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Oral delivery of pancreatitis-associated protein by Lactococcus lactis displays protective effects in dinitro-benzenesulfonic-acid-induced colitis model and is able to modulate the composition of the microbiota.

Breyner NM, Vilas Boas PB, Fernandes G, de Carvalho RD, Rochat T, Michel ML, Chain F, Sokol H, de Azevedo M, Myioshi A, Azevedo VA, Langella P, Bermúdez-Humarán LG, Chatel JM.

Environ Microbiol. 2019 Jul 19. doi: 10.1111/1462-2920.14748. [Epub ahead of print]


Recombinant invasive Lactobacillus plantarum expressing fibronectin binding protein A induce specific humoral immune response by stimulating differentiation of dendritic cells.

Liu J, Yang G, Gao X, Zhang Z, Liu Y, Liu Q, Chatel JM, Jiang Y, Wang C.

Benef Microbes. 2019 May 28;10(5):589-604. doi: 10.3920/BM2018.0157. Epub 2019 May 15.


Procyanidin-Cell Wall Interactions within Apple Matrices Decrease the Metabolization of Procyanidins by the Human Gut Microbiota and the Anti-Inflammatory Effect of the Resulting Microbial Metabolome In Vitro.

Le Bourvellec C, Bagano Vilas Boas P, Lepercq P, Comtet-Marre S, Auffret P, Ruiz P, Bott R, Renard CMGC, Dufour C, Chatel JM, Mosoni P.

Nutrients. 2019 Mar 19;11(3). pii: E664. doi: 10.3390/nu11030664.


Risk assessment of probiotics use requires clinical parameters.

Langella P, Chatel JM.

Nat Rev Gastroenterol Hepatol. 2019 Apr;16(4):202-204. doi: 10.1038/s41575-019-0111-4. No abstract available.


Gut microbiome modulation during treatment of mucositis with the dairy bacterium Lactococcus lactis and recombinant strain secreting human antimicrobial PAP.

Carvalho R, Vaz A, Pereira FL, Dorella F, Aguiar E, Chatel JM, Bermudez L, Langella P, Fernandes G, Figueiredo H, Goes-Neto A, Azevedo V.

Sci Rep. 2018 Oct 10;8(1):15072. doi: 10.1038/s41598-018-33469-w.


The regenerating family member 3 β instigates IL-17A-mediated neutrophil recruitment downstream of NOD1/2 signalling for controlling colonisation resistance independently of microbiota community structure.

Waldschmitt N, Kitamoto S, Secher T, Zacharioudaki V, Boulard O, Floquet E, Delacre M, Lamas B, Pham HP, Six A, Richard ML, Dagorn JC, Eberl G, Langella P, Chatel JM, Ryffel B, Iovanna JL, Poulin LF, Sokol H, Kamada N, Chamaillard M.

Gut. 2019 Jul;68(7):1190-1199. doi: 10.1136/gutjnl-2018-316757. Epub 2018 Oct 2.


New Insights into the Diversity of the Genus Faecalibacterium.

Benevides L, Burman S, Martin R, Robert V, Thomas M, Miquel S, Chain F, Sokol H, Bermudez-Humaran LG, Morrison M, Langella P, Azevedo VA, Chatel JM, Soares S.

Front Microbiol. 2017 Sep 22;8:1790. doi: 10.3389/fmicb.2017.01790. eCollection 2017.


Functional Characterization of Novel Faecalibacterium prausnitzii Strains Isolated from Healthy Volunteers: A Step Forward in the Use of F. prausnitzii as a Next-Generation Probiotic.

Martín R, Miquel S, Benevides L, Bridonneau C, Robert V, Hudault S, Chain F, Berteau O, Azevedo V, Chatel JM, Sokol H, Bermúdez-Humarán LG, Thomas M, Langella P.

Front Microbiol. 2017 Jun 30;8:1226. doi: 10.3389/fmicb.2017.01226. eCollection 2017.


Use of Wild Type or Recombinant Lactic Acid Bacteria as an Alternative Treatment for Gastrointestinal Inflammatory Diseases: A Focus on Inflammatory Bowel Diseases and Mucositis.

Carvalho RDO, do Carmo FLR, de Oliveira Junior A, Langella P, Chatel JM, Bermúdez-Humarán LG, Azevedo V, de Azevedo MS.

Front Microbiol. 2017 May 9;8:800. doi: 10.3389/fmicb.2017.00800. eCollection 2017. Review.


Plasmid transfer efficiency using Lactoccocus lactis strains depends on invasiveness status but also on plasmid copy number.

Mariat D, Robert V, Langella P, Chatel JM.

FEMS Microbiol Lett. 2017 Aug 1;364(14). doi: 10.1093/femsle/fnx100.


A New Broad Range Plasmid for DNA Delivery in Eukaryotic Cells Using Lactic Acid Bacteria: In Vitro and In Vivo Assays.

Mancha-Agresti P, Drumond MM, Carmo FL, Santos MM, Santos JS, Venanzi F, Chatel JM, Leclercq SY, Azevedo V.

Mol Ther Methods Clin Dev. 2016 Dec 24;4:83-91. doi: 10.1016/j.omtm.2016.12.005. eCollection 2017 Mar 17.


Microbial Anti-Inflammatory Molecule (MAM) from Faecalibacterium prausnitzii Shows a Protective Effect on DNBS and DSS-Induced Colitis Model in Mice through Inhibition of NF-κB Pathway.

Breyner NM, Michon C, de Sousa CS, Vilas Boas PB, Chain F, Azevedo VA, Langella P, Chatel JM.

Front Microbiol. 2017 Feb 1;8:114. doi: 10.3389/fmicb.2017.00114. eCollection 2017.


Secretion of biologically active pancreatitis-associated protein I (PAP) by genetically modified dairy Lactococcus lactis NZ9000 in the prevention of intestinal mucositis.

Carvalho RD, Breyner N, Menezes-Garcia Z, Rodrigues NM, Lemos L, Maioli TU, da Gloria Souza D, Carmona D, de Faria AM, Langella P, Chatel JM, Bermúdez-Humarán LG, Figueiredo HC, Azevedo V, de Azevedo MS.

Microb Cell Fact. 2017 Feb 13;16(1):27. doi: 10.1186/s12934-017-0624-x.


Erratum to: Protective effect of TSLP delivered at the gut mucosa level by recombinant lactic acid bacteria in DSS-induced colitis mouse model.

Aubry C, Michon C, Chain F, Chvatchko Y, Goffin L, Zimmerli SC, Leguin S, Langella P, Bermudez-Humaran L, Chatel JM.

Microb Cell Fact. 2016 Nov 10;15(1):188. No abstract available.


Lactococcus lactis carrying the pValac eukaryotic expression vector coding for IL-4 reduces chemically-induced intestinal inflammation by increasing the levels of IL-10-producing regulatory cells.

Souza BM, Preisser TM, Pereira VB, Zurita-Turk M, de Castro CP, da Cunha VP, de Oliveira RP, Gomes-Santos AC, de Faria AM, Machado DC, Chatel JM, Azevedo VA, Langella P, Miyoshi A.

Microb Cell Fact. 2016 Aug 30;15(1):150. doi: 10.1186/s12934-016-0548-x.


Evaluation of the biosafety of recombinant lactic acid bacteria designed to prevent and treat colitis.

de Moreno de LeBlanc A, Del Carmen S, Chatel JM, Azevedo V, Langella P, Bermudez-Humaran L, LeBlanc JG.

J Med Microbiol. 2016 Sep;65(9):1038-46. doi: 10.1099/jmm.0.000323. Epub 2016 Jul 26.


Display of recombinant proteins at the surface of lactic acid bacteria: strategies and applications.

Michon C, Langella P, Eijsink VG, Mathiesen G, Chatel JM.

Microb Cell Fact. 2016 May 3;15:70. doi: 10.1186/s12934-016-0468-9. Review.


Aqueous two-phase system cold-set gelation using natural and recombinant probiotic lactic acid bacteria as a gelling agent.

Léonard L, Husson F, Langella P, Châtel JM, Saurel R.

Colloids Surf B Biointerfaces. 2016 May 1;141:338-344. doi: 10.1016/j.colsurfb.2016.01.057. Epub 2016 Feb 3.


Expression of fibronectin binding protein A (FnBPA) from Staphylococcus aureus at the cell surface of Lactococcus lactis improves its immunomodulatory properties when used as protein delivery vector.

Almeida JF, Breyner NM, Mahi M, Ahmed B, Benbouziane B, Boas PC, Miyoshi A, Azevedo V, Langella P, Bermúdez-Humarán LG, Chatel JM.

Vaccine. 2016 Mar 4;34(10):1312-8. doi: 10.1016/j.vaccine.2016.01.022. Epub 2016 Feb 5.


Prospective uses of recombinant Lactococcus lactis expressing both listeriolysin O and mutated internalin A from Listeria monocytogenes as a tool for DNA vaccination.

De Azevedo MS, Santos Rocha C, Pereira VB, De Oliveira Junior AF, De Sousa CS, Azevedo V, LeBlanc JG, Chatel JM, Miyoshi A.

Genet Mol Res. 2015 Dec 28;14(4):18485-93. doi: 10.4238/2015.December.23.36.


Erratum to: Surface display of an anti-DEC-205 single chain Fv fragment in Lactobacillus plantarum increases internalization and plasmid transfer to dendritic cells in vitro and in vivo.

Michon C, Kuczkowska K, Langella P, Eijsink VG, Mathiesen G, Chatel JM.

Microb Cell Fact. 2015 Nov 17;14(1):184. doi: 10.1186/s12934-015-0366-6. No abstract available.


Protective effect of TSLP delivered at the gut mucosa level by recombinant lactic acid bacteria in DSS-induced colitis mouse model.

Aubry C, Michon C, Chain F, Chvatchenko Y, Goffin L, Zimmerli SC, Leguin S, Langella P, Bermudez-Humaran L, Chatel JM.

Microb Cell Fact. 2015 Nov 6;14:176. doi: 10.1186/s12934-015-0367-5. Erratum in: Microb Cell Fact. 2016 Nov 10;15(1):188.


Recombinant invasive Lactococcus lactis can transfer DNA vaccines either directly to dendritic cells or across an epithelial cell monolayer.

de Azevedo M, Meijerink M, Taverne N, Pereira VB, LeBlanc JG, Azevedo V, Miyoshi A, Langella P, Wells JM, Chatel JM.

Vaccine. 2015 Sep 11;33(38):4807-12. doi: 10.1016/j.vaccine.2015.07.077. Epub 2015 Aug 1.


Current Review of Genetically Modified Lactic Acid Bacteria for the Prevention and Treatment of Colitis Using Murine Models.

de Moreno de LeBlanc A, Del Carmen S, Chatel JM, Miyoshi A, Azevedo V, Langella P, Bermúdez-Humarán LG, LeBlanc JG.

Gastroenterol Res Pract. 2015;2015:146972. doi: 10.1155/2015/146972. Epub 2015 May 4. Review.


Identification of an anti-inflammatory protein from Faecalibacterium prausnitzii, a commensal bacterium deficient in Crohn's disease.

Quévrain E, Maubert MA, Michon C, Chain F, Marquant R, Tailhades J, Miquel S, Carlier L, Bermúdez-Humarán LG, Pigneur B, Lequin O, Kharrat P, Thomas G, Rainteau D, Aubry C, Breyner N, Afonso C, Lavielle S, Grill JP, Chassaing G, Chatel JM, Trugnan G, Xavier R, Langella P, Sokol H, Seksik P.

Gut. 2016 Mar;65(3):415-425. doi: 10.1136/gutjnl-2014-307649. Epub 2015 Jun 4.


Correlation between fibronectin binding protein A expression level at the surface of recombinant lactococcus lactis and plasmid transfer in vitro and in vivo.

Almeida JF, Mariat D, Azevedo V, Miyoshi A, de Moreno de LeBlanc A, Del Carmen S, Martin R, Langella P, LeBlanc JG, Chatel JM.

BMC Microbiol. 2014 Sep 25;14:248. doi: 10.1186/s12866-014-0248-9.


Lactococcus lactis carrying the pValac DNA expression vector coding for IL-10 reduces inflammation in a murine model of experimental colitis.

Zurita-Turk M, Del Carmen S, Santos AC, Pereira VB, Cara DC, Leclercq SY, de LeBlanc Ad, Azevedo V, Chatel JM, LeBlanc JG, Miyoshi A.

BMC Biotechnol. 2014 Aug 9;14:73. doi: 10.1186/1472-6750-14-73.


Immune response elicited by DNA vaccination using Lactococcus lactis is modified by the production of surface exposed pathogenic protein.

Pontes D, Azevedo M, Innocentin S, Blugeon S, Lefévre F, Azevedo V, Miyoshi A, Courtin P, Chapot-Chartier MP, Langella P, Chatel JM.

PLoS One. 2014 Jan 21;9(1):e84509. doi: 10.1371/journal.pone.0084509. eCollection 2014.


Engineering lactococci and lactobacilli for human health.

Bermúdez-Humarán LG, Aubry C, Motta JP, Deraison C, Steidler L, Vergnolle N, Chatel JM, Langella P.

Curr Opin Microbiol. 2013 Jun;16(3):278-83. doi: 10.1016/j.mib.2013.06.002. Epub 2013 Jul 11. Review.


Faecalibacterium prausnitzii and human intestinal health.

Miquel S, Martín R, Rossi O, Bermúdez-Humarán LG, Chatel JM, Sokol H, Thomas M, Wells JM, Langella P.

Curr Opin Microbiol. 2013 Jun;16(3):255-61. doi: 10.1016/j.mib.2013.06.003. Epub 2013 Jul 3. Review.


Mucosal targeting of therapeutic molecules using genetically modified lactic acid bacteria: an update.

LeBlanc JG, Aubry C, Cortes-Perez NG, de Moreno de LeBlanc A, Vergnolle N, Langella P, Azevedo V, Chatel JM, Miyoshi A, Bermúdez-Humarán LG.

FEMS Microbiol Lett. 2013 Jul;344(1):1-9. doi: 10.1111/1574-6968.12159. Epub 2013 May 16. Review.


Immunotherapy of allergic diseases using probiotics or recombinant probiotics.

de Azevedo MS, Innocentin S, Dorella FA, Rocha CS, Mariat D, Pontes DS, Miyoshi A, Azevedo V, Langella P, Chatel JM.

J Appl Microbiol. 2013 Aug;115(2):319-33. doi: 10.1111/jam.12174. Epub 2013 Mar 13. Review.


Implications of the human microbiome in inflammatory bowel diseases.

Bakhtiar SM, LeBlanc JG, Salvucci E, Ali A, Martin R, Langella P, Chatel JM, Miyoshi A, Bermúdez-Humarán LG, Azevedo V.

FEMS Microbiol Lett. 2013 May;342(1):10-7. doi: 10.1111/1574-6968.12111. Epub 2013 Mar 15. Review.


Identification of one novel candidate probiotic Lactobacillus plantarum strain active against influenza virus infection in mice by a large-scale screening.

Kechaou N, Chain F, Gratadoux JJ, Blugeon S, Bertho N, Chevalier C, Le Goffic R, Courau S, Molimard P, Chatel JM, Langella P, Bermúdez-Humarán LG.

Appl Environ Microbiol. 2013 Mar;79(5):1491-9. doi: 10.1128/AEM.03075-12. Epub 2012 Dec 21.


In vitro and in vivo characterization of DNA delivery using recombinant Lactococcus lactis expressing a mutated form of L. monocytogenes Internalin A.

de Azevedo M, Karczewski J, Lefévre F, Azevedo V, Miyoshi A, Wells JM, Langella P, Chatel JM.

BMC Microbiol. 2012 Dec 19;12:299. doi: 10.1186/1471-2180-12-299.


Production of Fibronectin Binding Protein A at the surface of Lactococcus lactis increases plasmid transfer in vitro and in vivo.

Pontes D, Innocentin S, Del Carmen S, Almeida JF, Leblanc JG, de Moreno de Leblanc A, Blugeon S, Cherbuy C, Lefèvre F, Azevedo V, Miyoshi A, Langella P, Chatel JM.

PLoS One. 2012;7(9):e44892. doi: 10.1371/journal.pone.0044892. Epub 2012 Sep 27.


Lactococci and lactobacilli as mucosal delivery vectors for therapeutic proteins and DNA vaccines.

Bermúdez-Humarán LG, Kharrat P, Chatel JM, Langella P.

Microb Cell Fact. 2011 Aug 30;10 Suppl 1:S4. doi: 10.1186/1475-2859-10-S1-S4. Epub 2011 Aug 30. Review.


Lactococcus lactis as a live vector: heterologous protein production and DNA delivery systems.

Pontes DS, de Azevedo MS, Chatel JM, Langella P, Azevedo V, Miyoshi A.

Protein Expr Purif. 2011 Oct;79(2):165-75. doi: 10.1016/j.pep.2011.06.005. Epub 2011 Jun 16. Review.


Block copolymers have differing adjuvant effects on the primary immune response elicited by genetic immunization and on further induced allergy.

Adel-Patient K, Pothelune L, Ah-Leung S, Wal JM, Créminon C, Chatel JM.

Clin Vaccine Immunol. 2010 Jan;17(1):36-42. doi: 10.1128/CVI.00275-09. Epub 2009 Nov 18.


Lactococcus lactis expressing either Staphylococcus aureus fibronectin-binding protein A or Listeria monocytogenes internalin A can efficiently internalize and deliver DNA in human epithelial cells.

Innocentin S, Guimarães V, Miyoshi A, Azevedo V, Langella P, Chatel JM, Lefèvre F.

Appl Environ Microbiol. 2009 Jul;75(14):4870-8. doi: 10.1128/AEM.00825-09. Epub 2009 May 29.


A new plasmid vector for DNA delivery using lactococci.

Guimarães V, Innocentin S, Chatel JM, Lefèvre F, Langella P, Azevedo V, Miyoshi A.

Genet Vaccines Ther. 2009 Feb 10;7:4. doi: 10.1186/1479-0556-7-4.


In vivo transfer of plasmid from food-grade transiting lactococci to murine epithelial cells.

Chatel JM, Pothelune L, Ah-Leung S, Corthier G, Wal JM, Langella P.

Gene Ther. 2008 Aug;15(16):1184-90. doi: 10.1038/gt.2008.59. Epub 2008 Apr 17.


Use of native lactococci as vehicles for delivery of DNA into mammalian epithelial cells.

Guimarães VD, Innocentin S, Lefèvre F, Azevedo V, Wal JM, Langella P, Chatel JM.

Appl Environ Microbiol. 2006 Nov;72(11):7091-7. Epub 2006 Sep 8.


Oral administration of recombinant Lactococcus lactis expressing bovine beta-lactoglobulin partially prevents mice from sensitization.

Adel-Patient K, Ah-Leung S, Creminon C, Nouaille S, Chatel JM, Langella P, Wal JM.

Clin Exp Allergy. 2005 Apr;35(4):539-46.


Improvement of bovine beta-lactoglobulin production and secretion by Lactococcus lactis.

Nouaille S, Bermúdez-Humarán LG, Adel-Patient K, Commissaire J, Gruss A, Wal JM, Azevedo V, Langella P, Chatel JM.

Braz J Med Biol Res. 2005 Mar;38(3):353-9. Epub 2005 Mar 8.


Characterization of a Lactococcus lactis strain that secretes a major epitope of bovine beta-lactoglobulin and evaluation of its immunogenicity in mice.

Chatel JM, Nouaille S, Adel-Patient K, Le Loir Y, Boe H, Gruss A, Wal JM, Langella P.

Appl Environ Microbiol. 2003 Nov;69(11):6620-7.


Isolation and characterization of two complete Ara h 2 isoforms cDNA.

Chatel JM, Bernard H, Orson FM.

Int Arch Allergy Immunol. 2003 May;131(1):14-8.


Epitopic characterization of native bovine beta-lactoglobulin.

Clement G, Boquet D, Frobert Y, Bernard H, Negroni L, Chatel JM, Adel-Patient K, Creminon C, Wal JM, Grassi J.

J Immunol Methods. 2002 Aug 1;266(1-2):67-78.


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