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Quantification of cerebral perfusion and cerebrovascular reserve using Turbo-QUASAR arterial spin labeling MRI.

Zhao MY, Václavů L, Petersen ET, Biemond BJ, Sokolska MJ, Suzuki Y, Thomas DL, Nederveen AJ, Chappell MA.

Magn Reson Med. 2019 Sep 12. doi: 10.1002/mrm.27956. [Epub ahead of print]


New potential players in hepcidin regulation.

Chappell M, Rivella S.

Haematologica. 2019 Sep;104(9):1691-1693. doi: 10.3324/haematol.2019.224311. No abstract available.


Model-based Bayesian inference of brain oxygenation using quantitative BOLD.

Cherukara MT, Stone AJ, Chappell MA, Blockley NP.

Neuroimage. 2019 Aug 17;202:116106. doi: 10.1016/j.neuroimage.2019.116106. [Epub ahead of print]


Robust estimation of quantitative perfusion from multi-phase pseudo-continuous arterial spin labeling.

Msayib Y, Craig M, Simard MA, Larkin JR, Shin DD, Liu TT, Sibson NR, Okell TW, Chappell MA.

Magn Reson Med. 2019 Aug 20. doi: 10.1002/mrm.27965. [Epub ahead of print]


A mechanistic modelling approach for the determination of the mechanisms of inhibition by cyclosporine on the uptake and metabolism of atorvastatin in rat hepatocytes using a high throughput uptake method.

Carter SJ, Ferecskó AS, King L, Ménochet K, Parton T, Chappell MJ.

Xenobiotica. 2019 Aug 19:1-12. doi: 10.1080/00498254.2019.1652781. [Epub ahead of print]


Cardiorenal Syndrome and Heart Failure-Challenges and Opportunities.

Yogasundaram H, Chappell MC, Braam B, Oudit GY.

Can J Cardiol. 2019 Sep;35(9):1208-1219. doi: 10.1016/j.cjca.2019.04.002. Epub 2019 Apr 12. Review.


Fatal myocarditis and rhabdomyositis in a patient with stage IV melanoma treated with combined ipilimumab and nivolumab.

Saibil SD, Bonilla L, Majeed H, Sotov V, Hogg D, Chappell MA, Cybulsky M, Butler MO.

Curr Oncol. 2019 Jun;26(3):e418-e421. doi: 10.3747/co.26.4381. Epub 2019 Jun 1.


ICA-based denoising for ASL perfusion imaging.

Carone D, Harston GWJ, Garrard J, De Angeli F, Griffanti L, Okell TW, Chappell MA, Kennedy J.

Neuroimage. 2019 Oct 15;200:363-372. doi: 10.1016/j.neuroimage.2019.07.002. Epub 2019 Jul 2.


Association of Midlife Cardiovascular Risk Profiles With Cerebral Perfusion at Older Ages.

Suri S, Topiwala A, Chappell MA, Okell TW, Zsoldos E, Singh-Manoux A, Kivimäki M, Mackay CE, Ebmeier KP.

JAMA Netw Open. 2019 Jun 5;2(6):e195776. doi: 10.1001/jamanetworkopen.2019.5776.


Partial volume correction for quantitative CEST imaging of acute ischemic stroke.

Msayib Y, Harston GWJ, Sheerin F, Blockley NP, Okell TW, Jezzard P, Kennedy J, Chappell MA.

Magn Reson Med. 2019 Nov;82(5):1920-1928. doi: 10.1002/mrm.27872. Epub 2019 Jun 14.


Measurement of collateral perfusion in acute stroke: a vessel-encoded arterial spin labeling study.

Okell TW, Harston GWJ, Chappell MA, Sheerin F, Kennedy J, Jezzard P.

Sci Rep. 2019 Jun 3;9(1):8181. doi: 10.1038/s41598-019-44417-7.


Effects of short- and long-term cold acclimation on morphology, physiology, and exercise performance of California mice (Peromyscus californicus): potential modulation by fatherhood.

Andrew JR, Garland T Jr, Chappell MA, Zhao M, Saltzman W.

J Comp Physiol B. 2019 Aug;189(3-4):471-487. doi: 10.1007/s00360-019-01219-7. Epub 2019 May 9.


Quantitative CEST imaging of amide proton transfer in acute ischaemic stroke.

Msayib Y, Harston GWJ, Tee YK, Sheerin F, Blockley NP, Okell TW, Jezzard P, Kennedy J, Chappell MA.

Neuroimage Clin. 2019;23:101833. doi: 10.1016/j.nicl.2019.101833. Epub 2019 Apr 23.


Parameter Identification for a Model of Neonatal Fc Receptor-Mediated Recycling of Endogenous Immunoglobulin G in Humans.

Kendrick F, Evans ND, Berlanga O, Harding SJ, Chappell MJ.

Front Immunol. 2019 Apr 8;10:674. doi: 10.3389/fimmu.2019.00674. eCollection 2019.


Central ANG-(1-7) infusion improves blood pressure regulation in antenatal betamethasone-exposed sheep and reveals sex-dependent effects on oxidative stress.

Hendricks AS, Lawson MJ, Figueroa JP, Chappell MC, Diz DI, Shaltout HA.

Am J Physiol Heart Circ Physiol. 2019 Jun 1;316(6):H1458-H1467. doi: 10.1152/ajpheart.00497.2018. Epub 2019 Apr 5.


High temporal resolution arterial spin labeling MRI with whole-brain coverage by combining time-encoding with Look-Locker and simultaneous multi-slice imaging.

van der Plas MCE, Teeuwisse WM, Schmid S, Chappell M, van Osch MJP.

Magn Reson Med. 2019 Jun;81(6):3734-3744. doi: 10.1002/mrm.27692. Epub 2019 Mar 3.


Building geochemically based quantitative analogies from soil classification systems using different compositional datasets.

Chappell MA, Seiter JM, West HM, Durham BD, Porter BE, Price CL.

PLoS One. 2019 Feb 19;14(2):e0212214. doi: 10.1371/journal.pone.0212214. eCollection 2019.


Hyperprogressive disease in early-phase immunotherapy trials: Clinical predictors and association with immune-related toxicities.

Kanjanapan Y, Day D, Wang L, Al-Sawaihey H, Abbas E, Namini A, Siu LL, Hansen A, Razak AA, Spreafico A, Leighl N, Joshua AM, Butler MO, Hogg D, Chappell MA, Soultani L, Chow K, Boujos S, Bedard PL.

Cancer. 2019 Apr 15;125(8):1341-1349. doi: 10.1002/cncr.31999. Epub 2019 Feb 15.


Gene Therapy for Beta-Hemoglobinopathies: Milestones, New Therapies and Challenges.

Ghiaccio V, Chappell M, Rivella S, Breda L.

Mol Diagn Ther. 2019 Apr;23(2):173-186. doi: 10.1007/s40291-019-00383-4. Review.


Tumor pH and Protein Concentration Contribute to the Signal of Amide Proton Transfer Magnetic Resonance Imaging.

Ray KJ, Simard MA, Larkin JR, Coates J, Kinchesh P, Smart SC, Higgins GS, Chappell MA, Sibson NR.

Cancer Res. 2019 Apr 1;79(7):1343-1352. doi: 10.1158/0008-5472.CAN-18-2168. Epub 2019 Jan 24.


Best Practices to Maximize the Use and Reuse of Quantitative and Systems Pharmacology Models: Recommendations From the United Kingdom Quantitative and Systems Pharmacology Network.

Cucurull-Sanchez L, Chappell MJ, Chelliah V, Amy Cheung SY, Derks G, Penney M, Phipps A, Malik-Sheriff RS, Timmis J, Tindall MJ, van der Graaf PH, Vicini P, Yates JWT.

CPT Pharmacometrics Syst Pharmacol. 2019 May;8(5):259-272. doi: 10.1002/psp4.12381. Epub 2019 Mar 22.


Fetal programming and the angiotensin-(1-7) axis: a review of the experimental and clinical data.

South AM, Shaltout HA, Washburn LK, Hendricks AS, Diz DI, Chappell MC.

Clin Sci (Lond). 2019 Jan 8;133(1):55-74. doi: 10.1042/CS20171550. Print 2019 Jan 15. Review.


A general framework for optimizing arterial spin labeling MRI experiments.

Woods JG, Chappell MA, Okell TW.

Magn Reson Med. 2019 Apr;81(4):2474-2488. doi: 10.1002/mrm.27580. Epub 2018 Dec 26.


Comparison of Candesartan and Angiotensin-(1-7) Combination to Mito-TEMPO Treatment for Normalizing Blood Pressure and Sympathovagal Balance in (mREN2)27 Rats.

Nautiyal M, Shaltout HA, Chappell MC, Diz DI.

J Cardiovasc Pharmacol. 2019 Mar;73(3):143-148. doi: 10.1097/FJC.0000000000000645.


Sensitivity of Multiphase Pseudocontinuous Arterial Spin Labelling (MP pCASL) Magnetic Resonance Imaging for Measuring Brain and Tumour Blood Flow in Mice.

Buck J, Larkin JR, Simard MA, Khrapitchev AA, Chappell MA, Sibson NR.

Contrast Media Mol Imaging. 2018 Nov 7;2018:4580919. doi: 10.1155/2018/4580919. eCollection 2018.


Delayed immune-related adverse events in assessment for dose-limiting toxicity in early phase immunotherapy trials.

Kanjanapan Y, Day D, Butler MO, Wang L, Joshua AM, Hogg D, Leighl NB, Razak ARA, Hansen AR, Boujos S, Chappell M, Chow K, Sherwin B, Stayner LA, Soultani L, Zambrana A, Siu LL, Bedard PL, Spreafico A.

Eur J Cancer. 2019 Jan;107:1-7. doi: 10.1016/j.ejca.2018.10.017. Epub 2018 Dec 7.


Assessing Reliability of Myocardial Blood Flow After Motion Correction With Dynamic PET Using a Bayesian Framework.

Saillant A, Armstrong I, Shah V, Zuehlsdorff S, Hayden C, Declerck J, Saint K, Memmott M, Jenkinson M, Chappell MA.

IEEE Trans Med Imaging. 2019 May;38(5):1216-1226. doi: 10.1109/TMI.2018.2881992. Epub 2018 Nov 19.


Obesity is Associated with Higher Blood Pressure and Higher Levels of Angiotensin II but Lower Angiotensin-(1-7) in Adolescents Born Preterm.

South AM, Nixon PA, Chappell MC, Diz DI, Russell GB, Shaltout HA, O'Shea TM, Washburn LK.

J Pediatr. 2019 Feb;205:55-60.e1. doi: 10.1016/j.jpeds.2018.09.058. Epub 2018 Nov 5.


Visualizing artery-specific blood flow patterns above the circle of Willis with vessel-encoded arterial spin labeling.

Okell TW, Garcia M, Chappell MA, Byrne JV, Jezzard P.

Magn Reson Med. 2019 Mar;81(3):1595-1604. doi: 10.1002/mrm.27507. Epub 2018 Oct 25.


A framework for motion correction of background suppressed arterial spin labeling perfusion images acquired with simultaneous multi-slice EPI.

Suzuki Y, Okell TW, Chappell MA, van Osch MJP.

Magn Reson Med. 2019 Mar;81(3):1553-1565. doi: 10.1002/mrm.27499. Epub 2018 Oct 12.


Extending the Human Connectome Project across ages: Imaging protocols for the Lifespan Development and Aging projects.

Harms MP, Somerville LH, Ances BM, Andersson J, Barch DM, Bastiani M, Bookheimer SY, Brown TB, Buckner RL, Burgess GC, Coalson TS, Chappell MA, Dapretto M, Douaud G, Fischl B, Glasser MF, Greve DN, Hodge C, Jamison KW, Jbabdi S, Kandala S, Li X, Mair RW, Mangia S, Marcus D, Mascali D, Moeller S, Nichols TE, Robinson EC, Salat DH, Smith SM, Sotiropoulos SN, Terpstra M, Thomas KM, Tisdall MD, Ugurbil K, van der Kouwe A, Woods RP, Zöllei L, Van Essen DC, Yacoub E.

Neuroimage. 2018 Dec;183:972-984. doi: 10.1016/j.neuroimage.2018.09.060. Epub 2018 Sep 24.


Renal function and blood pressure are altered in adolescents born preterm.

South AM, Nixon PA, Chappell MC, Diz DI, Russell GB, Jensen ET, Shaltout HA, O'Shea TM, Washburn LK.

Pediatr Nephrol. 2019 Jan;34(1):137-144. doi: 10.1007/s00467-018-4050-z. Epub 2018 Aug 15.


Learning pharmacokinetic models for in vivo glucocorticoid activation.

Bunte K, Smith DJ, Chappell MJ, Hassan-Smith ZK, Tomlinson JW, Arlt W, Tiňo P.

J Theor Biol. 2018 Oct 14;455:222-231. doi: 10.1016/j.jtbi.2018.07.025. Epub 2018 Jul 23.


Sex-dependent expression of brain medullary MAP and PI3 kinases in adult sheep with antenatal betamethasone exposure.

Hendricks AS, Shaltout HA, Westwood BM, Chappell MC, Diz DI.

Clin Sci (Lond). 2018 Sep 16;132(17):1953-1962. doi: 10.1042/CS20180417. Print 2018 Sep 14.


Chemical exchange saturation transfer MRI shows low cerebral 2-deoxy-D-glucose uptake in a model of Alzheimer's Disease.

Tolomeo D, Micotti E, Serra SC, Chappell M, Snellman A, Forloni G.

Sci Rep. 2018 Jun 22;8(1):9576. doi: 10.1038/s41598-018-27839-7.


Posterior fossa medulloblastoma in an atypical extra-axial location: A case report.

Presutto E, Chappell M, Fullmer J, Ezhapilli S.

Radiol Case Rep. 2018 Feb 3;13(2):365-370. doi: 10.1016/j.radcr.2018.01.007. eCollection 2018 Apr.


Association between preterm birth and the renin-angiotensin system in adolescence: influence of sex and obesity.

South AM, Nixon PA, Chappell MC, Diz DI, Russell GB, Jensen ET, Shaltout HA, OʼShea TM, Washburn LK.

J Hypertens. 2018 Oct;36(10):2092-2101. doi: 10.1097/HJH.0000000000001801.


4D-PET reconstruction using a spline-residue model with spatial and temporal roughness penalties.

Ralli GP, Chappell MA, McGowan DR, Sharma RA, Higgins GS, Fenwick JD.

Phys Med Biol. 2018 May 4;63(9):095013. doi: 10.1088/1361-6560/aabb62.


Seasonal temperature acclimatization in a semi-fossorial mammal and the role of burrows as thermal refuges.

Milling CR, Rachlow JL, Chappell MA, Camp MJ, Johnson TR, Shipley LA, Paul DR, Forbey JS.

PeerJ. 2018 Mar 16;6:e4511. doi: 10.7717/peerj.4511. eCollection 2018.


A DCE-MRI Driven 3-D Reaction-Diffusion Model of Solid Tumor Growth.

Roque T, Risser L, Kersemans V, Smart S, Allen D, Kinchesh P, Gilchrist S, Gomes AL, Schnabel JA, Chappell MA.

IEEE Trans Med Imaging. 2018 Mar;37(3):724-732. doi: 10.1109/TMI.2017.2779811.


Quantitative blood flow measurement in rat brain with multiphase arterial spin labelling magnetic resonance imaging.

Larkin JR, Simard MA, Khrapitchev AA, Meakin JA, Okell TW, Craig M, Ray KJ, Jezzard P, Chappell MA, Sibson NR.

J Cereb Blood Flow Metab. 2019 Aug;39(8):1557-1569. doi: 10.1177/0271678X18756218. Epub 2018 Mar 2.


Hydrogen sulfide, then nitric oxide and vasoprotection.

Chappell MC.

J Hypertens. 2018 Mar;36(3):493-494. doi: 10.1097/HJH.0000000000001617. No abstract available.


Effects of a physical and energetic challenge on male California mice (Peromyscus californicus): modulation by reproductive condition.

Zhao M, Garland T Jr, Chappell MA, Andrew JR, Harris BN, Saltzman W.

J Exp Biol. 2018 Jan 11;221(Pt 1). pii: jeb168559. doi: 10.1242/jeb.168559.


Arterial spin labeling for the measurement of cerebral perfusion and angiography.

Jezzard P, Chappell MA, Okell TW.

J Cereb Blood Flow Metab. 2018 Apr;38(4):603-626. doi: 10.1177/0271678X17743240. Epub 2017 Nov 23. Review.


Extending existing structural identifiability analysis methods to mixed-effects models.

Janzén DLI, Jirstrand M, Chappell MJ, Evans ND.

Math Biosci. 2018 Jan;295:1-10. doi: 10.1016/j.mbs.2017.10.009. Epub 2017 Oct 26.


Attenuation of pulmonary ACE2 activity impairs inactivation of des-Arg9 bradykinin/BKB1R axis and facilitates LPS-induced neutrophil infiltration.

Sodhi CP, Wohlford-Lenane C, Yamaguchi Y, Prindle T, Fulton WB, Wang S, McCray PB Jr, Chappell M, Hackam DJ, Jia H.

Am J Physiol Lung Cell Mol Physiol. 2018 Jan 1;314(1):L17-L31. doi: 10.1152/ajplung.00498.2016. Epub 2017 Sep 21.


The relationship between blood flow impairment and oxygen depletion in acute ischemic stroke imaged with magnetic resonance imaging.

Seiler A, Blockley NP, Deichmann R, Nöth U, Singer OC, Chappell MA, Klein JC, Wagner M.

J Cereb Blood Flow Metab. 2019 Mar;39(3):454-465. doi: 10.1177/0271678X17732448. Epub 2017 Sep 20.


A systematic study of the sensitivity of partial volume correction methods for the quantification of perfusion from pseudo-continuous arterial spin labeling MRI.

Zhao MY, Mezue M, Segerdahl AR, Okell TW, Tracey I, Xiao Y, Chappell MA.

Neuroimage. 2017 Nov 15;162:384-397. doi: 10.1016/j.neuroimage.2017.08.072. Epub 2017 Sep 5.


Sockeye salmon immunoglobulin VH usage and pathogen loads differ between spawning sites.

Chappell ME, Epp L, Zwollo P.

Dev Comp Immunol. 2017 Dec;77:297-306. doi: 10.1016/j.dci.2017.08.015. Epub 2017 Aug 25.


Multivariate soil fertility relationships for predicting the environmental persistence of 2,4,6-trinitrotoluene (TNT) and 1,3,5-trinitro-1,3,5-tricyclohexane (RDX) among taxonomically distinct soils.

Katseanes CK, Chappell MA, Hopkins BG, Durham BD, Price CL, Porter BE, Miller LF.

J Environ Manage. 2017 Dec 1;203(Pt 1):383-390. doi: 10.1016/j.jenvman.2017.08.005.

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