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The Diverse Functional Roles of Elongation Factor Tu (EF-Tu) in Microbial Pathogenesis.

Harvey KL, Jarocki VM, Charles IG, Djordjevic SP.

Front Microbiol. 2019 Oct 24;10:2351. doi: 10.3389/fmicb.2019.02351. eCollection 2019. Review.


A global genomic approach uncovers novel components for twitching motility-mediated biofilm expansion in Pseudomonas aeruginosa.

Nolan LM, Whitchurch CB, Barquist L, Katrib M, Boinett CJ, Mayho M, Goulding D, Charles IG, Filloux A, Parkhill J, Cain AK.

Microb Genom. 2018 Nov;4(11). doi: 10.1099/mgen.0.000229. Epub 2018 Nov 1.


Repurposing drugs to fast-track therapeutic agents for the treatment of cryptococcosis.

Truong M, Monahan LG, Carter DA, Charles IG.

PeerJ. 2018 May 4;6:e4761. doi: 10.7717/peerj.4761. eCollection 2018.


Identification of a novel qnrA allele, qnrA8, in environmental Shewanella algae.

Melvold JA, Wyrsch ER, McKinnon J, Roy Chowdhury P, Charles IG, Djordjevic SP.

J Antimicrob Chemother. 2017 Oct 1;72(10):2949-2952. doi: 10.1093/jac/dkx226. No abstract available.


Evaluation of ddRADseq for reduced representation metagenome sequencing.

Liu MY, Worden P, Monahan LG, DeMaere MZ, Burke CM, Djordjevic SP, Charles IG, Darling AE.

PeerJ. 2017 Sep 19;5:e3837. doi: 10.7717/peerj.3837. eCollection 2017.


Elongation factor Tu is a multifunctional and processed moonlighting protein.

Widjaja M, Harvey KL, Hagemann L, Berry IJ, Jarocki VM, Raymond BBA, Tacchi JL, Gründel A, Steele JR, Padula MP, Charles IG, Dumke R, Djordjevic SP.

Sci Rep. 2017 Sep 11;7(1):11227. doi: 10.1038/s41598-017-10644-z.


Genomic Epidemiology of NDM-1-Encoding Plasmids in Latin American Clinical Isolates Reveals Insights into the Evolution of Multidrug Resistance.

Marquez-Ortiz RA, Haggerty L, Olarte N, Duarte C, Garza-Ramos U, Silva-Sanchez J, Castro BE, Sim EM, Beltran M, Moncada MV, Valderrama A, Castellanos JE, Charles IG, Vanegas N, Escobar-Perez J, Petty NK.

Genome Biol Evol. 2017 Jun 1;9(6):1725-1741. doi: 10.1093/gbe/evx115.


Micro-Patterned Surfaces That Exploit Stigmergy to Inhibit Biofilm Expansion.

Gloag ES, Elbadawi C, Zachreson CJ, Aharonovich I, Toth M, Charles IG, Turnbull L, Whitchurch CB.

Front Microbiol. 2017 Jan 23;7:2157. doi: 10.3389/fmicb.2016.02157. eCollection 2016.


A genomic island in Vibrio cholerae with VPI-1 site-specific recombination characteristics contains CRISPR-Cas and type VI secretion modules.

Labbate M, Orata FD, Petty NK, Jayatilleke ND, King WL, Kirchberger PC, Allen C, Mann G, Mutreja A, Thomson NR, Boucher Y, Charles IG.

Sci Rep. 2016 Nov 15;6:36891. doi: 10.1038/srep36891.


Genomic Microbial Epidemiology Is Needed to Comprehend the Global Problem of Antibiotic Resistance and to Improve Pathogen Diagnosis.

Wyrsch ER, Roy Chowdhury P, Chapman TA, Charles IG, Hammond JM, Djordjevic SP.

Front Microbiol. 2016 Jun 15;7:843. doi: 10.3389/fmicb.2016.00843. eCollection 2016. Review.


Explosive cell lysis as a mechanism for the biogenesis of bacterial membrane vesicles and biofilms.

Turnbull L, Toyofuku M, Hynen AL, Kurosawa M, Pessi G, Petty NK, Osvath SR, Cárcamo-Oyarce G, Gloag ES, Shimoni R, Omasits U, Ito S, Yap X, Monahan LG, Cavaliere R, Ahrens CH, Charles IG, Nomura N, Eberl L, Whitchurch CB.

Nat Commun. 2016 Apr 14;7:11220. doi: 10.1038/ncomms11220.


Comparative genomic analysis of toxin-negative strains of Clostridium difficile from humans and animals with symptoms of gastrointestinal disease.

Roy Chowdhury P, DeMaere M, Chapman T, Worden P, Charles IG, Darling AE, Djordjevic SP.

BMC Microbiol. 2016 Mar 12;16:41. doi: 10.1186/s12866-016-0653-3.


Genomic islands 1 and 2 play key roles in the evolution of extensively drug-resistant ST235 isolates of Pseudomonas aeruginosa.

Roy Chowdhury P, Scott M, Worden P, Huntington P, Hudson B, Karagiannis T, Charles IG, Djordjevic SP.

Open Biol. 2016 Mar;6(3). pii: 150175. doi: 10.1098/rsob.150175.


Bacterial Communities Vary between Sinuses in Chronic Rhinosinusitis Patients.

Joss TV, Burke CM, Hudson BJ, Darling AE, Forer M, Alber DG, Charles IG, Stow NW.

Front Microbiol. 2016 Jan 22;6:1532. doi: 10.3389/fmicb.2015.01532. eCollection 2015.


Comparative genomic analysis of a multiple antimicrobial resistant enterotoxigenic E. coli O157 lineage from Australian pigs.

Wyrsch E, Roy Chowdhury P, Abraham S, Santos J, Darling AE, Charles IG, Chapman TA, Djordjevic SP.

BMC Genomics. 2015 Mar 10;16:165. doi: 10.1186/s12864-015-1382-y.


A role for Tn6029 in the evolution of the complex antibiotic resistance gene loci in genomic island 3 in enteroaggregative hemorrhagic Escherichia coli O104:H4.

Roy Chowdhury P, Charles IG, Djordjevic SP.

PLoS One. 2015 Feb 12;10(2):e0115781. doi: 10.1371/journal.pone.0115781. eCollection 2015. Erratum in: PLoS One. 2015;10(4):e0126197.


A draft genome of Escherichia coli sequence type 127 strain 2009-46.

Darling AE, McKinnon J, Worden P, Santos J, Charles IG, Chowdhury PR, Djordjevic SP.

Gut Pathog. 2014 Sep 1;6:32. doi: 10.1186/1757-4749-6-32. eCollection 2014.


Genomic interplay in bacterial communities: implications for growth promoting practices in animal husbandry.

Roy Chowdhury P, McKinnon J, Wyrsch E, Hammond JM, Charles IG, Djordjevic SP.

Front Microbiol. 2014 Aug 12;5:394. doi: 10.3389/fmicb.2014.00394. eCollection 2014. Review.


A genomic island integrated into recA of Vibrio cholerae contains a divergent recA and provides multi-pathway protection from DNA damage.

Rapa RA, Islam A, Monahan LG, Mutreja A, Thomson N, Charles IG, Stokes HW, Labbate M.

Environ Microbiol. 2015 Apr;17(4):1090-102. doi: 10.1111/1462-2920.12512. Epub 2014 Jun 26.


Coordinating bacterial cell division with nutrient availability: a role for glycolysis.

Monahan LG, Hajduk IV, Blaber SP, Charles IG, Harry EJ.

mBio. 2014 May 13;5(3):e00935-14. doi: 10.1128/mBio.00935-14.


The genome of Clostridium difficile 5.3.

Darling AE, Worden P, Chapman TA, Roy Chowdhury P, Charles IG, Djordjevic SP.

Gut Pathog. 2014 Feb 24;6(1):4. doi: 10.1186/1757-4749-6-4.


Rapid conversion of Pseudomonas aeruginosa to a spherical cell morphotype facilitates tolerance to carbapenems and penicillins but increases susceptibility to antimicrobial peptides.

Monahan LG, Turnbull L, Osvath SR, Birch D, Charles IG, Whitchurch CB.

Antimicrob Agents Chemother. 2014;58(4):1956-62. doi: 10.1128/AAC.01901-13. Epub 2014 Jan 13.


Self-organization of bacterial biofilms is facilitated by extracellular DNA.

Gloag ES, Turnbull L, Huang A, Vallotton P, Wang H, Nolan LM, Mililli L, Hunt C, Lu J, Osvath SR, Monahan LG, Cavaliere R, Charles IG, Wand MP, Gee ML, Prabhakar R, Whitchurch CB.

Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11541-6. doi: 10.1073/pnas.1218898110. Epub 2013 Jun 24.


Comprehensive assignment of roles for Salmonella typhimurium genes in intestinal colonization of food-producing animals.

Chaudhuri RR, Morgan E, Peters SE, Pleasance SJ, Hudson DL, Davies HM, Wang J, van Diemen PM, Buckley AM, Bowen AJ, Pullinger GD, Turner DJ, Langridge GC, Turner AK, Parkhill J, Charles IG, Maskell DJ, Stevens MP.

PLoS Genet. 2013 Apr;9(4):e1003456. doi: 10.1371/journal.pgen.1003456. Epub 2013 Apr 18.


Indigenous Vibrio cholerae strains from a non-endemic region are pathogenic.

Islam A, Labbate M, Djordjevic SP, Alam M, Darling A, Melvold J, Holmes AJ, Johura FT, Cravioto A, Charles IG, Stokes HW.

Open Biol. 2013 Feb 13;3(2):120181. doi: 10.1098/rsob.120181.


Crystallographic and microcalorimetric analyses reveal the structural basis for high arginine specificity in the Salmonella enterica serovar Typhimurium periplasmic binding protein STM4351.

Stamp AL, Owen P, El Omari K, Lockyer M, Lamb HK, Charles IG, Hawkins AR, Stammers DK.

Proteins. 2011 Jul;79(7):2352-7. doi: 10.1002/prot.23060. Epub 2011 May 10. No abstract available.


Structural and functional characterization of Salmonella enterica serovar Typhimurium YcbL: an unusual Type II glyoxalase.

Stamp AL, Owen P, El Omari K, Nichols CE, Lockyer M, Lamb HK, Charles IG, Hawkins AR, Stammers DK.

Protein Sci. 2010 Oct;19(10):1897-905. doi: 10.1002/pro.475.


Salmonella enterica serovar typhimurium trxA mutants are protective against virulent challenge and induce less inflammation than the live-attenuated vaccine strain SL3261.

Peters SE, Paterson GK, Bandularatne ES, Northen HC, Pleasance S, Willers C, Wang J, Foote AK, Constantino-Casas F, Scase TJ, Blacklaws BA, Bryant CE, Mastroeni P, Charles IG, Maskell DJ.

Infect Immun. 2010 Jan;78(1):326-36. doi: 10.1128/IAI.00768-09. Epub 2009 Nov 2.


Comprehensive identification of Salmonella enterica serovar typhimurium genes required for infection of BALB/c mice.

Chaudhuri RR, Peters SE, Pleasance SJ, Northen H, Willers C, Paterson GK, Cone DB, Allen AG, Owen PJ, Shalom G, Stekel DJ, Charles IG, Maskell DJ.

PLoS Pathog. 2009 Jul;5(7):e1000529. doi: 10.1371/journal.ppat.1000529. Epub 2009 Jul 31.


Comprehensive identification of essential Staphylococcus aureus genes using Transposon-Mediated Differential Hybridisation (TMDH).

Chaudhuri RR, Allen AG, Owen PJ, Shalom G, Stone K, Harrison M, Burgis TA, Lockyer M, Garcia-Lara J, Foster SJ, Pleasance SJ, Peters SE, Maskell DJ, Charles IG.

BMC Genomics. 2009 Jul 1;10:291. doi: 10.1186/1471-2164-10-291.


Structure of the ribosomal interacting GTPase YjeQ from the enterobacterial species Salmonella typhimurium.

Nichols CE, Johnson C, Lamb HK, Lockyer M, Charles IG, Hawkins AR, Stammers DK.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Nov 1;63(Pt 11):922-8. Epub 2007 Oct 24.


Functional analysis of the GTPases EngA and YhbZ encoded by Salmonella typhimurium.

Lamb HK, Thompson P, Elliott C, Charles IG, Richards J, Lockyer M, Watkins N, Nichols C, Stammers DK, Bagshaw CR, Cooper A, Hawkins AR.

Protein Sci. 2007 Nov;16(11):2391-402. Epub 2007 Sep 28.


Characterization of Salmonella typhimurium YegS, a putative lipid kinase homologous to eukaryotic sphingosine and diacylglycerol kinases.

Nichols CE, Lamb HK, Lockyer M, Charles IG, Pyne S, Hawkins AR, Stammers DK.

Proteins. 2007 Jul 1;68(1):13-25.


Structural characterization of Salmonella typhimurium YeaZ, an M22 O-sialoglycoprotein endopeptidase homolog.

Nichols CE, Johnson C, Lockyer M, Charles IG, Lamb HK, Hawkins AR, Stammers DK.

Proteins. 2006 Jul 1;64(1):111-23.


The affinity of a major Ca2+ binding site on GRP78 is differentially enhanced by ADP and ATP.

Lamb HK, Mee C, Xu W, Liu L, Blond S, Cooper A, Charles IG, Hawkins AR.

J Biol Chem. 2006 Mar 31;281(13):8796-805. Epub 2006 Jan 17.


Nitric oxide induces coupling of mitochondrial signalling with the endoplasmic reticulum stress response.

Xu W, Liu L, Charles IG, Moncada S.

Nat Cell Biol. 2004 Nov;6(11):1129-34. Epub 2004 Oct 24.


Biophysical and kinetic analysis of wild-type and site-directed mutants of the isolated and native dehydroquinate synthase domain of the AROM protein.

Park A, Lamb HK, Nichols C, Moore JD, Brown KA, Cooper A, Charles IG, Stammers DK, Hawkins AR.

Protein Sci. 2004 Aug;13(8):2108-19.


The role of nitric oxide in cancer.

Xu W, Liu LZ, Loizidou M, Ahmed M, Charles IG.

Cell Res. 2002 Dec;12(5-6):311-20. Review.


Crystal structure of SANOS, a bacterial nitric oxide synthase oxygenase protein from Staphylococcus aureus.

Bird LE, Ren J, Zhang J, Foxwell N, Hawkins AR, Charles IG, Stammers DK.

Structure. 2002 Dec;10(12):1687-96.


PDZ domains facilitate binding of high temperature requirement protease A (HtrA) and tail-specific protease (Tsp) to heterologous substrates through recognition of the small stable RNA A (ssrA)-encoded peptide.

Spiers A, Lamb HK, Cocklin S, Wheeler KA, Budworth J, Dodds AL, Pallen MJ, Maskell DJ, Charles IG, Hawkins AR.

J Biol Chem. 2002 Oct 18;277(42):39443-9. Epub 2002 Aug 12.


Microencapsulated iNOS-expressing cells cause tumor suppression in mice.

Xu W, Liu L, Charles IG.

FASEB J. 2002 Feb;16(2):213-5. Epub 2001 Dec 28.


Early responses to Salmonella typhimurium infection in mice occur at focal lesions in infected organs.

Khan SA, Strijbos PJ, Everest P, Moss D, Stratford R, Mastroeni P, Allen J, Servos S, Charles IG, Dougan G, Maskell DJ.

Microb Pathog. 2001 Jan;30(1):29-38.


Synthesis and biological evaluation of novel pyrazoles and indazoles as activators of the nitric oxide receptor, soluble guanylate cyclase.

Selwood DL, Brummell DG, Budworth J, Burtin GE, Campbell RO, Chana SS, Charles IG, Fernandez PA, Glen RC, Goggin MC, Hobbs AJ, Kling MR, Liu Q, Madge DJ, Meillerais S, Powell KL, Reynolds K, Spacey GD, Stables JN, Tatlock MA, Wheeler KA, Wishart G, Woo CK.

J Med Chem. 2001 Jan 4;44(1):78-93.


Survey of the allelic frequency of a NOS2A promoter microsatellite in human populations: assessment of the NOS2A gene and predisposition to infectious disease.

Xu W, Humphries S, Tomita M, Okuyama T, Matsuki M, Burgner D, Kwiatkowski D, Liu L, Charles IG.

Nitric Oxide. 2000 Aug;4(4):379-83.


Cloning and expression of human eNOS and nNOS using the baculovirus-insect cell system.

Charles IG, Foxwell N, Chubb A.

Methods Mol Biol. 1998;100:51-60. No abstract available.


The structures of the H(C) fragment of tetanus toxin with carbohydrate subunit complexes provide insight into ganglioside binding.

Emsley P, Fotinou C, Black I, Fairweather NF, Charles IG, Watts C, Hewitt E, Isaacs NW.

J Biol Chem. 2000 Mar 24;275(12):8889-94.


The CCTTT polymorphism in the NOS2A gene is associated with dementia with Lewy bodies.

Xu W, Liu L, Emson P, Harrington CR, McKeith IG, Perry RH, Morris CM, Charles IG.

Neuroreport. 2000 Feb 7;11(2):297-9.


Molecular characterization and in situ localization of a full-length cyclic nucleotide-gated channel in rat brain.

Strijbos PJ, Pratt GD, Khan S, Charles IG, Garthwaite J.

Eur J Neurosci. 1999 Dec;11(12):4463-7.


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