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Items: 18


Enzymatic preparation of monoubiquitinated FANCD2 and FANCI proteins.

Chaugule VK, Arkinson C, Toth R, Walden H.

Methods Enzymol. 2019;618:73-104. doi: 10.1016/bs.mie.2018.12.021. Epub 2019 Feb 11.


Specificity for deubiquitination of monoubiquitinated FANCD2 is driven by the N-terminus of USP1.

Arkinson C, Chaugule VK, Toth R, Walden H.

Life Sci Alliance. 2018 Oct 12;1(5):e201800162. doi: 10.26508/lsa.201800162. eCollection 2018 Oct.


Synergistic recruitment of UbcH7~Ub and phosphorylated Ubl domain triggers parkin activation.

Condos TE, Dunkerley KM, Freeman EA, Barber KR, Aguirre JD, Chaugule VK, Xiao Y, Konermann L, Walden H, Shaw GS.

EMBO J. 2018 Dec 3;37(23). pii: e100014. doi: 10.15252/embj.2018100014. Epub 2018 Nov 16.


DHX15 regulates CMTR1-dependent gene expression and cell proliferation.

Inesta-Vaquera F, Chaugule VK, Galloway A, Chandler L, Rojas-Fernandez A, Weidlich S, Peggie M, Cowling VH.

Life Sci Alliance. 2018 Jun 18;1(3):e201800092. doi: 10.26508/lsa.201800092.


RNF12 X-Linked Intellectual Disability Mutations Disrupt E3 Ligase Activity and Neural Differentiation.

Bustos F, Segarra-Fas A, Chaugule VK, Brandenburg L, Branigan E, Toth R, Macartney T, Knebel A, Hay RT, Walden H, Findlay GM.

Cell Rep. 2018 May 8;23(6):1599-1611. doi: 10.1016/j.celrep.2018.04.022.


Mind the Metal: A Fragment Library-Derived Zinc Impurity Binds the E2 Ubiquitin-Conjugating Enzyme Ube2T and Induces Structural Rearrangements.

Morreale FE, Testa A, Chaugule VK, Bortoluzzi A, Ciulli A, Walden H.

J Med Chem. 2017 Oct 12;60(19):8183-8191. doi: 10.1021/acs.jmedchem.7b01071. Epub 2017 Oct 3.


Allosteric Targeting of the Fanconi Anemia Ubiquitin-Conjugating Enzyme Ube2T by Fragment Screening.

Morreale FE, Bortoluzzi A, Chaugule VK, Arkinson C, Walden H, Ciulli A.

J Med Chem. 2017 May 11;60(9):4093-4098. doi: 10.1021/acs.jmedchem.7b00147. Epub 2017 May 2.


Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity.

Kumar A, Chaugule VK, Condos TEC, Barber KR, Johnson C, Toth R, Sundaramoorthy R, Knebel A, Shaw GS, Walden H.

Nat Struct Mol Biol. 2017 May;24(5):475-483. doi: 10.1038/nsmb.3400. Epub 2017 Apr 17.


A Fluorescent In Vitro Assay to Investigate Paralog-Specific SUMO Conjugation.

Eisenhardt N, Chaugule VK, Pichler A.

Methods Mol Biol. 2016;1475:67-78. doi: 10.1007/978-1-4939-6358-4_5.


The SUMO2/3 specific E3 ligase ZNF451-1 regulates PML stability.

Koidl S, Eisenhardt N, Fatouros C, Droescher M, Chaugule VK, Pichler A.

Int J Biochem Cell Biol. 2016 Oct;79:478-487. doi: 10.1016/j.biocel.2016.06.011. Epub 2016 Jun 22.


Specificity and disease in the ubiquitin system.

Chaugule VK, Walden H.

Biochem Soc Trans. 2016 Feb;44(1):212-27. doi: 10.1042/BST20150209. Review.


A new vertebrate SUMO enzyme family reveals insights into SUMO-chain assembly.

Eisenhardt N, Chaugule VK, Koidl S, Droescher M, Dogan E, Rettich J, Sutinen P, Imanishi SY, Hofmann K, Palvimo JJ, Pichler A.

Nat Struct Mol Biol. 2015 Dec;22(12):959-67. doi: 10.1038/nsmb.3114. Epub 2015 Nov 2.


Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis.

Kumar A, Aguirre JD, Condos TE, Martinez-Torres RJ, Chaugule VK, Toth R, Sundaramoorthy R, Mercier P, Knebel A, Spratt DE, Barber KR, Shaw GS, Walden H.

EMBO J. 2015 Oct 14;34(20):2506-21. doi: 10.15252/embj.201592337. Epub 2015 Aug 7.


The Fanconi Anemia DNA Repair Pathway Is Regulated by an Interaction between Ubiquitin and the E2-like Fold Domain of FANCL.

Miles JA, Frost MG, Carroll E, Rowe ML, Howard MJ, Sidhu A, Chaugule VK, Alpi AF, Walden H.

J Biol Chem. 2015 Aug 21;290(34):20995-1006. doi: 10.1074/jbc.M115.675835. Epub 2015 Jul 6.


SUMO rules: regulatory concepts and their implication in neurologic functions.

Droescher M, Chaugule VK, Pichler A.

Neuromolecular Med. 2013 Dec;15(4):639-60. doi: 10.1007/s12017-013-8258-6. Epub 2013 Aug 30. Review.


Ubc9 sumoylation controls SUMO chain formation and meiotic synapsis in Saccharomyces cerevisiae.

Klug H, Xaver M, Chaugule VK, Koidl S, Mittler G, Klein F, Pichler A.

Mol Cell. 2013 Jun 6;50(5):625-36. doi: 10.1016/j.molcel.2013.03.027. Epub 2013 May 2.


Small, N-terminal tags activate Parkin E3 ubiquitin ligase activity by disrupting its autoinhibited conformation.

Burchell L, Chaugule VK, Walden H.

PLoS One. 2012;7(4):e34748. doi: 10.1371/journal.pone.0034748. Epub 2012 Apr 4.


Autoregulation of Parkin activity through its ubiquitin-like domain.

Chaugule VK, Burchell L, Barber KR, Sidhu A, Leslie SJ, Shaw GS, Walden H.

EMBO J. 2011 Jun 21;30(14):2853-67. doi: 10.1038/emboj.2011.204.

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