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Items: 47

1.

Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases.

Haile PA, Casillas LN, Votta BJ, Wang GZ, Charnley AK, Dong X, Bury MJ, Romano JJ, Mehlmann JF, King BW, Erhard KF, Hanning CR, Lipshutz DB, Desai BM, Capriotti CA, Schaeffer MC, Berger SB, Mahajan MK, Reilly MA, Nagilla R, Rivera EJ, Sun HH, Kenna JK, Beal AM, Ouellette MT, Kelly M, Stemp G, Convery MA, Vossenkämper A, MacDonald TT, Gough PJ, Bertin J, Marquis RW.

J Med Chem. 2019 Jul 25;62(14):6482-6494. doi: 10.1021/acs.jmedchem.9b00575. Epub 2019 Jul 2.

PMID:
31265286
2.

Author Correction: Design of amidobenzimidazole STING receptor agonists with systemic activity.

Ramanjulu JM, Pesiridis GS, Yang J, Concha N, Singhaus R, Zhang SY, Tran JL, Moore P, Lehmann S, Eberl HC, Muelbaier M, Schneck JL, Clemens J, Adam M, Mehlmann J, Romano J, Morales A, Kang J, Leister L, Graybill TL, Charnley AK, Ye G, Nevins N, Behnia K, Wolf AI, Kasparcova V, Nurse K, Wang L, Puhl AC, Li Y, Klein M, Hopson CB, Guss J, Bantscheff M, Bergamini G, Reilly MA, Lian Y, Duffy KJ, Adams J, Foley KP, Gough PJ, Marquis RW, Smothers J, Hoos A, Bertin J.

Nature. 2019 Jun;570(7761):E53. doi: 10.1038/s41586-019-1265-5.

PMID:
31142845
3.

Design of amidobenzimidazole STING receptor agonists with systemic activity.

Ramanjulu JM, Pesiridis GS, Yang J, Concha N, Singhaus R, Zhang SY, Tran JL, Moore P, Lehmann S, Eberl HC, Muelbaier M, Schneck JL, Clemens J, Adam M, Mehlmann J, Romano J, Morales A, Kang J, Leister L, Graybill TL, Charnley AK, Ye G, Nevins N, Behnia K, Wolf AI, Kasparcova V, Nurse K, Wang L, Puhl AC, Li Y, Klein M, Hopson CB, Guss J, Bantscheff M, Bergamini G, Reilly MA, Lian Y, Duffy KJ, Adams J, Foley KP, Gough PJ, Marquis RW, Smothers J, Hoos A, Bertin J.

Nature. 2018 Dec;564(7736):439-443. doi: 10.1038/s41586-018-0705-y. Epub 2018 Nov 7. Erratum in: Nature. 2019 Jun;570(7761):E53.

PMID:
30405246
4.

Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel.

Haile PA, Casillas LN, Bury MJ, Mehlmann JF, Singhaus R Jr, Charnley AK, Hughes TV, DeMartino MP, Wang GZ, Romano JJ, Dong X, Plotnikov NV, Lakdawala AS, Convery MA, Votta BJ, Lipshutz DB, Desai BM, Swift B, Capriotti CA, Berger SB, Mahajan MK, Reilly MA, Rivera EJ, Sun HH, Nagilla R, LePage C, Ouellette MT, Totoritis RD, Donovan BT, Brown BS, Chaudhary KW, Gough PJ, Bertin J, Marquis RW.

ACS Med Chem Lett. 2018 Sep 26;9(10):1039-1044. doi: 10.1021/acsmedchemlett.8b00344. eCollection 2018 Oct 11.

5.

Implementation of medical retina virtual clinics in a tertiary eye care referral centre.

Kortuem K, Fasler K, Charnley A, Khambati H, Fasolo S, Katz M, Balaskas K, Rajendram R, Hamilton R, Keane PA, Sim DA.

Br J Ophthalmol. 2018 Oct;102(10):1391-1395. doi: 10.1136/bjophthalmol-2017-311494. Epub 2018 Jan 6.

PMID:
29306863
6.

The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase.

Haile PA, Votta BJ, Marquis RW, Bury MJ, Mehlmann JF, Singhaus R Jr, Charnley AK, Lakdawala AS, Convery MA, Lipshutz DB, Desai BM, Swift B, Capriotti CA, Berger SB, Mahajan MK, Reilly MA, Rivera EJ, Sun HH, Nagilla R, Beal AM, Finger JN, Cook MN, King BW, Ouellette MT, Totoritis RD, Pierdomenico M, Negroni A, Stronati L, Cucchiara S, Ziółkowski B, Vossenkämper A, MacDonald TT, Gough PJ, Bertin J, Casillas LN.

J Med Chem. 2016 May 26;59(10):4867-80. doi: 10.1021/acs.jmedchem.6b00211. Epub 2016 May 4.

PMID:
27109867
7.

Crystal structures of human RIP2 kinase catalytic domain complexed with ATP-competitive inhibitors: Foundations for understanding inhibitor selectivity.

Charnley AK, Convery MA, Lakdawala Shah A, Jones E, Hardwicke P, Bridges A, Ouellette M, Totoritis R, Schwartz B, King BW, Wisnoski DD, Kang J, Eidam PM, Votta BJ, Gough PJ, Marquis RW, Bertin J, Casillas L.

Bioorg Med Chem. 2015 Nov 1;23(21):7000-6. doi: 10.1016/j.bmc.2015.09.038. Epub 2015 Sep 25.

PMID:
26455654
8.

Maternally inherited diabetes and deafness (MIDD): diagnosis and management.

Naing A, Kenchaiah M, Krishnan B, Mir F, Charnley A, Egan C, Bano G.

J Diabetes Complications. 2014 Jul-Aug;28(4):542-6. doi: 10.1016/j.jdiacomp.2014.03.006. Epub 2014 Mar 12.

PMID:
24746802
9.

Assessment of automated disease detection in diabetic retinopathy screening using two-field photography.

Goatman K, Charnley A, Webster L, Nussey S.

PLoS One. 2011;6(12):e27524. doi: 10.1371/journal.pone.0027524. Epub 2011 Dec 8.

10.

The inhibitory effect of the fungal toxin, destruxin A, on behavioural fever in the desert locust.

Hunt VL, Charnley AK.

J Insect Physiol. 2011 Oct;57(10):1341-6. doi: 10.1016/j.jinsphys.2011.06.008. Epub 2011 Jun 25.

PMID:
21729702
11.

SDOCT imaging to identify macular pathology in patients diagnosed with diabetic maculopathy by a digital photographic retinal screening programme.

Mackenzie S, Schmermer C, Charnley A, Sim D, Vikas Tah, Dumskyj M, Nussey S, Egan C.

PLoS One. 2011 May 6;6(5):e14811. doi: 10.1371/journal.pone.0014811.

12.

Pyrrolinone-based peptidomimetics. "Let the enzyme or receptor be the judge".

Smith AB 3rd, Charnley AK, Hirschmann R.

Acc Chem Res. 2011 Mar 15;44(3):180-93. doi: 10.1021/ar1001186. Epub 2010 Dec 22.

13.

Design, synthesis, and structural analysis of D,L-mixed polypyrrolinones. 2. Macrocyclic hexapyrrolinones.

Smith AB 3rd, Xiong H, Charnley AK, Brenner M, Mesaros EF, Kenesky CS, Di Costanzo L, Christianson DW, Hirschmann R.

Org Lett. 2010 Jul 2;12(13):2994-7. doi: 10.1021/ol101008y.

14.

Design, synthesis, and structural analysis of D,L-mixed polypyrrolinones. 1. From nonpeptide peptidomimetics to nanotubes.

Smith AB 3rd, Wang W, Charnley AK, Carroll PJ, Kenesky CS, Hirschmann R.

Org Lett. 2010 Jul 2;12(13):2990-3. doi: 10.1021/ol101007n.

15.

Equilibrium exchange processes of the aqueous tryptophan dipeptide.

Bagchi S, Charnley AK, Smith Iii AB, Hochstrasser RM.

J Phys Chem B. 2009 Jun 18;113(24):8412-7. doi: 10.1021/jp811168x.

16.

Composition of Acridid gut bacterial communities as revealed by 16S rRNA gene analysis.

Dillon RJ, Webster G, Weightman AJ, Dillon VM, Blanford S, Charnley AK.

J Invertebr Pathol. 2008 Mar;97(3):265-72. Epub 2007 Sep 21.

PMID:
17967463
17.

Effects of Lecanicillium longisporum infection on the behaviour of the green peach aphid Myzus persicae.

Roditakis E, Couzin ID, Franks NR, Charnley AK.

J Insect Physiol. 2008 Jan;54(1):128-36. Epub 2007 Aug 28.

PMID:
17942112
18.
19.

Two-dimensional infrared investigation of N-acetyl tryptophan methyl amide in solution.

Bagchi S, Kim YS, Charnley AK, Smith AB 3rd, Hochstrasser RM.

J Phys Chem B. 2007 Mar 22;111(11):3010-8. Epub 2007 Feb 28.

PMID:
17388413
20.

The contribution of surface waxes to pre-penetration growth of an entomopathogenic fungus on host cuticle.

Jarrold SL, Moore D, Potter U, Charnley AK.

Mycol Res. 2007 Feb;111(Pt 2):240-9.

PMID:
17324760
21.

Identification of an extracellular acid trehalase and its gene involved in fungal pathogenesis of Metarizium anisopliae.

Zhao H, Charnley AK, Wang Z, Yin Y, Li Z, Li Y, Cao Y, Peng G, Xia Y.

J Biochem. 2006 Sep;140(3):319-27.

PMID:
16980715
22.

Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors possessing augmented P2' side chains.

Smith AB 3rd, Charnley AK, Harada H, Beiger JJ, Cantin LD, Kenesky CS, Hirschmann R, Munshi S, Olsen DB, Stahlhut MW, Schleif WA, Kuo LC.

Bioorg Med Chem Lett. 2006 Feb 15;16(4):859-63. Epub 2005 Nov 18.

PMID:
16298527
23.

Design, synthesis, and binding affinities of pyrrolinone-based somatostatin mimetics.

Smith AB 3rd, Charnley AK, Mesaros EF, Kikuchi O, Wang W, Benowitz A, Chu CL, Feng JJ, Chen KH, Lin A, Cheng FC, Taylor L, Hirschmann R.

Org Lett. 2005 Feb 3;7(3):399-402.

PMID:
15673249
24.

Hyperphagocytic haemocytes in Manduca sexta.

Dean P, Potter U, Richards EH, Edwards JP, Charnley AK, Reynolds SE.

J Insect Physiol. 2004 Nov;50(11):1027-36.

PMID:
15607505
25.
26.

Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors.

Smith AB 3rd, Cantin LD, Pasternak A, Guise-Zawacki L, Yao W, Charnley AK, Barbosa J, Sprengeler PA, Hirschmann R, Munshi S, Olsen DB, Schleif WA, Kuo LC.

J Med Chem. 2003 May 8;46(10):1831-44.

PMID:
12723947
27.

Eicosanoid involvement in the regulation of behavioral fever in the desert locust, Schistocerca gregaria.

Bundey S, Raymond S, Dean P, Roberts SK, Dillon RJ, Charnley AK.

Arch Insect Biochem Physiol. 2003 Apr;52(4):183-92.

PMID:
12655606
28.
29.
30.

A note: gut bacteria produce components of a locust cohesion pheromone.

Dillon RJ, Vennard CT, Charnley AK.

J Appl Microbiol. 2002;92(4):759-63.

31.

Acid phosphatases of Metarhizium anisopliae during infection of the tobacco hornworm Manduca sexta.

Xia Y, Clarkson JM, Charnley AK.

Arch Microbiol. 2001 Dec;176(6):427-34. Epub 2001 Sep 19.

PMID:
11734886
32.

Acid phosphatases in the haemolymph of the desert locust, Schistocerca gregaria, infected with the entomopathogenic fungus Metarhizium anisopliae.

Xia Y, Dean P, Judge AJ, Gillespie JP, Clarkson JM, Charnley AK.

J Insect Physiol. 2000 Sep 1;46(9):1249-1257.

PMID:
10844143
33.

Exploitation of gut bacteria in the locust.

Dillon RJ, Vennard CT, Charnley AK.

Nature. 2000 Feb 24;403(6772):851. No abstract available.

PMID:
10706273
34.

The role of destruxins in the pathogenicity of metarhizium anisopliae for three species of insect

Kershaw MJ, Moorhouse ER, Bateman R, Reynolds SE, Charnley AK.

J Invertebr Pathol. 1999 Nov;74(3):213-23.

PMID:
10534408
35.

Role of cuticle-degrading proteases in the virulence of metarhizium spp. for the desert locust, schistocerca gregaria

Gillespie JP, Bateman R, Charnley AK.

J Invertebr Pathol. 1998 Mar;71(2):128-37.

PMID:
9500951
36.

Colles' fracture: efficacy of pins and plaster.

Charnley AD.

Am J Orthop (Belle Mead NJ). 1997 Jun;26(6):413, 445. No abstract available.

PMID:
9193695
37.

Cloning and sequence analysis of an intron-containing domain from a peptide synthetase-encoding gene of the entomopathogenic fungus Metarhizium anisopliae.

Bailey AM, Kershaw MJ, Hunt BA, Paterson IC, Charnley AK, Reynolds SE, Clarkson JM.

Gene. 1996 Sep 16;173(2):195-7.

PMID:
8964498
38.

New insights into the mechanisms of fungal pathogenesis in insects.

Clarkson JM, Charnley AK.

Trends Microbiol. 1996 May;4(5):197-203. Review.

PMID:
8727600
39.

Cloning and characterisation of a gene encoding a cuticle-degrading protease from the insect pathogenic fungus Metarhizium anisopliae.

Smithson SL, Paterson IC, Bailey AM, Screen SE, Hunt BA, Cobb BD, Cooper RM, Charnley AK, Clarkson JM.

Gene. 1995 Dec 1;166(1):161-5.

PMID:
8529882
40.

Reflex sympathetic dystrophy.

Charnley AD.

Am J Orthop (Belle Mead NJ). 1995 Mar;24(3):212, 214. No abstract available.

PMID:
7773663
41.

Partial characterization of specific inducers of a cuticle-degrading protease from the insect pathogenic fungus Metarhizium anisopliae.

Paterson IC, Charnley AK, Cooper RM, Clarkson JM.

Microbiology. 1994 Nov;140 ( Pt 11):3153-9.

PMID:
7812455
42.

A cuticle-degrading proteinase from the moulting fluid of the tobacco hornworm, Manduca sexta.

Samuels RI, Charnley AK, Reynolds SE.

Insect Biochem Mol Biol. 1993 Jul;23(5):607-14.

PMID:
8353521
43.

Analysis of aminopeptidase and dipeptidylpeptidase IV from the entomopathogenic fungus Metarhizium anisopliae.

St Leger RJ, Cooper RM, Charnley AK.

J Gen Microbiol. 1993 Feb;139(2):237-43.

PMID:
8094738
44.

Distribution of chymoelastases and trypsin-like enzymes in five species of entomopathogenic deuteromycetes.

St Leger RJ, Cooper RM, Charnley AK.

Arch Biochem Biophys. 1987 Oct;258(1):123-31.

PMID:
3310895
45.

Characterization of cuticle-degrading proteases produced by the entomopathogen Metarhizium anisopliae.

St Leger RJ, Charnley AK, Cooper RM.

Arch Biochem Biophys. 1987 Feb 15;253(1):221-32.

PMID:
3545084
46.

The treatment of displaced fractures at the ankle by rigid internal fixation and early joint movement.

Burwell HN, Charnley AD.

J Bone Joint Surg Br. 1965 Nov;47(4):634-60. No abstract available.

PMID:
5846764
47.

TREATMENT OF FOREARM FRACTURES IN ADULTS WITH PARTICULAR REFERENCE TO PLATE FIXATION.

BURWELL HN, CHARNLEY AD.

J Bone Joint Surg Br. 1964 Aug;46:404-25. No abstract available.

PMID:
14216451

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