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Items: 14

1.

Modeling the receptor pharmacology, pharmacokinetics, and pharmacodynamics of NKTR-214, a kinetically-controlled interleukin-2 (IL2) receptor agonist for cancer immunotherapy.

Charych D, Khalili S, Dixit V, Kirk P, Chang T, Langowski J, Rubas W, Doberstein SK, Eldon M, Hoch U, Zalevsky J.

PLoS One. 2017 Jul 5;12(7):e0179431. doi: 10.1371/journal.pone.0179431. eCollection 2017.

2.

NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models.

Charych DH, Hoch U, Langowski JL, Lee SR, Addepalli MK, Kirk PB, Sheng D, Liu X, Sims PW, VanderVeen LA, Ali CF, Chang TK, Konakova M, Pena RL, Kanhere RS, Kirksey YM, Ji C, Wang Y, Huang J, Sweeney TD, Kantak SS, Doberstein SK.

Clin Cancer Res. 2016 Feb 1;22(3):680-90. doi: 10.1158/1078-0432.CCR-15-1631.

3.

Blockade of nonhormonal fibroblast growth factors by FP-1039 inhibits growth of multiple types of cancer.

Harding TC, Long L, Palencia S, Zhang H, Sadra A, Hestir K, Patil N, Levin A, Hsu AW, Charych D, Brennan T, Zanghi J, Halenbeck R, Marshall SA, Qin M, Doberstein SK, Hollenbaugh D, Kavanaugh WM, Williams LT, Baker KP.

Sci Transl Med. 2013 Mar 27;5(178):178ra39. doi: 10.1126/scitranslmed.3005414.

4.

Inhibition of Cdc7/Dbf4 kinase activity affects specific phosphorylation sites on MCM2 in cancer cells.

Charych DH, Coyne M, Yabannavar A, Narberes J, Chow S, Wallroth M, Shafer C, Walter AO.

J Cell Biochem. 2008 Jun 1;104(3):1075-86. doi: 10.1002/jcb.21698.

PMID:
18286467
5.

Cleavable hydrophilic linker for one-bead-one-compound sequencing of oligomer libraries by tandem mass spectrometry.

Paulick MG, Hart KM, Brinner KM, Tjandra M, Charych DH, Zuckermann RN.

J Comb Chem. 2006 May-Jun;8(3):417-26.

PMID:
16677012
6.

Incorporation of unprotected heterocyclic side chains into peptoid oligomers via solid-phase submonomer synthesis.

Burkoth TS, Fafarman AT, Charych DH, Connolly MD, Zuckermann RN.

J Am Chem Soc. 2003 Jul 23;125(29):8841-5.

PMID:
12862480
7.

Design and synthesis of novel glycopolythiophene assemblies for colorimetric detection of influenza virus and E. coli.

Baek MG, Stevens RC, Charych DH.

Bioconjug Chem. 2000 Nov-Dec;11(6):777-88.

PMID:
11087325
8.

Induced Color Change of Conjugated Polymeric Vesicles by Interfacial Catalysis of Phospholipase A2.

Okada SY, Jelinek R, Charych D.

Angew Chem Int Ed Engl. 1999 Mar 1;38(5):655-659. doi: 10.1002/(SICI)1521-3773(19990301)38:5<655::AID-ANIE655>3.0.CO;2-4.

PMID:
29711544
9.
10.

Carbohydrates in an acidic multivalent assembly: nanomolar P-selectin inhibitors.

Spevak W, Foxall C, Charych DH, Dasgupta F, Nagy JO.

J Med Chem. 1996 Mar 1;39(5):1018-20. No abstract available.

PMID:
8676335
11.

A 'litmus test' for molecular recognition using artificial membranes.

Charych D, Cheng Q, Reichert A, Kuziemko G, Stroh M, Nagy JO, Spevak W, Stevens RC.

Chem Biol. 1996 Feb;3(2):113-20.

12.

Total alignment of calcite at acidic polydiacetylene films: cooperativity at the organic-inorganic interface.

Berman A, Ahn DJ, Lio A, Salmeron M, Reichert A, Charych D.

Science. 1995 Jul 28;269(5223):515-8.

PMID:
17842362
13.

Nonlinear optical studies of monomolecular films under pressure.

Du Q, Xiao X, Charych D, Wolf F, Frantz P, Shen YR, Salmeron M.

Phys Rev B Condens Matter. 1995 Mar 15;51(12):7456-7463. No abstract available.

PMID:
9977325
14.

Direct colorimetric detection of a receptor-ligand interaction by a polymerized bilayer assembly.

Charych DH, Nagy JO, Spevak W, Bednarski MD.

Science. 1993 Jul 30;261(5121):585-8. Erratum in: Science 1993 Sep 10;261(5127):1375.

PMID:
8342021

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