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The Basoph8 Mice Enable an Unbiased Detection and a Conditional Depletion of Basophils.

Pellefigues C, Mehta P, Prout MS, Naidoo K, Yumnam B, Chandler J, Chappell S, Filbey K, Camberis M, Le Gros G.

Front Immunol. 2019 Sep 10;10:2143. doi: 10.3389/fimmu.2019.02143. eCollection 2019.


Relativistic redshift of the star S0-2 orbiting the Galactic Center supermassive black hole.

Do T, Hees A, Ghez A, Martinez GD, Chu DS, Jia S, Sakai S, Lu JR, Gautam AK, O'Neil KK, Becklin EE, Morris MR, Matthews K, Nishiyama S, Campbell R, Chappell S, Chen Z, Ciurlo A, Dehghanfar A, Gallego-Cano E, Kerzendorf WE, Lyke JE, Naoz S, Saida H, Schödel R, Takahashi M, Takamori Y, Witzel G, Wizinowich P.

Science. 2019 Aug 16;365(6454):664-668. doi: 10.1126/science.aav8137. Epub 2019 Jul 25.


The BASALT Research Program: Designing and Developing Mission Elements in Support of Human Scientific Exploration of Mars.

Lim DSS, Abercromby AFJ, Kobs Nawotniak SE, Lees DS, Miller MJ, Brady AL, Miller MJ, Mirmalek Z, Sehlke A, Payler SJ, Stevens AH, Haberle CW, Beaton KH, Chappell SP, Hughes SS, Cockell CS, Elphic RC, Downs MT, Heldmann JL.

Astrobiology. 2019 Mar;19(3):245-259. doi: 10.1089/ast.2018.1869.


Opportunities and Challenges of Promoting Scientific Dialog throughout Execution of Future Science-Driven Extravehicular Activity.

Kobs Nawotniak SE, Miller MJ, Stevens AH, Marquez JJ, Payler SJ, Brady AL, Hughes SS, Haberle CW, Sehlke A, Beaton KH, Chappell SP, Elphic RC, Lim DSS.

Astrobiology. 2019 Mar;19(3):426-439. doi: 10.1089/ast.2018.1901.


Assessing the Acceptability of Science Operations Concepts and the Level of Mission Enhancement of Capabilities for Human Mars Exploration Extravehicular Activity.

Beaton KH, Chappell SP, Abercromby AFJ, Miller MJ, Kobs Nawotniak SE, Brady AL, Stevens AH, Payler SJ, Hughes SS, Lim DSS.

Astrobiology. 2019 Mar;19(3):321-346. doi: 10.1089/ast.2018.1912.


Using Science-Driven Analog Research to Investigate Extravehicular Activity Science Operations Concepts and Capabilities for Human Planetary Exploration.

Beaton KH, Chappell SP, Abercromby AFJ, Miller MJ, Kobs Nawotniak SE, Brady AL, Stevens AH, Payler SJ, Hughes SS, Lim DSS.

Astrobiology. 2019 Mar;19(3):300-320. doi: 10.1089/ast.2018.1861.


Considerations in the Use of Codon Optimization for Recombinant Protein Expression.

Mauro VP, Chappell SA.

Methods Mol Biol. 2018;1850:275-288. doi: 10.1007/978-1-4939-8730-6_18.


Observations of extensive gene expression differences in the cerebellum and potential relevance to Alzheimer's disease.

Chappell S, Patel T, Guetta-Baranes T, Sang F, Francis PT, Morgan K, Brookes KJ.

BMC Res Notes. 2018 Sep 4;11(1):646. doi: 10.1186/s13104-018-3732-8.


Polygenic risk score in postmortem diagnosed sporadic early-onset Alzheimer's disease.

Chaudhury S, Patel T, Barber IS, Guetta-Baranes T, Brookes KJ, Chappell S, Turton J, Guerreiro R, Bras J, Hernandez D, Singleton A, Hardy J, Mann D; ARUK Consortium, Morgan K.

Neurobiol Aging. 2018 Feb;62:244.e1-244.e8. doi: 10.1016/j.neurobiolaging.2017.09.035. Epub 2017 Oct 10.


Methylation Profiling RIN3 and MEF2C Identifies Epigenetic Marks Associated with Sporadic Early Onset Alzheimer's Disease.

Boden KA, Barber IS, Clement N, Patel T, Guetta-Baranes T, Brookes KJ, Chappell S, Craigon J, Chapman NH; ARUK Consortium, Morgan K, Seymour GB, Bottley A.

J Alzheimers Dis Rep. 2017 Sep 13;1(1):97-108. doi: 10.3233/ADR-170015.


Variants in the fetal genome near FLT1 are associated with risk of preeclampsia.

McGinnis R, Steinthorsdottir V, Williams NO, Thorleifsson G, Shooter S, Hjartardottir S, Bumpstead S, Stefansdottir L, Hildyard L, Sigurdsson JK, Kemp JP, Silva GB, Thomsen LCV, Jääskeläinen T, Kajantie E, Chappell S, Kalsheker N, Moffett A, Hiby S, Lee WK, Padmanabhan S, Simpson NAB, Dolby VA, Staines-Urias E, Engel SM, Haugan A, Trogstad L, Svyatova G, Zakhidova N, Najmutdinova D; FINNPEC Consortium; GOPEC Consortium, Dominiczak AF, Gjessing HK, Casas JP, Dudbridge F, Walker JJ, Pipkin FB, Thorsteinsdottir U, Geirsson RT, Lawlor DA, Iversen AC, Magnus P, Laivuori H, Stefansson K, Morgan L.

Nat Genet. 2017 Aug;49(8):1255-1260. doi: 10.1038/ng.3895. Epub 2017 Jun 19.


Testing General Relativity with Stellar Orbits around the Supermassive Black Hole in Our Galactic Center.

Hees A, Do T, Ghez AM, Martinez GD, Naoz S, Becklin EE, Boehle A, Chappell S, Chu D, Dehghanfar A, Kosmo K, Lu JR, Matthews K, Morris MR, Sakai S, Schödel R, Witzel G.

Phys Rev Lett. 2017 May 26;118(21):211101. doi: 10.1103/PhysRevLett.118.211101. Epub 2017 May 25.


Longitudinal study of CTX-M ESBL-producing E. coli strains on a UK dairy farm.

Horton RA, Duncan D, Randall LP, Chappell S, Brunton LA, Warner R, Coldham NG, Teale CJ.

Res Vet Sci. 2016 Dec;109:107-113. doi: 10.1016/j.rvsc.2016.09.018. Epub 2016 Sep 30.


Mutation analysis of sporadic early-onset Alzheimer's disease using the NeuroX array.

Barber IS, Braae A, Clement N, Patel T, Guetta-Baranes T, Brookes K, Medway C, Chappell S, Guerreiro R, Bras J, Hernandez D, Singleton A, Hardy J, Mann DM; ARUK Consortium, Morgan K.

Neurobiol Aging. 2017 Jan;49:215.e1-215.e8. doi: 10.1016/j.neurobiolaging.2016.09.008. Epub 2016 Sep 23.


Exploring the Process of Implementing Healthy Workplace Initiatives: Mapping to Kotter's Leading Change Model.

Chappell S, Pescud M, Waterworth P, Shilton T, Roche D, Ledger M, Slevin T, Rosenberg M.

J Occup Environ Med. 2016 Oct;58(10):e341-e348.


The Nurse Leader Role in Crisis Management.

Edmonson C, Sumagaysay D, Cueman M, Chappell S.

J Nurs Adm. 2016 Sep;46(9):417-9. doi: 10.1097/NNA.0000000000000367.


Culture, management and finances as key aspects for healthy workplace initiatives.

Waterworth P, Pescud M, Chappell S, Davies C, Roche D, Shilton T, Ledger M, Slevin T, Rosenberg M.

Health Promot Int. 2018 Feb 1;33(1):162-172. doi: 10.1093/heapro/daw068.


Chemoradiotherapy with Brachytherapy or Electron Therapy Boost for Locally Advanced Squamous Cell Carcinoma of the Anus-Reducing the Colostomy Rate.

Kent C, Bessell EM, Scholefield JH, Chappell S, Marsh L, Mills J, Sayers I.

J Gastrointest Cancer. 2017 Mar;48(1):1-7. doi: 10.1007/s12029-016-9850-4.


Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12.

Jackson VE, Ntalla I, Sayers I, Morris R, Whincup P, Casas JP, Amuzu A, Choi M, Dale C, Kumari M, Engmann J, Kalsheker N, Chappell S, Guetta-Baranes T, McKeever TM, Palmer CN, Tavendale R, Holloway JW, Sayer AA, Dennison EM, Cooper C, Bafadhel M, Barker B, Brightling C, Bolton CE, John ME, Parker SG, Moffat MF, Wardlaw AJ, Connolly MJ, Porteous DJ, Smith BH, Padmanabhan S, Hocking L, Stirrups KE, Deloukas P, Strachan DP, Hall IP, Tobin MD, Wain LV.

Thorax. 2016 Jun;71(6):501-9. doi: 10.1136/thoraxjnl-2015-207876. Epub 2016 Feb 25.


Screening exons 16 and 17 of the amyloid precursor protein gene in sporadic early-onset Alzheimer's disease.

Barber IS, García-Cárdenas JM, Sakdapanichkul C, Deacon C, Zapata Erazo G, Guerreiro R, Bras J, Hernandez D, Singleton A, Guetta-Baranes T, Braae A, Clement N, Patel T, Brookes K, Medway C, Chappell S, Mann DM; ARUK Consortium, Morgan K.

Neurobiol Aging. 2016 Mar;39:220.e1-7. doi: 10.1016/j.neurobiolaging.2015.12.011. Epub 2015 Dec 29.


A cell-free expression and purification process for rapid production of protein biologics.

Sullivan CJ, Pendleton ED, Sasmor HH, Hicks WL, Farnum JB, Muto M, Amendt EM, Schoborg JA, Martin RW, Clark LG, Anderson MJ, Choudhury A, Fior R, Lo YH, Griffey RH, Chappell SA, Jewett MC, Mauro VP, Dresios J.

Biotechnol J. 2016 Feb;11(2):238-48. doi: 10.1002/biot.201500214. Epub 2015 Dec 7.


A critical analysis of codon optimization in human therapeutics.

Mauro VP, Chappell SA.

Trends Mol Med. 2014 Nov;20(11):604-13. doi: 10.1016/j.molmed.2014.09.003. Epub 2014 Sep 25. Review.


Copy number variation of the beta-defensin genes in europeans: no supporting evidence for association with lung function, chronic obstructive pulmonary disease or asthma.

Wain LV, Odenthal-Hesse L, Abujaber R, Sayers I, Beardsmore C, Gaillard EA, Chappell S, Dogaru CM, McKeever T, Guetta-Baranes T, Kalsheker N, Kuehni CE, Hall IP, Tobin MD, Hollox EJ.

PLoS One. 2014 Jan 3;9(1):e84192. doi: 10.1371/journal.pone.0084192. eCollection 2014.


BH3 helix-derived biophotonic nanoswitches regulate cytochrome c release in permeabilised cells.

Mart RJ, Errington RJ, Watkins CL, Chappell SC, Wiltshire M, Jones AT, Smith PJ, Allemann RK.

Mol Biosyst. 2013 Nov;9(11):2597-603. doi: 10.1039/c3mb70246d.


Prevalence, serovars, and antimicrobial susceptibility of Salmonella isolated from blue land crabs (Cardisoma guanhumi) in Grenada, West Indies.

Peterson R, Hariharan H, Matthew V, Chappell S, Davies R, Parker R, Sharma A.

J Food Prot. 2013 Jul;76(7):1270-3. doi: 10.4315/0362-028X.JFP-12-515.


NCAM polysialylation during adherence transitions: live cell monitoring using an antibody-mimetic EGFP-endosialidase and the viability dye DRAQ7.

Smith PJ, Furon E, Wiltshire M, Chappell S, Patterson LH, Shnyder SD, Falconer RA, Errington RJ.

Cytometry A. 2013 Jul;83(7):659-71. doi: 10.1002/cyto.a.22306. Epub 2013 May 28.


Time-lapse microscopy approaches to track cell cycle and lineage progression at the single-cell level.

Errington RJ, Chappell SC, Khan IA, Marquez N, Wiltshire M, Griesdoorn VD, Smith PJ.

Curr Protoc Cytom. 2013 Apr;Chapter 12:Unit12.4. doi: 10.1002/0471142956.cy1204s64.


Kinetic analysis of intracellular Hoechst 33342--DNA interactions by flow cytometry: misinterpretation of side population status?

Smith PJ, Wiltshire M, Chappell SC, Cosentino L, Burns PA, Pors K, Errington RJ.

Cytometry A. 2013 Jan;83(1):161-9. doi: 10.1002/cyto.a.22224. Epub 2012 Nov 7.


Automated cell identification and tracking using nanoparticle moving-light-displays.

Tonkin JA, Rees P, Brown MR, Errington RJ, Smith PJ, Chappell SC, Summers HD.

PLoS One. 2012;7(7):e40835. doi: 10.1371/journal.pone.0040835. Epub 2012 Jul 19.


A novel library screen identifies immunosuppressors that promote osteoblast differentiation.

Darcy A, Meltzer M, Miller J, Lee S, Chappell S, Ver Donck K, Montano M.

Bone. 2012 Jun;50(6):1294-303. doi: 10.1016/j.bone.2012.03.001. Epub 2012 Mar 13.


Neighborhood and parental supports for physical activity in minority adolescents.

Wilson DK, Lawman HG, Segal M, Chappell S.

Am J Prev Med. 2011 Oct;41(4):399-406. doi: 10.1016/j.amepre.2011.06.037.


Verocytotoxigenic Escherichia coli O157 in camelids.

Featherstone CA, Foster AP, Chappell SA, Carson T, Pritchard GC.

Vet Rec. 2011 Feb 19;168(7):194-5. doi: 10.1136/vr.d902. No abstract available.


A transfer function approach to measuring cell inheritance.

Rees P, Brown MR, Summers HD, Holton MD, Errington RJ, Chappell SC, Smith PJ.

BMC Syst Biol. 2011 Feb 22;5:31. doi: 10.1186/1752-0509-5-31.


Interoperability of time series cytometric data: a cross platform approach for modeling tumor heterogeneity.

Khan IA, Lupi M, Campbell L, Chappell SC, Brown MR, Wiltshire M, Smith PJ, Ubezio P, Errington RJ.

Cytometry A. 2011 Mar;79(3):214-26. doi: 10.1002/cyto.a.21023. Epub 2011 Feb 18.


The role of IREB2 and transforming growth factor beta-1 genetic variants in COPD: a replication case-control study.

Chappell SL, Daly L, Lotya J, Alsaegh A, Guetta-Baranes T, Roca J, Rabinovich R, Morgan K, Millar AB, Donnelly SC, Keatings V, MacNee W, Stolk J, Hiemstra PS, Miniati M, Monti S, O'Connor CM, Kalsheker N.

BMC Med Genet. 2011 Feb 14;12:24. doi: 10.1186/1471-2350-12-24.


Long-term time series analysis of quantum dot encoded cells by deconvolution of the autofluorescence signal.

Brown MR, Summers HD, Rees P, Chappell SC, Silvestre OF, Khan IA, Smith PJ, Errington RJ.

Cytometry A. 2010 Oct;77(10):925-32. doi: 10.1002/cyto.a.20936.


An evaluation of the implementation of the FACE Health and Social Assessment in routine psychiatric practice.

Commander M, Gillespie M, Chappell S, Jones J.

J Ment Health. 2011 Feb;20(1):52-9. doi: 10.3109/09638237.2010.542788.


Statistical analysis of nanoparticle dosing in a dynamic cellular system.

Summers HD, Rees P, Holton MD, Brown MR, Chappell SC, Smith PJ, Errington RJ.

Nat Nanotechnol. 2011 Mar;6(3):170-4. doi: 10.1038/nnano.2010.277. Epub 2011 Jan 23.


Group B Salmonella in lungworms from a harbour porpoise (Phocoena phocoena).

Davison N, Barnett J, Rule B, Chappell S, Wise G.

Vet Rec. 2010 Aug 28;167(9):351-2. doi: 10.1136/vr.c4495. No abstract available.


Prevalence of a host-adapted group B Salmonella enterica in harbour porpoises (Phocoena phocoena) from the south-west coast of England.

Davison NJ, Simpson VR, Chappell S, Monies RJ, Stubberfield EJ, Koylass M, Quinney S, Deaville R, Whatmore AM, Jepson PD.

Vet Rec. 2010 Jul 31;167(5):173-6. doi: 10.1136/vr.c3760.


Flow-based cytometric analysis of cell cycle via simulated cell populations.

Brown MR, Summers HD, Rees P, Smith PJ, Chappell SC, Errington RJ.

PLoS Comput Biol. 2010 Apr 15;6(4):e1000741. doi: 10.1371/journal.pcbi.1000741.


Association of MMP-2 polymorphisms with severe and very severe COPD: a case control study of MMPs-1, 9 and 12 in a European population.

Haq I, Chappell S, Johnson SR, Lotya J, Daly L, Morgan K, Guetta-Baranes T, Roca J, Rabinovich R, Millar AB, Donnelly SC, Keatings V, MacNee W, Stolk J, Hiemstra PS, Miniati M, Monti S, O'Connor CM, Kalsheker N.

BMC Med Genet. 2010 Jan 15;11:7. doi: 10.1186/1471-2350-11-7.


Single cell nanoparticle tracking to model cell cycle dynamics and compartmental inheritance.

Errington RJ, Brown MR, Silvestre OF, Njoh KL, Chappell SC, Khan IA, Rees P, Wilks SP, Smith PJ, Summers HD.

Cell Cycle. 2010 Jan 1;9(1):121-30. Epub 2010 Jan 5.


Polymorphism in the endoplasmic reticulum mannosidase I (MAN1B1) gene is not associated with liver disease in individuals homozygous for the Z variant of the alpha1-antitrypsin protease inhibitor (PiZZ individuals).

Chappell S, Guetta-Baranés T, Hadzic N, Stockley R, Kalsheker N.

Hepatology. 2009 Oct;50(4):1315; author reply 1315-6. doi: 10.1002/hep.23170. No abstract available.


The alpha-1-antitrypsin gene promoter in human A549 lung derived cells, and a novel transcription initiation site.

Morgan K, Chappell S, Guetta-Baranés T, Morley S, Kalsheker N.

Int J Biochem Cell Biol. 2009 May;41(5):1157-64. doi: 10.1016/j.biocel.2008.10.020. Epub 2008 Oct 28.


Time-lapse microscopy approaches to track cell cycle progression at the single-cell level.

Errington RJ, Marquez N, Chappell SC, Wiltshire M, Smith PJ.

Curr Protoc Cytom. 2005 Feb;Chapter 12:Unit 12.4. doi: 10.1002/0471142956.cy1204s31.


The new genetics and chronic obstructive pulmonary disease.

Kalsheker N, Chappell S.

COPD. 2008 Aug;5(4):257-64. doi: 10.1080/15412550802237556. Review.


Genetic variants of microsomal epoxide hydrolase and glutamate-cysteine ligase in COPD.

Chappell S, Daly L, Morgan K, Guetta-Baranes T, Roca J, Rabinovich R, Lotya J, Millar AB, Donnelly SC, Keatings V, MacNee W, Stolk J, Hiemstra PS, Miniati M, Monti S, O'Connor CM, Kalsheker N.

Eur Respir J. 2008 Oct;32(4):931-7. doi: 10.1183/09031936.00065308. Epub 2008 Jul 9.

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