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Items: 1 to 50 of 185

1.

Absorption, distribution, metabolism and excretion of the cholecystokinin-1 antagonist dexloxiglumide in the dog.

Webber C, Stokes CA, Persiani S, Makovec F, McBurney A, Kapil RP, John BA, D'Amato M, Chasseaud LF.

Eur J Drug Metab Pharmacokinet. 2004 Jan-Mar;29(1):15-23.

PMID:
15151166
2.

Absorption, distribution and excretion of 14C-pilocarpine following oral administration to rats.

Omori Y, Endo T, Hara Y, Nishiyama M, Midgley I, Smart CI, John AJ, Chasseaud LF, McBurney A, John BA.

Arzneimittelforschung. 2004;54(3):171-8.

PMID:
15112864
3.

Intramuscular injection of 125I-botulinum neurotoxin-complex versus 125I-botulinum-free neurotoxin: time course of tissue distribution.

Tang-Liu DD, Aoki KR, Dolly JO, de Paiva A, Houchen TL, Chasseaud LF, Webber C.

Toxicon. 2003 Oct;42(5):461-9.

PMID:
14529727
4.

Absorption, distribution, metabolism and excretion of the cholecystokinin-1 antagonist dexloxiglumide in the rat.

Webber C, Stokes CA, Persiani S, Makovec F, McBurney A, Kapil RP, John BA, Houchen TL, D'Amato M, Chasseaud LF.

Eur J Drug Metab Pharmacokinet. 2003 Jul-Sep;28(3):201-12.

PMID:
14527093
5.

Pharmacokinetics and metabolism of the cholecystokinin antagonist dexloxiglumide in male human subjects.

Webber C, Roth A, Persiani S, Peard AJ, Makovec F, Kapil RP, John BA, Holding JD, D'amato M, Cybulski ZR, Chasseaud LF, Rovati LC.

Xenobiotica. 2003 Jun;33(6):625-41.

PMID:
12851039
6.

Pharmacokinetics and metabolism of the anti-oestrogen droloxifene in female human subjects.

John BA, Brodie RR, Baldock GA, McBurney A, Chasseaud LF, Jank P, Von Nieciecki A.

Xenobiotica. 2002 Aug;32(8):699-713.

PMID:
12296990
7.

Validation of a liquid chromatographic-tandem mass spectrometric method for the measurement of (R)-1-[2,3-dihydro-2-oxo-1-pivaloylmethyl-5-(2-pyridyl)-1H-1,4-benzodiazepin-3-yl]-3-(3-methylaminophenyl)urea (YF476) in human plasma.

Redrup MJ, Leaf FC, Miyashita A, Watanabe T, Higuchi S, Chasseaud LF, Cheng KN.

J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Jun 5;772(2):317-25.

PMID:
12007777
9.

Identification of cytochrome P450 isozymes involved in metabolism of the alpha1-adrenoceptor blocker tamsulosin in human liver microsomes.

Kamimura H, Oishi S, Matsushima H, Watanabe T, Higuchi S, Hall M, Wood SG, Chasseaud LF.

Xenobiotica. 1998 Oct;28(10):909-22.

PMID:
9849639
10.

Absorption, metabolism and excretion after oral administration of a new Ca antagonist, 14C-benidipine hydrochloride to man.

Kobayashi H, Kobayashi S, Dalrymple PD, Wood SG, Chasseaud LF.

Xenobiotica. 1997 Jun;27(6):597-608.

PMID:
9211659
11.

Oncogenicity studies of the new serotonin (5-HT)3-receptor antagonist ramosetron in mice and rats.

Tabata H, Sakai T, Miki H, Suzuki H, Ruckman SA, Read RM, Gopinath C, Healey GF, Barker MH, Chasseaud LF, Gazeley MJ, Ince G, Hedge A.

Arzneimittelforschung. 1996 Jun;46(6):560-6.

PMID:
8767344
12.

Accelerating ADME studies.

Chasseaud LF.

Hum Exp Toxicol. 1995 Dec;14(12):991-2. No abstract available.

PMID:
8962749
13.

Effect of the cephalosporin cefepime on hepatic drug metabolising enzyme activity in rats.

Jordan MC, Waller AR, Chasseaud LF, Barbhaiya RH.

Toxicol Lett. 1994 Mar;71(1):63-7.

PMID:
8140590
14.

Metabolic fate of 14C-camostat mesylate in man, rat and dog after intravenous administration.

Midgley I, Hood AJ, Proctor P, Chasseaud LF, Irons SR, Cheng KN, Brindley CJ, Bonn R.

Xenobiotica. 1994 Jan;24(1):79-92.

PMID:
8165824
15.

Disposition of the novel anticancer agent vinorelbine ditartrate following intravenous administration in mice, rats and dogs.

Kobayashi S, Sakai T, Dalrymple PD, Wood SG, Chasseaud LF.

Arzneimittelforschung. 1993 Dec;43(12):1367-77.

PMID:
8141830
16.

Distribution of the recombinant coagulation factor 125I-rFVIIa in rats.

Beeby TL, Chasseaud LF, Taylor T, Thomsen MK.

Thromb Haemost. 1993 Sep 1;70(3):465-8.

PMID:
8259550
17.

Relationship between pharmacokinetics and pharmacodynamics of tinzaparin (logiparin), a low molecular weight heparin, in dogs.

Brindley CJ, Taylor T, Diness V, Oestergaard PB, Chasseaud LF.

Xenobiotica. 1993 Jun;23(6):575-88.

PMID:
8212732
18.

Metabolism of the anti-psoriatic agent 5-methoxypsoralen in humans: comparison with rat and dog.

John BA, Chasseaud LF, Wood SG, Forlot P.

Xenobiotica. 1992 Nov;22(11):1339-51.

PMID:
1492426
19.

Percutaneous absorption of co-administered N-methyl-2-[14C]pyrrolidinone and 2-[14C]pyrrolidinone in the rat.

Midgley I, Hood AJ, Chasseaud LF, Brindley CJ, Baughman S, Allan G.

Food Chem Toxicol. 1992 Jan;30(1):57-64.

PMID:
1544607
20.

Pharmacokinetics of benzydamine after intravenous, oral, and topical doses to human subjects.

Baldock GA, Brodie RR, Chasseaud LF, Taylor T, Walmsley LM, Catanese B.

Biopharm Drug Dispos. 1991 Oct;12(7):481-92.

PMID:
1932611
21.

Pharmacokinetics of the anti-inflammatory drug ximoprofen in healthy young and elderly subjects: comparison with elderly rheumatic patients.

Taylor IW, Chasseaud LF, Taylor T, James I, Dorf G, Darragh A.

Br J Clin Pharmacol. 1991 Aug;32(2):242-5.

22.

Pharmacokinetics of the anti-inflammatory drug ximoprofen in healthy subjects and in disease states.

Taylor IW, Taylor T, James I, Doyle G, Dorf G, Darragh A, Chasseaud LF.

Eur J Clin Pharmacol. 1991;40(1):101-6.

PMID:
2060536
23.

Dose-proportional pharmacokinetics of cefepime in rats.

Brindley CJ, Brodie RR, Cook SC, Oldfield PR, Chasseaud LF, Barbhaiya RH.

Eur J Drug Metab Pharmacokinet. 1991;Spec No 3:9-14.

PMID:
1820942
24.
25.

Determination of benzydamine and its N-oxide in biological fluids by high-performance liquid chromatography.

Baldock GA, Brodie RR, Chasseaud LF, Taylor T.

J Chromatogr. 1990 Jul 13;529(1):113-23.

PMID:
2211924
26.

The metabolic fate of 14C-ximoprofen in rats, baboons and humans.

Mayo BC, Chasseaud LF, Hawkins DR, Taylor IW, Legeai J.

Xenobiotica. 1990 Mar;20(3):233-46.

PMID:
2336835
27.

Determination of ximoprofen in human plasma by gas chromatography.

Taylor IW, Chasseaud LF.

J Chromatogr. 1989 Oct 27;495:275-80. No abstract available.

PMID:
2613813
28.

Absorption of amlodipine unaffected by food. Solid dose equivalent to solution dose.

Faulkner JK, Hayden ML, Chasseaud LF, Taylor T.

Arzneimittelforschung. 1989 Jul;39(7):799-801.

PMID:
2528959
29.

The metabolism and pharmacokinetics of 14C-cetirizine in humans.

Wood SG, John BA, Chasseaud LF, Yeh J, Chung M.

Ann Allergy. 1987 Dec;59(6 Pt 2):31-4.

PMID:
2892447
30.

Metabolic fate of the thrombolytic agent benzarone in man: comparison with the rat and dog.

Wood SG, John BA, Chasseaud LF, Bonn R, Grote H, Sandrock K, Darragh A, Lambe RF.

Xenobiotica. 1987 Jul;17(7):881-96.

PMID:
3660858
31.

Determination of tulobuterol in human plasma by capillary gas chromatography.

Wood SG, Chasseaud LF.

J Chromatogr. 1987 Apr 24;416(1):154-9. No abstract available.

PMID:
2885335
32.

Determination of physostigmine in plasma by high-performance liquid chromatography.

Brodie RR, Chasseaud LF, Robbins AD.

J Chromatogr. 1987 Apr 10;415(2):423-31. No abstract available.

PMID:
3584384
33.

Isosorbide 5-mononitrate pharmacokinetics.

Chasseaud LF.

Cardiology. 1987;74 Suppl 1:6-11. Review.

PMID:
3300979
34.

Plasma concentrations and relative bioavailability of naftidrofuryl from different salt forms.

Walmsley LM, Taylor T, Wilkinson PA, Brodie RR, Chasseaud LF, Alun-Jones V, Hunter JO.

Biopharm Drug Dispos. 1986 Jul-Aug;7(4):327-34.

PMID:
3768488
35.
36.

Pharmacokinetics and metabolism of 14C-tinidazole in humans.

Wood SG, John BA, Chasseaud LF, Brodie RR, Baker JM, Faulkner JK, Wood BA, Darragh A, Lambe RF.

J Antimicrob Chemother. 1986 Jun;17(6):801-9.

PMID:
3733593
37.

Pharmacokinetics and bioavailability of the anti-emetic agent bromopride.

Brodie RR, Chasseaud LF, Darragh A, Lambe RF, Rooney L, Taylor T.

Biopharm Drug Dispos. 1986 May-Jun;7(3):215-22.

PMID:
3730521
38.

Pharmacokinetics of the bronchodilator tulobuterol in man after repeated oral doses.

Chasseaud LF, Wood SG.

J Int Med Res. 1986;14(5):223-7.

PMID:
3770288
39.

Metabolism and pharmacokinetics of the dihydropyridine calcium antagonist, ryosidine, in man.

Midgley I, Chasseaud LF, Taylor IW, Walmsley LM, Fowkes AG, Darragh A, Lambe RF, Bonn R.

Xenobiotica. 1985 Nov;15(11):965-77.

PMID:
4082636
40.

Determination of ryosidine in human plasma by gas-liquid chromatography.

Taylor IW, Taylor T, Chasseaud LF.

J Chromatogr. 1985 Oct 11;343(2):427-30. No abstract available.

PMID:
4066884
41.

Metabolism of the anti-depressant lortalamine.

Elsom LF, Biggs SR, Chasseaud LF, Hawkins DR, Pulsford J, Darragh A.

Eur J Drug Metab Pharmacokinet. 1985 Jul-Sep;10(3):209-15.

PMID:
4085522
42.

The metabolic fate of 11-bromo[15-3H]vincamine in man.

Mayo BC, Biggs SR, Hawkins DR, Chasseaud LF, Darragh A, Leaf FC.

Eur J Drug Metab Pharmacokinet. 1985 Jul-Sep;10(3):189-96.

PMID:
4085521
43.

Bioequivalence of a sustained-release isosorbide dinitrate formulation at steady-state.

Taylor T, Chasseaud LF, Major RM, Leaf FC, Bonn R, Darragh A, Lambe RF.

Biopharm Drug Dispos. 1985 Apr-Jun;6(2):119-29.

PMID:
4005392
44.

Determination of naftidrofuryl in human plasma by high-performance liquid chromatography with fluorescence detection.

Walmsley LM, Wilkinson PA, Brodie RR, Chasseaud LF.

J Chromatogr. 1985 Mar 22;338(2):433-7. No abstract available.

PMID:
3998029
45.

A novel metabolite of tinidazole involving nitro-group migration.

Wood SG, Scott PW, Chasseaud LF, Faulkner JK, Matthews RW, Henrick K.

Xenobiotica. 1985 Feb;15(2):107-13.

PMID:
4002732
46.

Pharmacokinetics of benzydamine.

Chasseaud LF, Catanese B.

Int J Tissue React. 1985;7(3):195-204.

PMID:
4044147
47.

Bioavailability studies of etofibrate in rhesus monkeys.

Waller AR, Chasseaud LF, Taylor T, Schatton W.

Arzneimittelforschung. 1985;35(2):489-92.

PMID:
4039571
48.

Reasons for monitoring kinetics in safety evaluation studies.

Hawkins DR, Chasseaud LF.

Arch Toxicol Suppl. 1985;8:165-72.

PMID:
3868346
49.

Determination of carboxybupranolol, the major metabolite of bupranolol, in human plasma by high-performance liquid chromatography.

Walmsley LM, Brodie RR, Chasseaud LF.

J Chromatogr. 1984 Nov 9;311(1):227-33. No abstract available.

PMID:
6151568
50.

Determination of bromopride in human plasma and urine by high-performance liquid chromatography.

Brodie RR, Chasseaud LF, Rooney L.

J Chromatogr. 1984 Oct 12;310(2):353-60.

PMID:
6511853

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