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A high-grade glioma with SOS1 amplification.

Vidal B, Bryke C, Hsu N, Alterman R, Yeo AT, Charest A, Varma H.

Clin Neuropathol. 2019 Dec 16. doi: 10.5414/NP301182. [Epub ahead of print]


Phosphorylation of PD-1-Y248 is a marker of PD-1-mediated inhibitory function in human T cells.

Bardhan K, Aksoylar HI, Bourgeois TL, Strauss L, Weaver JD, Delcuze B, Charest A, Patsoukis N, Boussiotis VA.

Sci Rep. 2019 Nov 21;9(1):17252. doi: 10.1038/s41598-019-53463-0.


Characterization of plasma-derived protoporphyrin-IX-positive extracellular vesicles following 5-ALA use in patients with malignant glioma.

Jones PS, Yekula A, Lansbury E, Small JL, Ayinon C, Mordecai S, Hochberg FH, Tigges J, Delcuze B, Charest A, Ghiran I, Balaj L, Carter BS.

EBioMedicine. 2019 Oct;48:23-35. doi: 10.1016/j.ebiom.2019.09.025. Epub 2019 Oct 15.


Effects of regular-fat and low-fat dairy consumption on daytime ambulatory blood pressure and other cardiometabolic risk factors: a randomized controlled feeding trial.

Rancourt-Bouchard M, Gigleux I, Guay V, Charest A, Saint-Gelais D, Vuillemard JC, Lamarche B, Couture P.

Am J Clin Nutr. 2020 Jan 1;111(1):42-51. doi: 10.1093/ajcn/nqz251.


Physical and Molecular Landscapes of Mouse Glioma Extracellular Vesicles Define Heterogeneity.

Gyuris A, Navarrete-Perea J, Jo A, Cristea S, Zhou S, Fraser K, Wei Z, Krichevsky AM, Weissleder R, Lee H, Gygi SP, Charest A.

Cell Rep. 2019 Jun 25;27(13):3972-3987.e6. doi: 10.1016/j.celrep.2019.05.089.


The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research.

Das S; Extracellular RNA Communication Consortium, Ansel KM, Bitzer M, Breakefield XO, Charest A, Galas DJ, Gerstein MB, Gupta M, Milosavljevic A, McManus MT, Patel T, Raffai RL, Rozowsky J, Roth ME, Saugstad JA, Van Keuren-Jensen K, Weaver AM, Laurent LC.

Cell. 2019 Apr 4;177(2):231-242. doi: 10.1016/j.cell.2019.03.023. Review.


Chronic platelet-derived growth factor receptor signaling exerts control over initiation of protein translation in glioma.

Zhou S, Appleman VA, Rose CM, Jun HJ, Yang J, Zhou Y, Bronson RT, Gygi SP, Charest A.

Life Sci Alliance. 2018 Jun 19;1(3):e201800029. doi: 10.26508/lsa.201800029. eCollection 2018 Jun.


Comparing Interviewer-Administered and Web-Based Food Frequency Questionnaires to Predict Energy Requirements in Adults.

Brassard D, Lemieux S, Charest A, Lapointe A, Couture P, Labonté MÈ, Lamarche B.

Nutrients. 2018 Sep 12;10(9). pii: E1292. doi: 10.3390/nu10091292.


A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine.

Jun HJ, Appleman VA, Wu HJ, Rose CM, Pineda JJ, Yeo AT, Delcuze B, Lee C, Gyuris A, Zhu H, Woolfenden S, Bronisz A, Nakano I, Chiocca EA, Bronson RT, Ligon KL, Sarkaria JN, Gygi SP, Michor F, Mitchison TJ, Charest A.

Nat Commun. 2018 Aug 6;9(1):3116. doi: 10.1038/s41467-018-05036-4.


High-Dose DHA Has More Profound Effects on LDL-Related Features Than High-Dose EPA: The ComparED Study.

Allaire J, Vors C, Tremblay AJ, Marin J, Charest A, Tchernof A, Couture P, Lamarche B.

J Clin Endocrinol Metab. 2018 Aug 1;103(8):2909-2917. doi: 10.1210/jc.2017-02745.


Immunotherapies for malignant glioma.

Boussiotis VA, Charest A.

Oncogene. 2018 Mar;37(9):1121-1141. doi: 10.1038/s41388-017-0024-z. Epub 2017 Dec 15. Review.


Differential impact of the cheese matrix on the postprandial lipid response: a randomized, crossover, controlled trial.

Drouin-Chartier JP, Tremblay AJ, Maltais-Giguère J, Charest A, Guinot L, Rioux LE, Labrie S, Britten M, Lamarche B, Turgeon SL, Couture P.

Am J Clin Nutr. 2017 Dec;106(6):1358-1365. doi: 10.3945/ajcn.117.165027. Epub 2017 Oct 4.


Supplementation with high-dose docosahexaenoic acid increases the Omega-3 Index more than high-dose eicosapentaenoic acid.

Allaire J, Harris WS, Vors C, Charest A, Marin J, Jackson KH, Tchernof A, Couture P, Lamarche B.

Prostaglandins Leukot Essent Fatty Acids. 2017 May;120:8-14. doi: 10.1016/j.plefa.2017.03.008. Epub 2017 Mar 31.


Immune Checkpoint Blockade Biology in Mouse Models of Glioblastoma.

Yeo AT, Charest A.

J Cell Biochem. 2017 Sep;118(9):2516-2527. doi: 10.1002/jcb.25948. Epub 2017 May 3. Review.


Inflammatory gene expression in whole blood cells after EPA vs. DHA supplementation: Results from the ComparED study.

Vors C, Allaire J, Marin J, Lépine MC, Charest A, Tchernof A, Couture P, Lamarche B.

Atherosclerosis. 2017 Feb;257:116-122. doi: 10.1016/j.atherosclerosis.2017.01.025. Epub 2017 Jan 20.


A randomized, crossover, head-to-head comparison of eicosapentaenoic acid and docosahexaenoic acid supplementation to reduce inflammation markers in men and women: the Comparing EPA to DHA (ComparED) Study.

Allaire J, Couture P, Leclerc M, Charest A, Marin J, Lépine MC, Talbot D, Tchernof A, Lamarche B.

Am J Clin Nutr. 2016 Aug;104(2):280-7. doi: 10.3945/ajcn.116.131896. Epub 2016 Jun 8.


Extracellular Vesicles from High-Grade Glioma Exchange Diverse Pro-oncogenic Signals That Maintain Intratumoral Heterogeneity.

Ricklefs F, Mineo M, Rooj AK, Nakano I, Charest A, Weissleder R, Breakefield XO, Chiocca EA, Godlewski J, Bronisz A.

Cancer Res. 2016 May 15;76(10):2876-81. doi: 10.1158/0008-5472.CAN-15-3432. Epub 2016 Mar 24.


Global occurrence of Torque teno virus in water systems.

Charest AJ, Plummer JD, Long SC, Carducci A, Verani M, Sidhu JP.

J Water Health. 2015 Sep;13(3):777-89. doi: 10.2166/wh.2015.254.


Theory of Mind and Context Processing in Schizophrenia: The Role of Social Knowledge.

Champagne-Lavau M, Charest A.

Front Psychiatry. 2015 Jul 3;6:98. doi: 10.3389/fpsyt.2015.00098. eCollection 2015.


Focal therapy of neuroblastoma using silk films to deliver kinase and chemotherapeutic agents in vivo.

Seib FP, Coburn J, Konrad I, Klebanov N, Jones GT, Blackwood B, Charest A, Kaplan DL, Chiu B.

Acta Biomater. 2015 Jul;20:32-38. doi: 10.1016/j.actbio.2015.04.003. Epub 2015 Apr 8.


PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations.

Zou HY, Li Q, Engstrom LD, West M, Appleman V, Wong KA, McTigue M, Deng YL, Liu W, Brooun A, Timofeevski S, McDonnell SR, Jiang P, Falk MD, Lappin PB, Affolter T, Nichols T, Hu W, Lam J, Johnson TW, Smeal T, Charest A, Fantin VR.

Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3493-8. doi: 10.1073/pnas.1420785112. Epub 2015 Mar 2.


Impact of milk consumption on cardiometabolic risk in postmenopausal women with abdominal obesity.

Drouin-Chartier JP, Gagnon J, Labonté MÈ, Desroches S, Charest A, Grenier G, Dodin S, Lemieux S, Couture P, Lamarche B.

Nutr J. 2015 Jan 21;14:12. doi: 10.1186/1475-2891-14-12.


Oxido-reductive regulation of vascular remodeling by receptor tyrosine kinase ROS1.

Ali ZA, de Jesus Perez V, Yuan K, Orcholski M, Pan S, Qi W, Chopra G, Adams C, Kojima Y, Leeper NJ, Qu X, Zaleta-Rivera K, Kato K, Yamada Y, Oguri M, Kuchinsky A, Hazen SL, Jukema JW, Ganesh SK, Nabel EG, Channon K, Leon MB, Charest A, Quertermous T, Ashley EA.

J Clin Invest. 2014 Dec;124(12):5159-74. doi: 10.1172/JCI77484. Epub 2014 Nov 17.


Docosahexaenoic acid-enriched canola oil increases adiponectin concentrations: a randomized crossover controlled intervention trial.

Baril-Gravel L, Labonté ME, Couture P, Vohl MC, Charest A, Guay V, Jenkins DA, Connelly PW, West S, Kris-Etherton PM, Jones PJ, Fleming JA, Lamarche B.

Nutr Metab Cardiovasc Dis. 2015 Jan;25(1):52-9. doi: 10.1016/j.numecd.2014.08.003. Epub 2014 Aug 20.


Effect of sitagliptin therapy on triglyceride-rich lipoprotein kinetics in patients with type 2 diabetes.

Tremblay AJ, Lamarche B, Kelly I, Charest A, Lépine MC, Droit A, Couture P.

Diabetes Obes Metab. 2014 Dec;16(12):1223-9. doi: 10.1111/dom.12359. Epub 2014 Aug 19.


ROS1 signaling regulates epithelial differentiation in the epididymis.

Jun HJ, Roy J, Smith TB, Wood LB, Lane K, Woolfenden S, Punko D, Bronson RT, Haigis KM, Breton S, Charest A.

Endocrinology. 2014 Sep;155(9):3661-73. doi: 10.1210/en.2014-1341. Epub 2014 Jun 27.


Surgery combined with controlled-release doxorubicin silk films as a treatment strategy in an orthotopic neuroblastoma mouse model.

Chiu B, Coburn J, Pilichowska M, Holcroft C, Seib FP, Charest A, Kaplan DL.

Br J Cancer. 2014 Aug 12;111(4):708-15. doi: 10.1038/bjc.2014.324. Epub 2014 Jun 12.


DHA-enriched high-oleic acid canola oil improves lipid profile and lowers predicted cardiovascular disease risk in the canola oil multicenter randomized controlled trial.

Jones PJ, Senanayake VK, Pu S, Jenkins DJ, Connelly PW, Lamarche B, Couture P, Charest A, Baril-Gravel L, West SG, Liu X, Fleming JA, McCrea CE, Kris-Etherton PM.

Am J Clin Nutr. 2014 Jul;100(1):88-97. doi: 10.3945/ajcn.113.081133. Epub 2014 May 14.


Effect of Mediterranean diet with and without weight loss on apolipoprotein B100 metabolism in men with metabolic syndrome.

Richard C, Couture P, Ooi EM, Tremblay AJ, Desroches S, Charest A, Lichtenstein AH, Lamarche B.

Arterioscler Thromb Vasc Biol. 2014 Feb;34(2):433-8. doi: 10.1161/ATVBAHA.113.302185. Epub 2013 Nov 21.


Inhibition of EGFR induces a c-MET-driven stem cell population in glioblastoma.

Jun HJ, Bronson RT, Charest A.

Stem Cells. 2014 Feb;32(2):338-48. doi: 10.1002/stem.1554.


Short-term, high-fat diet increases the expression of key intestinal genes involved in lipoprotein metabolism in healthy men.

Tremblay AJ, Lamarche B, Guay V, Charest A, Lemelin V, Couture P.

Am J Clin Nutr. 2013 Jul;98(1):32-41. doi: 10.3945/ajcn.113.060251. Epub 2013 May 29.


Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy.

Shao H, Chung J, Balaj L, Charest A, Bigner DD, Carter BS, Hochberg FH, Breakefield XO, Weissleder R, Lee H.

Nat Med. 2012 Dec;18(12):1835-40. doi: 10.1038/nm.2994. Epub 2012 Nov 11.


Theory of mind and context processing in schizophrenia: the role of cognitive flexibility.

Champagne-Lavau M, Charest A, Anselmo K, Rodriguez JP, Blouin G.

Psychiatry Res. 2012 Dec 30;200(2-3):184-92. doi: 10.1016/j.psychres.2012.06.011. Epub 2012 Jul 4.


The oncogenic lung cancer fusion kinase CD74-ROS activates a novel invasiveness pathway through E-Syt1 phosphorylation.

Jun HJ, Johnson H, Bronson RT, de Feraudy S, White F, Charest A.

Cancer Res. 2012 Aug 1;72(15):3764-74. doi: 10.1158/0008-5472.CAN-11-3990. Epub 2012 Jun 1.


Infection and upregulation of proinflammatory cytokines in human brain vascular pericytes by human cytomegalovirus.

Alcendor DJ, Charest AM, Zhu WQ, Vigil HE, Knobel SM.

J Neuroinflammation. 2012 May 18;9:95. doi: 10.1186/1742-2094-9-95.


Randomized controlled study of the effect of a butter naturally enriched in trans fatty acids on blood lipids in healthy women.

Lacroix E, Charest A, Cyr A, Baril-Gravel L, Lebeuf Y, Paquin P, Chouinard PY, Couture P, Lamarche B.

Am J Clin Nutr. 2012 Feb;95(2):318-25. doi: 10.3945/ajcn.111.023408. Epub 2011 Dec 28.


Acquired MET expression confers resistance to EGFR inhibition in a mouse model of glioblastoma multiforme.

Jun HJ, Acquaviva J, Chi D, Lessard J, Zhu H, Woolfenden S, Bronson RT, Pfannl R, White F, Housman DE, Iyer L, Whittaker CA, Boskovitz A, Raval A, Charest A.

Oncogene. 2012 Jun 21;31(25):3039-50. doi: 10.1038/onc.2011.474. Epub 2011 Oct 24.


Chronic activation of wild-type epidermal growth factor receptor and loss of Cdkn2a cause mouse glioblastoma formation.

Acquaviva J, Jun HJ, Lessard J, Ruiz R, Zhu H, Donovan M, Woolfenden S, Boskovitz A, Raval A, Bronson RT, Pfannl R, Whittaker CA, Housman DE, Charest A.

Cancer Res. 2011 Dec 1;71(23):7198-206. doi: 10.1158/0008-5472.CAN-11-1514. Epub 2011 Oct 10.


Effect of short-term low- and high-fat diets on low-density lipoprotein particle size in normolipidemic subjects.

Guay V, Lamarche B, Charest A, Tremblay AJ, Couture P.

Metabolism. 2012 Jan;61(1):76-83. doi: 10.1016/j.metabol.2011.06.002. Epub 2011 Aug 3.


Report from the fifth National Cancer Institute Mouse Models of Human Cancers Consortium Nervous System Tumors Workshop.

Gutmann DH, Stiles CD, Lowe SW, Bollag GE, Furnari FB, Charest AL.

Neuro Oncol. 2011 Jul;13(7):692-9. doi: 10.1093/neuonc/nor080. Review.


Genetic modeling of gliomas in mice: new tools to tackle old problems.

Hambardzumyan D, Parada LF, Holland EC, Charest A.

Glia. 2011 Aug;59(8):1155-68. doi: 10.1002/glia.21142. Epub 2011 Feb 8. Review.


The novel Hsp90 inhibitor NXD30001 induces tumor regression in a genetically engineered mouse model of glioblastoma multiforme.

Zhu H, Woolfenden S, Bronson RT, Jaffer ZM, Barluenga S, Winssinger N, Rubenstein AE, Chen R, Charest A.

Mol Cancer Ther. 2010 Sep;9(9):2618-26. doi: 10.1158/1535-7163.MCT-10-0248. Epub 2010 Jul 19.


Effect of the Mediterranean diet with and without weight loss on cardiovascular risk factors in men with the metabolic syndrome.

Richard C, Couture P, Desroches S, Charest A, Lamarche B.

Nutr Metab Cardiovasc Dis. 2011 Sep;21(9):628-35. doi: 10.1016/j.numecd.2010.01.012. Epub 2010 Jun 2.


Functional delivery of siRNA in mice using dendriworms.

Agrawal A, Min DH, Singh N, Zhu H, Birjiniuk A, von Maltzahn G, Harris TJ, Xing D, Woolfenden SD, Sharp PA, Charest A, Bhatia S.

ACS Nano. 2009 Sep 22;3(9):2495-504. doi: 10.1021/nn900201e.


A Cre/LoxP conditional luciferase reporter transgenic mouse for bioluminescence monitoring of tumorigenesis.

Woolfenden S, Zhu H, Charest A.

Genesis. 2009 Oct;47(10):659-66. doi: 10.1002/dvg.20545.


Implantable diagnostic device for cancer monitoring.

Daniel KD, Kim GY, Vassiliou CC, Galindo M, Guimaraes AR, Weissleder R, Charest A, Langer R, Cima MJ.

Biosens Bioelectron. 2009 Jul 15;24(11):3252-7. doi: 10.1016/j.bios.2009.04.010. Epub 2009 Apr 16.


Epigenetic regulation of c-ROS receptor tyrosine kinase expression in malignant gliomas.

Jun HJ, Woolfenden S, Coven S, Lane K, Bronson R, Housman D, Charest A.

Cancer Res. 2009 Mar 15;69(6):2180-4. doi: 10.1158/0008-5472.CAN-08-3351. Epub 2009 Mar 10.


Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis.

Zhu H, Acquaviva J, Ramachandran P, Boskovitz A, Woolfenden S, Pfannl R, Bronson RT, Chen JW, Weissleder R, Housman DE, Charest A.

Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2712-6. doi: 10.1073/pnas.0813314106. Epub 2009 Feb 5.


The multifaceted roles of the receptor tyrosine kinase ROS in development and cancer.

Acquaviva J, Wong R, Charest A.

Biochim Biophys Acta. 2009 Jan;1795(1):37-52. doi: 10.1016/j.bbcan.2008.07.006. Epub 2008 Aug 3. Review.


mTORC1 promotes survival through translational control of Mcl-1.

Mills JR, Hippo Y, Robert F, Chen SM, Malina A, Lin CJ, Trojahn U, Wendel HG, Charest A, Bronson RT, Kogan SC, Nadon R, Housman DE, Lowe SW, Pelletier J.

Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10853-8. doi: 10.1073/pnas.0804821105. Epub 2008 Jul 29.

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