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Modelling monotonic effects of ordinal predictors in Bayesian regression models.

Bürkner PC, Charpentier E.

Br J Math Stat Psychol. 2020 Jan 13. doi: 10.1111/bmsp.12195. [Epub ahead of print]


Evolutionary classification of CRISPR-Cas systems: a burst of class 2 and derived variants.

Makarova KS, Wolf YI, Iranzo J, Shmakov SA, Alkhnbashi OS, Brouns SJJ, Charpentier E, Cheng D, Haft DH, Horvath P, Moineau S, Mojica FJM, Scott D, Shah SA, Siksnys V, Terns MP, Venclovas Č, White MF, Yakunin AF, Yan W, Zhang F, Garrett RA, Backofen R, van der Oost J, Barrangou R, Koonin EV.

Nat Rev Microbiol. 2020 Feb;18(2):67-83. doi: 10.1038/s41579-019-0299-x. Epub 2019 Dec 19. Review.


Specific antibacterial activity of copper alloy touch surfaces in five long-term care facilities for older adults.

Colin M, Charpentier E, Klingelschmitt F, Bontemps C, De Champs C, Reffuveille F, Gangloff SC.

J Hosp Infect. 2019 Dec 3. pii: S0195-6701(19)30491-8. doi: 10.1016/j.jhin.2019.11.021. [Epub ahead of print]


Outcomes of solid organ transplant recipients with invasive aspergillosis and other mold infections.

Farges C, Cointault O, Murris M, Lavayssiere L, Lakhdar-Ghazal S, Del Bello A, Hebral AL, Esposito L, Nogier MB, Sallusto F, Iriart X, Charpentier E, Guitard J, Muscari F, Dambrin C, Porte L, Kamar N, Cassaing S, Faguer S.

Transpl Infect Dis. 2019 Oct 20:e13200. doi: 10.1111/tid.13200. [Epub ahead of print]


Classical Ehlers-Danlos syndrome with a propensity to arterial events: A new report on a French family with a COL1A1 p.(Arg312Cys) variant.

Adham S, Dupuis-Girod S, Charpentier E, Mazzella JM, Jeunemaitre X, Legrand A.

Clin Genet. 2020 Feb;97(2):357-361. doi: 10.1111/cge.13643. Epub 2019 Oct 1.


Real-time PCR for diagnosis of imported schistosomiasis.

Guegan H, Fillaux J, Charpentier E, Robert-Gangneux F, Chauvin P, Guemas E, Boissier J, Valentin A, Cassaing S, Gangneux JP, Berry A, Iriart X.

PLoS Negl Trop Dis. 2019 Sep 11;13(9):e0007711. doi: 10.1371/journal.pntd.0007711. eCollection 2019 Sep.


A 2-year multicenter, observational, prospective, cohort study on extracorporeal CO2 removal in a large metropolis area.

Augy JL, Aissaoui N, Richard C, Maury E, Fartoukh M, Mekontso-Dessap A, Paulet R, Anguel N, Blayau C, Cohen Y, Chiche JD, Gaudry S, Voicu S, Demoule A, Combes A, Megarbane B, Charpentier E, Haghighat S, Panczer M, Diehl JL.

J Intensive Care. 2019 Aug 20;7:45. doi: 10.1186/s40560-019-0399-8. eCollection 2019.


Performance of seven commercial automated assays for the detection of low levels of anti-Toxoplasma IgG in French immunocompromised patients.

Douet T, Armengol C, Charpentier E, Chauvin P, Cassaing S, Iriart X, Berry A, Fillaux J.

Parasite. 2019;26:51. doi: 10.1051/parasite/2019052. Epub 2019 Aug 23.


Catalytically Active Cas9 Mediates Transcriptional Interference to Facilitate Bacterial Virulence.

Ratner HK, Escalera-Maurer A, Le Rhun A, Jaggavarapu S, Wozniak JE, Crispell EK, Charpentier E, Weiss DS.

Mol Cell. 2019 Aug 8;75(3):498-510.e5. doi: 10.1016/j.molcel.2019.05.029. Epub 2019 Jun 27.


Iniparib administered weekly or twice-weekly in combination with gemcitabine/carboplatin in patients with metastatic triple-negative breast cancer: a phase II randomized open-label study with pharmacokinetics.

Diéras V, Bonnefoi H, Alba E, Awada A, Coudert B, Pivot X, Gligorov J, Jager A, Zambelli S, Lindeman GJ, Charpentier E, Emmons GT, Garcia-Ribas I, Paridaens R, Verweij J.

Breast Cancer Res Treat. 2019 Sep;177(2):383-393. doi: 10.1007/s10549-019-05305-w. Epub 2019 Jun 6.


Performance evaluation of different strategies based on microscopy techniques, rapid diagnostic test and molecular loop-mediated isothermal amplification assay for the diagnosis of imported malaria.

Charpentier E, Benichou E, Pagès A, Chauvin P, Fillaux J, Valentin A, Guegan H, Guemas E, Salabert AS, Armengol C, Menard S, Cassaing S, Berry A, Iriart X.

Clin Microbiol Infect. 2020 Jan;26(1):115-121. doi: 10.1016/j.cmi.2019.05.010. Epub 2019 May 31.


Multicentre study to determine the Etest epidemiological cut-off values of antifungal drugs in Candida spp. and Aspergillus fumigatus species complex.

Salsé M, Gangneux JP, Cassaing S, Delhaes L, Fekkar A, Dupont D, Botterel F, Costa D, Bourgeois N, Bouteille B, Houzé S, Dannaoui E, Guegan H, Charpentier E, Persat F, Favennec L, Lachaud L, Sasso M.

Clin Microbiol Infect. 2019 Dec;25(12):1546-1552. doi: 10.1016/j.cmi.2019.04.027. Epub 2019 May 11.


Finding Her Niche: An Interview with Emmanuelle Charpentier.

Davies K, Charpentier E.

CRISPR J. 2019 Feb;2:17-22. doi: 10.1089/crispr.2019.29042.kda. No abstract available.


CRISPR-Cas: more than ten years and still full of mysteries.

Charpentier E, Elsholz A, Marchfelder A.

RNA Biol. 2019 Apr;16(4):377-379. doi: 10.1080/15476286.2019.1591659. No abstract available.


Phase I trial of isatuximab monotherapy in the treatment of refractory multiple myeloma.

Martin T, Strickland S, Glenn M, Charpentier E, Guillemin H, Hsu K, Mikhael J.

Blood Cancer J. 2019 Mar 29;9(4):41. doi: 10.1038/s41408-019-0198-4.


Adopt a moratorium on heritable genome editing.

Lander ES, Baylis F, Zhang F, Charpentier E, Berg P, Bourgain C, Friedrich B, Joung JK, Li J, Liu D, Naldini L, Nie JB, Qiu R, Schoene-Seifert B, Shao F, Terry S, Wei W, Winnacker EL.

Nature. 2019 Mar;567(7747):165-168. doi: 10.1038/d41586-019-00726-5. No abstract available.


CRISPR-Cas in Streptococcus pyogenes.

Le Rhun A, Escalera-Maurer A, Bratovič M, Charpentier E.

RNA Biol. 2019 Apr;16(4):380-389. doi: 10.1080/15476286.2019.1582974. Epub 2019 Mar 11. Review.


Copper Alloy Touch Surfaces in Healthcare Facilities: An Effective Solution to Prevent Bacterial Spreading.

Colin M, Klingelschmitt F, Charpentier E, Josse J, Kanagaratnam L, De Champs C, Gangloff SC.

Materials (Basel). 2018 Dec 6;11(12). pii: E2479. doi: 10.3390/ma11122479.


In vivo 3'-to-5' exoribonuclease targetomes of Streptococcus pyogenes.

Lécrivain AL, Le Rhun A, Renault TT, Ahmed-Begrich R, Hahnke K, Charpentier E.

Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):11814-11819. doi: 10.1073/pnas.1809663115. Epub 2018 Oct 31.


RNase Y-mediated regulation of the streptococcal pyrogenic exotoxin B.

Broglia L, Materne S, Lécrivain AL, Hahnke K, Le Rhun A, Charpentier E.

RNA Biol. 2018;15(10):1336-1347. doi: 10.1080/15476286.2018.1532253. Epub 2018 Oct 18.


Contribution of Fluorescence Techniques in Determining the Efficiency of the Non-thermal Plasma Treatment.

Carré G, Charpentier E, Audonnet S, Terryn C, Boudifa M, Doliwa C, Belgacem ZB, Gangloff SC, Gelle MP.

Front Microbiol. 2018 Sep 10;9:2171. doi: 10.3389/fmicb.2018.02171. eCollection 2018.


A threshold value of 3.5 mm of passive anterior tibial subluxation on MRI is highly specific for complete ACL tears.

Hardy A, Klouche S, Szarzynski P, Charpentier E, Beranger JS, Bauer T, Rousselin B, Judet O, Hardy P.

Knee Surg Sports Traumatol Arthrosc. 2019 Mar;27(3):885-892. doi: 10.1007/s00167-018-5159-0. Epub 2018 Sep 22.


Presumption of pericardial endometriosis using MRI: Case report and review of the literature.

Charpentier E, Petit E, Beranger S, Azarine A.

J Gynecol Obstet Hum Reprod. 2019 Jan;48(1):71-73. doi: 10.1016/j.jogoh.2018.06.009. Epub 2018 Jul 4. Review.


Quantitative PCR (qPCR) Detection of Mucorales DNA in Bronchoalveolar Lavage Fluid To Diagnose Pulmonary Mucormycosis.

Scherer E, Iriart X, Bellanger AP, Dupont D, Guitard J, Gabriel F, Cassaing S, Charpentier E, Guenounou S, Cornet M, Botterel F, Rocchi S, Berceanu A, Millon L.

J Clin Microbiol. 2018 Jul 26;56(8). pii: e00289-18. doi: 10.1128/JCM.00289-18. Print 2018 Aug.


Extracellular Vesicle RNA: A Universal Mediator of Microbial Communication?

Tsatsaronis JA, Franch-Arroyo S, Resch U, Charpentier E.

Trends Microbiol. 2018 May;26(5):401-410. doi: 10.1016/j.tim.2018.02.009. Epub 2018 Mar 13. Review.


The Biology of CRISPR-Cas: Backward and Forward.

Hille F, Richter H, Wong SP, Bratovič M, Ressel S, Charpentier E.

Cell. 2018 Mar 8;172(6):1239-1259. doi: 10.1016/j.cell.2017.11.032. Review.


Ex Vivo Expanded Human Non-Cytotoxic CD8+CD45RClow/- Tregs Efficiently Delay Skin Graft Rejection and GVHD in Humanized Mice.

Bézie S, Meistermann D, Boucault L, Kilens S, Zoppi J, Autrusseau E, Donnart A, Nerrière-Daguin V, Bellier-Waast F, Charpentier E, Duteille F, David L, Anegon I, Guillonneau C.

Front Immunol. 2018 Jan 31;8:2014. doi: 10.3389/fimmu.2017.02014. eCollection 2017.


Spotlight on… Emmanuelle Charpentier.

Charpentier E.

FEMS Microbiol Lett. 2018 Feb 1;365(4). doi: 10.1093/femsle/fnx271. No abstract available.


Parallel derivation of isogenic human primed and naive induced pluripotent stem cells.

Kilens S, Meistermann D, Moreno D, Chariau C, Gaignerie A, Reignier A, Lelièvre Y, Casanova M, Vallot C, Nedellec S, Flippe L, Firmin J, Song J, Charpentier E, Lammers J, Donnart A, Marec N, Deb W, Bihouée A, Le Caignec C, Pecqueur C, Redon R, Barrière P, Bourdon J, Pasque V, Soumillon M, Mikkelsen TS, Rougeulle C, Fréour T, David L; Milieu Intérieur Consortium.

Nat Commun. 2018 Jan 24;9(1):360. doi: 10.1038/s41467-017-02107-w.


Functionally Convergent B Cell Receptor Sequences in Transgenic Rats Expressing a Human B Cell Repertoire in Response to Tetanus Toxoid and Measles Antigens.

Bürckert JP, Dubois ARSX, Faison WJ, Farinelle S, Charpentier E, Sinner R, Wienecke-Baldacchino A, Muller CP.

Front Immunol. 2017 Dec 22;8:1834. doi: 10.3389/fimmu.2017.01834. eCollection 2017.


IgG antibody prevalence suggests high immunization needs in newcomers to Luxembourg, 2012.

Hübschen JM, Charpentier E, Weicherding P, Muller CP.

Vaccine. 2018 Feb 1;36(6):899-905. doi: 10.1016/j.vaccine.2017.12.041. Epub 2018 Jan 3.


Refined sgRNA efficacy prediction improves large- and small-scale CRISPR-Cas9 applications.

Labuhn M, Adams FF, Ng M, Knoess S, Schambach A, Charpentier EM, Schwarzer A, Mateo JL, Klusmann JH, Heckl D.

Nucleic Acids Res. 2018 Feb 16;46(3):1375-1385. doi: 10.1093/nar/gkx1268.


De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability.

Küry S, van Woerden GM, Besnard T, Proietti Onori M, Latypova X, Towne MC, Cho MT, Prescott TE, Ploeg MA, Sanders S, Stessman HAF, Pujol A, Distel B, Robak LA, Bernstein JA, Denommé-Pichon AS, Lesca G, Sellars EA, Berg J, Carré W, Busk ØL, van Bon BWM, Waugh JL, Deardorff M, Hoganson GE, Bosanko KB, Johnson DS, Dabir T, Holla ØL, Sarkar A, Tveten K, de Bellescize J, Braathen GJ, Terhal PA, Grange DK, van Haeringen A, Lam C, Mirzaa G, Burton J, Bhoj EJ, Douglas J, Santani AB, Nesbitt AI, Helbig KL, Andrews MV, Begtrup A, Tang S, van Gassen KLI, Juusola J, Foss K, Enns GM, Moog U, Hinderhofer K, Paramasivam N, Lincoln S, Kusako BH, Lindenbaum P, Charpentier E, Nowak CB, Cherot E, Simonet T, Ruivenkamp CAL, Hahn S, Brownstein CA, Xia F, Schmitt S, Deb W, Bonneau D, Nizon M, Quinquis D, Chelly J, Rudolf G, Sanlaville D, Parent P, Gilbert-Dussardier B, Toutain A, Sutton VR, Thies J, Peart-Vissers LELM, Boisseau P, Vincent M, Grabrucker AM, Dubourg C; Undiagnosed Diseases Network, Tan WH, Verbeek NE, Granzow M, Santen GWE, Shendure J, Isidor B, Pasquier L, Redon R, Yang Y, State MW, Kleefstra T, Cogné B; GEM HUGO; Deciphering Developmental Disorders Study, Petrovski S, Retterer K, Eichler EE, Rosenfeld JA, Agrawal PB, Bézieau S, Odent S, Elgersma Y, Mercier S.

Am J Hum Genet. 2017 Nov 2;101(5):768-788. doi: 10.1016/j.ajhg.2017.10.003.


An intermediate level of CD161 expression defines a novel activated, inflammatory, and pathogenic subset of CD8+ T cells involved in multiple sclerosis.

Nicol B, Salou M, Vogel I, Garcia A, Dugast E, Morille J, Kilens S, Charpentier E, Donnart A, Nedellec S, Jacq-Foucher M, Le Frère F, Wiertlewski S, Bourreille A, Brouard S, Michel L, David L, Gourraud PA, Degauque N, Nicot AB, Berthelot L, Laplaud DA.

J Autoimmun. 2018 Mar;88:61-74. doi: 10.1016/j.jaut.2017.10.005. Epub 2017 Oct 18.


Hypothesis: RNA and DNA Viral Sequence Integration into the Mammalian Host Genome Supports Long-Term B Cell and T Cell Adaptive Immunity.

Hurwitz JL, Jones BG, Charpentier E, Woodland DL.

Viral Immunol. 2017 Nov;30(9):628-632. doi: 10.1089/vim.2017.0099. Epub 2017 Oct 13.


A flagellum-specific chaperone facilitates assembly of the core type III export apparatus of the bacterial flagellum.

Fabiani FD, Renault TT, Peters B, Dietsche T, Gálvez EJC, Guse A, Freier K, Charpentier E, Strowig T, Franz-Wachtel M, Macek B, Wagner S, Hensel M, Erhardt M.

PLoS Biol. 2017 Aug 3;15(8):e2002267. doi: 10.1371/journal.pbio.2002267. eCollection 2017 Aug.


Functional Diversity of AAA+ Protease Complexes in Bacillus subtilis.

Elsholz AKW, Birk MS, Charpentier E, Turgay K.

Front Mol Biosci. 2017 Jul 12;4:44. doi: 10.3389/fmolb.2017.00044. eCollection 2017. Review.


Added Value of Next-Generation Sequencing for Multilocus Sequence Typing Analysis of a Pneumocystis jirovecii Pneumonia Outbreak1.

Charpentier E, Garnaud C, Wintenberger C, Bailly S, Murat JB, Rendu J, Pavese P, Drouet T, Augier C, Malvezzi P, Thiébaut-Bertrand A, Mallaret MR, Epaulard O, Cornet M, Larrat S, Maubon D.

Emerg Infect Dis. 2017 Aug;23(8):1237-1245. doi: 10.3201/eid2308.161295.


Innovative non-thermal plasma disinfection process inside sealed bags: Assessment of bactericidal and sporicidal effectiveness in regard to current sterilization norms.

Ben Belgacem Z, Carré G, Charpentier E, Le-Bras F, Maho T, Robert E, Pouvesle JM, Polidor F, Gangloff SC, Boudifa M, Gelle MP.

PLoS One. 2017 Jun 29;12(6):e0180183. doi: 10.1371/journal.pone.0180183. eCollection 2017.


Killer Immunoglobulin-Like Receptor Allele Determination Using Next-Generation Sequencing Technology.

Maniangou B, Legrand N, Alizadeh M, Guyet U, Willem C, David G, Charpentier E, Walencik A, Retière C, Gagne K.

Front Immunol. 2017 May 19;8:547. doi: 10.3389/fimmu.2017.00547. eCollection 2017.


CRISPR-Cas9-induced t(11;19)/MLL-ENL translocations initiate leukemia in human hematopoietic progenitor cells in vivo.

Reimer J, Knöß S, Labuhn M, Charpentier EM, Göhring G, Schlegelberger B, Klusmann JH, Heckl D.

Haematologica. 2017 Sep;102(9):1558-1566. doi: 10.3324/haematol.2017.164046. Epub 2017 Jun 1.


A phase 1b study of isatuximab plus lenalidomide and dexamethasone for relapsed/refractory multiple myeloma.

Martin T, Baz R, Benson DM, Lendvai N, Wolf J, Munster P, Lesokhin AM, Wack C, Charpentier E, Campana F, Vij R.

Blood. 2017 Jun 22;129(25):3294-3303. doi: 10.1182/blood-2016-09-740787. Epub 2017 May 8.


Asymptomatic aortic coarctation diagnosed because of large abdominal arterial collateral.

Charpentier E, Bacquet D, Pontnau F, Azarine A.

Vasc Med. 2017 Aug;22(4):347-348. doi: 10.1177/1358863X17692423. Epub 2017 Mar 19. No abstract available.


Switchable Cas9.

Richter F, Fonfara I, Gelfert R, Nack J, Charpentier E, Möglich A.

Curr Opin Biotechnol. 2017 Dec;48:119-126. doi: 10.1016/j.copbio.2017.03.025. Epub 2017 Apr 26. Review.


Bacterial flagella grow through an injection-diffusion mechanism.

Renault TT, Abraham AO, Bergmiller T, Paradis G, Rainville S, Charpentier E, Guet CC, Tu Y, Namba K, Keener JP, Minamino T, Erhardt M.

Elife. 2017 Mar 6;6. pii: e23136. doi: 10.7554/eLife.23136.


Transient antibody targeting of CD45RC induces transplant tolerance and potent antigen-specific regulatory T cells.

Picarda E, Bézie S, Boucault L, Autrusseau E, Kilens S, Meistermann D, Martinet B, Daguin V, Donnart A, Charpentier E, David L, Anegon I, Guillonneau C.

JCI Insight. 2017 Feb 9;2(3):e90088. doi: 10.1172/jci.insight.90088.


Identification of endoribonuclease specific cleavage positions reveals novel targets of RNase III in Streptococcus pyogenes.

Le Rhun A, Lécrivain AL, Reimegård J, Proux-Wéra E, Broglia L, Della Beffa C, Charpentier E.

Nucleic Acids Res. 2017 Mar 17;45(5):2329-2340. doi: 10.1093/nar/gkw1316.


Improved bi-allelic modification of a transcriptionally silent locus in patient-derived iPSC by Cas9 nickase.

Eggenschwiler R, Moslem M, Fráguas MS, Galla M, Papp O, Naujock M, Fonfara I, Gensch I, Wähner A, Beh-Pajooh A, Mussolino C, Tauscher M, Steinemann D, Wegner F, Petri S, Schambach A, Charpentier E, Cathomen T, Cantz T.

Sci Rep. 2016 Dec 2;6:38198. doi: 10.1038/srep38198.


Grouped Cases of Pulmonary Pneumocystosis After Solid Organ Transplantation: Advantages of Coordination by an Infectious Diseases Unit for Overall Management and Epidemiological Monitoring.

Wintenberger C, Maubon D, Charpentier E, Rendu J, Pavese P, Augier C, Malvezzi P, Camara B, Mallaret MR, Bouillet L, Epaulard O.

Infect Control Hosp Epidemiol. 2017 Feb;38(2):179-185. doi: 10.1017/ice.2016.274. Epub 2016 Nov 28.


A Two-Component Regulatory System Impacts Extracellular Membrane-Derived Vesicle Production in Group A Streptococcus.

Resch U, Tsatsaronis JA, Le Rhun A, Stübiger G, Rohde M, Kasvandik S, Holzmeister S, Tinnefeld P, Wai SN, Charpentier E.

mBio. 2016 Nov 1;7(6). pii: e00207-16. doi: 10.1128/mBio.00207-16.

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