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Items: 1 to 50 of 138

1.

N-Acetylcysteine Resolves Placental Inflammatory-Vasculopathic Changes in Mice Consuming a High-Fat Diet.

Williams L, Burgos ES, Vuguin PM, Manuel CR, Pekson R, Munnangi S, Reznik SE, Charron MJ.

Am J Pathol. 2019 Nov;189(11):2246-2257. doi: 10.1016/j.ajpath.2019.07.010. Epub 2019 Aug 17.

PMID:
31430466
2.

Glucagon: The Name Says It All, or Not!

Dean ED, Vuguin PM, Charron MJ.

Endocrinology. 2019 May 1;160(5):1359-1361. doi: 10.1210/en.2019-00251. No abstract available.

PMID:
31144717
3.

Regulation of Hepatic Follistatin Expression at Rest and during Exercise in Mice.

Peppler WT, Castellani LN, Root-McCaig J, Townsend LK, Sutton CD, Frendo-Cumbo S, Medak KD, Macpherson REK, Charron MJ, Wright DC.

Med Sci Sports Exerc. 2019 Jun;51(6):1116-1125. doi: 10.1249/MSS.0000000000001893.

PMID:
30694975
4.

Loss of glucagon signaling alters white adipose tissue browning.

Townsend LK, Medak KD, Knuth CM, Peppler WT, Charron MJ, Wright DC.

FASEB J. 2019 Apr;33(4):4824-4835. doi: 10.1096/fj.201802048RR. Epub 2019 Jan 7.

PMID:
30615494
5.

GLP-2 receptor signaling controls circulating bile acid levels but not glucose homeostasis in Gcgr-/- mice and is dispensable for the metabolic benefits ensuing after vertical sleeve gastrectomy.

Patel A, Yusta B, Matthews D, Charron MJ, Seeley RJ, Drucker DJ.

Mol Metab. 2018 Oct;16:45-54. doi: 10.1016/j.molmet.2018.06.006. Epub 2018 Jun 9.

6.

Saturated and unsaturated fatty acids differentially regulate in vitro and ex vivo placental antioxidant capacity.

Manuel CR, Charron MJ, Ashby CR Jr, Reznik SE.

Am J Reprod Immunol. 2018 Sep;80(3):e12868. doi: 10.1111/aji.12868. Epub 2018 May 7.

PMID:
29736947
7.

Disruption of glucagon receptor signaling causes hyperaminoacidemia exposing a possible liver-alpha-cell axis.

Galsgaard KD, Winther-Sørensen M, Ørskov C, Kissow H, Poulsen SS, Vilstrup H, Prehn C, Adamski J, Jepsen SL, Hartmann B, Hunt J, Charron MJ, Pedersen J, Wewer Albrechtsen NJ, Holst JJ.

Am J Physiol Endocrinol Metab. 2018 Jan 1;314(1):E93-E103. doi: 10.1152/ajpendo.00198.2017. Epub 2017 Oct 3.

8.

In Utero Exposure to a High-Fat Diet Programs Hepatic Hypermethylation and Gene Dysregulation and Development of Metabolic Syndrome in Male Mice.

Seki Y, Suzuki M, Guo X, Glenn AS, Vuguin PM, Fiallo A, Du Q, Ko YA, Yu Y, Susztak K, Zheng D, Greally JM, Katz EB, Charron MJ.

Endocrinology. 2017 Sep 1;158(9):2860-2872. doi: 10.1210/en.2017-00334.

9.

A High Fat Diet During Pregnancy and Lactation Induces Cardiac and Renal Abnormalities in GLUT4 +/- Male Mice.

Kruse M, Fiallo A, Tao J, Susztak K, Amann K, Katz EB, Charron MJ.

Kidney Blood Press Res. 2017;42(3):468-482. doi: 10.1159/000479383. Epub 2017 Jul 27.

10.

High post-natal mortality associated with defects in lung maturation and reduced adiposity in mice with gestational exposure to high fat and N-acetylcysteine.

Williams L, Charron MJ, Sellers RS.

Res Vet Sci. 2017 Oct;114:262-265. doi: 10.1016/j.rvsc.2017.05.020. Epub 2017 May 14.

PMID:
28531807
11.

Glucagon receptor knockout mice are protected against acute olanzapine-induced hyperglycemia.

Castellani LN, Peppler WT, Sutton CD, Whitfield J, Charron MJ, Wright DC.

Psychoneuroendocrinology. 2017 Aug;82:38-45. doi: 10.1016/j.psyneuen.2017.05.005. Epub 2017 May 3.

PMID:
28500893
12.

Hypoglycemic Effect of Combined Ghrelin and Glucagon Receptor Blockade.

Mani BK, Uchida A, Lee Y, Osborne-Lawrence S, Charron MJ, Unger RH, Berglund ED, Zigman JM.

Diabetes. 2017 Jul;66(7):1847-1857. doi: 10.2337/db16-1303. Epub 2017 May 9.

13.

Serum and follicular fluid monocyte chemotactic protein-1 levels are elevated in obese women and are associated with poorer clinical pregnancy rate after in vitro fertilization: a pilot study.

Buyuk E, Asemota OA, Merhi Z, Charron MJ, Berger DS, Zapantis A, Jindal SK.

Fertil Steril. 2017 Mar;107(3):632-640.e3. doi: 10.1016/j.fertnstert.2016.12.023. Epub 2017 Jan 16.

PMID:
28104240
14.

Glucagon receptor gene deletion in insulin knockout mice modestly reduces blood glucose and ketones but does not promote survival.

Neumann UH, Ho JSS, Mojibian M, Covey SD, Charron MJ, Kieffer TJ.

Mol Metab. 2016 May 30;5(8):731-736. doi: 10.1016/j.molmet.2016.05.014. eCollection 2016 Aug.

15.

Statement of Retraction. Hepatic Glucagon Action Is Essential for Exercise-Induced Reversal of Mouse Fatty Liver. Diabetes 2011;60:2720-2729. DOI: 10.2337/db11-0455.

Berglund ED, Lustig DG, Baheza RA, Hasenour CM, Lee-Young RS, Donahue EP, Lynes SE, Swift LL, Charron MJ, Damon BM, Wasserman DH.

Diabetes. 2016 Aug;65(8):2463. doi: 10.2337/db16-rt08. No abstract available.

16.

DNA hypermethylation of CD3(+) T cells from cord blood of infants exposed to intrauterine growth restriction.

Williams L, Seki Y, Delahaye F, Cheng A, Fuloria M, Hughes Einstein F, Charron MJ.

Diabetologia. 2016 Aug;59(8):1714-23. doi: 10.1007/s00125-016-3983-7. Epub 2016 May 17.

PMID:
27185256
17.

Blockade of glucagon signaling prevents or reverses diabetes onset only if residual β-cells persist.

Damond N, Thorel F, Moyers JS, Charron MJ, Vuguin PM, Powers AC, Herrera PL.

Elife. 2016 Apr 19;5. pii: e13828. doi: 10.7554/eLife.13828.

18.

Ovarian kisspeptin expression is related to age and to monocyte chemoattractant protein-1.

Merhi Z, Thornton K, Bonney E, Cipolla MJ, Charron MJ, Buyuk E.

J Assist Reprod Genet. 2016 Apr;33(4):535-43. doi: 10.1007/s10815-016-0672-x. Epub 2016 Feb 15.

19.

Berry intake changes hepatic gene expression and DNA methylation patterns associated with high-fat diet.

Heyman-Lindén L, Seki Y, Storm P, Jones HA, Charron MJ, Berger K, Holm C.

J Nutr Biochem. 2016 Jan;27:79-95. doi: 10.1016/j.jnutbio.2015.08.022. Epub 2015 Sep 2.

20.

Inhibition of the Prostaglandin Transporter PGT Lowers Blood Pressure in Hypertensive Rats and Mice.

Chi Y, Jasmin JF, Seki Y, Lisanti MP, Charron MJ, Lefer DJ, Schuster VL.

PLoS One. 2015 Jun 29;10(6):e0131735. doi: 10.1371/journal.pone.0131735. eCollection 2015.

21.

Cardiomyocyte glucagon receptor signaling modulates outcomes in mice with experimental myocardial infarction.

Ali S, Ussher JR, Baggio LL, Kabir MG, Charron MJ, Ilkayeva O, Newgard CB, Drucker DJ.

Mol Metab. 2014 Nov 29;4(2):132-43. doi: 10.1016/j.molmet.2014.11.005. eCollection 2015 Feb.

22.

Maintenance of GLUT4 expression in smooth muscle prevents hypertension-induced changes in vascular reactivity.

Atkins KB, Seki Y, Saha J, Eichinger F, Charron MJ, Brosius FC.

Physiol Rep. 2015 Feb 12;3(2). pii: e12299. doi: 10.14814/phy2.12299. Print 2015 Feb 1.

23.

Lack of glucagon receptor signaling and its implications beyond glucose homeostasis.

Charron MJ, Vuguin PM.

J Endocrinol. 2015 Mar;224(3):R123-30. doi: 10.1530/JOE-14-0614. Epub 2015 Jan 7. Review.

PMID:
25568163
24.

Hyperglycemia in rodent models of type 2 diabetes requires insulin-resistant alpha cells.

Lee Y, Berglund ED, Yu X, Wang MY, Evans MR, Scherer PE, Holland WL, Charron MJ, Roth MG, Unger RH.

Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13217-22. doi: 10.1073/pnas.1409638111. Epub 2014 Aug 25.

25.

Critical periods of increased fetal vulnerability to a maternal high fat diet.

Plata Mdel M, Williams L, Seki Y, Hartil K, Kaur H, Lin CL, Fiallo A, Glenn AS, Katz EB, Fuloria M, Charron MJ, Vuguin PM.

Reprod Biol Endocrinol. 2014 Aug 18;12:80. doi: 10.1186/1477-7827-12-80.

26.

Effects of genetics and in utero diet on murine pancreatic development.

Lin CL, Williams L, Seki Y, Kaur H, Hartil K, Fiallo A, Glenn AS, Katz EB, Charron MJ, Vuguin PM.

J Endocrinol. 2014 Aug;222(2):217-27. doi: 10.1530/JOE-14-0114. Epub 2014 Jun 3.

27.

Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones.

Maianti JP, McFedries A, Foda ZH, Kleiner RE, Du XQ, Leissring MA, Tang WJ, Charron MJ, Seeliger MA, Saghatelian A, Liu DR.

Nature. 2014 Jul 3;511(7507):94-8. doi: 10.1038/nature13297. Epub 2014 May 21.

28.

In utero exposure to a maternal high-fat diet alters the epigenetic histone code in a murine model.

Suter MA, Ma J, Vuguin PM, Hartil K, Fiallo A, Harris RA, Charron MJ, Aagaard KM.

Am J Obstet Gynecol. 2014 May;210(5):463.e1-463.e11. doi: 10.1016/j.ajog.2014.01.045.

29.

Oxyntomodulin increases intrinsic heart rate through the glucagon receptor.

Mukharji A, Drucker DJ, Charron MJ, Swoap SJ.

Physiol Rep. 2013 Oct;1(5):e00112. doi: 10.1002/phy2.112. Epub 2013 Oct 20.

30.

Evidence for a regulatory role of Cullin-RING E3 ubiquitin ligase 7 in insulin signaling.

Scheufele F, Wolf B, Kruse M, Hartmann T, Lempart J, Mühlich S, Pfeiffer AFH, Field LJ, Charron MJ, Pan ZQ, Engelhardt S, Sarikas A.

Cell Signal. 2014 Feb;26(2):233-239. doi: 10.1016/j.cellsig.2013.11.005. Epub 2013 Nov 9.

31.

Animal models of in utero exposure to a high fat diet: a review.

Williams L, Seki Y, Vuguin PM, Charron MJ.

Biochim Biophys Acta. 2014 Mar;1842(3):507-519. doi: 10.1016/j.bbadis.2013.07.006. Epub 2013 Jul 18. Review.

32.

High-fat intake during pregnancy and lactation exacerbates high-fat diet-induced complications in male offspring in mice.

Kruse M, Seki Y, Vuguin PM, Du XQ, Fiallo A, Glenn AS, Singer S, Breuhahn K, Katz EB, Charron MJ.

Endocrinology. 2013 Oct;154(10):3565-76. doi: 10.1210/en.2012-1877. Epub 2013 Jul 16.

33.

Shared effects of genetic and intrauterine and perinatal environment on the development of metabolic syndrome.

Vuguin PM, Hartil K, Kruse M, Kaur H, Lin CL, Fiallo A, Glenn AS, Patel A, Williams L, Seki Y, Katz EB, Charron MJ.

PLoS One. 2013 May 17;8(5):e63021. doi: 10.1371/journal.pone.0063021. Print 2013.

34.

Hypothalamic glucagon signaling inhibits hepatic glucose production.

Mighiu PI, Yue JT, Filippi BM, Abraham MA, Chari M, Lam CK, Yang CS, Christian NR, Charron MJ, Lam TK.

Nat Med. 2013 Jun;19(6):766-72. doi: 10.1038/nm.3115. Epub 2013 May 19.

PMID:
23685839
35.

Major facilitator superfamily domain-containing protein 2a (MFSD2A) has roles in body growth, motor function, and lipid metabolism.

Berger JH, Charron MJ, Silver DL.

PLoS One. 2012;7(11):e50629. doi: 10.1371/journal.pone.0050629. Epub 2012 Nov 29.

36.

Liver-specific disruption of the murine glucagon receptor produces α-cell hyperplasia: evidence for a circulating α-cell growth factor.

Longuet C, Robledo AM, Dean ED, Dai C, Ali S, McGuinness I, de Chavez V, Vuguin PM, Charron MJ, Powers AC, Drucker DJ.

Diabetes. 2013 Apr;62(4):1196-205. doi: 10.2337/db11-1605. Epub 2012 Nov 16.

37.

Metabolic manifestations of insulin deficiency do not occur without glucagon action.

Lee Y, Berglund ED, Wang MY, Fu X, Yu X, Charron MJ, Burgess SC, Unger RH.

Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):14972-6. doi: 10.1073/pnas.1205983109. Epub 2012 Aug 13.

38.

Regulation of mouse intestinal L cell progenitors proliferation by the glucagon family of peptides.

Grigoryan M, Kedees MH, Charron MJ, Guz Y, Teitelman G.

Endocrinology. 2012 Jul;153(7):3076-88. doi: 10.1210/en.2012-1120. Epub 2012 May 8.

39.

Minireview: Epigenetic programming of diabetes and obesity: animal models.

Seki Y, Williams L, Vuguin PM, Charron MJ.

Endocrinology. 2012 Mar;153(3):1031-8. doi: 10.1210/en.2011-1805. Epub 2012 Jan 17. Review.

40.

Hypoglycemia, hyperglucagonemia, and fetoplacental defects in glucagon receptor knockout mice: a role for glucagon action in pregnancy maintenance.

Ouhilal S, Vuguin P, Cui L, Du XQ, Gelling RW, Reznik SE, Russell R, Parlow AF, Karpovsky C, Santoro N, Charron MJ.

Am J Physiol Endocrinol Metab. 2012 Mar 1;302(5):E522-31. doi: 10.1152/ajpendo.00420.2011. Epub 2011 Dec 13.

41.

Hepatic glucagon action is essential for exercise-induced reversal of mouse fatty liver.

Berglund ED, Lustig DG, Baheza RA, Hasenour CM, Lee-Young RS, Donahue EP, Lynes SE, Swift LL, Charron MJ, Damon BM, Wasserman DH.

Diabetes. 2011 Nov;60(11):2720-9. doi: 10.2337/db11-0455. Epub 2011 Sep 1. Retraction in: Berglund ED, Lustig DG, Baheza RA, Hasenour CM, Lee-Young RS, Donahue EP, Lynes SE, Swift LL, Charron MJ, Damon BM, Wasserman DH. Diabetes. 2016 Aug;65(8):2463.

42.

Novel insight into glucagon receptor action: lessons from knockout and transgenic mouse models.

Vuguin PM, Charron MJ.

Diabetes Obes Metab. 2011 Oct;13 Suppl 1:144-50. doi: 10.1111/j.1463-1326.2011.01447.x. Review.

43.

Reduced neurotrophin receptor tropomyosin-related kinase A expression in human granulosa cells: a novel marker of diminishing ovarian reserve.

Buyuk E, Santoro N, Cohen HW, Charron MJ, Jindal S.

Fertil Steril. 2011 Aug;96(2):474-478.e4. doi: 10.1016/j.fertnstert.2011.05.017. Epub 2011 Jun 8.

44.

Dual elimination of the glucagon and GLP-1 receptors in mice reveals plasticity in the incretin axis.

Ali S, Lamont BJ, Charron MJ, Drucker DJ.

J Clin Invest. 2011 May;121(5):1917-29. doi: 10.1172/JCI43615. Epub 2011 Apr 11.

45.

Glucagon receptor knockout prevents insulin-deficient type 1 diabetes in mice.

Lee Y, Wang MY, Du XQ, Charron MJ, Unger RH.

Diabetes. 2011 Feb;60(2):391-7. doi: 10.2337/db10-0426.

46.

Glucagon and lipid interactions in the regulation of hepatic AMPK signaling and expression of PPARalpha and FGF21 transcripts in vivo.

Berglund ED, Kang L, Lee-Young RS, Hasenour CM, Lustig DG, Lynes SE, Donahue EP, Swift LL, Charron MJ, Wasserman DH.

Am J Physiol Endocrinol Metab. 2010 Oct;299(4):E607-14. doi: 10.1152/ajpendo.00263.2010. Epub 2010 Jul 27. Retraction in: Am J Physiol Endocrinol Metab. 2016 Nov 1;311(5):E850.

47.

Leptin therapy in insulin-deficient type I diabetes.

Wang MY, Chen L, Clark GO, Lee Y, Stevens RD, Ilkayeva OR, Wenner BR, Bain JR, Charron MJ, Newgard CB, Unger RH.

Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):4813-9. doi: 10.1073/pnas.0909422107. Epub 2010 Mar 1.

48.

Hepatic energy state is regulated by glucagon receptor signaling in mice.

Berglund ED, Lee-Young RS, Lustig DG, Lynes SE, Donahue EP, Camacho RC, Meredith ME, Magnuson MA, Charron MJ, Wasserman DH.

J Clin Invest. 2009 Aug;119(8):2412-22.

49.

Pancreatic beta-cell overexpression of the glucagon receptor gene results in enhanced beta-cell function and mass.

Gelling RW, Vuguin PM, Du XQ, Cui L, Rømer J, Pederson RA, Leiser M, Sørensen H, Holst JJ, Fledelius C, Johansen PB, Fleischer N, McIntosh CH, Nishimura E, Charron MJ.

Am J Physiol Endocrinol Metab. 2009 Sep;297(3):E695-707. doi: 10.1152/ajpendo.00082.2009. Epub 2009 Jul 14.

50.

Maternal substrate utilization programs the development of the metabolic syndrome in male mice exposed to high fat in utero.

Hartil K, Vuguin PM, Kruse M, Schmuel E, Fiallo A, Vargas C, Warner MJ, Durand JL, Jelicks LA, Charron MJ.

Pediatr Res. 2009 Oct;66(4):368-73. doi: 10.1203/PDR.0b013e3181b33375.

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