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Neuroprotective Biomarkers and Cognitive Function in a Long-Term Prospective Population-based Study of Aging US Adults.

Paulsen AJ, Schubert CR, Pinto A, Carlsson CM, Chappell RJ, Fischer ME, Klein BEK, Klein R, Tsai MY, Cruickshanks KJ.

Alzheimer Dis Assoc Disord. 2019 Aug 2. doi: 10.1097/WAD.0000000000000341. [Epub ahead of print]


Arp2/3 complex-driven spatial patterning of the BCR enhances immune synapse formation, BCR signaling and B cell activation.

Bolger-Munro M, Choi K, Scurll JM, Abraham L, Chappell RS, Sheen D, Dang-Lawson M, Wu X, Priatel JJ, Coombs D, Hammer JA, Gold MR.

Elife. 2019 Jun 3;8. pii: e44574. doi: 10.7554/eLife.44574.


Using simple radiologic measurements to anticipate surgical challenge in endometrial cancer: a prospective study.

Harrison RF, Mcnamara JE, Beaumont CB, Sadowski EA, Chappell RJ, Shahzad MM, Spencer RJ, Al-Niaimi AN, Barroilhet LM, Rose SL, Kushner DM.

Int J Gynecol Cancer. 2019 Jan;29(1):102-107. doi: 10.1136/ijgc-2018-000037.


Characterizing the Effects of Sex, APOE ɛ4, and Literacy on Mid-life Cognitive Trajectories: Application of Information-Theoretic Model Averaging and Multi-model Inference Techniques to the Wisconsin Registry for Alzheimer's Prevention Study.

Koscik RL, Norton DL, Allison SL, Jonaitis EM, Clark LR, Mueller KD, Hermann BP, Engelman CD, Gleason CE, Sager MA, Chappell RJ, Johnson SC.

J Int Neuropsychol Soc. 2019 Feb;25(2):119-133. doi: 10.1017/S1355617718000954. Epub 2018 Dec 7.


Longitudinal Standards for Mid-life Cognitive Performance: Identifying Abnormal Within-Person Changes in the Wisconsin Registry for Alzheimer's Prevention.

Koscik RL, Jonaitis EM, Clark LR, Mueller KD, Allison SL, Gleason CE, Chappell RJ, Hermann BP, Johnson SC.

J Int Neuropsychol Soc. 2019 Jan;25(1):1-14. doi: 10.1017/S1355617718000929. Epub 2018 Nov 28.


Comment on Vickers et al.

Chappell R.

Clin Trials. 2019 Apr;16(2):214-215. doi: 10.1177/1740774518806868. Epub 2018 Oct 13. No abstract available.


Concurrent-Adjuvant Chemoradiation Therapy for Stage III-IVB Nasopharyngeal Carcinoma-Exploration for Achieving Optimal 10-Year Therapeutic Ratio.

Ng WT, Tung SY, Lee V, Ngan RKC, Choi HCW, Chan LLK, Leung TW, Siu LL, Lu TX, Tan T, Tan EH, Sze HCK, Ng AWY, Yiu HHY, O'Sullivan B, Chappell R, Lee AWM.

Int J Radiat Oncol Biol Phys. 2018 Aug 1;101(5):1078-1086. doi: 10.1016/j.ijrobp.2018.04.069. Epub 2018 May 2.


Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms.

Wolach O, Sellar RS, Martinod K, Cherpokova D, McConkey M, Chappell RJ, Silver AJ, Adams D, Castellano CA, Schneider RK, Padera RF, DeAngelo DJ, Wadleigh M, Steensma DP, Galinsky I, Stone RM, Genovese G, McCarroll SA, Iliadou B, Hultman C, Neuberg D, Mullally A, Wagner DD, Ebert BL.

Sci Transl Med. 2018 Apr 11;10(436). pii: eaan8292. doi: 10.1126/scitranslmed.aan8292.


The effect of solifenacin on postvoid dribbling in women: results of a randomized, double-blind placebo-controlled trial.

Ablove T, Bell LN, Liang H, Chappell RJ, Toklu HZ, Yale SH.

Int Urogynecol J. 2018 Jul;29(7):1051-1060. doi: 10.1007/s00192-018-3594-6. Epub 2018 Mar 24.


Extended Multiple-Field High-Definition transcranial direct current stimulation (HD-tDCS) is well tolerated and safe in healthy adults.

Turski CA, Kessler-Jones A, Chow C, Hermann B, Hsu D, Jones J, Seeger SK, Chappell R, Boly M, Ikonomidou C.

Restor Neurol Neurosci. 2017;35(6):631-642. doi: 10.3233/RNN-170757.


Promoting Hearing Health Collaboration Through an Interprofessional Education Experience.

James J, Chappell R, Mercante DE, Gunaldo TP.

Am J Audiol. 2017 Dec 12;26(4):570-575. doi: 10.1044/2017_AJA-17-0040.


SETD2 alterations impair DNA damage recognition and lead to resistance to chemotherapy in leukemia.

Mar BG, Chu SH, Kahn JD, Krivtsov AV, Koche R, Castellano CA, Kotlier JL, Zon RL, McConkey ME, Chabon J, Chappell R, Grauman PV, Hsieh JJ, Armstrong SA, Ebert BL.

Blood. 2017 Dec 14;130(24):2631-2641. doi: 10.1182/blood-2017-03-775569. Epub 2017 Oct 10.



Sim RR, Stringer E, Donovan D, Chappell R, Flora P, Hall J, Pillay S, Willis BG, McCain S.

J Zoo Wildl Med. 2017 Sep;48(3):891-896. doi: 10.1638/2016-0212.1.


University of Pennsylvania ninth annual conference on statistical issues in clinical trials: Where are we with adaptive clinical trial designs? (morning panel discussion).

Chappell R, Durkalski V, Joffe S.

Clin Trials. 2017 Oct;14(5):441-450. doi: 10.1177/1740774517723590. Epub 2017 Aug 19. No abstract available.


A multicenter, phase 3, randomized trial of concurrent chemoradiotherapy plus adjuvant chemotherapy versus radiotherapy alone in patients with regionally advanced nasopharyngeal carcinoma: 10-year outcomes for efficacy and toxicity.

Lee AWM, Tung SY, Ng WT, Lee V, Ngan RKC, Choi HCW, Chan LLK, Siu LL, Ng AWY, Leung TW, Yiu HHY, O'Sullivan B, Chappell R.

Cancer. 2017 Nov 1;123(21):4147-4157. doi: 10.1002/cncr.30850. Epub 2017 Jun 29.


An Examination of Brain Abnormalities and Mobility in Individuals with Mild Cognitive Impairment and Alzheimer's Disease.

Fischer BL, Bacher R, Bendlin BB, Birdsill AC, Ly M, Hoscheidt SM, Chappell RJ, Mahoney JE, Gleason CE.

Front Aging Neurosci. 2017 Apr 5;9:86. doi: 10.3389/fnagi.2017.00086. eCollection 2017.


Physiologic Expression of Sf3b1(K700E) Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation.

Obeng EA, Chappell RJ, Seiler M, Chen MC, Campagna DR, Schmidt PJ, Schneider RK, Lord AM, Wang L, Gambe RG, McConkey ME, Ali AM, Raza A, Yu L, Buonamici S, Smith PG, Mullally A, Wu CJ, Fleming MD, Ebert BL.

Cancer Cell. 2016 Sep 12;30(3):404-417. doi: 10.1016/j.ccell.2016.08.006.


Incentivizing Patient Choices: The Ethics of Inclusive Shared Savings.

Chappell RY.

Bioethics. 2016 Oct;30(8):597-600. doi: 10.1111/bioe.12267. Epub 2016 Jul 2.


Increased tumor response to neoadjuvant therapy among rectal cancer patients taking angiotensin-converting enzyme inhibitors or angiotensin receptor blockers.

Morris ZS, Saha S, Magnuson WJ, Morris BA, Borkenhagen JF, Ching A, Hirose G, McMurry V, Francis DM, Harari PM, Chappell R, Tsuji S, Ritter MA.

Cancer. 2016 Aug 15;122(16):2487-95. doi: 10.1002/cncr.30079. Epub 2016 May 20.


Describing Differences in Survival Curves.

Chappell R, Zhu X.

JAMA Oncol. 2016 Jul 1;2(7):906-7. doi: 10.1001/jamaoncol.2016.0001. No abstract available.


Beta-amyloid and cognitive decline in late middle age: Findings from the Wisconsin Registry for Alzheimer's Prevention study.

Clark LR, Racine AM, Koscik RL, Okonkwo OC, Engelman CD, Carlsson CM, Asthana S, Bendlin BB, Chappell R, Nicholas CR, Rowley HA, Oh JM, Hermann BP, Sager MA, Christian BT, Johnson SC.

Alzheimers Dement. 2016 Jul;12(7):805-14. doi: 10.1016/j.jalz.2015.12.009. Epub 2016 Jan 21.


Quality of life outcomes from a dose-per-fraction escalation trial of hypofractionation in prostate cancer.

Brower JV, Forman JD, Kupelian PA, Petereit DG, Gondi V, Lawton CA, Anger N, Saha S, Chappell R, Ritter MA.

Radiother Oncol. 2016 Jan;118(1):99-104. doi: 10.1016/j.radonc.2015.12.018. Epub 2016 Jan 2.


Sample size under the additive hazards model.

McDaniel LS, Yu M, Chappell R.

Clin Trials. 2016 Apr;13(2):188-98. doi: 10.1177/1740774515614542. Epub 2015 Nov 15.


Against 'Saving Lives': Equal Concern and Differential Impact.

Chappell RY.

Bioethics. 2016 Mar;30(3):159-64. doi: 10.1111/bioe.12171. Epub 2015 Jul 1.


Imaging-based enrichment criteria using deep learning algorithms for efficient clinical trials in mild cognitive impairment.

Ithapu VK, Singh V, Okonkwo OC, Chappell RJ, Dowling NM, Johnson SC; Alzheimer's Disease Neuroimaging Initiative.

Alzheimers Dement. 2015 Dec;11(12):1489-1499. doi: 10.1016/j.jalz.2015.01.010. Epub 2015 Jun 18.


NSAID Use and Incident Cognitive Impairment in a Population-based Cohort.

Wichmann MA, Cruickshanks KJ, Carlsson CM, Chappell R, Fischer ME, Klein BE, Klein R, Schubert CR.

Alzheimer Dis Assoc Disord. 2016 Apr-Jun;30(2):105-12. doi: 10.1097/WAD.0000000000000098.


Atypical meningioma: randomized trials are required to resolve contradictory retrospective results regarding the role of adjuvant radiotherapy.

Yoon H, Mehta MP, Perumal K, Helenowski IB, Chappell RJ, Akture E, Lin Y, Marymont MA, Sejpal S, Parsa A, Chandler JR, Bendok BR, Rosenow J, Salamat S, Kumthekar P, Raizer JK, Baskaya MK.

J Cancer Res Ther. 2015 Jan-Mar;11(1):59-66. doi: 10.4103/0973-1482.148708.


Molecular imaging biomarkers of resistance to radiation therapy for spontaneous nasal tumors in canines.

Bradshaw TJ, Bowen SR, Deveau MA, Kubicek L, White P, Bentzen SM, Chappell RJ, Forrest LJ, Jeraj R.

Int J Radiat Oncol Biol Phys. 2015 Mar 15;91(4):787-95. doi: 10.1016/j.ijrobp.2014.12.011.


Patient characteristics influencing the variability of distributed parameter-based models in DCE-CT kinetic analysis.

La Fontaine MD, McDaniel LS, Kubicek LN, Chappell RJ, Forrest LJ, Jeraj R.

Vet Comp Oncol. 2017 Mar;15(1):105-117. doi: 10.1111/vco.12143. Epub 2015 Feb 23.


Transversus abdominis plane block in robotic gynecologic oncology: a randomized, placebo-controlled trial.

Hotujec BT, Spencer RJ, Donnelly MJ, Bruggink SM, Rose SL, Al-Niaimi A, Chappell R, Stewart SL, Kushner DM.

Gynecol Oncol. 2015 Mar;136(3):460-5. doi: 10.1016/j.ygyno.2014.11.013. Epub 2014 Nov 20.


Review: Zinc's functional significance in the vertebrate retina.

Ripps H, Chappell RL.

Mol Vis. 2014 Jul 31;20:1067-74. eCollection 2014. Review.


Bilateral administration of autologous CD133+ cells in ambulatory patients with refractory critical limb ischemia: lessons learned from a pilot randomized, double-blind, placebo-controlled trial.

Raval AN, Schmuck EG, Tefera G, Leitzke C, Ark CV, Hei D, Centanni JM, de Silva R, Koch J, Chappell RG, Hematti P.

Cytotherapy. 2014 Dec;16(12):1720-32. doi: 10.1016/j.jcyt.2014.07.011. Epub 2014 Sep 18.


Long-term systemic inflammation and cognitive impairment in a population-based cohort.

Wichmann MA, Cruickshanks KJ, Carlsson CM, Chappell R, Fischer ME, Klein BE, Klein R, Tsai MY, Schubert CR.

J Am Geriatr Soc. 2014 Sep;62(9):1683-91. doi: 10.1111/jgs.12994. Epub 2014 Aug 14.


University of Pennsylvania 6th annual conference on statistical issues in clinical trials: Dynamic treatment regimes (afternoon session).

Chuang-Stein C, Follman D, Chappell R.

Clin Trials. 2014 Aug;11(4):457-466. Epub 2014 Jul 22. No abstract available.


Tests for equivalence of two survival functions: Alternative to the tests under proportional hazards.

Martinez EE, Sinha D, Wang W, Lipsitz SR, Chappell RJ.

Stat Methods Med Res. 2017 Feb;26(1):75-87. doi: 10.1177/0962280214539282. Epub 2016 Jul 11.


Cytoprotection by endogenous zinc in the vertebrate retina.

Anastassov I, Ripps H, Chappell RL.

J Neurochem. 2014 Apr;129(2):249-55. doi: 10.1111/jnc.12627. Epub 2013 Dec 13.


Dose-limiting toxicity after hypofractionated dose-escalated radiotherapy in non-small-cell lung cancer.

Cannon DM, Mehta MP, Adkison JB, Khuntia D, Traynor AM, Tomé WA, Chappell RJ, Tolakanahalli R, Mohindra P, Bentzen SM, Cannon GM.

J Clin Oncol. 2013 Dec 1;31(34):4343-8. doi: 10.1200/JCO.2013.51.5353. Epub 2013 Oct 21.


Advanced colorectal neoplasia risk stratification by penalized logistic regression.

Lin Y, Yu M, Wang S, Chappell R, Imperiale TF.

Stat Methods Med Res. 2016 Aug;25(4):1677-91. doi: 10.1177/0962280213497432. Epub 2013 Jul 30.


Long-term variability of inflammatory markers and associated factors in a population-based cohort.

Nash SD, Cruickshanks KJ, Klein R, Klein BE, Nieto FJ, Chappell R, Schubert CR, Tsai MY.

J Am Geriatr Soc. 2013 Aug;61(8):1269-76. doi: 10.1111/jgs.12382. Epub 2013 Jul 26.


Association of Biomarkers for Inflammation, Endothelial Dysfunction and Oxidative Stress with Cognitive Impairment. The Epidemiology of Hearing Loss Study (EHLS).

Obasi CN, Cruickshanks KJ, Nondahl DM, Klein BE, Klein R, Nieto FJ, Shankar A, Fischer ME, Tsai MY, Chappell R.

Oxid Antioxid Med Sci. 2012 Jun 26;1(3):169-173.


Increased local failure risk with prolonged radiation treatment time in head and neck cancer treated with concurrent chemotherapy.

Cannon DM, Geye HM, Hartig GK, Traynor AM, Hoang T, McCulloch TM, Wiederholt PA, Chappell RJ, Harari PM.

Head Neck. 2014 Aug;36(8):1120-5. doi: 10.1002/hed.23419. Epub 2013 Nov 27.


Changes in environmental tobacco smoke exposure: the Beaver Dam experience.

Wichmann MA, Cruickshanks KJ, Nondahl DM, Chappell R, Klein BE, Klein R, Fischer ME.

WMJ. 2013 Apr;112(2):53-7.


Long-term assessment of systemic inflammation and the cumulative incidence of age-related hearing impairment in the epidemiology of hearing loss study.

Nash SD, Cruickshanks KJ, Zhan W, Tsai MY, Klein R, Chappell R, Nieto FJ, Klein BE, Schubert CR, Dalton DS, Tweed TS.

J Gerontol A Biol Sci Med Sci. 2014 Feb;69(2):207-14. doi: 10.1093/gerona/glt075. Epub 2013 Jun 5.


A systematic selection method for the development of cancer staging systems.

Lin Y, Chappell R, Gönen M.

Stat Methods Med Res. 2016 Aug;25(4):1438-51. doi: 10.1177/0962280213486853. Epub 2013 May 22.


Pulse wave velocity and cognitive function in older adults.

Zhong W, Cruickshanks KJ, Schubert CR, Carlsson CM, Chappell RJ, Klein BE, Klein R, Acher CW.

Alzheimer Dis Assoc Disord. 2014 Jan-Mar;28(1):44-9. doi: 10.1097/WAD.0b013e3182949f06.


Zinc modulation of calcium activity at the photoreceptor terminal: a calcium imaging study.

Anastassov I, Shen W, Ripps H, Chappell RL.

Exp Eye Res. 2013 Jul;112:37-44. doi: 10.1016/j.exer.2013.04.011. Epub 2013 Apr 22.


Lasso tree for cancer staging with survival data.

Lin Y, Wang S, Chappell RJ.

Biostatistics. 2013 Apr;14(2):327-39. doi: 10.1093/biostatistics/kxs044. Epub 2012 Dec 5.


Carotid atherosclerosis and 10-year changes in cognitive function.

Zhong W, Cruickshanks KJ, Schubert CR, Acher CW, Carlsson CM, Klein BE, Klein R, Chappell RJ.

Atherosclerosis. 2012 Oct;224(2):506-10. doi: 10.1016/j.atherosclerosis.2012.07.024. Epub 2012 Jul 25.

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