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Items: 1 to 50 of 146

1.

Efficacy of Chemokine Receptor Inhibition in Treating IL-36α-Induced Psoriasiform Inflammation.

Campbell JJ, Ebsworth K, Ertl LS, McMahon JP, Wang Y, Yau S, Mali VR, Chhina V, Kumamoto A, Liu S, Dang T, Newland D, Charo IF, Zhang P, Schall TJ, Singh R.

J Immunol. 2019 Mar 15;202(6):1687-1692. doi: 10.4049/jimmunol.1801519. Epub 2019 Feb 4.

PMID:
30718298
2.

CCL7 Is a Negative Regulator of Cutaneous Inflammation Following Leishmania major Infection.

Ford J, Hughson A, Lim K, Bardina SV, Lu W, Charo IF, Lim JK, Fowell DJ.

Front Immunol. 2019 Jan 8;9:3063. doi: 10.3389/fimmu.2018.03063. eCollection 2018.

3.

Correction: Characterization of Pharmacologic and Pharmacokinetic Properties of CCX168, a Potent and Selective Orally Administered Complement 5a Receptor Inhibitor, Based on Preclinical Evaluation and Randomized Phase 1 Clinical Study.

Bekker P, Dairaghi D, Seitz L, Leleti M, Wang Y, Ertl L, Baumgart T, Shugarts S, Lohr L, Dang T, Miao S, Zeng Y, Fan P, Zhang P, Johnson D, Powers J, Jaen J, Charo I, Schall TJ.

PLoS One. 2019 Jan 4;14(1):e0210593. doi: 10.1371/journal.pone.0210593. eCollection 2019.

4.

CCR2 antagonism leads to marked reduction in proteinuria and glomerular injury in murine models of focal segmental glomerulosclerosis (FSGS).

Miao Z, Ertl LS, Newland D, Zhao B, Wang Y, Zang X, Campbell JJ, Liu X, Dang T, Miao S, Krasinski A, Punna S, Zeng Y, McMahon J, Zhang P, Charo IF, Schall TJ, Singh R.

PLoS One. 2018 Mar 21;13(3):e0192405. doi: 10.1371/journal.pone.0192405. eCollection 2018.

5.

CC chemokine receptor 2 promotes recruitment of myeloid cells associated with insulin resistance in nonalcoholic fatty liver disease.

Parker R, Weston CJ, Miao Z, Corbett C, Armstrong MJ, Ertl L, Ebsworth K, Walters MJ, Baumart T, Newland D, McMahon J, Zhang P, Singh R, Campbell J, Newsome PN, Charo I, Schall TJ, Adams DH.

Am J Physiol Gastrointest Liver Physiol. 2018 Apr 1;314(4):G483-G493. doi: 10.1152/ajpgi.00213.2017. Epub 2018 Feb 8.

6.

IL-17-Secreting γδ T Cells Are Completely Dependent upon CCR6 for Homing to Inflamed Skin.

Campbell JJ, Ebsworth K, Ertl LS, McMahon JP, Newland D, Wang Y, Liu S, Miao Z, Dang T, Zhang P, Charo IF, Singh R, Schall TJ.

J Immunol. 2017 Nov 1;199(9):3129-3136. doi: 10.4049/jimmunol.1700826. Epub 2017 Sep 29.

7.

Correction: Selective Chemokine Receptor Usage by Central Nervous System Myeloid Cells in CCR2-Red Fluorescent Protein Knock-In Mice.

Saederup N, Cardona AE, Croft K, Mizutani M, Cotleur AC, Tsou CL, Ransohoff RM, Charo IF.

PLoS One. 2017 Apr 27;12(4):e0176931. doi: 10.1371/journal.pone.0176931. eCollection 2017.

8.

Characterization of Pharmacologic and Pharmacokinetic Properties of CCX168, a Potent and Selective Orally Administered Complement 5a Receptor Inhibitor, Based on Preclinical Evaluation and Randomized Phase 1 Clinical Study.

Bekker P, Dairaghi D, Seitz L, Leleti M, Wang Y, Ertl L, Baumgart T, Shugarts S, Lohr L, Dang T, Miao S, Zeng Y, Fan P, Zhang P, Johnson D, Powers J, Jaen J, Charo I, Schall TJ.

PLoS One. 2016 Oct 21;11(10):e0164646. doi: 10.1371/journal.pone.0164646. eCollection 2016. Erratum in: PLoS One. 2019 Jan 4;14(1):e0210593.

9.

Differential Roles of Chemokines CCL2 and CCL7 in Monocytosis and Leukocyte Migration during West Nile Virus Infection.

Bardina SV, Michlmayr D, Hoffman KW, Obara CJ, Sum J, Charo IF, Lu W, Pletnev AG, Lim JK.

J Immunol. 2015 Nov 1;195(9):4306-18. doi: 10.4049/jimmunol.1500352. Epub 2015 Sep 23.

10.

Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation.

Ryu JK, Petersen MA, Murray SG, Baeten KM, Meyer-Franke A, Chan JP, Vagena E, Bedard C, Machado MR, Rios Coronado PE, Prod'homme T, Charo IF, Lassmann H, Degen JL, Zamvil SS, Akassoglou K.

Nat Commun. 2015 Sep 10;6:8164. doi: 10.1038/ncomms9164.

11.

A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2+ monocytes at a site of sterile injury.

Dal-Secco D, Wang J, Zeng Z, Kolaczkowska E, Wong CH, Petri B, Ransohoff RM, Charo IF, Jenne CN, Kubes P.

J Exp Med. 2015 Apr 6;212(4):447-56. doi: 10.1084/jem.20141539. Epub 2015 Mar 23.

12.

Differential roles of microglia and monocytes in the inflamed central nervous system.

Yamasaki R, Lu H, Butovsky O, Ohno N, Rietsch AM, Cialic R, Wu PM, Doykan CE, Lin J, Cotleur AC, Kidd G, Zorlu MM, Sun N, Hu W, Liu L, Lee JC, Taylor SE, Uehlein L, Dixon D, Gu J, Floruta CM, Zhu M, Charo IF, Weiner HL, Ransohoff RM.

J Exp Med. 2014 Jul 28;211(8):1533-49. doi: 10.1084/jem.20132477. Epub 2014 Jul 7.

13.

CCR2 deficiency impairs macrophage infiltration and improves cognitive function after traumatic brain injury.

Hsieh CL, Niemi EC, Wang SH, Lee CC, Bingham D, Zhang J, Cozen ML, Charo I, Huang EJ, Liu J, Nakamura MC.

J Neurotrauma. 2014 Oct 15;31(20):1677-88. doi: 10.1089/neu.2013.3252. Epub 2014 Jul 21.

14.

Alkylsulfone-containing trisubstituted cyclohexanes as potent and bioavailable chemokine receptor 2 (CCR2) antagonists.

Cherney RJ, Mo R, Yang MG, Xiao Z, Zhao Q, Mandlekar S, Cvijic ME, Charo IF, Barrish JC, Decicco CP, Carter PH.

Bioorg Med Chem Lett. 2014 Apr 1;24(7):1843-5. doi: 10.1016/j.bmcl.2014.02.013. Epub 2014 Feb 21.

15.

The transcriptional repressor BLIMP1 curbs host defenses by suppressing expression of the chemokine CCL8.

Severa M, Islam SA, Waggoner SN, Jiang Z, Kim ND, Ryan G, Kurt-Jones E, Charo I, Caffrey DR, Boyartchuk VL, Luster AD, Fitzgerald KA.

J Immunol. 2014 Mar 1;192(5):2291-304. doi: 10.4049/jimmunol.1301799. Epub 2014 Jan 29.

16.

CCR2(+) monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice.

Sennlaub F, Auvynet C, Calippe B, Lavalette S, Poupel L, Hu SJ, Dominguez E, Camelo S, Levy O, Guyon E, Saederup N, Charo IF, Rooijen NV, Nandrot E, Bourges JL, Behar-Cohen F, Sahel JA, Guillonneau X, Raoul W, Combadiere C.

EMBO Mol Med. 2013 Nov;5(11):1775-93. doi: 10.1002/emmm.201302692. Epub 2013 Oct 21.

17.

B lymphocytes trigger monocyte mobilization and impair heart function after acute myocardial infarction.

Zouggari Y, Ait-Oufella H, Bonnin P, Simon T, Sage AP, Guérin C, Vilar J, Caligiuri G, Tsiantoulas D, Laurans L, Dumeau E, Kotti S, Bruneval P, Charo IF, Binder CJ, Danchin N, Tedgui A, Tedder TF, Silvestre JS, Mallat Z.

Nat Med. 2013 Oct;19(10):1273-80. doi: 10.1038/nm.3284. Epub 2013 Sep 15.

18.

CCR2 antagonist CCX140-B provides renal and glycemic benefits in diabetic transgenic human CCR2 knockin mice.

Sullivan T, Miao Z, Dairaghi DJ, Krasinski A, Wang Y, Zhao BN, Baumgart T, Ertl LS, Pennell A, Seitz L, Powers J, Zhao R, Ungashe S, Wei Z, Boring L, Tsou CL, Charo I, Berahovich RD, Schall TJ, Jaen JC.

Am J Physiol Renal Physiol. 2013 Nov 1;305(9):F1288-97. doi: 10.1152/ajprenal.00316.2013. Epub 2013 Aug 28.

19.

Dual effect of chemokine CCL7/MCP-3 in the development of renal tubulointerstitial fibrosis.

Gonzalez J, Mouttalib S, Delage C, Calise D, Maoret JJ, Pradère JP, Klein J, Buffin-Meyer B, Van der Veen B, Charo IF, Heeringa P, Duchene J, Bascands JL, Schanstra JP.

Biochem Biophys Res Commun. 2013 Aug 23;438(2):257-63. doi: 10.1016/j.bbrc.2013.07.025. Epub 2013 Jul 19.

20.

Regulation of adaptive immunity by the fractalkine receptor during autoimmune inflammation.

Garcia JA, Pino PA, Mizutani M, Cardona SM, Charo IF, Ransohoff RM, Forsthuber TG, Cardona AE.

J Immunol. 2013 Aug 1;191(3):1063-72. doi: 10.4049/jimmunol.1300040. Epub 2013 Jul 1.

21.

Blinding the monocytes to protect the heart.

Charo IF.

Circulation. 2013 May 21;127(20):2006-8. doi: 10.1161/CIRCULATIONAHA.113.003045. Epub 2013 Apr 24. No abstract available.

22.

Microglial repopulation model reveals a robust homeostatic process for replacing CNS myeloid cells.

Varvel NH, Grathwohl SA, Baumann F, Liebig C, Bosch A, Brawek B, Thal DR, Charo IF, Heppner FL, Aguzzi A, Garaschuk O, Ransohoff RM, Jucker M.

Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):18150-5. doi: 10.1073/pnas.1210150109. Epub 2012 Oct 15.

23.

Characterization of CCX140-B, an orally bioavailable antagonist of the CCR2 chemokine receptor, for the treatment of type 2 diabetes and associated complications.

Sullivan TJ, Dairaghi DJ, Krasinski A, Miao Z, Wang Y, Zhao BN, Baumgart T, Berahovich R, Ertl LS, Pennell A, Seitz L, Miao S, Ungashe S, Wei Z, Johnson D, Boring L, Tsou CL, Charo IF, Bekker P, Schall TJ, Jaen JC.

J Pharmacol Exp Ther. 2012 Jun 5. doi: 10.1124/jpet.111.190918. Epub 2012 Jun 5. Retraction in: J Pharmacol Exp Ther. 2012 Jul;342(1):234.

PMID:
22378937
24.

Resolving postoperative neuroinflammation and cognitive decline.

Terrando N, Eriksson LI, Ryu JK, Yang T, Monaco C, Feldmann M, Jonsson Fagerlund M, Charo IF, Akassoglou K, Maze M.

Ann Neurol. 2011 Dec;70(6):986-995. doi: 10.1002/ana.22664.

25.

The fractalkine receptor but not CCR2 is present on microglia from embryonic development throughout adulthood.

Mizutani M, Pino PA, Saederup N, Charo IF, Ransohoff RM, Cardona AE.

J Immunol. 2012 Jan 1;188(1):29-36. doi: 10.4049/jimmunol.1100421. Epub 2011 Nov 11.

26.

Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine.

Lewis KL, Caton ML, Bogunovic M, Greter M, Grajkowska LT, Ng D, Klinakis A, Charo IF, Jung S, Gommerman JL, Ivanov II, Liu K, Merad M, Reizis B.

Immunity. 2011 Nov 23;35(5):780-91. doi: 10.1016/j.immuni.2011.08.013. Epub 2011 Oct 20.

27.

Anti-inflammatory therapeutics for the treatment of atherosclerosis.

Charo IF, Taub R.

Nat Rev Drug Discov. 2011 May;10(5):365-76. doi: 10.1038/nrd3444. Review.

28.

Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells.

Islam SA, Chang DS, Colvin RA, Byrne MH, McCully ML, Moser B, Lira SA, Charo IF, Luster AD.

Nat Immunol. 2011 Feb;12(2):167-77. doi: 10.1038/ni.1984. Epub 2011 Jan 9.

29.

Selective chemokine receptor usage by central nervous system myeloid cells in CCR2-red fluorescent protein knock-in mice.

Saederup N, Cardona AE, Croft K, Mizutani M, Cotleur AC, Tsou CL, Ransohoff RM, Charo IF.

PLoS One. 2010 Oct 27;5(10):e13693. doi: 10.1371/journal.pone.0013693. Erratum in: PLoS One. 2017 Apr 27;12 (4):e0176931.

30.

Macrophages recruited via CCR2 produce insulin-like growth factor-1 to repair acute skeletal muscle injury.

Lu H, Huang D, Saederup N, Charo IF, Ransohoff RM, Zhou L.

FASEB J. 2011 Jan;25(1):358-69. doi: 10.1096/fj.10-171579. Epub 2010 Oct 1.

31.

Zmynd15 encodes a histone deacetylase-dependent transcriptional repressor essential for spermiogenesis and male fertility.

Yan W, Si Y, Slaymaker S, Li J, Zheng H, Young DL, Aslanian A, Saunders L, Verdin E, Charo IF.

J Biol Chem. 2010 Oct 8;285(41):31418-26. doi: 10.1074/jbc.M110.116418. Epub 2010 Jul 30.

32.

Neutrophil-dominant experimental autoimmune uveitis in CC-chemokine receptor 2 knockout mice.

Sonoda KH, Yoshimura T, Egashira K, Charo IF, Ishibashi T.

Acta Ophthalmol. 2011 Mar;89(2):e180-8. doi: 10.1111/j.1755-3768.2010.01953.x.

33.

Inhibition of chemokine-glycosaminoglycan interactions in donor tissue reduces mouse allograft vasculopathy and transplant rejection.

Dai E, Liu LY, Wang H, McIvor D, Sun YM, Macaulay C, King E, Munuswamy-Ramanujam G, Bartee MY, Williams J, Davids J, Charo I, McFadden G, Esko JD, Lucas AR.

PLoS One. 2010 May 6;5(5):e10510. doi: 10.1371/journal.pone.0010510.

34.

CCR2 mediates hematopoietic stem and progenitor cell trafficking to sites of inflammation in mice.

Si Y, Tsou CL, Croft K, Charo IF.

J Clin Invest. 2010 Apr;120(4):1192-203. doi: 10.1172/JCI40310. Epub 2010 Mar 15.

35.

Angiotensin II infusion promotes ascending aortic aneurysms: attenuation by CCR2 deficiency in apoE-/- mice.

Daugherty A, Rateri DL, Charo IF, Owens AP, Howatt DA, Cassis LA.

Clin Sci (Lond). 2010 Mar 9;118(11):681-9. doi: 10.1042/CS20090372.

36.

CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation.

Auffray C, Fogg DK, Narni-Mancinelli E, Senechal B, Trouillet C, Saederup N, Leemput J, Bigot K, Campisi L, Abitbol M, Molina T, Charo I, Hume DA, Cumano A, Lauvau G, Geissmann F.

J Exp Med. 2009 Mar 16;206(3):595-606. doi: 10.1084/jem.20081385. Epub 2009 Mar 9.

37.

Increased expression of CCL2 in insulin-producing cells of transgenic mice promotes mobilization of myeloid cells from the bone marrow, marked insulitis, and diabetes.

Martin AP, Rankin S, Pitchford S, Charo IF, Furtado GC, Lira SA.

Diabetes. 2008 Nov;57(11):3025-33. doi: 10.2337/db08-0625. Epub 2008 Jul 15.

38.

Inhibition of MCP-1/CCR2 signaling does not inhibit intimal proliferation in a mouse aortic transplant model.

Alexis JD, Pyo RT, Chereshnev I, Katz J, Rollins BJ, Charo IF, Taubman MB.

J Vasc Res. 2008;45(6):538-46. doi: 10.1159/000129688. Epub 2008 May 7.

PMID:
18463419
39.

Additive roles for MCP-1 and MCP-3 in CCR2-mediated recruitment of inflammatory monocytes during Listeria monocytogenes infection.

Jia T, Serbina NV, Brandl K, Zhong MX, Leiner IM, Charo IF, Pamer EG.

J Immunol. 2008 May 15;180(10):6846-53.

40.

Fractalkine deficiency markedly reduces macrophage accumulation and atherosclerotic lesion formation in CCR2-/- mice: evidence for independent chemokine functions in atherogenesis.

Saederup N, Chan L, Lira SA, Charo IF.

Circulation. 2008 Apr 1;117(13):1642-8. doi: 10.1161/CIRCULATIONAHA.107.743872. Epub 2007 Dec 28.

41.
42.

CCR2 regulates development of Theiler's murine encephalomyelitis virus-induced demyelinating disease.

Bennett JL, Elhofy A, Charo I, Miller SD, Dal Canto MC, Karpus WJ.

Viral Immunol. 2007 Spring;20(1):19-33.

PMID:
17425418
43.

Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites.

Tsou CL, Peters W, Si Y, Slaymaker S, Aslanian AM, Weisberg SP, Mack M, Charo IF.

J Clin Invest. 2007 Apr;117(4):902-9. Epub 2007 Mar 15.

44.

Chemokine regulation of the inflammatory response to a low-dose influenza infection in CCR2-/- mice.

Wareing MD, Lyon A, Inglis C, Giannoni F, Charo I, Sarawar SR.

J Leukoc Biol. 2007 Mar;81(3):793-801. Epub 2006 Dec 19.

PMID:
17179466
45.

CC chemokine receptor 2 is protective against noise-induced hair cell death: studies in CX3CR1(+/GFP) mice.

Sautter NB, Shick EH, Ransohoff RM, Charo IF, Hirose K.

J Assoc Res Otolaryngol. 2006 Dec;7(4):361-72. Epub 2006 Oct 31.

46.

Chemokine fractalkine/CX3CL1 negatively modulates active glutamatergic synapses in rat hippocampal neurons.

Ragozzino D, Di Angelantonio S, Trettel F, Bertollini C, Maggi L, Gross C, Charo IF, Limatola C, Eusebi F.

J Neurosci. 2006 Oct 11;26(41):10488-98.

47.

Targeted disruption of the scavenger receptor and chemokine CXCL16 accelerates atherosclerosis.

Aslanian AM, Charo IF.

Circulation. 2006 Aug 8;114(6):583-90. Epub 2006 Jul 31.

PMID:
16880330
48.

The CC chemokine MCP-1 stimulates surface expression of CX3CR1 and enhances the adhesion of monocytes to fractalkine/CX3CL1 via p38 MAPK.

Green SR, Han KH, Chen Y, Almazan F, Charo IF, Miller YI, Quehenberger O.

J Immunol. 2006 Jun 15;176(12):7412-20.

49.

Monocyte recruitment in venous thrombus resolution.

Ali T, Humphries J, Burnand K, Sawyer B, Bursill C, Channon K, Greaves D, Rollins B, Charo IF, Smith A.

J Vasc Surg. 2006 Mar;43(3):601-8.

50.

The many roles of chemokines and chemokine receptors in inflammation.

Charo IF, Ransohoff RM.

N Engl J Med. 2006 Feb 9;354(6):610-21. Review. No abstract available.

PMID:
16467548

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