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F-Actin Interactome Reveals Vimentin as a Key Regulator of Actin Organization and Cell Mechanics in Mitosis.

Serres MP, Samwer M, Truong Quang BA, Lavoie G, Perera U, Görlich D, Charras G, Petronczki M, Roux PP, Paluch EK.

Dev Cell. 2020 Jan 9. pii: S1534-5807(19)31032-9. doi: 10.1016/j.devcel.2019.12.011. [Epub ahead of print]


Actomyosin controls planarity and folding of epithelia in response to compression.

Wyatt TPJ, Fouchard J, Lisica A, Khalilgharibi N, Baum B, Recho P, Kabla AJ, Charras GT.

Nat Mater. 2020 Jan;19(1):109-117. doi: 10.1038/s41563-019-0461-x. Epub 2019 Aug 26.


Single-cell approaches to cell competition: High-throughput imaging, machine learning and simulations.

Gradeci D, Bove A, Charras G, Lowe AR, Banerjee S.

Semin Cancer Biol. 2019 May 18. pii: S1044-579X(18)30178-0. doi: 10.1016/j.semcancer.2019.05.007. [Epub ahead of print] Review.


Automating multimodal microscopy with NanoJ-Fluidics.

Almada P, Pereira PM, Culley S, Caillol G, Boroni-Rueda F, Dix CL, Charras G, Baum B, Laine RF, Leterrier C, Henriques R.

Nat Commun. 2019 Mar 15;10(1):1223. doi: 10.1038/s41467-019-09231-9.


A role for actomyosin contractility in Notch signaling.

Hunter GL, He L, Perrimon N, Charras G, Giniger E, Baum B.

BMC Biol. 2019 Feb 11;17(1):12. doi: 10.1186/s12915-019-0625-9.


Polarization of Myosin II Refines Tissue Material Properties to Buffer Mechanical Stress.

Duda M, Kirkland NJ, Khalilgharibi N, Tozluoglu M, Yuen AC, Carpi N, Bove A, Piel M, Charras G, Baum B, Mao Y.

Dev Cell. 2019 Jan 28;48(2):245-260.e7. doi: 10.1016/j.devcel.2018.12.020.


Redistribution of Adhesive Forces through Src/FAK Drives Contact Inhibition of Locomotion in Neural Crest.

Roycroft A, Szabó A, Bahm I, Daly L, Charras G, Parsons M, Mayor R.

Dev Cell. 2018 Jun 4;45(5):565-579.e3. doi: 10.1016/j.devcel.2018.05.003.


Tensile Forces and Mechanotransduction at Cell-Cell Junctions.

Charras G, Yap AS.

Curr Biol. 2018 Apr 23;28(8):R445-R457. doi: 10.1016/j.cub.2018.02.003. Review.


Microfluidic Devices for Examining the Physical Limits of Migration in Confined Environments.

Malboubi M, Jayo A, Parsons M, Charras G.

Methods Mol Biol. 2018;1749:375-386. doi: 10.1007/978-1-4939-7701-7_27.


Tissue stiffening coordinates morphogenesis by triggering collective cell migration in vivo.

Barriga EH, Franze K, Charras G, Mayor R.

Nature. 2018 Feb 22;554(7693):523-527. doi: 10.1038/nature25742. Epub 2018 Feb 14.


Loss of E-cadherin provides tolerance to centrosome amplification in epithelial cancer cells.

Rhys AD, Monteiro P, Smith C, Vaghela M, Arnandis T, Kato T, Leitinger B, Sahai E, McAinsh A, Charras G, Godinho SA.

J Cell Biol. 2018 Jan 2;217(1):195-209. doi: 10.1083/jcb.201704102. Epub 2017 Nov 13.


Local cellular neighborhood controls proliferation in cell competition.

Bove A, Gradeci D, Fujita Y, Banerjee S, Charras G, Lowe AR.

Mol Biol Cell. 2017 Nov 7;28(23):3215-3228. doi: 10.1091/mbc.E17-06-0368. Epub 2017 Sep 20.


Actin cortex architecture regulates cell surface tension.

Chugh P, Clark AG, Smith MB, Cassani DAD, Dierkes K, Ragab A, Roux PP, Charras G, Salbreux G, Paluch EK.

Nat Cell Biol. 2017 Jun;19(6):689-697. doi: 10.1038/ncb3525. Epub 2017 May 22.


Self-organizing actin patterns shape membrane architecture but not cell mechanics.

Fritzsche M, Li D, Colin-York H, Chang VT, Moeendarbary E, Felce JH, Sezgin E, Charras G, Betzig E, Eggeling C.

Nat Commun. 2017 Feb 13;8:14347. doi: 10.1038/ncomms14347.


Optogenetic control of cellular forces and mechanotransduction.

Valon L, Marín-Llauradó A, Wyatt T, Charras G, Trepat X.

Nat Commun. 2017 Feb 10;8:14396. doi: 10.1038/ncomms14396.


Fascin Regulates Nuclear Movement and Deformation in Migrating Cells.

Jayo A, Malboubi M, Antoku S, Chang W, Ortiz-Zapater E, Groen C, Pfisterer K, Tootle T, Charras G, Gundersen GG, Parsons M.

Dev Cell. 2016 Aug 22;38(4):371-83. doi: 10.1016/j.devcel.2016.07.021.


The dynamic mechanical properties of cellularised aggregates.

Khalilgharibi N, Fouchard J, Recho P, Charras G, Kabla A.

Curr Opin Cell Biol. 2016 Oct;42:113-120. doi: 10.1016/ Epub 2016 Jun 29. Review.


A Worldwide Competition to Compare the Speed and Chemotactic Accuracy of Neutrophil-Like Cells.

Skoge M, Wong E, Hamza B, Bae A, Martel J, Kataria R, Keizer-Gunnink I, Kortholt A, Van Haastert PJ, Charras G, Janetopoulos C, Irimia D.

PLoS One. 2016 Jun 22;11(6):e0154491. doi: 10.1371/journal.pone.0154491. eCollection 2016.


Coordinated control of Notch/Delta signalling and cell cycle progression drives lateral inhibition-mediated tissue patterning.

Hunter GL, Hadjivasiliou Z, Bonin H, He L, Perrimon N, Charras G, Baum B.

Development. 2016 Jul 1;143(13):2305-10. doi: 10.1242/dev.134213. Epub 2016 May 25.


Actin kinetics shapes cortical network structure and mechanics.

Fritzsche M, Erlenkämper C, Moeendarbary E, Charras G, Kruse K.

Sci Adv. 2016 Apr 22;2(4):e1501337. doi: 10.1126/sciadv.1501337. eCollection 2016 Apr.


Regulation and integrated functions of the actin cytoskeleton.

Charras G, Brieher WM.

Mol Biol Cell. 2016 Mar 15;27(6):881. doi: 10.1091/mbc.E15-11-0766. No abstract available.


A question of time: tissue adaptation to mechanical forces.

Wyatt T, Baum B, Charras G.

Curr Opin Cell Biol. 2016 Feb;38:68-73. doi: 10.1016/ Epub 2016 Mar 3. Review.


Directional memory arises from long-lived cytoskeletal asymmetries in polarized chemotactic cells.

Prentice-Mott HV, Meroz Y, Carlson A, Levine MA, Davidson MW, Irimia D, Charras GT, Mahadevan L, Shah JV.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1267-72. doi: 10.1073/pnas.1513289113. Epub 2016 Jan 13.


Cdc42EP3/BORG2 and Septin Network Enables Mechano-transduction and the Emergence of Cancer-Associated Fibroblasts.

Calvo F, Ranftl R, Hooper S, Farrugia AJ, Moeendarbary E, Bruckbauer A, Batista F, Charras G, Sahai E.

Cell Rep. 2015 Dec 29;13(12):2699-714. doi: 10.1016/j.celrep.2015.11.052. Epub 2015 Dec 17.


WASp-dependent actin cytoskeleton stability at the dendritic cell immunological synapse is required for extensive, functional T cell contacts.

Malinova D, Fritzsche M, Nowosad CR, Armer H, Munro PM, Blundell MP, Charras G, Tolar P, Bouma G, Thrasher AJ.

J Leukoc Biol. 2016 May;99(5):699-710. doi: 10.1189/jlb.2A0215-050RR. Epub 2015 Nov 20.


Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis.

Madsen CD, Pedersen JT, Venning FA, Singh LB, Moeendarbary E, Charras G, Cox TR, Sahai E, Erler JT.

EMBO Rep. 2015 Oct;16(10):1394-408. doi: 10.15252/embr.201540107. Epub 2015 Aug 31.


Immunodeficiency and severe susceptibility to bacterial infection associated with a loss-of-function homozygous mutation of MKL1.

Record J, Malinova D, Zenner HL, Plagnol V, Nowak K, Syed F, Bouma G, Curtis J, Gilmour K, Cale C, Hackett S, Charras G, Moulding D, Nejentsev S, Thrasher AJ, Burns SO.

Blood. 2015 Sep 24;126(13):1527-35. doi: 10.1182/blood-2014-12-611012. Epub 2015 Jul 29.


Emergence of homeostatic epithelial packing and stress dissipation through divisions oriented along the long cell axis.

Wyatt TP, Harris AR, Lam M, Cheng Q, Bellis J, Dimitracopoulos A, Kabla AJ, Charras GT, Baum B.

Proc Natl Acad Sci U S A. 2015 May 5;112(18):5726-31. doi: 10.1073/pnas.1420585112. Epub 2015 Apr 23.


Dissecting protein reaction dynamics in living cells by fluorescence recovery after photobleaching.

Fritzsche M, Charras G.

Nat Protoc. 2015 May;10(5):660-80. doi: 10.1038/nprot.2015.042. Epub 2015 Apr 2.


L-selectin shedding is activated specifically within transmigrating pseudopods of monocytes to regulate cell polarity in vitro.

Rzeniewicz K, Newe A, Rey Gallardo A, Davies J, Holt MR, Patel A, Charras GT, Stramer B, Molenaar C, Tedder TF, Parsons M, Ivetic A.

Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):E1461-70. doi: 10.1073/pnas.1417100112. Epub 2015 Mar 9.


Force transmission during adhesion-independent migration.

Bergert M, Erzberger A, Desai RA, Aspalter IM, Oates AC, Charras G, Salbreux G, Paluch EK.

Nat Cell Biol. 2015 Apr;17(4):524-9. doi: 10.1038/ncb3134. Epub 2015 Mar 16.


Cell mechanics: Hydraulic cracking.

Moeendarbary E, Charras G.

Nat Mater. 2015 Mar;14(3):268-9. doi: 10.1038/nmat4229. No abstract available.


The toxoplasma-host cell junction is anchored to the cell cortex to sustain parasite invasive force.

Bichet M, Joly C, Henni AH, Guilbert T, Xémard M, Tafani V, Lagal V, Charras G, Tardieux I.

BMC Biol. 2014 Dec 31;12:773. doi: 10.1186/s12915-014-0108-y.


A phenomenological density-scaling approach to lamellipodial actin dynamics(†).

Lewalle A, Fritzsche M, Wilson K, Thorogate R, Duke T, Charras G.

Interface Focus. 2014 Dec 6;4(6):20140006. doi: 10.1098/rsfs.2014.0006.


Nanoscale stiffness topography reveals structure and mechanics of the transport barrier in intact nuclear pore complexes.

Bestembayeva A, Kramer A, Labokha AA, Osmanović D, Liashkovich I, Orlova EV, Ford IJ, Charras G, Fassati A, Hoogenboom BW.

Nat Nanotechnol. 2015 Jan;10(1):60-64. doi: 10.1038/nnano.2014.262. Epub 2014 Nov 24.


Physical influences of the extracellular environment on cell migration.

Charras G, Sahai E.

Nat Rev Mol Cell Biol. 2014 Dec;15(12):813-24. doi: 10.1038/nrm3897. Epub 2014 Oct 30. Review.


Cellular control of cortical actin nucleation.

Bovellan M, Romeo Y, Biro M, Boden A, Chugh P, Yonis A, Vaghela M, Fritzsche M, Moulding D, Thorogate R, Jégou A, Thrasher AJ, Romet-Lemonne G, Roux PP, Paluch EK, Charras G.

Curr Biol. 2014 Jul 21;24(14):1628-1635. doi: 10.1016/j.cub.2014.05.069. Epub 2014 Jul 10.


In vivo collective cell migration requires an LPAR2-dependent increase in tissue fluidity.

Kuriyama S, Theveneau E, Benedetto A, Parsons M, Tanaka M, Charras G, Kabla A, Mayor R.

J Cell Biol. 2014 Jul 7;206(1):113-27. doi: 10.1083/jcb.201402093.


Biological physics: Liquid crystals in living tissue.

Hirst LS, Charras G.

Nature. 2017 Apr 12;544(7649):164-165. doi: 10.1038/544164a. No abstract available.


Formation of adherens junctions leads to the emergence of a tissue-level tension in epithelial monolayers.

Harris AR, Daeden A, Charras GT.

J Cell Sci. 2014 Jun 1;127(Pt 11):2507-17. doi: 10.1242/jcs.142349. Epub 2014 Mar 21.


Spatiotemporal control of gene expression using microfluidics.

Benedetto A, Accetta G, Fujita Y, Charras G.

Lab Chip. 2014 Apr 7;14(7):1336-47. doi: 10.1039/c3lc51281a.


Epithelial repair is a two-stage process driven first by dying cells and then by their neighbours.

Kuipers D, Mehonic A, Kajita M, Peter L, Fujita Y, Duke T, Charras G, Gale JE.

J Cell Sci. 2014 Mar 15;127(Pt 6):1229-41. doi: 10.1242/jcs.138289. Epub 2014 Jan 24.


Quantitative analysis of ezrin turnover dynamics in the actin cortex.

Fritzsche M, Thorogate R, Charras G.

Biophys J. 2014 Jan 21;106(2):343-53. doi: 10.1016/j.bpj.2013.11.4499.


Mechanisms of leading edge protrusion in interstitial migration.

Wilson K, Lewalle A, Fritzsche M, Thorogate R, Duke T, Charras G.

Nat Commun. 2013;4:2896. doi: 10.1038/ncomms3896.


Generating suspended cell monolayers for mechanobiological studies.

Harris AR, Bellis J, Khalilgharibi N, Wyatt T, Baum B, Kabla AJ, Charras GT.

Nat Protoc. 2013 Dec;8(12):2516-30. doi: 10.1038/nprot.2013.151. Epub 2013 Nov 21.


Cell cortex composition and homeostasis resolved by integrating proteomics and quantitative imaging.

Biro M, Romeo Y, Kroschwald S, Bovellan M, Boden A, Tcherkezian J, Roux PP, Charras G, Paluch EK.

Cytoskeleton (Hoboken). 2013 Nov;70(11):741-54. doi: 10.1002/cm.21142. Epub 2013 Oct 17.


Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts.

Calvo F, Ege N, Grande-Garcia A, Hooper S, Jenkins RP, Chaudhry SI, Harrington K, Williamson P, Moeendarbary E, Charras G, Sahai E.

Nat Cell Biol. 2013 Jun;15(6):637-46. doi: 10.1038/ncb2756. Epub 2013 May 26.


Analysis of turnover dynamics of the submembranous actin cortex.

Fritzsche M, Lewalle A, Duke T, Kruse K, Charras G.

Mol Biol Cell. 2013 Mar;24(6):757-67. doi: 10.1091/mbc.E12-06-0485. Epub 2013 Jan 23.


The cytoplasm of living cells behaves as a poroelastic material.

Moeendarbary E, Valon L, Fritzsche M, Harris AR, Moulding DA, Thrasher AJ, Stride E, Mahadevan L, Charras GT.

Nat Mater. 2013 Mar;12(3):253-61. doi: 10.1038/nmat3517. Epub 2013 Jan 6.

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