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PIP2 drives Ca2+-independent membrane penetration by the tandem C2 domain proteins synaptotagmin-1 and Doc2β.

Bradberry MM, Bao H, Lou X, Chapman ER.

J Biol Chem. 2019 May 30. pii: jbc.RA119.007929. doi: 10.1074/jbc.RA119.007929. [Epub ahead of print]


Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling.

Sun J, Wang L, Bao H, Premi S, Das U, Chapman ER, Roy S.

Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11113-11115. doi: 10.1073/pnas.1903049116. Epub 2019 May 20.


Structural Basis for the Distinct Membrane Binding Activity of the Homologous C2A Domains of Myoferlin and Dysferlin.

Harsini FM, Bui AA, Rice AM, Chebrolu S, Fuson KL, Turtoi A, Bradberry M, Chapman ER, Sutton RB.

J Mol Biol. 2019 May 17;431(11):2112-2126. doi: 10.1016/j.jmb.2019.04.006. Epub 2019 Apr 18.


Author Correction: Stability, affinity, and chromatic variants of the glutamate sensor iGluSnFR.

Marvin JS, Scholl B, Wilson DE, Podgorski K, Kazemipour A, Müller JA, Schoch S, Quiroz FJU, Rebola N, Bao H, Little JP, Tkachuk AN, Cai E, Hantman AW, Wang SS, DePiero VJ, Borghuis BG, Chapman ER, Dietrich D, DiGregorio DA, Fitzpatrick D, Looger LL.

Nat Methods. 2019 Apr;16(4):351. doi: 10.1038/s41592-019-0363-5.


Reduced mitochondrial fusion and Huntingtin levels contribute to impaired dendritic maturation and behavioral deficits in Fmr1-mutant mice.

Shen M, Wang F, Li M, Sah N, Stockton ME, Tidei JJ, Gao Y, Korabelnikov T, Kannan S, Vevea JD, Chapman ER, Bhattacharyya A, van Praag H, Zhao X.

Nat Neurosci. 2019 Mar;22(3):386-400. doi: 10.1038/s41593-019-0338-y. Epub 2019 Feb 11.


Determining the pharmacokinetics of nicotinic drugs in the endoplasmic reticulum using biosensors.

Shivange AV, Borden PM, Muthusamy AK, Nichols AL, Bera K, Bao H, Bishara I, Jeon J, Mulcahy MJ, Cohen B, O'Riordan SL, Kim C, Dougherty DA, Chapman ER, Marvin JS, Looger LL, Lester HA.

J Gen Physiol. 2019 Jun 3;151(6):738-757. doi: 10.1085/jgp.201812201. Epub 2019 Feb 4.


Publisher Correction: Stability, affinity, and chromatic variants of the glutamate sensor iGluSnFR.

Marvin JS, Scholl B, Wilson DE, Podgorski K, Kazemipour A, Müller JA, Schoch S, Urra Quiroz FJ, Rebola N, Bao H, Little JP, Tkachuk AN, Cai E, Hantman AW, Wang SS, DePiero VJ, Borghuis BG, Chapman ER, Dietrich D, DiGregorio DA, Fitzpatrick D, Looger LL.

Nat Methods. 2019 Feb;16(2):206. doi: 10.1038/s41592-018-0300-z.


Stability, affinity, and chromatic variants of the glutamate sensor iGluSnFR.

Marvin JS, Scholl B, Wilson DE, Podgorski K, Kazemipour A, Müller JA, Schoch S, Quiroz FJU, Rebola N, Bao H, Little JP, Tkachuk AN, Cai E, Hantman AW, Wang SS, DePiero VJ, Borghuis BG, Chapman ER, Dietrich D, DiGregorio DA, Fitzpatrick D, Looger LL.

Nat Methods. 2018 Nov;15(11):936-939. doi: 10.1038/s41592-018-0171-3. Epub 2018 Oct 30. Erratum in: Nat Methods. 2019 Feb;16(2):206. Nat Methods. 2019 Feb 28;:.


Pathogenic TFG Mutations Underlying Hereditary Spastic Paraplegia Impair Secretory Protein Trafficking and Axon Fasciculation.

Slosarek EL, Schuh AL, Pustova I, Johnson A, Bird J, Johnson M, Frankel EB, Bhattacharya N, Hanna MG, Burke JE, Ruhl DA, Quinney K, Block S, Peotter JL, Chapman ER, Sheets MD, Butcher SE, Stagg SM, Audhya A.

Cell Rep. 2018 Aug 28;24(9):2248-2260. doi: 10.1016/j.celrep.2018.07.081.


Doc2-mediated superpriming supports synaptic augmentation.

Xue R, Ruhl DA, Briguglio JS, Figueroa AG, Pearce RA, Chapman ER.

Proc Natl Acad Sci U S A. 2018 Jun 12;115(24):E5605-E5613. doi: 10.1073/pnas.1802104115. Epub 2018 May 29.


A Ca2+ Sensor for Exocytosis.

Chapman ER.

Trends Neurosci. 2018 Jun;41(6):327-330. doi: 10.1016/j.tins.2018.03.012.


Excitatory and Inhibitory Neurons Utilize Different Ca2+ Sensors and Sources to Regulate Spontaneous Release.

Courtney NA, Briguglio JS, Bradberry MM, Greer C, Chapman ER.

Neuron. 2018 Jun 6;98(5):977-991.e5. doi: 10.1016/j.neuron.2018.04.022. Epub 2018 May 10.


The synaptotagmin C2B domain calcium-binding loops modulate the rate of fusion pore expansion.

Bendahmane M, Bohannon KP, Bradberry MM, Rao TC, Schmidtke MW, Abbineni PS, Chon NL, Tran S, Lin H, Chapman ER, Knight JD, Anantharam A.

Mol Biol Cell. 2018 Feb 14;29(7):773-880. doi: 10.1091/mbc.E17-11-0623. [Epub ahead of print]


Dynamics and number of trans-SNARE complexes determine nascent fusion pore properties.

Bao H, Das D, Courtney NA, Jiang Y, Briguglio JS, Lou X, Roston D, Cui Q, Chanda B, Chapman ER.

Nature. 2018 Feb 8;554(7691):260-263. doi: 10.1038/nature25481. Epub 2018 Jan 31.


The Krebs Cycle Enzyme Isocitrate Dehydrogenase 3A Couples Mitochondrial Metabolism to Synaptic Transmission.

Ugur B, Bao H, Stawarski M, Duraine LR, Zuo Z, Lin YQ, Neely GG, Macleod GT, Chapman ER, Bellen HJ.

Cell Rep. 2017 Dec 26;21(13):3794-3806. doi: 10.1016/j.celrep.2017.12.005.


Synaptotagmin isoforms confer distinct activation kinetics and dynamics to chromaffin cell granules.

Rao TC, Santana Rodriguez Z, Bradberry MM, Ranski AH, Dahl PJ, Schmidtke MW, Jenkins PM, Axelrod D, Chapman ER, Giovannucci DR, Anantharam A.

J Gen Physiol. 2017 Aug 7;149(8):763-780. doi: 10.1085/jgp.201711757. Epub 2017 Jul 7.


Gβγ directly modulates vesicle fusion by competing with synaptotagmin for binding to neuronal SNARE proteins embedded in membranes.

Zurawski Z, Page B, Chicka MC, Brindley RL, Wells CA, Preininger AM, Hyde K, Gilbert JA, Cruz-Rodriguez O, Currie KPM, Chapman ER, Alford S, Hamm HE.

J Biol Chem. 2017 Jul 21;292(29):12165-12177. doi: 10.1074/jbc.M116.773523. Epub 2017 May 17.


Transport of a kinesin-cargo pair along microtubules into dendritic spines undergoing synaptic plasticity.

McVicker DP, Awe AM, Richters KE, Wilson RL, Cowdrey DA, Hu X, Chapman ER, Dent EW.

Nat Commun. 2016 Sep 23;7:12741. doi: 10.1038/ncomms12741.


Interneuronal Transfer and Distal Action of Tetanus Toxin and Botulinum Neurotoxins A and D in Central Neurons.

Bomba-Warczak E, Vevea JD, Brittain JM, Figueroa-Bernier A, Tepp WH, Johnson EA, Yeh FL, Chapman ER.

Cell Rep. 2016 Aug 16;16(7):1974-87. doi: 10.1016/j.celrep.2016.06.104. Epub 2016 Aug 4.


Increased expression of AT-1/SLC33A1 causes an autistic-like phenotype in mice by affecting dendritic branching and spine formation.

Hullinger R, Li M, Wang J, Peng Y, Dowell JA, Bomba-Warczak E, Mitchell HA, Burger C, Chapman ER, Denu JM, Li L, Puglielli L.

J Exp Med. 2016 Jun 27;213(7):1267-84. doi: 10.1084/jem.20151776. Epub 2016 May 30.


Synaptotagmin-7 Functions to Replenish Insulin Granules for Exocytosis in Human Islet β-Cells.

Dolai S, Xie L, Zhu D, Liang T, Qin T, Xie H, Kang Y, Chapman ER, Gaisano HY.

Diabetes. 2016 Jul;65(7):1962-76. doi: 10.2337/db15-1436. Epub 2016 Apr 26.


Different states of synaptotagmin regulate evoked versus spontaneous release.

Bai H, Xue R, Bao H, Zhang L, Yethiraj A, Cui Q, Chapman ER.

Nat Commun. 2016 Mar 22;7:10971. doi: 10.1038/ncomms10971.


Functional analysis of the interface between the tandem C2 domains of synaptotagmin-1.

Evans CS, He Z, Bai H, Lou X, Jeggle P, Sutton RB, Edwardson JM, Chapman ER.

Mol Biol Cell. 2016 Mar 15;27(6):979-89. doi: 10.1091/mbc.E15-07-0503. Epub 2016 Jan 20.


Lipid-anchored Synaptobrevin Provides Little or No Support for Exocytosis or Liposome Fusion.

Chang CW, Chiang CW, Gaffaney JD, Chapman ER, Jackson MB.

J Biol Chem. 2016 Feb 5;291(6):2848-57. doi: 10.1074/jbc.M115.701169. Epub 2015 Dec 8.


Exocytotic fusion pores are composed of both lipids and proteins.

Bao H, Goldschen-Ohm M, Jeggle P, Chanda B, Edwardson JM, Chapman ER.

Nat Struct Mol Biol. 2016 Jan;23(1):67-73. doi: 10.1038/nsmb.3141. Epub 2015 Dec 14.


Sar1 GTPase Activity Is Regulated by Membrane Curvature.

Hanna MG 4th, Mela I, Wang L, Henderson RM, Chapman ER, Edwardson JM, Audhya A.

J Biol Chem. 2016 Jan 15;291(3):1014-27. doi: 10.1074/jbc.M115.672287. Epub 2015 Nov 6.


Sex-specific regulation of follicle-stimulating hormone secretion by synaptotagmin 9.

Roper LK, Briguglio JS, Evans CS, Jackson MB, Chapman ER.

Nat Commun. 2015 Oct 20;6:8645. doi: 10.1038/ncomms9645.


An Engineered Metal Sensor Tunes the Kinetics of Synaptic Transmission.

Evans CS, Ruhl DA, Chapman ER.

J Neurosci. 2015 Aug 26;35(34):11769-79. doi: 10.1523/JNEUROSCI.1694-15.2015.


Structural elements that underlie Doc2β function during asynchronous synaptic transmission.

Xue R, Gaffaney JD, Chapman ER.

Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):E4316-25. doi: 10.1073/pnas.1502288112. Epub 2015 Jul 20.


A structural role for the synaptobrevin 2 transmembrane domain in dense-core vesicle fusion pores.

Chang CW, Hui E, Bai J, Bruns D, Chapman ER, Jackson MB.

J Neurosci. 2015 Apr 8;35(14):5772-80. doi: 10.1523/JNEUROSCI.3983-14.2015.


Deterministic HOX patterning in human pluripotent stem cell-derived neuroectoderm.

Lippmann ES, Williams CE, Ruhl DA, Estevez-Silva MC, Chapman ER, Coon JJ, Ashton RS.

Stem Cell Reports. 2015 Apr 14;4(4):632-44. doi: 10.1016/j.stemcr.2015.02.018. Epub 2015 Apr 2.


Distinct fusion properties of synaptotagmin-1 and synaptotagmin-7 bearing dense core granules.

Rao TC, Passmore DR, Peleman AR, Das M, Chapman ER, Anantharam A.

Mol Biol Cell. 2014 Aug 15;25(16):2416-27. doi: 10.1091/mbc.E14-02-0702. Epub 2014 Jun 18.


Linker mutations reveal the complexity of synaptotagmin 1 action during synaptic transmission.

Liu H, Bai H, Xue R, Takahashi H, Edwardson JM, Chapman ER.

Nat Neurosci. 2014 May;17(5):670-7. doi: 10.1038/nn.3681. Epub 2014 Mar 23.


Synaptotagmin 7 functions as a Ca2+-sensor for synaptic vesicle replenishment.

Liu H, Bai H, Hui E, Yang L, Evans CS, Wang Z, Kwon SE, Chapman ER.

Elife. 2014 Feb 25;3:e01524. doi: 10.7554/eLife.01524.


Mutations that disrupt Ca²⁺-binding activity endow Doc2β with novel functional properties during synaptic transmission.

Gaffaney JD, Xue R, Chapman ER.

Mol Biol Cell. 2014 Feb;25(4):481-94. doi: 10.1091/mbc.E13-10-0571. Epub 2013 Dec 19.


Multivalency amplifies the selection and affinity of bradykinin-derived peptides for lipid nanovesicles.

Saludes JP, Morton LA, Coulup SK, Fiorini Z, Cook BM, Beninson L, Chapman ER, Fleshner M, Yin H.

Mol Biosyst. 2013 Aug;9(8):2005-9. doi: 10.1039/c3mb70109c. Epub 2013 May 28.


"Self" versus "non-self" connectivity dictates properties of synaptic transmission and plasticity.

Liu H, Chapman ER, Dean C.

PLoS One. 2013 Apr 29;8(4):e62414. doi: 10.1371/journal.pone.0062414. Print 2013.


Inhibition of TFG function causes hereditary axon degeneration by impairing endoplasmic reticulum structure.

Beetz C, Johnson A, Schuh AL, Thakur S, Varga RE, Fothergill T, Hertel N, Bomba-Warczak E, Thiele H, Nürnberg G, Altmüller J, Saxena R, Chapman ER, Dent EW, Nürnberg P, Audhya A.

Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5091-6. doi: 10.1073/pnas.1217197110. Epub 2013 Mar 11.


MARCKS-ED peptide as a curvature and lipid sensor.

Morton LA, Yang H, Saludes JP, Fiorini Z, Beninson L, Chapman ER, Fleshner M, Xue D, Yin H.

ACS Chem Biol. 2013 Jan 18;8(1):218-25. doi: 10.1021/cb300429e. Epub 2012 Oct 29.


Glycosylation is dispensable for sorting of synaptotagmin 1 but is critical for targeting of SV2 and synaptophysin to recycling synaptic vesicles.

Kwon SE, Chapman ER.

J Biol Chem. 2012 Oct 12;287(42):35658-68. doi: 10.1074/jbc.M112.398883. Epub 2012 Aug 20.


All three components of the neuronal SNARE complex contribute to secretory vesicle docking.

Wu Y, Gu Y, Morphew MK, Yao J, Yeh FL, Dong M, Chapman ER.

J Cell Biol. 2012 Aug 6;198(3):323-30. doi: 10.1083/jcb.201106158.


Detection of highly curved membrane surfaces using a cyclic peptide derived from synaptotagmin-I.

Saludes JP, Morton LA, Ghosh N, Beninson LA, Chapman ER, Fleshner M, Yin H.

ACS Chem Biol. 2012 Oct 19;7(10):1629-35. doi: 10.1021/cb3002705. Epub 2012 Jul 17.


Botulinum neurotoxins B and E translocate at different rates and exhibit divergent responses to GT1b and low pH.

Sun S, Tepp WH, Johnson EA, Chapman ER.

Biochemistry. 2012 Jul 17;51(28):5655-62. Epub 2012 Jul 2.


Distinct subsets of Syt-IV/BDNF vesicles are sorted to axons versus dendrites and recruited to synapses by activity.

Dean C, Liu H, Staudt T, Stahlberg MA, Vingill S, Bückers J, Kamin D, Engelhardt J, Jackson MB, Hell SW, Chapman ER.

J Neurosci. 2012 Apr 18;32(16):5398-413. doi: 10.1523/JNEUROSCI.4515-11.2012.


Axonal and dendritic synaptotagmin isoforms revealed by a pHluorin-syt functional screen.

Dean C, Dunning FM, Liu H, Bomba-Warczak E, Martens H, Bharat V, Ahmed S, Chapman ER.

Mol Biol Cell. 2012 May;23(9):1715-27. doi: 10.1091/mbc.E11-08-0707. Epub 2012 Mar 7.


Calcium binding by synaptotagmin's C2A domain is an essential element of the electrostatic switch that triggers synchronous synaptic transmission.

Striegel AR, Biela LM, Evans CS, Wang Z, Delehoy JB, Sutton RB, Chapman ER, Reist NE.

J Neurosci. 2012 Jan 25;32(4):1253-60. doi: 10.1523/JNEUROSCI.4652-11.2012.


Uncoupling the roles of synaptotagmin I during endo- and exocytosis of synaptic vesicles.

Yao J, Kwon SE, Gaffaney JD, Dunning FM, Chapman ER.

Nat Neurosci. 2011 Dec 25;15(2):243-9. doi: 10.1038/nn.3013.


Reconstituted synaptotagmin I mediates vesicle docking, priming, and fusion.

Wang Z, Liu H, Gu Y, Chapman ER.

J Cell Biol. 2011 Dec 26;195(7):1159-70. doi: 10.1083/jcb.201104079. Epub 2011 Dec 19.


Retargeted clostridial neurotoxins as novel agents for treating chronic diseases.

Yeh FL, Zhu Y, Tepp WH, Johnson EA, Bertics PJ, Chapman ER.

Biochemistry. 2011 Dec 6;50(48):10419-21. doi: 10.1021/bi201490t. Epub 2011 Nov 7.


Doc2 is a Ca2+ sensor required for asynchronous neurotransmitter release.

Yao J, Gaffaney JD, Kwon SE, Chapman ER.

Cell. 2011 Oct 28;147(3):666-77. doi: 10.1016/j.cell.2011.09.046.

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