crevicular fluid levels can differentiate periodontal health from disease in humans.

Kajikawa T, Meshikhes F, Maekawa T, Hajishengallis E, Hosur KB, Abe T, Moss K, Chavakis T, Hajishengallis G.

J Clin Periodontol. 2017 May;44(5):472-483. doi: 10.1111/jcpe.12707. Epub 2017 Apr 12.

39.

The human longevity gene homolog INDY and interleukin-6 interact in hepatic lipid metabolism.

von Loeffelholz C, Lieske S, Neuschäfer-Rube F, Willmes DM, Raschzok N, Sauer IM, König J, Fromm MF, Horn P, Chatzigeorgiou A, Pathe-Neuschäfer-Rube A, Jordan J, Pfeiffer AFH, Mingrone G, Bornstein SR, Stroehle P, Harms C, Wunderlich FT, Helfand SL, Bernier M, de Cabo R, Shulman GI, Chavakis T, Püschel GP, Birkenfeld AL.

Hepatology. 2017 Aug;66(2):616-630. doi: 10.1002/hep.29089. Epub 2017 Jun 26.

40.

No Role for Mast Cells in Obesity-Related Metabolic Dysregulation.

Chmelař J, Chatzigeorgiou A, Chung KJ, Prucnal M, Voehringer D, Roers A, Chavakis T.

Front Immunol. 2016 Nov 24;7:524. eCollection 2016.

41.

S100A9 induces monocyte/ macrophage migration via EMMPRIN.

Alexaki VI, May AE, Fujii C, V Ungern-Sternberg SN, Mund C, Gawaz M, Chavakis T, Seizer P.

Thromb Haemost. 2017 Feb 28;117(3):636-639. doi: 10.1160/TH16-06-0434. Epub 2016 Nov 3. No abstract available.

PMID:
27808344
42.

Increased EPO Levels Are Associated With Bone Loss in Mice Lacking PHD2 in EPO-Producing Cells.

Rauner M, Franke K, Murray M, Singh RP, Hiram-Bab S, Platzbecker U, Gassmann M, Socolovsky M, Neumann D, Gabet Y, Chavakis T, Hofbauer LC, Wielockx B.

J Bone Miner Res. 2016 Oct;31(10):1877-1887. doi: 10.1002/jbmr.2857. Epub 2016 May 13.

43.

Complement C3 inhibitor Cp40 attenuates xenoreactions in pig hearts perfused with human blood.

Abicht JM, Kourtzelis I, Reichart B, Koutsogiannaki S, Primikyri A, Lambris JD, Chavakis T, Holdt L, Kind A, Guethoff S, Mayr T.

Xenotransplantation. 2017 Jan;24(1). doi: 10.1111/xen.12262. Epub 2016 Sep 27.

44.

Selective and differential interactions of BNN27, a novel C17-spiroepoxy steroid derivative, with TrkA receptors, regulating neuronal survival and differentiation.

Pediaditakis I, Efstathopoulos P, Prousis KC, Zervou M, Arévalo JC, Alexaki VI, Nikoletopoulou V, Karagianni E, Potamitis C, Tavernarakis N, Chavakis T, Margioris AN, Venihaki M, Calogeropoulou T, Charalampopoulos I, Gravanis A.

Neuropharmacology. 2016 Dec;111:266-282. doi: 10.1016/j.neuropharm.2016.09.007. Epub 2016 Sep 9.

PMID:
27618740
45.

Current concepts in chronic inflammatory diseases: Interactions between microbes, cellular metabolism, and inflammation.

Garn H, Bahn S, Baune BT, Binder EB, Bisgaard H, Chatila TA, Chavakis T, Culmsee C, Dannlowski U, Gay S, Gern J, Haahtela T, Kircher T, Müller-Ladner U, Neurath MF, Preissner KT, Reinhardt C, Rook G, Russell S, Schmeck B, Stappenbeck T, Steinhoff U, van Os J, Weiss S, Zemlin M, Renz H.

J Allergy Clin Immunol. 2016 Jul;138(1):47-56. doi: 10.1016/j.jaci.2016.02.046. Review.

PMID:
27373325
46.

Comparison of Gene Expression Patterns Between Mouse Models of Nonalcoholic Fatty Liver Disease and Liver Tissues From Patients.

Teufel A, Itzel T, Erhart W, Brosch M, Wang XY, Kim YO, von Schönfels W, Herrmann A, Brückner S, Stickel F, Dufour JF, Chavakis T, Hellerbrand C, Spang R, Maass T, Becker T, Schreiber S, Schafmayer C, Schuppan D, Hampe J.

Gastroenterology. 2016 Sep;151(3):513-525.e0. doi: 10.1053/j.gastro.2016.05.051. Epub 2016 Jun 16.

PMID:
27318147
47.

Activation of proteinase 3 contributes to Non-alcoholic Fatty Liver Disease (NAFLD) and insulin resistance.

Toonen EJ, Mirea AM, Tack CJ, Stienstra R, Ballak DB, van Diepen JA, Hijmans A, Chavakis T, Dokter WH, Pham CT, Netea MG, Dinarello CA, Joosten LA.

Mol Med. 2016 May 24;22. doi: 10.2119/molmed.2016.00033.

48.

Breast cancer cells compete with hematopoietic stem and progenitor cells for intercellular adhesion molecule 1-mediated binding to the bone marrow microenvironment.

Dhawan A, Friedrichs J, Bonin MV, Bejestani EP, Werner C, Wobus M, Chavakis T, Bornhäuser M.

Carcinogenesis. 2016 Aug;37(8):759-767. doi: 10.1093/carcin/bgw057. Epub 2016 May 4.

PMID:
27207667
49.

Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells.

Göbel K, Pankratz S, Asaridou CM, Herrmann AM, Bittner S, Merker M, Ruck T, Glumm S, Langhauser F, Kraft P, Krug TF, Breuer J, Herold M, Gross CC, Beckmann D, Korb-Pap A, Schuhmann MK, Kuerten S, Mitroulis I, Ruppert C, Nolte MW, Panousis C, Klotz L, Kehrel B, Korn T, Langer HF, Pap T, Nieswandt B, Wiendl H, Chavakis T, Kleinschnitz C, Meuth SG.

Nat Commun. 2016 May 18;7:11626. doi: 10.1038/ncomms11626.

50.

Epithelial calcineurin controls microbiota-dependent intestinal tumor development.

Peuker K, Muff S, Wang J, Künzel S, Bosse E, Zeissig Y, Luzzi G, Basic M, Strigli A, Ulbricht A, Kaser A, Arlt A, Chavakis T, van den Brink GR, Schafmayer C, Egberts JH, Becker T, Bianchi ME, Bleich A, Röcken C, Hampe J, Schreiber S, Baines JF, Blumberg RS, Zeissig S.

Nat Med. 2016 May;22(5):506-15. doi: 10.1038/nm.4072. Epub 2016 Apr 4.

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