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Items: 1 to 50 of 112

1.

Oncometabolite induced primary cilia loss in pheochromocytoma.

O'Toole SM, Watson DS, Novoselova TV, Romano LEL, King PJ, Bradshaw TY, Thompson CL, Knight MM, Sharp TV, Barnes MR, Srirangalingam U, Drake WM, Chapple JP.

Endocr Relat Cancer. 2019 Jan 1;26(1):165-180. doi: 10.1530/ERC-18-0134.

2.

Sacsin, mutated in the ataxia ARSACS, regulates intermediate filament assembly and dynamics.

Gentil BJ, Lai GT, Menade M, Larivière R, Minotti S, Gehring K, Chapple JP, Brais B, Durham HD.

FASEB J. 2019 Feb;33(2):2982-2994. doi: 10.1096/fj.201801556R. Epub 2018 Oct 17.

PMID:
30332300
3.

Optical coherence tomography in autosomal recessive spastic ataxia of Charlevoix-Saguenay.

Parkinson MH, Bartmann AP, Clayton LMS, Nethisinghe S, Pfundt R, Chapple JP, Reilly MM, Manji H, Wood NJ, Bremner F, Giunti P.

Brain. 2018 Apr 1;141(4):989-999. doi: 10.1093/brain/awy028.

PMID:
29538656
4.

Chondrocyte expansion is associated with loss of primary cilia and disrupted hedgehog signalling.

Thompson CL, Plant JC, Wann AK, Bishop CL, Novak P, Mitchison HM, Beales PL, Chapple JP, Knight MM.

Eur Cell Mater. 2017 Sep 20;34:128-141. doi: 10.22203/eCM.v034a09.

5.

Arl3 and RP2 regulate the trafficking of ciliary tip kinesins.

Schwarz N, Lane A, Jovanovic K, Parfitt DA, Aguila M, Thompson CL, da Cruz L, Coffey PJ, Chapple JP, Hardcastle AJ, Cheetham ME.

Hum Mol Genet. 2017 Sep 1;26(17):3451. doi: 10.1093/hmg/ddx245. No abstract available.

6.

Altered organization of the intermediate filament cytoskeleton and relocalization of proteostasis modulators in cells lacking the ataxia protein sacsin.

Duncan EJ, Larivière R, Bradshaw TY, Longo F, Sgarioto N, Hayes MJ, Romano LEL, Nethisinghe S, Giunti P, Bruntraeger MB, Durham HD, Brais B, Maltecca F, Gentil BJ, Chapple JP.

Hum Mol Genet. 2017 Aug 15;26(16):3130-3143. doi: 10.1093/hmg/ddx197.

7.

Topography of calcium phosphate ceramics regulates primary cilia length and TGF receptor recruitment associated with osteogenesis.

Zhang J, Dalbay MT, Luo X, Vrij E, Barbieri D, Moroni L, de Bruijn JD, van Blitterswijk CA, Chapple JP, Knight MM, Yuan H.

Acta Biomater. 2017 Jul 15;57:487-497. doi: 10.1016/j.actbio.2017.04.004. Epub 2017 Apr 27.

8.

Arl3 and RP2 regulate the trafficking of ciliary tip kinesins.

Schwarz N, Lane A, Jovanovic K, Parfitt DA, Aguila M, Thompson CL, da Cruz L, Coffey PJ, Chapple JP, Hardcastle AJ, Cheetham ME.

Hum Mol Genet. 2017 Jul 1;26(13):2480-2492. doi: 10.1093/hmg/ddx143. Erratum in: Hum Mol Genet. 2017 Sep 1;26(17 ):3451.

9.

Unexpected acoustic stimulation during action preparation reveals gradual re-specification of movement direction.

Marinovic W, Tresilian J, Chapple JL, Riek S, Carroll TJ.

Neuroscience. 2017 Apr 21;348:23-32. doi: 10.1016/j.neuroscience.2017.02.016. Epub 2017 Feb 17.

PMID:
28215747
10.

Primary cilia: a link between hormone signalling and endocrine-related cancers?

O'Toole SM, Chapple JP.

Biochem Soc Trans. 2016 Oct 15;44(5):1227-1234. Review.

PMID:
27911704
11.

A reduction in Drp1-mediated fission compromises mitochondrial health in autosomal recessive spastic ataxia of Charlevoix Saguenay.

Bradshaw TY, Romano LE, Duncan EJ, Nethisinghe S, Abeti R, Michael GJ, Giunti P, Vermeer S, Chapple JP.

Hum Mol Genet. 2016 Aug 1;25(15):3232-3244. doi: 10.1093/hmg/ddw173. Epub 2016 Jun 10.

12.

Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1β.

Thompson CL, Patel R, Kelly TA, Wann AK, Hung CT, Chapple JP, Knight MM.

Arthritis Res Ther. 2015 Dec 24;17:373. doi: 10.1186/s13075-015-0891-z.

13.

Molecular and functional studies of retinal degeneration as a clinical presentation of SACS-related disorder.

Blumkin L, Bradshaw T, Michelson M, Kopler T, Dahari D, Lerman-Sagie T, Lev D, Chapple JP, Leshinsky-Silver E.

Eur J Paediatr Neurol. 2015 Jul;19(4):472-6. doi: 10.1016/j.ejpn.2015.02.005. Epub 2015 Mar 3.

PMID:
25819952
14.

Adipogenic Differentiation of hMSCs is Mediated by Recruitment of IGF-1r Onto the Primary Cilium Associated With Cilia Elongation.

Dalbay MT, Thorpe SD, Connelly JT, Chapple JP, Knight MM.

Stem Cells. 2015 Jun;33(6):1952-61. doi: 10.1002/stem.1975.

15.

The role of HSP70 and its co-chaperones in protein misfolding, aggregation and disease.

Duncan EJ, Cheetham ME, Chapple JP, van der Spuy J.

Subcell Biochem. 2015;78:243-73. doi: 10.1007/978-3-319-11731-7_12. Review.

PMID:
25487025
16.

The co-chaperone and reductase ERdj5 facilitates rod opsin biogenesis and quality control.

Athanasiou D, Bevilacqua D, Aguila M, McCulley C, Kanuga N, Iwawaki T, Chapple JP, Cheetham ME.

Hum Mol Genet. 2014 Dec 15;23(24):6594-606. doi: 10.1093/hmg/ddu385. Epub 2014 Jul 23.

17.

The primary cilium influences interleukin-1β-induced NFκB signalling by regulating IKK activity.

Wann AK, Chapple JP, Knight MM.

Cell Signal. 2014 Aug;26(8):1735-42. doi: 10.1016/j.cellsig.2014.04.004. Epub 2014 Apr 12.

18.

Primary cilia disassembly down-regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes.

Thompson CL, Chapple JP, Knight MM.

Osteoarthritis Cartilage. 2014 Mar;22(3):490-8. doi: 10.1016/j.joca.2013.12.016. Epub 2014 Jan 21.

19.

Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium.

Wann AK, Thompson CL, Chapple JP, Knight MM.

Cilia. 2013 Dec 13;2(1):17. doi: 10.1186/2046-2530-2-17.

20.

Familial glucocorticoid deficiency: New genes and mechanisms.

Meimaridou E, Hughes CR, Kowalczyk J, Guasti L, Chapple JP, King PJ, Chan LF, Clark AJ, Metherell LA.

Mol Cell Endocrinol. 2013 May 22;371(1-2):195-200. doi: 10.1016/j.mce.2012.12.010. Epub 2012 Dec 29. Review.

PMID:
23279877
21.

BiP prevents rod opsin aggregation.

Athanasiou D, Kosmaoglou M, Kanuga N, Novoselov SS, Paton AW, Paton JC, Chapple JP, Cheetham ME.

Mol Biol Cell. 2012 Sep;23(18):3522-31. doi: 10.1091/mbc.E12-02-0168. Epub 2012 Aug 1.

22.

Heat shock induces rapid resorption of primary cilia.

Prodromou NV, Thompson CL, Osborn DP, Cogger KF, Ashworth R, Knight MM, Beales PL, Chapple JP.

J Cell Sci. 2012 Sep 15;125(Pt 18):4297-305. doi: 10.1242/jcs.100545. Epub 2012 Jun 20.

23.

Somatostatin analogs modulate AIP in somatotroph adenomas: the role of the ZAC1 pathway.

Chahal HS, Trivellin G, Leontiou CA, Alband N, Fowkes RC, Tahir A, Igreja SC, Chapple JP, Jordan S, Lupp A, Schulz S, Ansorge O, Karavitaki N, Carlsen E, Wass JA, Grossman AB, Korbonits M.

J Clin Endocrinol Metab. 2012 Aug;97(8):E1411-20. doi: 10.1210/jc.2012-1111. Epub 2012 Jun 1.

PMID:
22659247
24.

Mutations in NNT encoding nicotinamide nucleotide transhydrogenase cause familial glucocorticoid deficiency.

Meimaridou E, Kowalczyk J, Guasti L, Hughes CR, Wagner F, Frommolt P, Nürnberg P, Mann NP, Banerjee R, Saka HN, Chapple JP, King PJ, Clark AJ, Metherell LA.

Nat Genet. 2012 May 27;44(7):740-2. doi: 10.1038/ng.2299.

25.

Mitochondrial dysfunction and Purkinje cell loss in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS).

Girard M, Larivière R, Parfitt DA, Deane EC, Gaudet R, Nossova N, Blondeau F, Prenosil G, Vermeulen EG, Duchen MR, Richter A, Shoubridge EA, Gehring K, McKinney RA, Brais B, Chapple JP, McPherson PS.

Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1661-6. doi: 10.1073/pnas.1113166109. Epub 2012 Jan 17.

26.

The cytosolic chaperone Hsc70 promotes traffic to the cell surface of intracellular retained melanocortin-4 receptor mutants.

Meimaridou E, Gooljar SB, Ramnarace N, Anthonypillai L, Clark AJ, Chapple JP.

Mol Endocrinol. 2011 Sep;25(9):1650-60. doi: 10.1210/me.2011-1020. Epub 2011 Jun 30.

27.

Clinical, genetic and molecular characterization of patients with familial isolated pituitary adenomas (FIPA).

Chahal HS, Chapple JP, Frohman LA, Grossman AB, Korbonits M.

Trends Endocrinol Metab. 2010 Jul;21(7):419-27. doi: 10.1016/j.tem.2010.02.007. Epub 2010 Jun 1. Review.

PMID:
20570174
28.

Characterization of aryl hydrocarbon receptor interacting protein (AIP) mutations in familial isolated pituitary adenoma families.

Igreja S, Chahal HS, King P, Bolger GB, Srirangalingam U, Guasti L, Chapple JP, Trivellin G, Gueorguiev M, Guegan K, Stals K, Khoo B, Kumar AV, Ellard S, Grossman AB, Korbonits M; International FIPA Consortium.

Hum Mutat. 2010 Aug;31(8):950-60. doi: 10.1002/humu.21292.

29.

The binding of the molecular chaperone Hsc70 to the prion protein PrP is modulated by pH and copper.

Wilkins S, Choglay AA, Chapple JP, van der Spuy J, Rhie A, Birkett CR, Cheetham ME.

Int J Biochem Cell Biol. 2010 Jul;42(7):1226-32. doi: 10.1016/j.biocel.2010.04.013. Epub 2010 Apr 29.

PMID:
20434583
30.

Deficiency of ferritin heavy-chain nuclear import in triple a syndrome implies nuclear oxidative damage as the primary disease mechanism.

Storr HL, Kind B, Parfitt DA, Chapple JP, Lorenz M, Koehler K, Huebner A, Clark AJ.

Mol Endocrinol. 2009 Dec;23(12):2086-94. doi: 10.1210/me.2009-0056. Epub 2009 Oct 23.

31.

Can faulty antennae increase adiposity? The link between cilia proteins and obesity.

Sen Gupta P, Prodromou NV, Chapple JP.

J Endocrinol. 2009 Dec;203(3):327-36. doi: 10.1677/JOE-09-0116. Epub 2009 May 21. Review.

PMID:
19460851
32.

MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family.

Chan LF, Webb TR, Chung TT, Meimaridou E, Cooray SN, Guasti L, Chapple JP, Egertová M, Elphick MR, Cheetham ME, Metherell LA, Clark AJ.

Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6146-51. doi: 10.1073/pnas.0809918106. Epub 2009 Mar 27.

33.

The ataxia protein sacsin is a functional co-chaperone that protects against polyglutamine-expanded ataxin-1.

Parfitt DA, Michael GJ, Vermeulen EG, Prodromou NV, Webb TR, Gallo JM, Cheetham ME, Nicoll WS, Blatch GL, Chapple JP.

Hum Mol Genet. 2009 May 1;18(9):1556-65. doi: 10.1093/hmg/ddp067. Epub 2009 Feb 10.

34.

From hatching to dispatching: the multiple cellular roles of the Hsp70 molecular chaperone machinery.

Meimaridou E, Gooljar SB, Chapple JP.

J Mol Endocrinol. 2009 Jan;42(1):1-9. doi: 10.1677/JME-08-0116. Epub 2008 Oct 13. Review.

PMID:
18852216
35.

The majority of adrenocorticotropin receptor (melanocortin 2 receptor) mutations found in familial glucocorticoid deficiency type 1 lead to defective trafficking of the receptor to the cell surface.

Chung TT, Webb TR, Chan LF, Cooray SN, Metherell LA, King PJ, Chapple JP, Clark AJ.

J Clin Endocrinol Metab. 2008 Dec;93(12):4948-54. doi: 10.1210/jc.2008-1744. Epub 2008 Oct 7.

36.

Focal distortion of the nuclear envelope by huntingtin aggregates revealed by lamin immunostaining.

Chapple JP, Bros-Facer V, Butler R, Gallo JM.

Neurosci Lett. 2008 Dec 12;447(2-3):172-4. doi: 10.1016/j.neulet.2008.09.075. Epub 2008 Oct 1.

37.

Distinct melanocortin 2 receptor accessory protein domains are required for melanocortin 2 receptor interaction and promotion of receptor trafficking.

Webb TR, Chan L, Cooray SN, Cheetham ME, Chapple JP, Clark AJ.

Endocrinology. 2009 Feb;150(2):720-6. doi: 10.1210/en.2008-0941. Epub 2008 Sep 25.

PMID:
18818285
38.

The use of behavioural change techniques in the treatment of paediatric obesity: qualitative evaluation of parental perspectives on treatment.

Stewart L, Chapple J, Hughes AR, Poustie V, Reilly JJ.

J Hum Nutr Diet. 2008 Oct;21(5):464-73. doi: 10.1111/j.1365-277X.2008.00888.x. Epub 2008 Jul 18.

PMID:
18647212
39.

The role of the aryl hydrocarbon receptor-interacting protein gene in familial and sporadic pituitary adenomas.

Leontiou CA, Gueorguiev M, van der Spuy J, Quinton R, Lolli F, Hassan S, Chahal HS, Igreja SC, Jordan S, Rowe J, Stolbrink M, Christian HC, Wray J, Bishop-Bailey D, Berney DM, Wass JA, Popovic V, Ribeiro-Oliveira A Jr, Gadelha MR, Monson JP, Akker SA, Davis JR, Clayton RN, Yoshimoto K, Iwata T, Matsuno A, Eguchi K, Musat M, Flanagan D, Peters G, Bolger GB, Chapple JP, Frohman LA, Grossman AB, Korbonits M.

J Clin Endocrinol Metab. 2008 Jun;93(6):2390-401. doi: 10.1210/jc.2007-2611. Epub 2008 Apr 1.

PMID:
18381572
40.

Randomized, controlled trial of a best-practice individualized behavioral program for treatment of childhood overweight: Scottish Childhood Overweight Treatment Trial (SCOTT).

Hughes AR, Stewart L, Chapple J, McColl JH, Donaldson MD, Kelnar CJ, Zabihollah M, Ahmed F, Reilly JJ.

Pediatrics. 2008 Mar;121(3):e539-46. doi: 10.1542/peds.2007-1786.

PMID:
18310175
41.

The melanocortin 2 receptor accessory protein exists as a homodimer and is essential for the function of the melanocortin 2 receptor in the mouse y1 cell line.

Cooray SN, Almiro Do Vale I, Leung KY, Webb TR, Chapple JP, Egertová M, Cheetham ME, Elphick MR, Clark AJ.

Endocrinology. 2008 Apr;149(4):1935-41. Epub 2007 Dec 27.

PMID:
18162519
42.

Parents' journey through treatment for their child's obesity: a qualitative study.

Stewart L, Chapple J, Hughes AR, Poustie V, Reilly JJ.

Arch Dis Child. 2008 Jan;93(1):35-9. Epub 2007 Oct 4.

PMID:
17916586
43.

Expression, localization and tau exon 10 splicing activity of the brain RNA-binding protein TNRC4.

Chapple JP, Anthony K, Martin TR, Dev A, Cooper TA, Gallo JM.

Hum Mol Genet. 2007 Nov 15;16(22):2760-9. Epub 2007 Aug 28.

PMID:
17725984
44.

Hsp40 Molecules That Target to the Ubiquitin-proteasome System Decrease Inclusion Formation in Models of Polyglutamine Disease.

Howarth JL, Kelly S, Keasey MP, Glover C, Lee YB, Mitrophanous K, Chapple JP, Gallo JM, Cheetham ME, Uney JB.

Mol Ther. 2007 Jun;15(6):1100-1105. doi: 10.1038/sj.mt.6300163. Epub 2016 Dec 7.

PMID:
28182921
45.

Hsp40 molecules that target to the ubiquitin-proteasome system decrease inclusion formation in models of polyglutamine disease.

Howarth JL, Kelly S, Keasey MP, Glover CP, Lee YB, Mitrophanous K, Chapple JP, Gallo JM, Cheetham ME, Uney JB.

Mol Ther. 2007 Jun;15(6):1100-5. Epub 2007 Apr 10.

46.

The Notch-1 intracellular domain is found in sub-nuclear bodies in SH-SY5Y neuroblastomas and in primary cortical neurons.

Hooper C, Chapple JP, Lovestone S, Killick R.

Neurosci Lett. 2007 Mar 26;415(2):135-9. Epub 2007 Jan 27.

47.

Cytosolic and ER J-domains of mammalian and parasitic origin can functionally interact with DnaK.

Nicoll WS, Botha M, McNamara C, Schlange M, Pesce ER, Boshoff A, Ludewig MH, Zimmermann R, Cheetham ME, Chapple JP, Blatch GL.

Int J Biochem Cell Biol. 2007;39(4):736-51. Epub 2006 Nov 23.

48.

TAp73 isoforms antagonize Notch signalling in SH-SY5Y neuroblastomas and in primary neurones.

Hooper C, Tavassoli M, Chapple JP, Uwanogho D, Goodyear R, Melino G, Lovestone S, Killick R.

J Neurochem. 2006 Nov;99(3):989-99.

49.

Over-complete discrete wavelet transformation of the normal auditory brainstem response improves prediction of outcome following severe acute closed head injury.

Wilson WJ, Chapple JA, Phillips KM, Snell KT, Bradley AP, Darnell R.

Audiol Neurootol. 2006;11(4):249-58. Epub 2006 May 4.

PMID:
16679759
50.

Assay and functional analysis of the ARL3 effector RP2 involved in X-linked retinitis pigmentosa.

Evans RJ, Chapple JP, Grayson C, Hardcastle AJ, Cheetham ME.

Methods Enzymol. 2005;404:468-80.

PMID:
16413292

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