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Caught between a "Rho" and a hard place: are CCN1/CYR61 and CCN2/CTGF the arbiters of microvascular stiffness?

Chaqour B.

J Cell Commun Signal. 2019 Aug 2. doi: 10.1007/s12079-019-00529-3. [Epub ahead of print] Review.


CCN1-Yes-Associated Protein Feedback Loop Regulates Physiological and Pathological Angiogenesis.

Lee S, Ahad A, Luu M, Moon S, Caesar J, Cardoso WV, Grant MB, Chaqour B.

Mol Cell Biol. 2019 Aug 27;39(18). pii: e00107-19. doi: 10.1128/MCB.00107-19. Print 2019 Sep 15.


Abscisic acid - an anti-angiogenic phytohormone that modulates the phenotypical plasticity of endothelial cells and macrophages.

Chaqour J, Lee S, Ravichandra A, Chaqour B.

J Cell Sci. 2018 Feb 2;131(3). pii: jcs210492. doi: 10.1242/jcs.210492.


Interplay between CCN1 and Wnt5a in endothelial cells and pericytes determines the angiogenic outcome in a model of ischemic retinopathy.

Lee S, Elaskandrany M, Lau LF, Lazzaro D, Grant MB, Chaqour B.

Sci Rep. 2017 May 3;7(1):1405. doi: 10.1038/s41598-017-01585-8.


Analysis of CCN Protein Expression and Activities in Vasoproliferative Retinopathies.

Lee S, Elaskandrany M, Ahad A, Chaqour B.

Methods Mol Biol. 2017;1489:543-556.


Per2-Mediated Vascular Dysfunction Is Caused by the Upregulation of the Connective Tissue Growth Factor (CTGF).

Jadhav V, Luo Q, M Dominguez J 2nd, Al-Sabah J, Chaqour B, Grant MB, Bhatwadekar AD.

PLoS One. 2016 Sep 23;11(9):e0163367. doi: 10.1371/journal.pone.0163367. eCollection 2016.


Regulating the regulators of angiogenesis by CCN1 and taking it up a Notch.

Chaqour B.

J Cell Commun Signal. 2016 Sep;10(3):259-261. Epub 2016 May 4.


miR-92a Corrects CD34+ Cell Dysfunction in Diabetes by Modulating Core Circadian Genes Involved in Progenitor Differentiation.

Bhatwadekar AD, Yan Y, Stepps V, Hazra S, Korah M, Bartelmez S, Chaqour B, Grant MB.

Diabetes. 2015 Dec;64(12):4226-37. doi: 10.2337/db15-0521. Epub 2015 Aug 17.


Single and Compound Knock-outs of MicroRNA (miRNA)-155 and Its Angiogenic Gene Target CCN1 in Mice Alter Vascular and Neovascular Growth in the Retina via Resident Microglia.

Yan L, Lee S, Lazzaro DR, Aranda J, Grant MB, Chaqour B.

J Biol Chem. 2015 Sep 18;290(38):23264-81. doi: 10.1074/jbc.M115.646950. Epub 2015 Aug 4.


The matricellular protein CCN1 controls retinal angiogenesis by targeting VEGF, Src homology 2 domain phosphatase-1 and Notch signaling.

Chintala H, Krupska I, Yan L, Lau L, Grant M, Chaqour B.

Development. 2015 Jul 1;142(13):2364-74. doi: 10.1242/dev.121913. Epub 2015 May 22.


MicroRNA signature and function in retinal neovascularization.

Agrawal S, Chaqour B.

World J Biol Chem. 2014 Feb 26;5(1):1-11. doi: 10.4331/wjbc.v5.i1.1. Review.


Degradome products of the matricellular protein CCN1 as modulators of pathological angiogenesis in the retina.

Choi J, Lin A, Shrier E, Lau LF, Grant MB, Chaqour B.

J Biol Chem. 2013 Aug 9;288(32):23075-89. doi: 10.1074/jbc.M113.475418. Epub 2013 Jun 24.


Cysteine-rich protein 61 (CCN1) and connective tissue growth factor (CCN2) at the crosshairs of ocular neovascular and fibrovascular disease therapy.

Yan L, Chaqour B.

J Cell Commun Signal. 2013 Dec;7(4):253-63. doi: 10.1007/s12079-013-0206-6. Epub 2013 Jun 7.


Connective tissue growth factor regulates retinal neovascularization through p53 protein-dependent transactivation of the matrix metalloproteinase (MMP)-2 gene.

Chintala H, Liu H, Parmar R, Kamalska M, Kim YJ, Lovett D, Grant MB, Chaqour B.

J Biol Chem. 2012 Nov 23;287(48):40570-85. doi: 10.1074/jbc.M112.386565. Epub 2012 Oct 9.


HEXIM1 controls satellite cell expansion after injury to regulate skeletal muscle regeneration.

Hong P, Chen K, Huang B, Liu M, Cui M, Rozenberg I, Chaqour B, Pan X, Barton ER, Jiang XC, Siddiqui MA.

J Clin Invest. 2012 Nov;122(11):3873-87.


The matricellular protein cysteine-rich protein 61 (CCN1/Cyr61) enhances physiological adaptation of retinal vessels and reduces pathological neovascularization associated with ischemic retinopathy.

Hasan A, Pokeza N, Shaw L, Lee HS, Lazzaro D, Chintala H, Rosenbaum D, Grant MB, Chaqour B.

J Biol Chem. 2011 Mar 18;286(11):9542-54. doi: 10.1074/jbc.M110.198689. Epub 2011 Jan 6.


Selective blockade of cytoskeletal actin remodeling reduces experimental choroidal neovascularization.

Caballero S, Yang R, Grant MB, Chaqour B.

Invest Ophthalmol Vis Sci. 2011 Apr 16;52(5):2490-6. doi: 10.1167/iovs.10-6351. Print 2011 Apr.


Mechanical regulation of the proangiogenic factor CCN1/CYR61 gene requires the combined activities of MRTF-A and CREB-binding protein histone acetyltransferase.

Hanna M, Liu H, Amir J, Sun Y, Morris SW, Siddiqui MA, Lau LF, Chaqour B.

J Biol Chem. 2009 Aug 21;284(34):23125-36. doi: 10.1074/jbc.M109.019059. Epub 2009 Jun 20.


Positive transcription elongation factor b activity in compensatory myocardial hypertrophy is regulated by cardiac lineage protein-1.

Espinoza-Derout J, Wagner M, Salciccioli L, Lazar JM, Bhaduri S, Mascareno E, Chaqour B, Siddiqui MA.

Circ Res. 2009 Jun 19;104(12):1347-54. doi: 10.1161/CIRCRESAHA.108.191726. Epub 2009 May 14.


Mechanical strain activates a program of genes functionally involved in paracrine signaling of angiogenesis.

Yang R, Amir J, Liu H, Chaqour B.

Physiol Genomics. 2008 Dec 12;36(1):1-14. doi: 10.1152/physiolgenomics.90291.2008. Epub 2008 Oct 14.


Cysteine-rich protein 61 and connective tissue growth factor induce deadhesion and anoikis of retinal pericytes.

Liu H, Yang R, Tinner B, Choudhry A, Schutze N, Chaqour B.

Endocrinology. 2008 Apr;149(4):1666-77. doi: 10.1210/en.2007-1415. Epub 2008 Jan 10.


Effect of fibroblast growth factor-1 on the expression of early growth response-1 in human periodontal ligament cells.

Tamura I, Chaqour B, Howard PS, Ikeo T, Macarak EJ.

J Periodontal Res. 2008 Jun;43(3):305-10. doi: 10.1111/j.1600-0765.2007.01030.x. Epub 2007 Dec 21.


Pivotal role of cardiac lineage protein-1 (CLP-1) in transcriptional elongation factor P-TEFb complex formation in cardiac hypertrophy.

Espinoza-Derout J, Wagner M, Shahmiri K, Mascareno E, Chaqour B, Siddiqui MA.

Cardiovasc Res. 2007 Jul 1;75(1):129-38. Epub 2007 Mar 28.


Matrix metalloproteinase-2 expression and apoptogenic activity in retinal pericytes: implications in diabetic retinopathy.

Yang R, Liu H, Williams I, Chaqour B.

Ann N Y Acad Sci. 2007 Apr;1103:196-201. Epub 2007 Mar 1.


Forkhead transcription factor FOXO3a is a negative regulator of angiogenic immediate early gene CYR61, leading to inhibition of vascular smooth muscle cell proliferation and neointimal hyperplasia.

Lee HY, Chung JW, Youn SW, Kim JY, Park KW, Koo BK, Oh BH, Park YB, Chaqour B, Walsh K, Kim HS.

Circ Res. 2007 Feb 16;100(3):372-80. Epub 2007 Jan 18. Erratum in: Circ Res. 2007 Jul 6;101(1):e1..


Mechanical regulation of the Cyr61/CCN1 and CTGF/CCN2 proteins.

Chaqour B, Goppelt-Struebe M.

FEBS J. 2006 Aug;273(16):3639-49. Epub 2006 Jul 19. Review.


Molecular response of the bladder to obstruction.

Kirsch AJ, Macarak EJ, Chaqour B, Quinn T, Zderic S, Flake A, Crombleholme T, Adzick NS, Canning D, Hubbard AM, Rosenbloom J, Snyder HM, Howard PS.

Adv Exp Med Biol. 2003;539(Pt A):195-216. No abstract available.


Regulation of Cyr61/CCN1 gene expression through RhoA GTPase and p38MAPK signaling pathways.

Han JS, Macarak E, Rosenbloom J, Chung KC, Chaqour B.

Eur J Biochem. 2003 Aug;270(16):3408-21.


Expression of angiogenic factor Cyr61 during neuronal cell death via the activation of c-Jun N-terminal kinase and serum response factor.

Kim KH, Min YK, Baik JH, Lau LF, Chaqour B, Chung KC.

J Biol Chem. 2003 Apr 18;278(16):13847-54. Epub 2003 Feb 7.


Cyr61 and CTGF are molecular markers of bladder wall remodeling after outlet obstruction.

Chaqour B, Whitbeck C, Han JS, Macarak E, Horan P, Chichester P, Levin R.

Am J Physiol Endocrinol Metab. 2002 Oct;283(4):E765-74.


Beta-cyclodextrin tetradecasulfate, a novel cyclic oligosaccharide, inhibits thrombus and neointimal formation after coronary vascular injury.

Meneveau NF, Klugherz BD, Chaqour B, Anand V, Tomaszewski JE, JoulliƩ MM, Macarak E, Golden M, Weisz PB, Wilensky RL.

Coron Artery Dis. 2002 May;13(3):189-97.


Mechanical regulation of IGF-I and IGF-binding protein gene transcription in bladder smooth muscle cells.

Chaqour B, Han JS, Tamura I, Macarak E.

J Cell Biochem. 2002;84(2):264-77.


Regulation of Cyr61 gene expression by mechanical stretch through multiple signaling pathways.

Tamura I, Rosenbloom J, Macarak E, Chaqour B.

Am J Physiol Cell Physiol. 2001 Nov;281(5):C1524-32.


Mechanical stretch induces platelet-activating factor receptor gene expression through the NF-kappaB transcription factor.

Chaqour B, Howard PS, Richards CF, Macarak EJ.

J Mol Cell Cardiol. 1999 Jul;31(7):1345-55.


Influence of transforming growth factor beta1 (TGF-beta1) on the behaviour of porcine thyroid epithelial cells in primary culture through thrombospondin-1 synthesis.

Claisse D, Martiny I, Chaqour B, Wegrowski Y, Petitfrere E, Schneider C, Haye B, Bellon G.

J Cell Sci. 1999 May;112 ( Pt 9):1405-16.


All-trans-retinoic acid enhances collagen gene expression in irradiated and non-irradiated hairless mouse skin.

Chaqour B, Bellon G, Seite S, Borel JP, Fourtanier A.

J Photochem Photobiol B. 1997 Jan;37(1-2):52-9.


Isolation of a developmentally-regulated expressed sequence tag from bladder tissue using the mRNA differential display.

Chaqour B, Howard PS, Macarak EJ.

Biochem Mol Biol Int. 1996 Nov;40(5):1011-6.


Glutamine increases collagen gene transcription in cultured human fibroblasts.

Bellon G, Chaqour B, Wegrowski Y, Monboisse JC, Borel JP.

Biochim Biophys Acta. 1995 Sep 21;1268(3):311-23.


Differential expression of thrombospondin, collagen, and thyroglobulin by thyroid-stimulating hormone and tumor-promoting phorbol ester in cultured porcine thyroid cells.

Bellon G, Chaqour B, Antonicelli F, Wegrowski J, Claisse D, Haye B, Borel JP.

J Cell Physiol. 1994 Jul;160(1):75-88.


In vivo stimulation of connective tissue accumulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ in rat experimental wounds.

Maquart FX, Bellon G, Chaqour B, Wegrowski J, Patt LM, Trachy RE, Monboisse JC, Chastang F, Birembaut P, Gillery P, et al.

J Clin Invest. 1993 Nov;92(5):2368-76.

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