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Investigating musculoskeletal health and wellbeing; a cohort study protocol.

Millar B, McWilliams DF, Abhishek A, Akin-Akinyosoye K, Auer DP, Chapman V, Doherty M, Ferguson E, Gladman JRF, Greenhaff P, Stocks J, Valdes AM, Walsh DA.

BMC Musculoskelet Disord. 2020 Mar 21;21(1):182. doi: 10.1186/s12891-020-03195-4.


Lipidomic identification of plasma lipids associated with pain behaviour and pathology in a mouse model of osteoarthritis.

Pousinis P, Gowler PRW, Burston JJ, Ortori CA, Chapman V, Barrett DA.

Metabolomics. 2020 Feb 27;16(3):32. doi: 10.1007/s11306-020-01652-8.


Peripheral brain-derived neurotrophic factor contributes to chronic osteoarthritis joint pain.

Gowler PRW, Li L, Woodhams SG, Bennett AJ, Suzuki R, Walsh DA, Chapman V.

Pain. 2020 Jan;161(1):61-73. doi: 10.1097/j.pain.0000000000001694.


Cell type-specific super-resolution imaging reveals an increase in calcium-permeable AMPA receptors at spinal peptidergic terminals as an anatomical correlate of inflammatory pain.

Woodhams SG, Markus R, Gowler PRW, Self TJ, Chapman V.

Pain. 2019 Nov;160(11):2641-2650. doi: 10.1097/j.pain.0000000000001672.


The polyadenylation inhibitor cordycepin reduces pain, inflammation and joint pathology in rodent models of osteoarthritis.

Ashraf S, Radhi M, Gowler P, Burston JJ, Gandhi RD, Thorn GJ, Piccinini AM, Walsh DA, Chapman V, de Moor CH.

Sci Rep. 2019 Mar 18;9(1):4696. doi: 10.1038/s41598-019-41140-1.


The impact of anxiety on chronic musculoskeletal pain and the role of astrocyte activation.

Burston JJ, Valdes AM, Woodhams SG, Mapp PI, Stocks J, Watson DJG, Gowler PRW, Xu L, Sagar DR, Fernandes G, Frowd N, Marshall L, Zhang W, Doherty M, Walsh DA, Chapman V.

Pain. 2019 Mar;160(3):658-669. doi: 10.1097/j.pain.0000000000001445.


Analgesic effects of the cathepsin K inhibitor L-006235 in the monosodium iodoacetate model of osteoarthritis pain.

Nwosu LN, Gowler PRW, Burston JJ, Rizoska B, Tunblad K, Lindström E, Grabowska U, Li L, McWilliams DF, Walsh DA, Chapman V.

Pain Rep. 2018 Oct 5;3(6):e685. doi: 10.1097/PR9.0000000000000685. eCollection 2018 Nov.


n-3 polyunsaturated N-acylethanolamines are CB2 cannabinoid receptor-preferring endocannabinoids.

Alharthi N, Christensen P, Hourani W, Ortori C, Barrett DA, Bennett AJ, Chapman V, Alexander SPH.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Nov;1863(11):1433-1440. doi: 10.1016/j.bbalip.2018.08.003. Epub 2018 Aug 7.


Lamina-specific population encoding of cutaneous signals in the spinal dorsal horn using multi-electrode arrays.

Greenspon CM, Battell EE, Devonshire IM, Donaldson LF, Chapman V, Hathway GJ.

J Physiol. 2019 Jan;597(2):377-397. doi: 10.1113/JP277036. Epub 2018 Dec 5.


Omega-6 oxylipins generated by soluble epoxide hydrolase are associated with knee osteoarthritis.

Valdes AM, Ravipati S, Pousinis P, Menni C, Mangino M, Abhishek A, Chapman V, Barrett DA, Doherty M.

J Lipid Res. 2018 Sep;59(9):1763-1770. doi: 10.1194/jlr.P085118. Epub 2018 Jul 9.


Systemic administration of WY-14643, a selective synthetic agonist of peroxisome proliferator activator receptor-alpha, alters spinal neuronal firing in a rodent model of neuropathic pain.

Okine BN, Spicer C, Millns P, Bennett A, Chapman V.

Scand J Pain. 2015 Oct 1;9(1):42-48. doi: 10.1016/j.sjpain.2015.06.004.


Differential contributions of peripheral and central mechanisms to pain in a rodent model of osteoarthritis.

Haywood AR, Hathway GJ, Chapman V.

Sci Rep. 2018 May 8;8(1):7122. doi: 10.1038/s41598-018-25581-8.


Local and systemic inflammatory lipid profiling in a rat model of osteoarthritis with metabolic dysregulation.

de Visser HM, Mastbergen SC, Ravipati S, Welsing PMJ, Pinto FC, Lafeber FPJG, Chapman V, Barrett DA, Weinans H.

PLoS One. 2018 Apr 23;13(4):e0196308. doi: 10.1371/journal.pone.0196308. eCollection 2018.


Protection of sheep by vaccination against experimental challenge with Leptospira borgpetersenii serovar Hardjo and L. interrogans serovar Pomona.

Clough WJ, Little PR, Hodge A, Chapman VC, Holz DK.

N Z Vet J. 2018 May;66(3):138-143. doi: 10.1080/00480169.2018.1441078. Epub 2018 Mar 8.


Therapeutic Benefit for Late, but Not Early, Passage Mesenchymal Stem Cells on Pain Behaviour in an Animal Model of Osteoarthritis.

Chapman V, Markides H, Sagar DR, Xu L, Burston JJ, Mapp P, Kay A, Morris RH, Kehoe O, El Haj AJ.

Stem Cells Int. 2017;2017:2905104. doi: 10.1155/2017/2905104. Epub 2017 Dec 24.


Association of the resolvin precursor 17-HDHA, but not D- or E- series resolvins, with heat pain sensitivity and osteoarthritis pain in humans.

Valdes AM, Ravipati S, Menni C, Abhishek A, Metrustry S, Harris J, Nessa A, Williams FMK, Spector TD, Doherty M, Chapman V, Barrett DA.

Sci Rep. 2017 Sep 7;7(1):10748. doi: 10.1038/s41598-017-09516-3.


Age-dependent plasticity in endocannabinoid modulation of pain processing through postnatal development.

Kwok CH, Devonshire IM, Imraish A, Greenspon CM, Lockwood S, Fielden C, Cooper A, Woodhams S, Sarmad S, Ortori CA, Barrett DA, Kendall D, Bennett AJ, Chapman V, Hathway GJ.

Pain. 2017 Nov;158(11):2222-2232. doi: 10.1097/j.pain.0000000000001027.


Manganese-enhanced magnetic resonance imaging depicts brain activity in models of acute and chronic pain: A new window to study experimental spontaneous pain?

Devonshire IM, Burston JJ, Xu L, Lillywhite A, Prior MJ, Watson DJG, Greenspon CM, Iwabuchi SJ, Auer DP, Chapman V.

Neuroimage. 2017 Aug 15;157:500-510. doi: 10.1016/j.neuroimage.2017.06.034. Epub 2017 Jun 17.


The cannabinoid system and pain.

Woodhams SG, Chapman V, Finn DP, Hohmann AG, Neugebauer V.

Neuropharmacology. 2017 Sep 15;124:105-120. doi: 10.1016/j.neuropharm.2017.06.015. Epub 2017 Jun 15. Review.


Pain prediction by serum biomarkers of bone turnover in people with knee osteoarthritis: an observational study of TRAcP5b and cathepsin K in OA.

Nwosu LN, Allen M, Wyatt L, Huebner JL, Chapman V, Walsh DA, Kraus VB.

Osteoarthritis Cartilage. 2017 Jun;25(6):858-865. doi: 10.1016/j.joca.2017.01.002. Epub 2017 Jan 10.


Targeting the D Series Resolvin Receptor System for the Treatment of Osteoarthritis Pain.

Huang J, Burston JJ, Li L, Ashraf S, Mapp PI, Bennett AJ, Ravipati S, Pousinis P, Barrett DA, Scammell BE, Chapman V.

Arthritis Rheumatol. 2017 May;69(5):996-1008. doi: 10.1002/art.40001.


Relationship between structural pathology and pain behaviour in a model of osteoarthritis (OA).

Nwosu LN, Mapp PI, Chapman V, Walsh DA.

Osteoarthritis Cartilage. 2016 Nov;24(11):1910-1917. doi: 10.1016/j.joca.2016.06.012. Epub 2016 Jun 24.


Inhibitory effects of aspirin-triggered resolvin D1 on spinal nociceptive processing in rat pain models.

Meesawatsom P, Burston J, Hathway G, Bennett A, Chapman V.

J Neuroinflammation. 2016 Sep 2;13(1):233. doi: 10.1186/s12974-016-0676-6.


Robust anti-nociceptive effects of monoacylglycerol lipase inhibition in a model of osteoarthritis pain.

Burston JJ, Mapp PI, Sarmad S, Barrett DA, Niphakis MJ, Cravatt BF, Walsh DA, Chapman V.

Br J Pharmacol. 2016 Nov;173(21):3134-3144. doi: 10.1111/bph.13574. Epub 2016 Sep 23.


Anti-nociceptive and desensitizing effects of olvanil on capsaicin-induced thermal hyperalgesia in the rat.

Alsalem M, Millns P, Altarifi A, El-Salem K, Chapman V, Kendall DA.

BMC Pharmacol Toxicol. 2016 Jul 21;17(1):31. doi: 10.1186/s40360-016-0074-9.


The anti-NGF antibody muMab 911 both prevents and reverses pain behaviour and subchondral osteoclast numbers in a rat model of osteoarthritis pain.

Xu L, Nwosu LN, Burston JJ, Millns PJ, Sagar DR, Mapp PI, Meesawatsom P, Li L, Bennett AJ, Walsh DA, Chapman V.

Osteoarthritis Cartilage. 2016 Sep;24(9):1587-95. doi: 10.1016/j.joca.2016.05.015. Epub 2016 May 18.


Neuron-immune mechanisms contribute to pain in early stages of arthritis.

Nieto FR, Clark AK, Grist J, Hathway GJ, Chapman V, Malcangio M.

J Neuroinflammation. 2016 Apr 29;13(1):96. doi: 10.1186/s12974-016-0556-0.


Neural correlates of hyperalgesia in the monosodium iodoacetate model of osteoarthritis pain.

Abaei M, Sagar DR, Stockley EG, Spicer CH, Prior M, Chapman V, Auer DP.

Mol Pain. 2016 Apr 11;12. pii: 1744806916642445. doi: 10.1177/1744806916642445. Print 2016.


Evaluation of 5-methylcytosine and 5-hydroxymethylcytosine as potential biomarkers for characterisation of chemical allergens.

Chapman VL, Terranova R, Moggs JG, Kimber I, Dearman RJ.

Toxicology. 2016 Jan 18;340:17-26. doi: 10.1016/j.tox.2015.12.003. Epub 2015 Dec 28.


Blocking the tropomyosin receptor kinase A (TrkA) receptor inhibits pain behaviour in two rat models of osteoarthritis.

Nwosu LN, Mapp PI, Chapman V, Walsh DA.

Ann Rheum Dis. 2016 Jun;75(6):1246-54. doi: 10.1136/annrheumdis-2014-207203. Epub 2015 Aug 18.


The role of the endocannabinoid system in pain.

Woodhams SG, Sagar DR, Burston JJ, Chapman V.

Handb Exp Pharmacol. 2015;227:119-43. doi: 10.1007/978-3-662-46450-2_7. Review.


Characterisation of pain responses in the high fat diet/streptozotocin model of diabetes and the analgesic effects of antidiabetic treatments.

Byrne FM, Cheetham S, Vickers S, Chapman V.

J Diabetes Res. 2015;2015:752481. doi: 10.1155/2015/752481. Epub 2015 Feb 9.


Calcitonin gene-related peptide-expressing sensory neurons and spinal microglial reactivity contribute to pain states in collagen-induced arthritis.

Nieto FR, Clark AK, Grist J, Chapman V, Malcangio M.

Arthritis Rheumatol. 2015 Jun;67(6):1668-77. doi: 10.1002/art.39082.


Effects of pro-inflammatory cytokines on cannabinoid CB1 and CB2 receptors in immune cells.

Jean-Gilles L, Braitch M, Latif ML, Aram J, Fahey AJ, Edwards LJ, Robins RA, Tanasescu R, Tighe PJ, Gran B, Showe LC, Alexander SP, Chapman V, Kendall DA, Constantinescu CS.

Acta Physiol (Oxf). 2015 May;214(1):63-74. doi: 10.1111/apha.12474. Epub 2015 Mar 10.


Dissecting the contribution of knee joint NGF to spinal nociceptive sensitization in a model of OA pain in the rat.

Sagar DR, Nwosu L, Walsh DA, Chapman V.

Osteoarthritis Cartilage. 2015 Jun;23(6):906-13. doi: 10.1016/j.joca.2015.01.010. Epub 2015 Jan 24.


Simultaneous tissue profiling of eicosanoid and endocannabinoid lipid families in a rat model of osteoarthritis.

Wong A, Sagar DR, Ortori CA, Kendall DA, Chapman V, Barrett DA.

J Lipid Res. 2014 Sep;55(9):1902-13. doi: 10.1194/jlr.M048694. Epub 2014 Jul 25.


Design, study quality and evidence of analgesic efficacy in studies of drugs in models of OA pain: a systematic review and a meta-analysis.

Suokas AK, Sagar DR, Mapp PI, Chapman V, Walsh DA.

Osteoarthritis Cartilage. 2014 Sep;22(9):1207-23. doi: 10.1016/j.joca.2014.06.015. Epub 2014 Jul 4. Review.


Chemical allergen induced perturbations of the mouse lymph node DNA methylome.

Chapman VL, Zollinger T, Terranova R, Moggs J, Kimber I, Dearman RJ.

Toxicol Sci. 2014 Jun;139(2):350-61. doi: 10.1093/toxsci/kfu047. Epub 2014 Mar 27.


Cannabinoid CB2 receptors regulate central sensitization and pain responses associated with osteoarthritis of the knee joint.

Burston JJ, Sagar DR, Shao P, Bai M, King E, Brailsford L, Turner JM, Hathway GJ, Bennett AJ, Walsh DA, Kendall DA, Lichtman A, Chapman V.

PLoS One. 2013 Nov 25;8(11):e80440. doi: 10.1371/journal.pone.0080440. eCollection 2013.


Increased function of pronociceptive TRPV1 at the level of the joint in a rat model of osteoarthritis pain.

Kelly S, Chapman RJ, Woodhams S, Sagar DR, Turner J, Burston JJ, Bullock C, Paton K, Huang J, Wong A, McWilliams DF, Okine BN, Barrett DA, Hathway GJ, Walsh DA, Chapman V.

Ann Rheum Dis. 2015 Jan;74(1):252-9. doi: 10.1136/annrheumdis-2013-203413. Epub 2013 Oct 23.


Differences in structural and pain phenotypes in the sodium monoiodoacetate and meniscal transection models of osteoarthritis.

Mapp PI, Sagar DR, Ashraf S, Burston JJ, Suri S, Chapman V, Walsh DA.

Osteoarthritis Cartilage. 2013 Sep;21(9):1336-45. doi: 10.1016/j.joca.2013.06.031.


Augmented pain behavioural responses to intra-articular injection of nerve growth factor in two animal models of osteoarthritis.

Ashraf S, Mapp PI, Burston J, Bennett AJ, Chapman V, Walsh DA.

Ann Rheum Dis. 2014 Sep;73(9):1710-8. doi: 10.1136/annrheumdis-2013-203416. Epub 2013 Jul 13.


Evaluation of NHS carbamates as a potent and selective class of endocannabinoid hydrolase inhibitors.

Niphakis MJ, Cognetta AB 3rd, Chang JW, Buczynski MW, Parsons LH, Byrne F, Burston JJ, Chapman V, Cravatt BF.

ACS Chem Neurosci. 2013 Sep 18;4(9):1322-32. doi: 10.1021/cn400116z. Epub 2013 Jun 17.


Osteoprotegerin reduces the development of pain behaviour and joint pathology in a model of osteoarthritis.

Sagar DR, Ashraf S, Xu L, Burston JJ, Menhinick MR, Poulter CL, Bennett AJ, Walsh DA, Chapman V.

Ann Rheum Dis. 2014 Aug;73(8):1558-65. doi: 10.1136/annrheumdis-2013-203260. Epub 2013 May 30.


The contribution of the endogenous TRPV1 ligands 9-HODE and 13-HODE to nociceptive processing and their role in peripheral inflammatory pain mechanisms.

Alsalem M, Wong A, Millns P, Arya PH, Chan MS, Bennett A, Barrett DA, Chapman V, Kendall DA.

Br J Pharmacol. 2013 Apr;168(8):1961-74. doi: 10.1111/bph.12092.


Dynamic changes to the endocannabinoid system in models of chronic pain.

Rani Sagar D, Burston JJ, Woodhams SG, Chapman V.

Philos Trans R Soc Lond B Biol Sci. 2012 Dec 5;367(1607):3300-11. doi: 10.1098/rstb.2011.0390. Review.


Spinal administration of the monoacylglycerol lipase inhibitor JZL184 produces robust inhibitory effects on nociceptive processing and the development of central sensitization in the rat.

Woodhams SG, Wong A, Barrett DA, Bennett AJ, Chapman V, Alexander SP.

Br J Pharmacol. 2012 Dec;167(8):1609-19. doi: 10.1111/j.1476-5381.2012.02179.x.


Regulation of allergic responses to chemicals and drugs: possible roles of epigenetic mechanisms.

Moggs JG, Terranova R, Kammüller ME, Chibout SD, Chapman V, Dearman RJ, Kimber I.

Toxicol Sci. 2012 Nov;130(1):60-9. doi: 10.1093/toxsci/kfs207. Epub 2012 Jun 15. Review.


Lack of effect of chronic pre-treatment with the FAAH inhibitor URB597 on inflammatory pain behaviour: evidence for plastic changes in the endocannabinoid system.

Okine BN, Norris LM, Woodhams S, Burston J, Patel A, Alexander SP, Barrett DA, Kendall DA, Bennett AJ, Chapman V.

Br J Pharmacol. 2012 Oct;167(3):627-40. doi: 10.1111/j.1476-5381.2012.02028.x.


Higher-dose oxytocin and hemorrhage after vaginal delivery: a randomized controlled trial.

Tita AT, Szychowski JM, Rouse DJ, Bean CM, Chapman V, Nothern A, Figueroa D, Quinn R, Andrews WW, Hauth JC.

Obstet Gynecol. 2012 Feb;119(2 Pt 1):293-300. doi: 10.1097/AOG.0b013e318242da74.

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