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Items: 32

1.

Gene activation of SMN by selective disruption of lncRNA-mediated recruitment of PRC2 for the treatment of spinal muscular atrophy.

Woo CJ, Maier VK, Davey R, Brennan J, Li G, Brothers J 2nd, Schwartz B, Gordo S, Kasper A, Okamoto TR, Johansson HE, Mandefro B, Sareen D, Bialek P, Chau BN, Bhat B, Bullough D, Barsoum J.

Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1509-E1518. doi: 10.1073/pnas.1616521114. Epub 2017 Feb 13.

2.

Lipid Nanoparticle-Mediated Delivery of Anti-miR-17 Family Oligonucleotide Suppresses Hepatocellular Carcinoma Growth.

Huang X, Magnus J, Kaimal V, Karmali P, Li J, Walls M, Prudente R, Sung E, Sorourian M, Lee R, Davis S, Yang X, Estrella H, Lee EC, Chau BN, Pavlicek A, Zabludoff S.

Mol Cancer Ther. 2017 May;16(5):905-913. doi: 10.1158/1535-7163.MCT-16-0613. Epub 2017 Feb 6.

3.

Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit.

Bertero T, Cottrill KA, Lu Y, Haeger CM, Dieffenbach P, Annis S, Hale A, Bhat B, Kaimal V, Zhang YY, Graham BB, Kumar R, Saggar R, Saggar R, Wallace WD, Ross DJ, Black SM, Fratz S, Fineman JR, Vargas SO, Haley KJ, Waxman AB, Chau BN, Fredenburgh LE, Chan SY.

Cell Rep. 2015 Nov 3;13(5):1016-32. doi: 10.1016/j.celrep.2015.09.049. Epub 2015 Oct 22.

4.

Polysome shift assay for direct measurement of miRNA inhibition by anti-miRNA drugs.

Androsavich JR, Sobczynski DJ, Liu X, Pandya S, Kaimal V, Owen T, Liu K, MacKenna DA, Chau BN.

Nucleic Acids Res. 2016 Jan 29;44(2):e13. doi: 10.1093/nar/gkv893. Epub 2015 Sep 17.

5.

Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension.

White K, Lu Y, Annis S, Hale AE, Chau BN, Dahlman JE, Hemann C, Opotowsky AR, Vargas SO, Rosas I, Perrella MA, Osorio JC, Haley KJ, Graham BB, Kumar R, Saggar R, Saggar R, Wallace WD, Ross DJ, Khan OF, Bader A, Gochuico BR, Matar M, Polach K, Johannessen NM, Prosser HM, Anderson DG, Langer R, Zweier JL, Bindoff LA, Systrom D, Waxman AB, Jin RC, Chan SY.

EMBO Mol Med. 2015 Jun;7(6):695-713. doi: 10.15252/emmm.201404511.

6.

The microRNA-130/301 family controls vasoconstriction in pulmonary hypertension.

Bertero T, Cottrill K, Krauszman A, Lu Y, Annis S, Hale A, Bhat B, Waxman AB, Chau BN, Kuebler WM, Chan SY.

J Biol Chem. 2015 Jan 23;290(4):2069-85. doi: 10.1074/jbc.M114.617845. Epub 2014 Dec 12.

7.

Anti-microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways.

Gomez IG, MacKenna DA, Johnson BG, Kaimal V, Roach AM, Ren S, Nakagawa N, Xin C, Newitt R, Pandya S, Xia TH, Liu X, Borza DB, Grafals M, Shankland SJ, Himmelfarb J, Portilla D, Liu S, Chau BN, Duffield JS.

J Clin Invest. 2015 Jan;125(1):141-56. doi: 10.1172/JCI75852. Epub 2014 Nov 21.

8.

Let-7 coordinately suppresses components of the amino acid sensing pathway to repress mTORC1 and induce autophagy.

Dubinsky AN, Dastidar SG, Hsu CL, Zahra R, Djakovic SN, Duarte S, Esau CC, Spencer B, Ashe TD, Fischer KM, MacKenna DA, Sopher BL, Masliah E, Gaasterland T, Chau BN, Pereira de Almeida L, Morrison BE, La Spada AR.

Cell Metab. 2014 Oct 7;20(4):626-38. doi: 10.1016/j.cmet.2014.09.001.

9.

Anti-miRs competitively inhibit microRNAs in Argonaute complexes.

Hogan DJ, Vincent TM, Fish S, Marcusson EG, Bhat B, Chau BN, Zisoulis DG.

PLoS One. 2014 Jul 3;9(7):e100951. doi: 10.1371/journal.pone.0100951. eCollection 2014.

10.

Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension.

Bertero T, Lu Y, Annis S, Hale A, Bhat B, Saggar R, Saggar R, Wallace WD, Ross DJ, Vargas SO, Graham BB, Kumar R, Black SM, Fratz S, Fineman JR, West JD, Haley KJ, Waxman AB, Chau BN, Cottrill KA, Chan SY.

J Clin Invest. 2014 Aug;124(8):3514-28. doi: 10.1172/JCI74773. Epub 2014 Jun 24.

11.

Non-inhibited miRNAs shape the cellular response to anti-miR.

Androsavich JR, Chau BN.

Nucleic Acids Res. 2014 Jun;42(11):6945-55. doi: 10.1093/nar/gku344. Epub 2014 May 7.

12.

Method for widespread microRNA-155 inhibition prolongs survival in ALS-model mice.

Koval ED, Shaner C, Zhang P, du Maine X, Fischer K, Tay J, Chau BN, Wu GF, Miller TM.

Hum Mol Genet. 2013 Oct 15;22(20):4127-35. doi: 10.1093/hmg/ddt261. Epub 2013 Jun 4.

13.

Disease-linked microRNA-21 exhibits drastically reduced mRNA binding and silencing activity in healthy mouse liver.

Androsavich JR, Chau BN, Bhat B, Linsley PS, Walter NG.

RNA. 2012 Aug;18(8):1510-26. doi: 10.1261/rna.033308.112. Epub 2012 Jun 27.

14.

Functional genomics identifies therapeutic targets for MYC-driven cancer.

Toyoshima M, Howie HL, Imakura M, Walsh RM, Annis JE, Chang AN, Frazier J, Chau BN, Loboda A, Linsley PS, Cleary MA, Park JR, Grandori C.

Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9545-50. doi: 10.1073/pnas.1121119109. Epub 2012 May 23.

15.

MicroRNA-21 promotes fibrosis of the kidney by silencing metabolic pathways.

Chau BN, Xin C, Hartner J, Ren S, Castano AP, Linn G, Li J, Tran PT, Kaimal V, Huang X, Chang AN, Li S, Kalra A, Grafals M, Portilla D, MacKenna DA, Orkin SH, Duffield JS.

Sci Transl Med. 2012 Feb 15;4(121):121ra18. doi: 10.1126/scitranslmed.3003205.

16.

What goes up must come down: the emerging role of microRNA in fibrosis.

Chau BN, Brenner DA.

Hepatology. 2011 Jan;53(1):4-6. doi: 10.1002/hep.24071. No abstract available.

PMID:
21254156
17.

Cell cycle arrest or apoptosis by p53: are microRNAs-192/215 and -34 making the decision?

Georges SA, Chau BN, Braun CJ, Zhang X, Dobbelstein M.

Cell Cycle. 2009 Mar 1;8(5):680-1. Epub 2009 Mar 9. No abstract available.

PMID:
19223766
18.

Identification of SULF2 as a novel transcriptional target of p53 by use of integrated genomic analyses.

Chau BN, Diaz RL, Saunders MA, Cheng C, Chang AN, Warrener P, Bradshaw J, Linsley PS, Cleary MA.

Cancer Res. 2009 Feb 15;69(4):1368-74. doi: 10.1158/0008-5472.CAN-08-2742. Epub 2009 Feb 3.

19.

Coordinated regulation of cell cycle transcripts by p53-Inducible microRNAs, miR-192 and miR-215.

Georges SA, Biery MC, Kim SY, Schelter JM, Guo J, Chang AN, Jackson AL, Carleton MO, Linsley PS, Cleary MA, Chau BN.

Cancer Res. 2008 Dec 15;68(24):10105-12. doi: 10.1158/0008-5472.CAN-08-1846.

20.

Aven-dependent activation of ATM following DNA damage.

Guo JY, Yamada A, Kajino T, Wu JQ, Tang W, Freel CD, Feng J, Chau BN, Wang MZ, Margolis SS, Yoo HY, Wang XF, Dunphy WG, Irusta PM, Hardwick JM, Kornbluth S.

Curr Biol. 2008 Jul 8;18(13):933-42. doi: 10.1016/j.cub.2008.05.045. Epub 2008 Jun 19.

22.

Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity.

Jackson AL, Burchard J, Schelter J, Chau BN, Cleary M, Lim L, Linsley PS.

RNA. 2006 Jul;12(7):1179-87. Epub 2006 May 8.

23.

Tumor necrosis factor alpha-induced apoptosis requires p73 and c-ABL activation downstream of RB degradation.

Chau BN, Chen TT, Wan YY, DeGregori J, Wang JY.

Mol Cell Biol. 2004 May;24(10):4438-47.

24.

Coordinated regulation of life and death by RB.

Chau BN, Wang JY.

Nat Rev Cancer. 2003 Feb;3(2):130-8. Review.

PMID:
12563312
25.

Signal-dependent protection from apoptosis in mice expressing caspase-resistant Rb.

Chau BN, Borges HL, Chen TT, Masselli A, Hunton IC, Wang JY.

Nat Cell Biol. 2002 Oct;4(10):757-65.

PMID:
12360286
26.

Pro-apoptotic cleavage products of Bcl-xL form cytochrome c-conducting pores in pure lipid membranes.

BasaƱez G, Zhang J, Chau BN, Maksaev GI, Frolov VA, Brandt TA, Burch J, Hardwick JM, Zimmerberg J.

J Biol Chem. 2001 Aug 17;276(33):31083-91. Epub 2001 Jun 8.

27.

Survival motor neuron protein modulates neuron-specific apoptosis.

Kerr DA, Nery JP, Traystman RJ, Chau BN, Hardwick JM.

Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13312-7.

28.

Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1.

Chau BN, Cheng EH, Kerr DA, Hardwick JM.

Mol Cell. 2000 Jul;6(1):31-40.

29.

Antiapoptotic herpesvirus Bcl-2 homologs escape caspase-mediated conversion to proapoptotic proteins.

Bellows DS, Chau BN, Lee P, Lazebnik Y, Burns WH, Hardwick JM.

J Virol. 2000 Jun;74(11):5024-31.

30.

Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c.

Kirsch DG, Doseff A, Chau BN, Lim DS, de Souza-Pinto NC, Hansford R, Kastan MB, Lazebnik YA, Hardwick JM.

J Biol Chem. 1999 Jul 23;274(30):21155-61.

31.

Inhibition of virus-induced neuronal apoptosis by Bax.

Lewis J, Oyler GA, Ueno K, Fannjiang YR, Chau BN, Vornov J, Korsmeyer SJ, Zou S, Hardwick JM.

Nat Med. 1999 Jul;5(7):832-5.

PMID:
10395331
32.

The EGF receptor binding of recombinant heregulinbeta1/EGF hybrids is blocked by heregulin residue glutamate 195.

Chau BN, Nandagopal K, Niyogi SK, Campion SR.

Biochem Biophys Res Commun. 1996 Dec 24;229(3):882-6.

PMID:
8954988

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