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Peptide-Cleavable Self-immolative Maytansinoid Antibody-Drug Conjugates Designed To Provide Improved Bystander Killing.

Costoplus JA, Veale KH, Qiu Q, Ponte JF, Lanieri L, Setiady Y, Dong L, Skaletskaya A, Bartle LM, Salomon P, Wu R, Maloney EK, Kovtun YV, Ab O, Lai K, Chari RVJ, Widdison WC.

ACS Med Chem Lett. 2019 Sep 27;10(10):1393-1399. doi: 10.1021/acsmedchemlett.9b00310. eCollection 2019 Oct 10.


Synthesis and Evaluation of Camptothecin Antibody-Drug Conjugates.

Li W, Veale KH, Qiu Q, Sinkevicius KW, Maloney EK, Costoplus JA, Lau J, Evans HL, Setiady Y, Ab O, Abbott SM, Lee J, Wisitpitthaya S, Skaletskaya A, Wang L, Keating TA, Chari RVJ, Widdison WC.

ACS Med Chem Lett. 2019 Sep 6;10(10):1386-1392. doi: 10.1021/acsmedchemlett.9b00301. eCollection 2019 Oct 10.


Optimizing lysosomal activation of antibody-drug conjugates (ADCs) by incorporation of novel cleavable dipeptide linkers.

Salomon PL, Reid EE, Archer KE, Harris L, Maloney EK, Wilhelm AJ, Miller ML, Chari RVJ, Keating TA, Singh R.

Mol Pharm. 2019 Oct 14. doi: 10.1021/acs.molpharmaceut.9b00696. [Epub ahead of print]


Synthesis of Highly Potent N-10 Amino-Linked DNA-Alkylating Indolinobenzodiazepine Antibody-Drug Conjugates (ADCs).

Archer KE, Reid EE, Shizuka M, Woods J, Harris L, Maloney EK, Bartle LM, Ab O, Wilhelm A, Setiady Y, Ponte JF, Singh R, Keating TA, Chari RVJ, Miller ML.

ACS Med Chem Lett. 2019 Jul 22;10(8):1211-1215. doi: 10.1021/acsmedchemlett.9b00254. eCollection 2019 Aug 8.


Effect of Linker Stereochemistry on the Activity of Indolinobenzodiazepine Containing Antibody-Drug Conjugates (ADCs).

Reid EE, Archer KE, Shizuka M, Wilhelm A, Yoder NC, Bai C, Fishkin NE, Harris L, Maloney EK, Salomon P, Hong E, Wu R, Ab O, Jin S, Lai KC, Sikka S, Chari RVJ, Miller ML.

ACS Med Chem Lett. 2019 Jul 10;10(8):1193-1197. doi: 10.1021/acsmedchemlett.9b00240. eCollection 2019 Aug 8.


Circadian variation in the release of small extracellular vesicles can be normalized by vesicle number or TSG101.

Koritzinsky EH, Street JM, Chari RR, Glispie DM, Bellomo TR, Aponte AM, Star RA, Yuen PST.

Am J Physiol Renal Physiol. 2019 Nov 1;317(5):F1098-F1110. doi: 10.1152/ajprenal.00568.2017. Epub 2019 Aug 7.


Design, synthesis and evaluation of novel, potent DNA alkylating agents and their antibody-drug conjugates (ADCs).

Reid EE, Archer KE, Shizuka M, McShea MA, Maloney EK, Ab O, Lanieri L, Wilhelm A, Ponte JF, Yoder NC, Chari RVJ, Miller ML.

Bioorg Med Chem Lett. 2019 Sep 1;29(17):2455-2458. doi: 10.1016/j.bmcl.2019.07.031. Epub 2019 Jul 19.


Optimizing energy expenditure and oxygenation toward ventilator tolerance is associated with lower ventilator and intensive care unit days.

Ang D, Chari R, Garcia A, Clark J, Farrah J, Hagan J, Watson C, Richards W, Liu H, Donaldson D, Barde J, Alderman T.

J Trauma Acute Care Surg. 2019 Sep;87(3):559-565. doi: 10.1097/TA.0000000000002404.


Blunted sympathetic neurovascular transduction during normotensive pregnancy.

Steinback CD, Fraser GM, Usselman CW, Reyes LM, Julian CG, Stickland MK, Chari RS, Khurana R, Davidge ST, Davenport MH.

J Physiol. 2019 Jul;597(14):3687-3696. doi: 10.1113/JP277714. Epub 2019 Jun 13.


Gaining Insight Into Ondansetron Safety in Early Pregnancy.

Lavecchia M, Chari R, Ross S.

J Obstet Gynaecol Can. 2019 Apr;41(4):419-420. doi: 10.1016/j.jogc.2019.01.001. Epub 2019 Jan 24. No abstract available.


Prenatal Exercise and Pre-gestational Diseases: A Systematic Review and Meta-analysis.

Adesegun D, Cai C, Sivak A, Chari R, Davenport MH.

J Obstet Gynaecol Can. 2019 Aug;41(8):1134-1143.e17. doi: 10.1016/j.jogc.2018.10.007. Epub 2018 Dec 28.


Injury and Illness Surveillance of U.S. Agricultural Workers: Assessment of Recommendations and Actions.

Chari R, Kress AM, Madrigano J.

Rand Health Q. 2018 Oct 11;8(2):10. eCollection 2018 Oct.


Canadian Stroke Best Practice Consensus Statement: Acute Stroke Management during pregnancy.

Ladhani NNN, Swartz RH, Foley N, Nerenberg K, Smith EE, Gubitz G, Dowlatshahi D, Potts J, Ray JG, Barrett J, Bushnell C, Bal S, Chan WS, Chari R, El Amrani M, Gandhi S, Hill MD, James A, Jeerakathil T, Jin A, Kirton A, Lanthier S, Lausman A, Leffert LR, Mandzia J, Menon B, Pikula A, Poppe A, Saposnik G, Sharma M, Bhogal S, Smitko E, Lindsay MP.

Int J Stroke. 2018 Oct;13(7):743-758. doi: 10.1177/1747493018786617. Epub 2018 Jul 18.


Fugitive Chemicals and Environmental Justice: A Model for Environmental Monitoring Following Climate-Related Disasters.

Madrigano J, Osorio JC, Bautista E, Chavez R, Chaisson CF, Meza E, Shih RA, Chari R.

Environ Justice. 2018 Jun 1;11(3):95-100. doi: 10.1089/env.2017.0044.


Regional Caesarean Delivery Practices, the Maternal-Infant Microbiome, and Risk for Asthma.

Entz R, Rai U, Rycroft J, Chari RS, Kozyrskyj AL.

J Obstet Gynaecol Can. 2018 Aug;40(8):1061-1065. doi: 10.1016/j.jogc.2018.01.025. Epub 2018 Jun 7. No abstract available.


Impact of maternal pre-pregnancy overweight on infant overweight at 1 year of age: associations and sex-specific differences.

Bridgman SL, Azad MB, Persaud RR, Chari RS, Becker AB, Sears MR, Mandhane PJ, Turvey SE, Subbarao P, Haqq AM, Kozyrskyj AL.

Pediatr Obes. 2018 Oct;13(10):579-589. doi: 10.1111/ijpo.12291. Epub 2018 May 25.


Ondansetron in Pregnancy and the Risk of Congenital Malformations: A Systematic Review.

Lavecchia M, Chari R, Campbell S, Ross S.

J Obstet Gynaecol Can. 2018 Jul;40(7):910-918. doi: 10.1016/j.jogc.2017.10.024. Epub 2018 May 10.


A CD123-targeting antibody-drug conjugate, IMGN632, designed to eradicate AML while sparing normal bone marrow cells.

Kovtun Y, Jones GE, Adams S, Harvey L, Audette CA, Wilhelm A, Bai C, Rui L, Laleau R, Liu F, Ab O, Setiady Y, Yoder NC, Goldmacher VS, Chari RVJ, Pinkas J, Chittenden T.

Blood Adv. 2018 Apr 24;2(8):848-858. doi: 10.1182/bloodadvances.2018017517.


Expanding the Paradigm of Occupational Safety and Health: A New Framework for Worker Well-Being.

Chari R, Chang CC, Sauter SL, Petrun Sayers EL, Cerully JL, Schulte P, Schill AL, Uscher-Pines L.

J Occup Environ Med. 2018 Jul;60(7):589-593. doi: 10.1097/JOM.0000000000001330.


Maternal Physical Activity Is Associated With Improved Blood Pressure Regulation During Late Pregnancy.

Sobierajski FM, Purdy GM, Usselman CW, Skow RJ, James MA, Chari RS, Khurana R, Stickland MK, Davidge ST, Devolin M, Steinback CD, Davenport MH.

Can J Cardiol. 2018 Apr;34(4):485-491. doi: 10.1016/j.cjca.2018.01.021. Epub 2018 Jan 31.


Practice guideline: joint CCMG-SOGC recommendations for the use of chromosomal microarray analysis for prenatal diagnosis and assessment of fetal loss in Canada.

Armour CM, Dougan SD, Brock JA, Chari R, Chodirker BN, DeBie I, Evans JA, Gibson WT, Kolomietz E, Nelson TN, Tihy F, Thomas MA, Stavropoulos DJ; On-Behalf-Of the Canadian College of Medical Geneticists.

J Med Genet. 2018 Apr;55(4):215-221. doi: 10.1136/jmedgenet-2017-105013. Epub 2018 Mar 1.


Roles of Birth Mode and Infant Gut Microbiota in Intergenerational Transmission of Overweight and Obesity From Mother to Offspring.

Tun HM, Bridgman SL, Chari R, Field CJ, Guttman DS, Becker AB, Mandhane PJ, Turvey SE, Subbarao P, Sears MR, Scott JA, Kozyrskyj AL; Canadian Healthy Infant Longitudinal Development (CHILD) Study Investigators.

JAMA Pediatr. 2018 Apr 1;172(4):368-377. doi: 10.1001/jamapediatrics.2017.5535.


A DNA-Interacting Payload Designed to Eliminate Cross-Linking Improves the Therapeutic Index of Antibody-Drug Conjugates (ADCs).

Miller ML, Shizuka M, Wilhelm A, Salomon P, Reid EE, Lanieri L, Sikka S, Maloney EK, Harvey L, Qiu Q, Archer KE, Bai C, Vitharana D, Harris L, Singh R, Ponte JF, Yoder NC, Kovtun Y, Lai KC, Ab O, Pinkas J, Keating TA, Chari RVJ.

Mol Cancer Ther. 2018 Mar;17(3):650-660. doi: 10.1158/1535-7163.MCT-17-0940. Epub 2018 Feb 13.


Perspectives of Immigrant Women on the Gender of Provider During Childbirth.

Aubrey C, Mumtaz Z, Patterson P, Chari R, Mitchell BFP.

J Obstet Gynaecol Can. 2018 Jun;40(6):677-683. doi: 10.1016/j.jogc.2017.09.022. Epub 2017 Dec 21.


Canadian stroke best practice consensus statement: Secondary stroke prevention during pregnancy.

Swartz RH, Ladhani NNN, Foley N, Nerenberg K, Bal S, Barrett J, Bushnell C, Chan WS, Chari R, Dowlatshahi D, Amrani ME, Gandhi S, Gubitz G, Hill MD, James A, Jeerakathil T, Jin A, Kirton A, Lanthier S, Lausman A, Leffert LR, Mandzia J, Menon B, Pikula A, Poppe A, Potts J, Ray J, Saposnik G, Sharma M, Smith EE, Bhogal S, Smitko E, Lindsay MP; Heart and Stroke Foundation Canadian Stroke Best Practice Advisory Committees.

Int J Stroke. 2018 Jun;13(4):406-419. doi: 10.1177/1747493017743801. Epub 2017 Nov 24.


Activity of muscle sympathetic neurons during normotensive pregnancy.

Schmidt SML, Usselman CW, Martinek E, Stickland MK, Julian CG, Chari R, Khurana R, Davidge ST, Davenport MH, Steinback CD.

Am J Physiol Regul Integr Comp Physiol. 2018 Feb 1;314(2):R153-R160. doi: 10.1152/ajpregu.00121.2016. Epub 2017 Oct 18.


Cesarean Section, Formula Feeding, and Infant Antibiotic Exposure: Separate and Combined Impacts on Gut Microbial Changes in Later Infancy.

Yasmin F, Tun HM, Konya TB, Guttman DS, Chari RS, Field CJ, Becker AB, Mandhane PJ, Turvey SE, Subbarao P, Sears MR; CHILD Study Investigators, Scott JA, Dinu I, Kozyrskyj AL.

Front Pediatr. 2017 Sep 26;5:200. doi: 10.3389/fped.2017.00200. eCollection 2017.


Family Integrated Care (FICare) in Level II Neonatal Intensive Care Units: study protocol for a cluster randomized controlled trial.

Benzies KM, Shah V, Aziz K, Isaranuwatchai W, Palacio-Derflingher L, Scotland J, Larocque J, Mrklas K, Suter E, Naugler C, Stelfox HT, Chari R, Lodha A; Alberta FICare Level II NICU Study Team.

Trials. 2017 Oct 10;18(1):467. doi: 10.1186/s13063-017-2181-3.


Governing Academic Medical Center Systems: Evaluating and Choosing Among Alternative Governance Approaches.

Chari R, O'Hanlon C, Chen P, Leuschner K, Nelson C.

Acad Med. 2018 Feb;93(2):192-198. doi: 10.1097/ACM.0000000000001903.


No 347-Prise en charge obstétricale près de la limite de viabilité du fœtus.

Ladhani NNN, Chari RS, Dunn MS, Jones G, Shah P, Barrett JFR.

J Obstet Gynaecol Can. 2017 Sep;39(9):792-804. doi: 10.1016/j.jogc.2017.06.011. French. No abstract available.


No. 347-Obstetric Management at Borderline Viability.

Ladhani NNN, Chari RS, Dunn MS, Jones G, Shah P, Barrett JFR.

J Obstet Gynaecol Can. 2017 Sep;39(9):781-791. doi: 10.1016/j.jogc.2017.03.108.


Beyond editing to writing large genomes.

Chari R, Church GM.

Nat Rev Genet. 2017 Dec;18(12):749-760. doi: 10.1038/nrg.2017.59. Epub 2017 Aug 30.


Muscle sympathetic nerve activity and volume-regulating factors in healthy pregnant and nonpregnant women.

Charkoudian N, Usselman CW, Skow RJ, Staab JS, Julian CG, Stickland MK, Chari RS, Khurana R, Davidge ST, Davenport MH, Steinback CD.

Am J Physiol Heart Circ Physiol. 2017 Oct 1;313(4):H782-H787. doi: 10.1152/ajpheart.00312.2017. Epub 2017 Jul 21.


Gender of Provider-Barrier to Immigrant Women's Obstetrical Care: A Narrative Review.

Aubrey C, Chari R, Mitchell BFP, Mumtaz Z.

J Obstet Gynaecol Can. 2017 Jul;39(7):567-577. doi: 10.1016/j.jogc.2017.01.013. Review.


Accommodating Immigrant Women's Preferences for Female Health Care Providers.

Aubrey C, Mumtaz Z, Patterson PB, Chari R, Mitchell BFP.

Obstet Gynecol. 2017 May;129(5):919-924. doi: 10.1097/AOG.0000000000001984.


Effects of Drug-Antibody Ratio on Pharmacokinetics, Biodistribution, Efficacy, and Tolerability of Antibody-Maytansinoid Conjugates.

Sun X, Ponte JF, Yoder NC, Laleau R, Coccia J, Lanieri L, Qiu Q, Wu R, Hong E, Bogalhas M, Wang L, Dong L, Setiady Y, Maloney EK, Ab O, Zhang X, Pinkas J, Keating TA, Chari R, Erickson HK, Lambert JM.

Bioconjug Chem. 2017 May 17;28(5):1371-1381. doi: 10.1021/acs.bioconjchem.7b00062. Epub 2017 Apr 13.


Exposure to household furry pets influences the gut microbiota of infant at 3-4 months following various birth scenarios.

Tun HM, Konya T, Takaro TK, Brook JR, Chari R, Field CJ, Guttman DS, Becker AB, Mandhane PJ, Turvey SE, Subbarao P, Sears MR, Scott JA, Kozyrskyj AL; CHILD Study Investigators.

Microbiome. 2017 Apr 6;5(1):40. doi: 10.1186/s40168-017-0254-x.


sgRNA Scorer 2.0: A Species-Independent Model To Predict CRISPR/Cas9 Activity.

Chari R, Yeo NC, Chavez A, Church GM.

ACS Synth Biol. 2017 May 19;6(5):902-904. doi: 10.1021/acssynbio.6b00343. Epub 2017 Feb 10.


Lignes directrices pour la prise en charge d'une patiente enceinte ayant subi un traumatisme.

Jain V, Chari R, Maslovitz S, Farine D.

J Obstet Gynaecol Can. 2016 Dec;38(12S):S665-S687. doi: 10.1016/j.jogc.2016.09.070. Epub 2017 Jan 4. No abstract available.


Expanding the Reach of Antibody-Drug Conjugates.

Chari RV.

ACS Med Chem Lett. 2016 Sep 15;7(11):974-976. eCollection 2016 Nov 10.


Post-Policy Implementation Review of Rapid Fetal Fibronectin (fFN) Testing for Preterm Labour in Alberta.

Chuck AW, Thanh NX, Chari RS, Wilson RD, Janes-Kelley S, Wesenberg JC.

J Obstet Gynaecol Can. 2016 Jul;38(7):659-666.e6. doi: 10.1016/j.jogc.2016.02.013. Epub 2016 May 12.


The Promise of Direct-to-Consumer Telehealth for Disaster Response and Recovery.

Uscher-Pines L, Fischer S, Chari R.

Prehosp Disaster Med. 2016 Aug;31(4):454-6. doi: 10.1017/S1049023X16000558. Epub 2016 May 24.


A New Class of Antibody-Drug Conjugates with Potent DNA Alkylating Activity.

Miller ML, Fishkin NE, Li W, Whiteman KR, Kovtun Y, Reid EE, Archer KE, Maloney EK, Audette CA, Mayo MF, Wilhelm A, Modafferi HA, Singh R, Pinkas J, Goldmacher V, Lambert JM, Chari RV.

Mol Cancer Ther. 2016 Aug;15(8):1870-8. doi: 10.1158/1535-7163.MCT-16-0184. Epub 2016 May 23.


Comparison of Cas9 activators in multiple species.

Chavez A, Tuttle M, Pruitt BW, Ewen-Campen B, Chari R, Ter-Ovanesyan D, Haque SJ, Cecchi RJ, Kowal EJK, Buchthal J, Housden BE, Perrimon N, Collins JJ, Church G.

Nat Methods. 2016 Jul;13(7):563-567. doi: 10.1038/nmeth.3871. Epub 2016 May 23.


A New Triglycyl Peptide Linker for Antibody-Drug Conjugates (ADCs) with Improved Targeted Killing of Cancer Cells.

Singh R, Setiady YY, Ponte J, Kovtun YV, Lai KC, Hong EE, Fishkin N, Dong L, Jones GE, Coccia JA, Lanieri L, Veale K, Costoplus JA, Skaletskaya A, Gabriel R, Salomon P, Wu R, Qiu Q, Erickson HK, Lambert JM, Chari RV, Widdison WC.

Mol Cancer Ther. 2016 Jun;15(6):1311-20. doi: 10.1158/1535-7163.MCT-16-0021. Epub 2016 Mar 29.


Understanding How the Stability of the Thiol-Maleimide Linkage Impacts the Pharmacokinetics of Lysine-Linked Antibody-Maytansinoid Conjugates.

Ponte JF, Sun X, Yoder NC, Fishkin N, Laleau R, Coccia J, Lanieri L, Bogalhas M, Wang L, Wilhelm S, Widdison W, Pinkas J, Keating TA, Chari R, Erickson HK, Lambert JM.

Bioconjug Chem. 2016 Jul 20;27(7):1588-98. doi: 10.1021/acs.bioconjchem.6b00117. Epub 2016 Jun 20.


Exercise During Pregnancy: Current Recommendations by Canadian Maternity Health Care Providers.

Schmidt SM, Chari R, Davenport MH.

J Obstet Gynaecol Can. 2016 Feb;38(2):177-8. doi: 10.1016/j.jogc.2015.12.012. Epub 2016 Feb 13. No abstract available.


A general strategy to construct small molecule biosensors in eukaryotes.

Feng J, Jester BW, Tinberg CE, Mandell DJ, Antunes MS, Chari R, Morey KJ, Rios X, Medford JI, Church GM, Fields S, Baker D.

Elife. 2015 Dec 29;4. pii: e10606. doi: 10.7554/eLife.10606.


Neutralizing antibodies against West Nile virus identified directly from human B cells by single-cell analysis and next generation sequencing.

Tsioris K, Gupta NT, Ogunniyi AO, Zimnisky RM, Qian F, Yao Y, Wang X, Stern JN, Chari R, Briggs AW, Clouser CR, Vigneault F, Church GM, Garcia MN, Murray KO, Montgomery RR, Kleinstein SH, Love JC.

Integr Biol (Camb). 2015 Dec;7(12):1587-97. doi: 10.1039/c5ib00169b. Epub 2015 Oct 20.


Youth Resilience Corps: An Innovative Model to Engage Youth in Building Disaster Resilience.

Acosta J, Towe V, Chandra A, Chari R.

Disaster Med Public Health Prep. 2016 Feb;10(1):47-50. doi: 10.1017/dmp.2015.132. Epub 2015 Oct 20.


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