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Items: 1 to 50 of 84

1.

SVM recursive feature elimination analyses of structural brain MRI predicts near-term relapses in patients with clinically isolated syndromes suggestive of multiple sclerosis.

Wottschel V, Chard DT, Enzinger C, Filippi M, Frederiksen JL, Gasperini C, Giorgio A, Rocca MA, Rovira A, De Stefano N, Tintoré M, Alexander DC, Barkhof F, Ciccarelli O; MAGNIMS study group and the EuroPOND consortium.

Neuroimage Clin. 2019 Oct 22;24:102011. doi: 10.1016/j.nicl.2019.102011. [Epub ahead of print]

2.

A 30-Year Clinical and Magnetic Resonance Imaging Observational Study of Multiple Sclerosis and Clinically Isolated Syndromes.

Chung KK, Altmann D, Barkhof F, Miszkiel K, Brex PA, O'Riordan J, Ebner M, Prados F, Cardoso MJ, Vercauteren T, Ourselin S, Thompson A, Ciccarelli O, Chard DT.

Ann Neurol. 2019 Nov 6. doi: 10.1002/ana.25637. [Epub ahead of print]

PMID:
31693200
3.

An asymptomatic new lesion on MRI is a relapse and should be treated accordingly - No.

Chard DT, Trip SA.

Mult Scler. 2019 Dec;25(14):1843-1845. doi: 10.1177/1352458519845111. Epub 2019 Nov 1. No abstract available.

PMID:
31674874
4.

Periventricular magnetisation transfer ratio abnormalities in multiple sclerosis improve after alemtuzumab.

Brown JWL, Prados Carrasco F, Eshaghi A, Sudre CH, Button T, Pardini M, Samson RS, Ourselin S, Wheeler-Kingshott CAG, Jones JL, Coles AJ, Chard DT.

Mult Scler. 2019 Jun 6:1352458519852093. doi: 10.1177/1352458519852093. [Epub ahead of print]

PMID:
31169059
5.

Magnetisation transfer ratio abnormalities in primary and secondary progressive multiple sclerosis.

Brown JWL, Chowdhury A, Kanber B, Prados Carrasco F, Eshaghi A, Sudre CH, Pardini M, Samson RS, van de Pavert SH, Wheeler-Kingshott CG, Chard DT.

Mult Scler. 2019 Apr 8:1352458519841810. doi: 10.1177/1352458519841810. [Epub ahead of print]

PMID:
30957691
6.

Structural network disruption markers explain disability in multiple sclerosis.

Charalambous T, Tur C, Prados F, Kanber B, Chard DT, Ourselin S, Clayden JD, A M Gandini Wheeler-Kingshott C, Thompson AJ, Toosy AT.

J Neurol Neurosurg Psychiatry. 2019 Feb;90(2):219-226. doi: 10.1136/jnnp-2018-318440. Epub 2018 Nov 22.

7.

New MS diagnostic criteria in practice.

De Angelis F, Brownlee WJ, Chard DT, Trip SA.

Pract Neurol. 2019 Feb;19(1):64-67. doi: 10.1136/practneurol-2018-001945. Epub 2018 Sep 22. No abstract available.

PMID:
30244196
8.

Commentary on Al Hussona et al. 'New-onset seizures as a sole clinical presentation of multiple sclerosis'.

Chard DT.

Mult Scler. 2019 Feb;25(2):298-299. doi: 10.1177/1352458518781978. Epub 2018 Jun 19.

PMID:
29916300
9.

Response to the commentary of Yates RL and DeLuca GC on the study: HLA-DRB1*1501 associations with magnetic resonance imaging measures of grey matter pathology in multiple sclerosis.

Yaldizli Ö, Sethi V, Pardini M, Tur C, Mok KY, Muhlert N, Liu Z, Samson RS, Wheeler-Kingshott CAM, Yousry TA, Houlden H, Hardy J, Miller DH, Chard DT.

Mult Scler Relat Disord. 2018 Jan;19:168-170. doi: 10.1016/j.msard.2016.08.006. Epub 2016 Aug 12. No abstract available.

PMID:
29409599
10.

Commentary on: Neuromyelitis optica spectrum disorder related tonic spams responsive to lacosamide - Authors reply.

Brownlee WJ, Baheerathan A, Rugg-Gunn F, Chard DT, Trip SA.

Mult Scler Relat Disord. 2017 Oct;17:146-147. doi: 10.1016/j.msard.2017.07.021. Epub 2017 Jul 24. No abstract available.

PMID:
29055447
11.

Volumetric reconstruction from printed films: Enabling 30 year longitudinal analysis in MR neuroimaging.

Ebner M, Chung KK, Prados F, Cardoso MJ, Chard DT, Vercauteren T, Ourselin S.

Neuroimage. 2018 Jan 15;165:238-250. doi: 10.1016/j.neuroimage.2017.09.056. Epub 2017 Oct 7.

12.

Neuromyelitis optica spectrum disorder related tonic spasms responsive to lacosamide.

Baheerathan A, Brownlee WJ, Rugg-Gunn F, Chard DT, Trip SA.

Mult Scler Relat Disord. 2017 Apr;13:73-74. doi: 10.1016/j.msard.2017.02.009. Epub 2017 Feb 14.

PMID:
28427706
13.

Antecedent anti-NMDA receptor encephalitis in two patients with multiple sclerosis.

Baheerathan A, Brownlee WJ, Chard DT, Shields K, Gregory R, Trip SA.

Mult Scler Relat Disord. 2017 Feb;12:20-22. doi: 10.1016/j.msard.2016.12.009. Epub 2016 Dec 29.

PMID:
28283100
14.

An abnormal periventricular magnetization transfer ratio gradient occurs early in multiple sclerosis.

Brown JW, Pardini M, Brownlee WJ, Fernando K, Samson RS, Prados Carrasco F, Ourselin S, Gandini Wheeler-Kingshott CA, Miller DH, Chard DT.

Brain. 2017 Feb;140(2):387-398. doi: 10.1093/brain/aww296. Epub 2017 Jan 2.

15.

Relationship of grey and white matter abnormalities with distance from the surface of the brain in multiple sclerosis.

Pardini M, Sudre CH, Prados F, Yaldizli Ö, Sethi V, Muhlert N, Samson RS, van de Pavert SH, Cardoso MJ, Ourselin S, Gandini Wheeler-Kingshott CA, Miller DH, Chard DT.

J Neurol Neurosurg Psychiatry. 2016 Nov;87(11):1212-1217. doi: 10.1136/jnnp-2016-313979. Epub 2016 Sep 6.

PMID:
27601434
16.

Visualization of cortical MS lesions with MRI need not be further improved - YES.

Geurts JJ, Chard DT.

Mult Scler. 2017 Jan;23(1):15-17. doi: 10.1177/1352458516665498. Epub 2016 Sep 28. No abstract available.

PMID:
27566450
17.

HLA-DRB*1501 associations with magnetic resonance imaging measures of grey matter pathology in multiple sclerosis.

Yaldizli Ö, Sethi V, Pardini M, Tur C, Mok KY, Muhlert N, Liu Z, Samson RS, Wheeler-Kingshott CA, Yousry TA, Houlden H, Hardy J, Miller DH, Chard DT.

Mult Scler Relat Disord. 2016 May;7:47-52. doi: 10.1016/j.msard.2016.03.003. Epub 2016 Mar 7.

PMID:
27237756
18.

What lies beneath grey matter atrophy in multiple sclerosis?

Chard DT, Miller DH.

Brain. 2016 Jan;139(Pt 1):7-10. doi: 10.1093/brain/awv354. No abstract available.

PMID:
26747854
19.

The association between olfactory bulb volume, cognitive dysfunction, physical disability and depression in multiple sclerosis.

Yaldizli Ö, Penner IK, Yonekawa T, Naegelin Y, Kuhle J, Pardini M, Chard DT, Stippich C, Kira JI, Bendfeldt K, Amann M, Radue EW, Kappos L, Sprenger T.

Eur J Neurol. 2016 Mar;23(3):510-9. doi: 10.1111/ene.12891. Epub 2015 Nov 19.

PMID:
26699999
20.

The role of MRI in the evaluation of secondary progressive multiple sclerosis.

Brown JW, Chard DT.

Expert Rev Neurother. 2016;16(2):157-71. doi: 10.1586/14737175.2016.1134323. Epub 2016 Jan 22. Review. Erratum in: Expert Rev Neurother. 2016;16(4):463.

PMID:
26692498
21.

Motor network efficiency and disability in multiple sclerosis.

Pardini M, Yaldizli Ö, Sethi V, Muhlert N, Liu Z, Samson RS, Altmann DR, Ron MA, Wheeler-Kingshott CA, Miller DH, Chard DT.

Neurology. 2015 Sep 29;85(13):1115-22. doi: 10.1212/WNL.0000000000001970. Epub 2015 Aug 28.

22.

A longitudinal study of cortical grey matter lesion subtypes in relapse-onset multiple sclerosis.

Sethi V, Yousry T, Muhlert N, Tozer DJ, Altmann D, Ron M, Wheeler-Kingshott C, Miller DH, Chard DT.

J Neurol Neurosurg Psychiatry. 2016 Jul;87(7):750-3. doi: 10.1136/jnnp-2015-311102. Epub 2015 Aug 13.

23.

Characteristics of lesional and extra-lesional cortical grey matter in relapsing-remitting and secondary progressive multiple sclerosis: A magnetisation transfer and diffusion tensor imaging study.

Yaldizli Ö, Pardini M, Sethi V, Muhlert N, Liu Z, Tozer DJ, Samson RS, Wheeler-Kingshott CA, Yousry TA, Miller DH, Chard DT.

Mult Scler. 2016 Feb;22(2):150-9. doi: 10.1177/1352458515586085. Epub 2015 May 26.

PMID:
26014608
24.

DIR-visible grey matter lesions and atrophy in multiple sclerosis: partners in crime?

van de Pavert SH, Muhlert N, Sethi V, Wheeler-Kingshott CA, Ridgway GR, Geurts JJ, Ron M, Yousry TA, Thompson AJ, Miller DH, Chard DT, Ciccarelli O.

J Neurol Neurosurg Psychiatry. 2016 May;87(5):461-7. doi: 10.1136/jnnp-2014-310142. Epub 2015 Apr 29.

25.

Magnetization transfer ratio measures in normal-appearing white matter show periventricular gradient abnormalities in multiple sclerosis.

Liu Z, Pardini M, Yaldizli Ö, Sethi V, Muhlert N, Wheeler-Kingshott CA, Samson RS, Miller DH, Chard DT.

Brain. 2015 May;138(Pt 5):1239-46. doi: 10.1093/brain/awv065. Epub 2015 Mar 29.

26.

Cervical cord area measurement using volumetric brain magnetic resonance imaging in multiple sclerosis.

Liu Z, Yaldizli Ö, Pardini M, Sethi V, Kearney H, Muhlert N, Wheeler-Kingshott C, Miller DH, Chard DT.

Mult Scler Relat Disord. 2015 Jan;4(1):52-7. doi: 10.1016/j.msard.2014.11.004. Epub 2014 Nov 18.

PMID:
25787053
27.

Paradoxes in thalamic function and cognition in people with multiple sclerosis: less is more.

Chard DT, Benedict RH.

Neurology. 2015 Feb 24;84(8):764-5. doi: 10.1212/WNL.0000000000001293. Epub 2015 Jan 23. No abstract available.

PMID:
25616482
28.

Predicting outcome in clinically isolated syndrome using machine learning.

Wottschel V, Alexander DC, Kwok PP, Chard DT, Stromillo ML, De Stefano N, Thompson AJ, Miller DH, Ciccarelli O.

Neuroimage Clin. 2014 Dec 4;7:281-7. doi: 10.1016/j.nicl.2014.11.021. eCollection 2015.

29.

Regional patterns of grey matter atrophy and magnetisation transfer ratio abnormalities in multiple sclerosis clinical subgroups: a voxel-based analysis study.

Mallik S, Muhlert N, Samson RS, Sethi V, Wheeler-Kingshott CA, Miller DH, Chard DT.

Mult Scler. 2015 Apr;21(4):423-32. doi: 10.1177/1352458514546513. Epub 2014 Aug 21.

30.

Accurate GM atrophy quantification in MS using lesion-filling with co-registered 2D lesion masks.

Popescu V, Ran NC, Barkhof F, Chard DT, Wheeler-Kingshott CA, Vrenken H.

Neuroimage Clin. 2014 Jan 18;4:366-73. doi: 10.1016/j.nicl.2014.01.004. eCollection 2014.

31.

Investigation of outer cortical magnetisation transfer ratio abnormalities in multiple sclerosis clinical subgroups.

Samson RS, Cardoso MJ, Muhlert N, Sethi V, Wheeler-Kingshott CA, Ron M, Ourselin S, Miller DH, Chard DT.

Mult Scler. 2014 Sep;20(10):1322-30. doi: 10.1177/1352458514522537. Epub 2014 Feb 19.

PMID:
24552746
32.

MS cortical lesions on DIR: not quite what they seem?

Sethi V, Muhlert N, Ron M, Golay X, Wheeler-Kingshott CA, Miller DH, Chard DT, Yousry TA.

PLoS One. 2013 Nov 11;8(11):e78879. doi: 10.1371/journal.pone.0078879. eCollection 2013.

33.

Magnetic resonance imaging correlates of physical disability in relapse onset multiple sclerosis of long disease duration.

Kearney H, Rocca MA, Valsasina P, Balk L, Sastre-Garriga J, Reinhardt J, Ruggieri S, Rovira A, Stippich C, Kappos L, Sprenger T, Tortorella P, Rovaris M, Gasperini C, Montalban X, Geurts JJ, Polman CH, Barkhof F, Filippi M, Altmann DR, Ciccarelli O, Miller DH, Chard DT.

Mult Scler. 2014 Jan;20(1):72-80. doi: 10.1177/1352458513492245. Epub 2013 Jun 27.

34.

Sulcal and gyral crown cortical grey matter involvement in multiple sclerosis: A magnetisation transfer ratio study.

Samson RS, Muhlert N, Sethi V, Wheeler-Kingshott CA, Ron MA, Miller DH, Chard DT.

Mult Scler Relat Disord. 2013 Jul;2(3):204-12. doi: 10.1016/j.msard.2013.01.001. Epub 2013 Feb 13.

PMID:
25877727
35.

Brain atrophy and lesion load predict long term disability in multiple sclerosis.

Popescu V, Agosta F, Hulst HE, Sluimer IC, Knol DL, Sormani MP, Enzinger C, Ropele S, Alonso J, Sastre-Garriga J, Rovira A, Montalban X, Bodini B, Ciccarelli O, Khaleeli Z, Chard DT, Matthews L, Palace J, Giorgio A, De Stefano N, Eisele P, Gass A, Polman CH, Uitdehaag BM, Messina MJ, Comi G, Filippi M, Barkhof F, Vrenken H; MAGNIMS Study Group.

J Neurol Neurosurg Psychiatry. 2013 Oct;84(10):1082-91. doi: 10.1136/jnnp-2012-304094. Epub 2013 Mar 23.

PMID:
23524331
36.

Diffusion MRI-based cortical complexity alterations associated with executive function in multiple sclerosis.

Muhlert N, Sethi V, Schneider T, Daga P, Cipolotti L, Haroon HA, Parker GJ, Ourselin S, Wheeler-Kingshott CA, Miller DH, Ron MA, Chard DT.

J Magn Reson Imaging. 2013 Jul;38(1):54-63. doi: 10.1002/jmri.23970. Epub 2012 Dec 12.

PMID:
23238865
37.

ADvanced IMage Algebra (ADIMA): a novel method for depicting multiple sclerosis lesion heterogeneity, as demonstrated by quantitative MRI.

Yiannakas MC, Tozer DJ, Schmierer K, Chard DT, Anderson VM, Altmann DR, Miller DH, Wheeler-Kingshott CA.

Mult Scler. 2013 May;19(6):732-41. doi: 10.1177/1352458512462074. Epub 2012 Oct 4.

38.

Feasibility of grey matter and white matter segmentation of the upper cervical cord in vivo: a pilot study with application to magnetisation transfer measurements.

Yiannakas MC, Kearney H, Samson RS, Chard DT, Ciccarelli O, Miller DH, Wheeler-Kingshott CA.

Neuroimage. 2012 Nov 15;63(3):1054-9. doi: 10.1016/j.neuroimage.2012.07.048. Epub 2012 Jul 28.

PMID:
22850571
39.

Improved detection of cortical MS lesions with phase-sensitive inversion recovery MRI.

Sethi V, Yousry TA, Muhlert N, Ron M, Golay X, Wheeler-Kingshott C, Miller DH, Chard DT.

J Neurol Neurosurg Psychiatry. 2012 Sep;83(9):877-82. doi: 10.1136/jnnp-2012-303023. Epub 2012 Jul 17.

PMID:
22807559
40.

Advances in imaging to support the development of novel therapies for multiple sclerosis.

Miller DH, Altmann DR, Chard DT.

Clin Pharmacol Ther. 2012 Apr;91(4):621-34. doi: 10.1038/clpt.2011.349. Epub 2012 Mar 7. Review.

PMID:
22398971
41.

Clinically isolated syndromes.

Miller DH, Chard DT, Ciccarelli O.

Lancet Neurol. 2012 Feb;11(2):157-69. doi: 10.1016/S1474-4422(11)70274-5. Review.

PMID:
22265211
42.

Linking white matter tracts to associated cortical grey matter: a tract extension methodology.

Tozer DJ, Chard DT, Bodini B, Ciccarelli O, Miller DH, Thompson AJ, Wheeler-Kingshott CA.

Neuroimage. 2012 Feb 15;59(4):3094-102. doi: 10.1016/j.neuroimage.2011.10.088. Epub 2011 Nov 4.

PMID:
22100664
43.

Brain lesion location and clinical status 20 years after a diagnosis of clinically isolated syndrome suggestive of multiple sclerosis.

Dalton CM, Bodini B, Samson RS, Battaglini M, Fisniku LK, Thompson AJ, Ciccarelli O, Miller DH, Chard DT.

Mult Scler. 2012 Mar;18(3):322-8. doi: 10.1177/1352458511420269. Epub 2011 Aug 30.

PMID:
21878451
44.

Predicting the development of multiple sclerosis: is gray matter a missing piece of the puzzle?

Chard DT, Geurts JJ.

Neurology. 2011 Jul 19;77(3):210-1. doi: 10.1212/WNL.0b013e318220ac31. Epub 2011 May 25. No abstract available.

PMID:
21613598
45.

Consensus recommendations for MS cortical lesion scoring using double inversion recovery MRI.

Geurts JJ, Roosendaal SD, Calabrese M, Ciccarelli O, Agosta F, Chard DT, Gass A, Huerga E, Moraal B, Pareto D, Rocca MA, Wattjes MP, Yousry TA, Uitdehaag BM, Barkhof F; MAGNIMS Study Group.

Neurology. 2011 Feb 1;76(5):418-24. doi: 10.1212/WNL.0b013e31820a0cc4. Epub 2011 Jan 5.

PMID:
21209373
46.

Cervical cord and brain grey matter atrophy independently associate with long-term MS disability.

Bonati U, Fisniku LK, Altmann DR, Yiannakas MC, Furby J, Thompson AJ, Miller DH, Chard DT.

J Neurol Neurosurg Psychiatry. 2011 Apr;82(4):471-2. doi: 10.1136/jnnp.2010.205021. Epub 2010 Aug 14. No abstract available.

PMID:
20710012
47.

Reducing the impact of white matter lesions on automated measures of brain gray and white matter volumes.

Chard DT, Jackson JS, Miller DH, Wheeler-Kingshott CA.

J Magn Reson Imaging. 2010 Jul;32(1):223-8. doi: 10.1002/jmri.22214.

PMID:
20575080
48.

MRI only conversion to multiple sclerosis following a clinically isolated syndrome.

Chard DT, Dalton CM, Swanton J, Fisniku LK, Miszkiel KA, Thompson AJ, Plant GT, Miller DH.

J Neurol Neurosurg Psychiatry. 2011 Feb;82(2):176-9. doi: 10.1136/jnnp.2010.208660. Epub 2010 Jun 2.

PMID:
20519235
49.

TI-relaxation time changes over five years in relapsing-remitting multiple sclerosis.

Papadopoulos K, Tozer DJ, Fisniku L, Altmann DR, Davies G, Rashid W, Thompson AJ, Miller DH, Chard DT.

Mult Scler. 2010 Apr;16(4):427-33. doi: 10.1177/1352458509359924. Epub 2010 Jan 19.

PMID:
20086026
50.

What you see depends on how you look: Gray matter lesions in multiple sclerosis.

Chard DT, Miller DH.

Neurology. 2009 Sep 22;73(12):918-9. doi: 10.1212/WNL.0b013e3181b99a1e. Epub 2009 Aug 19. No abstract available.

PMID:
19692676

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