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Combined diffusion-relaxometry MRI to identify dysfunction in the human placenta.

Slator PJ, Hutter J, Palombo M, Jackson LH, Ho A, Panagiotaki E, Chappell LC, Rutherford MA, Hajnal JV, Alexander DC.

Magn Reson Med. 2019 Mar 18. doi: 10.1002/mrm.27733. [Epub ahead of print]


Temporal and external validation of the fullPIERS model for the prediction of adverse maternal outcomes in women with pre-eclampsia.

Ukah UV, Payne B, Karjalainen H, Kortelainen E, Seed PT, Conti-Ramsden FI, Cao V, Laivuori H, Hutcheon J, Chappell L, Mark Ansermino J, Vatish M, Redman C, Lee T, Li L, Magee LA, von Dadelszen P; fullPIERS Group.

Pregnancy Hypertens. 2019 Jan;15:42-50. doi: 10.1016/j.preghy.2018.01.004. Epub 2018 Jan 5.


Effect of a novel vital sign device on maternal mortality and morbidity in low-resource settings: a pragmatic, stepped-wedge, cluster-randomised controlled trial.

Vousden N, Lawley E, Nathan HL, Seed PT, Gidiri MF, Goudar S, Sandall J, Chappell LC, Shennan AH; CRADLE Trial Collaborative Group.

Lancet Glob Health. 2019 Mar;7(3):e347-e356. doi: 10.1016/S2214-109X(18)30526-6.


Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses.

Ovadia C, Seed PT, Sklavounos A, Geenes V, Di Illio C, Chambers J, Kohari K, Bacq Y, Bozkurt N, Brun-Furrer R, Bull L, Estiú MC, Grymowicz M, Gunaydin B, Hague WM, Haslinger C, Hu Y, Kawakita T, Kebapcilar AG, Kebapcilar L, Kondrackienė J, Koster MPH, Kowalska-Kańka A, Kupčinskas L, Lee RH, Locatelli A, Macias RIR, Marschall HU, Oudijk MA, Raz Y, Rimon E, Shan D, Shao Y, Tribe R, Tripodi V, Yayla Abide C, Yenidede I, Thornton JG, Chappell LC, Williamson C.

Lancet. 2019 Mar 2;393(10174):899-909. doi: 10.1016/S0140-6736(18)31877-4. Epub 2019 Feb 14.


Reducing maternal deaths from hypertensive disorders: learning from confidential inquiries.

Conti-Ramsden F, Knight M, Green M, Shennan AH, Chappell LC.

BMJ. 2019 Feb 5;364:l230. doi: 10.1136/bmj.l230. No abstract available.


Planned delivery or expectant management for late preterm pre-eclampsia: study protocol for a randomised controlled trial (PHOENIX trial).

Chappell LC, Green M, Marlow N, Sandall J, Hunter R, Robson S, Bowler U, Chiocchia V, Hardy P, Juszczak E, Linsell L, Placzek A, Brocklehurst P, Shennan A.

Trials. 2019 Jan 28;20(1):85. doi: 10.1186/s13063-018-3150-1.


Uncertainties in screening and prevention of Group B Streptococcus disease.

Le Doare K, Heath PT, Plumb J, Owen NA, Brocklehurst P, Chappell LC.

Clin Infect Dis. 2018 Dec 17. doi: 10.1093/cid/ciy1069. [Epub ahead of print]


Prospective biomarkers in preterm preeclampsia: A review.

McCarthy FP, Ryan RM, Chappell LC.

Pregnancy Hypertens. 2018 Oct;14:72-78. doi: 10.1016/j.preghy.2018.03.010. Epub 2018 Mar 23. Review.


Schizont transcriptome variation among clinical isolates and laboratory-adapted clones of the malaria parasite Plasmodium falciparum.

Tarr SJ, Díaz-Ingelmo O, Stewart LB, Hocking SE, Murray L, Duffy CW, Otto TD, Chappell L, Rayner JC, Awandare GA, Conway DJ.

BMC Genomics. 2018 Dec 10;19(1):894. doi: 10.1186/s12864-018-5257-x.


Ursodeoxycholic acid versus placebo in the treatment of women with intrahepatic cholestasis of pregnancy (ICP) to improve perinatal outcomes: protocol for a randomised controlled trial (PITCHES).

Chappell LC, Chambers J, Dixon PH, Dorling J, Hunter R, Bell JL, Bowler U, Hardy P, Juszczak E, Linsell L, Rounding C, Smith A, Williamson C, Thornton JG.

Trials. 2018 Nov 27;19(1):657. doi: 10.1186/s13063-018-3018-4.


Development and evaluation of a novel Vital Signs Alert device for use in pregnancy in low-resource settings.

Nathan HL, Vousden N, Lawley E, de Greeff A, Hezelgrave NL, Sloan N, Tanna N, Goudar SS, Gidiri MF, Sandall J, Chappell LC, Shennan AH.

BMJ Innov. 2018 Oct;4(4):192-198. doi: 10.1136/bmjinnov-2017-000235. Epub 2018 Sep 19.


The impact of ethnicity on adverse perinatal outcome in women with chronic hypertension: a cohort study.

Webster LM, Bramham K, Seed PT, Homsy M, Widdows K, Webb AJ, Nelson-Piercy C, Magee L, Thilaganathan B, Myers JE, Chappell LC.

Ultrasound Obstet Gynecol. 2018 Oct 14. doi: 10.1002/uog.20132. [Epub ahead of print]


An Innovative Audiovisual Reflective Portfolio for Nursing Students.

Ackerman C, Chappell L.

Nurse Educ. 2018 Oct 6. doi: 10.1097/NNE.0000000000000607. [Epub ahead of print] No abstract available.


Prediction of pre-eclampsia: review of reviews.

Townsend R, Khalil A, Premakumar Y, Allotey J, Snell KIE, Chan C, Chappell LC, Hooper R, Green M, Mol BW, Thilaganathan B, Thangaratinam S; IPPIC Network.

Ultrasound Obstet Gynecol. 2018 Sep 28. doi: 10.1002/uog.20117. [Epub ahead of print] Review.


Multi-modal functional MRI to explore placental function over gestation.

Hutter J, Slator PJ, Jackson L, Gomes ADS, Ho A, Story L, O'Muircheartaigh J, Teixeira RPAG, Chappell LC, Alexander DC, Rutherford MA, Hajnal JV.

Magn Reson Med. 2019 Feb;81(2):1191-1204. doi: 10.1002/mrm.27447. Epub 2018 Sep 21.


Why is the search for pre-eclampsia prevention so elusive?

Myers JE, Green M, Chappell LC.

BMJ. 2018 Sep 12;362:k3536. doi: 10.1136/bmj.k3536. No abstract available.


Creating biobanks in low and middle-income countries to improve knowledge - The PREPARE initiative.

De Oliveira L, Dias MAB, Jeyabalan A, Payne B, Redman CW, Magee L, Poston L, Chappell L, Seed P, von Dadelszen P, Roberts JM.

Pregnancy Hypertens. 2018 Jul;13:62-64. doi: 10.1016/j.preghy.2018.05.007. Epub 2018 May 24.


Postpartum evaluation of cardiovascular disease risk for women with pregnancies complicated by hypertension.

Escouto DC, Green A, Kurlak L, Walker K, Loughna P, Chappell L, Broughton Pipkin F, Bramham K.

Pregnancy Hypertens. 2018 Jul;13:218-224. doi: 10.1016/j.preghy.2018.06.019. Epub 2018 Jun 30.


What is the evidence for using labetalol as a first-line treatment option for hypertension in pregnancy?

Webster LM, Webb AJ, Chappell LC.

Drug Ther Bull. 2018 Sep;56(9):107-111. doi: 10.1136/dtb.2018.9.000008. Epub 2018 Aug 27. Review. No abstract available.


Maternal and perinatal adverse outcomes in women with pre-eclampsia cared for at facility-level in South Africa: a prospective cohort study.

Nathan HL, Seed PT, Hezelgrave NL, De Greeff A, Lawley E, Conti-Ramsden F, Anthony J, Steyn W, Hall DR, Chappell LC, Shennan AH.

J Glob Health. 2018 Dec;8(2):020401. doi: 10.7189/jogh.08-020401.


Publisher Correction: Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures.

Sozen B, Amadei G, Cox A, Wang R, Na E, Czukiewska S, Chappell L, Voet T, Michel G, Jing N, Glover DM, Zernicka-Goetz M.

Nat Cell Biol. 2018 Oct;20(10):1229. doi: 10.1038/s41556-018-0187-z.


The mRNA cap methyltransferase gene TbCMT1 is not essential in vitro but is a virulence factor in vivo for bloodstream form Trypanosoma brucei.

Kelner A, Tinti M, Guther MLS, Foth BJ, Chappell L, Berriman M, Cowling VH, Ferguson MAJ.

PLoS One. 2018 Jul 24;13(7):e0201263. doi: 10.1371/journal.pone.0201263. eCollection 2018.


Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures.

Sozen B, Amadei G, Cox A, Wang R, Na E, Czukiewska S, Chappell L, Voet T, Michel G, Jing N, Glover DM, Zernicka-Goetz M.

Nat Cell Biol. 2018 Aug;20(8):979-989. doi: 10.1038/s41556-018-0147-7. Epub 2018 Jul 23. Erratum in: Nat Cell Biol. 2018 Oct;20(10):1229.


RecQ helicases in the malaria parasite Plasmodium falciparum affect genome stability, gene expression patterns and DNA replication dynamics.

Claessens A, Harris LM, Stanojcic S, Chappell L, Stanton A, Kuk N, Veneziano-Broccia P, Sterkers Y, Rayner JC, Merrick CJ.

PLoS Genet. 2018 Jul 2;14(7):e1007490. doi: 10.1371/journal.pgen.1007490. eCollection 2018 Jul.


Radiation Exposure and Mortality from Cardiovascular Disease and Cancer in Early NASA Astronauts.

Elgart SR, Little MP, Chappell LJ, Milder CM, Shavers MR, Huff JL, Patel ZS.

Sci Rep. 2018 May 31;8(1):8480. doi: 10.1038/s41598-018-25467-9.


Single-Cell (Multi)omics Technologies.

Chappell L, Russell AJC, Voet T.

Annu Rev Genomics Hum Genet. 2018 Aug 31;19:15-41. doi: 10.1146/annurev-genom-091416-035324. Epub 2018 May 4.


Evaluation of a novel vital sign device to reduce maternal mortality and morbidity in low-resource settings: a mixed method feasibility study for the CRADLE-3 trial.

Vousden N, Lawley E, Nathan HL, Seed PT, Brown A, Muchengwa T, Charantimath U, Bellad M, Gidiri MF, Goudar S, Chappell LC, Sandall J, Shennan AH; CRADLE Trial Collaborative Group.

BMC Pregnancy Childbirth. 2018 Apr 27;18(1):115. doi: 10.1186/s12884-018-1737-x.


Placental Growth Factor informed management of suspected pre-eclampsia or fetal growth restriction: The MAPPLE cohort study.

Sharp A, Chappell LC, Dekker G, Pelletier S, Garnier Y, Zeren O, Hillerer KM, Fischer T, Seed PT, Turner M, Shennan AH, Alfirevic Z.

Pregnancy Hypertens. 2018 Oct;14:228-233. doi: 10.1016/j.preghy.2018.03.013. Epub 2018 Mar 26.


Evaluation of a novel device for the management of high blood pressure and shock in pregnancy in low-resource settings: study protocol for a stepped-wedge cluster-randomised controlled trial (CRADLE-3 trial).

Nathan HL, Duhig K, Vousden N, Lawley E, Seed PT, Sandall J, Bellad MB, Brown AC, Chappell LC, Goudar SS, Gidiri MF, Shennan AH; CRADLE-3 Trial Collaboration Group.

Trials. 2018 Mar 27;19(1):206. doi: 10.1186/s13063-018-2581-z.


Comparison of three commercially available placental growth factor-based tests in women with suspected preterm pre-eclampsia: the COMPARE study.

McCarthy FP, Gill C, Seed PT, Bramham K, Chappell LC, Shennan AH.

Ultrasound Obstet Gynecol. 2019 Jan;53(1):62-67. doi: 10.1002/uog.19051. Epub 2018 Dec 5.


The effect of labetalol and nifedipine MR on blood pressure in women with chronic hypertension in pregnancy.

Shawkat E, Mistry H, Chmiel C, Webster L, Chappell L, Johnstone ED, Myers JE.

Pregnancy Hypertens. 2018 Jan;11:92-98. doi: 10.1016/j.preghy.2017.12.007. Epub 2018 Jan 2.


Chronic hypertension in pregnancy: impact of ethnicity and superimposed preeclampsia on placental, endothelial, and renal biomarkers.

Webster LM, Gill C, Seed PT, Bramham K, Wiesender C, Nelson-Piercy C, Myers JE, Chappell LC.

Am J Physiol Regul Integr Comp Physiol. 2018 Jul 1;315(1):R36-R47. doi: 10.1152/ajpregu.00139.2017. Epub 2018 Mar 7.


Reduced fetal movements.

Jakes AD, Whybrow R, Spencer C, Chappell LC.

BMJ. 2018 Mar 6;360:k570. doi: 10.1136/bmj.k570. No abstract available.


Does ursodeoxycholic acid improve perinatal outcomes in women with intrahepatic cholestasis of pregnancy?

Chappell LC, Chambers J, Thornton JG, Williamson C.

BMJ. 2018 Feb 1;360:k104. doi: 10.1136/bmj.k104. No abstract available.


Longitudinal changes in vascular function parameters in pregnant women with chronic hypertension and association with adverse outcome: a cohort study.

Webster LM, Myers JE, Nelson-Piercy C, Mills C, Watt-Coote I, Khalil A, Seed PT, Cruickshank JK, Chappell LC.

Ultrasound Obstet Gynecol. 2018 Jan 30. doi: 10.1002/uog.19021. [Epub ahead of print]


The CRADLE vital signs alert: qualitative evaluation of a novel device designed for use in pregnancy by healthcare workers in low-resource settings.

Nathan HL, Boene H, Munguambe K, Sevene E, Akeju D, Adetoro OO, Charanthimath U, Bellad MB, de Greeff A, Anthony J, Hall DR, Steyn W, Vidler M, von Dadelszen P, Chappell LC, Sandall J, Shennan AH; CLIP Working Group.

Reprod Health. 2018 Jan 5;15(1):5. doi: 10.1186/s12978-017-0450-y.


Implementation of guidelines for multidisciplinary team management of pregnancy in women with pre-existing diabetes or cardiac conditions: results from a UK national survey.

Taylor C, McCance DR, Chappell L, Nelson-Piercy C, Thorne SA, Ismail KMK, Green JSA, Bick D.

BMC Pregnancy Childbirth. 2017 Dec 22;17(1):434. doi: 10.1186/s12884-017-1609-9.


The feasibility and acceptability of self-testing for proteinuria during pregnancy: A mixed methods approach.

Tucker KL, Bowen L, Crawford C, Mallon P, Hinton L, Lee MM, Oke J, Taylor KS, Heneghan C, Bankhead C, Mackillop L, James T, Oakeshott P, Chappell LC, McManus RJ.

Pregnancy Hypertens. 2018 Apr;12:161-168. doi: 10.1016/j.preghy.2017.11.009. Epub 2017 Nov 23.


Early warning system hypertension thresholds to predict adverse outcomes in pre-eclampsia: A prospective cohort study.

Nathan HL, Seed PT, Hezelgrave NL, De Greeff A, Lawley E, Anthony J, Hall DR, Steyn W, Chappell LC, Shennan AH.

Pregnancy Hypertens. 2018 Apr;12:183-188. doi: 10.1016/j.preghy.2017.11.003. Epub 2017 Nov 21.


Preterm pre-eclampsia: What every neonatologist should know.

Story L, Chappell LC.

Early Hum Dev. 2017 Nov;114:26-30. doi: 10.1016/j.earlhumdev.2017.09.010. Epub 2017 Sep 13. Review.


Labetalol Versus Nifedipine as Antihypertensive Treatment for Chronic Hypertension in Pregnancy: A Randomized Controlled Trial.

Webster LM, Myers JE, Nelson-Piercy C, Harding K, Cruickshank JK, Watt-Coote I, Khalil A, Wiesender C, Seed PT, Chappell LC.

Hypertension. 2017 Nov;70(5):915-922. doi: 10.1161/HYPERTENSIONAHA.117.09972. Epub 2017 Sep 11.


The exported chaperone Hsp70-x supports virulence functions for Plasmodium falciparum blood stage parasites.

Charnaud SC, Dixon MWA, Nie CQ, Chappell L, Sanders PR, Nebl T, Hanssen E, Berriman M, Chan JA, Blanch AJ, Beeson JG, Rayner JC, Przyborski JM, Tilley L, Crabb BS, Gilson PR.

PLoS One. 2017 Jul 21;12(7):e0181656. doi: 10.1371/journal.pone.0181656. eCollection 2017.


Impact of Antihypertensive Treatment on Maternal and Perinatal Outcomes in Pregnancy Complicated by Chronic Hypertension: A Systematic Review and Meta-Analysis.

Webster LM, Conti-Ramsden F, Seed PT, Webb AJ, Nelson-Piercy C, Chappell LC.

J Am Heart Assoc. 2017 May 17;6(5). pii: e005526. doi: 10.1161/JAHA.117.005526. Review.


Predicting delivery of a small-for-gestational-age infant and adverse perinatal outcome in women with suspected pre-eclampsia.

Griffin M, Seed PT, Duckworth S, North R, Myers J, Mackillop L, Simpson N, Waugh J, Anumba D, Kenny LC, Redman CWG, Shennan AH, Chappell LC.

Ultrasound Obstet Gynecol. 2018 Mar;51(3):387-395. doi: 10.1002/uog.17490. Epub 2018 Feb 7.


Maternal deaths in the UK: pre-eclampsia deaths are avoidable.

Shennan AH, Green M, Chappell LC.

Lancet. 2017 Feb 11;389(10069):582-584. doi: 10.1016/S0140-6736(17)30184-8. No abstract available.


A Knockout Screen of ApiAP2 Genes Reveals Networks of Interacting Transcriptional Regulators Controlling the Plasmodium Life Cycle.

Modrzynska K, Pfander C, Chappell L, Yu L, Suarez C, Dundas K, Gomes AR, Goulding D, Rayner JC, Choudhary J, Billker O.

Cell Host Microbe. 2017 Jan 11;21(1):11-22. doi: 10.1016/j.chom.2016.12.003.


Determination of Normal Ranges of Shock Index and Other Haemodynamic Variables in the Immediate Postpartum Period: A Cohort Study.

Nathan HL, Cottam K, Hezelgrave NL, Seed PT, Briley A, Bewley S, Chappell LC, Shennan AH.

PLoS One. 2016 Dec 20;11(12):e0168535. doi: 10.1371/journal.pone.0168535. eCollection 2016.


Improving the Pipeline for Developing and Testing Pharmacological Treatments in Pregnancy.

Chappell LC, David AL.

PLoS Med. 2016 Nov 1;13(11):e1002161. doi: 10.1371/journal.pmed.1002161. eCollection 2016 Nov.


Placental Growth Factor (PlGF) in Women with Suspected Pre-Eclampsia Prior to 35 Weeks' Gestation: A Budget Impact Analysis.

Duckworth S, Chappell LC, Seed PT, Mackillop L, Shennan AH, Hunter R.

PLoS One. 2016 Oct 14;11(10):e0164276. doi: 10.1371/journal.pone.0164276. eCollection 2016.


Oxidative stress in pregnancy and reproduction.

Duhig K, Chappell LC, Shennan AH.

Obstet Med. 2016 Sep;9(3):113-6. doi: 10.1177/1753495X16648495. Epub 2016 May 17. Review.

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