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Items: 10


Newly synthesized polycystin-1 takes different trafficking pathways to the apical and ciliary membranes.

Gilder AL, Chapin HC, Padovano V, Hueschen CL, Rajendran V, Caplan MJ.

Traffic. 2018 Dec;19(12):933-945. doi: 10.1111/tra.12612. Epub 2018 Sep 24.


The polycystins are modulated by cellular oxygen-sensing pathways and regulate mitochondrial function.

Padovano V, Kuo IY, Stavola LK, Aerni HR, Flaherty BJ, Chapin HC, Ma M, Somlo S, Boletta A, Ehrlich BE, Rinehart J, Caplan MJ.

Mol Biol Cell. 2017 Jan 15;28(2):261-269. doi: 10.1091/mbc.E16-08-0597. Epub 2016 Nov 23.


Tissue-specific autophagy responses to aging and stress in C. elegans.

Chapin HC, Okada M, Merz AJ, Miller DL.

Aging (Albany NY). 2015 Jun;7(6):419-34.


Polycystin-1 cleavage and the regulation of transcriptional pathways.

Merrick D, Bertuccio CA, Chapin HC, Lal M, Chauvet V, Caplan MJ.

Pediatr Nephrol. 2014 Apr;29(4):505-11. doi: 10.1007/s00467-013-2548-y. Epub 2013 Jul 4. Review.


Termination of isoform-selective Vps21/Rab5 signaling at endolysosomal organelles by Msb3/Gyp3.

Nickerson DP, Russell MRG, Lo SY, Chapin HC, Milnes J, Merz AJ.

Traffic. 2012 Oct;13(10):1411-1428. doi: 10.1111/j.1600-0854.2012.01390.x. Epub 2012 Aug 5.


Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases.

Choi YH, Suzuki A, Hajarnis S, Ma Z, Chapin HC, Caplan MJ, Pontoglio M, Somlo S, Igarashi P.

Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10679-84. doi: 10.1073/pnas.1016214108. Epub 2011 Jun 13.


The cell biology of polycystic kidney disease.

Chapin HC, Caplan MJ.

J Cell Biol. 2010 Nov 15;191(4):701-10. doi: 10.1083/jcb.201006173. Review.


Polycystin-1 surface localization is stimulated by polycystin-2 and cleavage at the G protein-coupled receptor proteolytic site.

Chapin HC, Rajendran V, Caplan MJ.

Mol Biol Cell. 2010 Dec;21(24):4338-48. doi: 10.1091/mbc.E10-05-0407. Epub 2010 Oct 27.


Polycystin-1 C-terminal cleavage is modulated by polycystin-2 expression.

Bertuccio CA, Chapin HC, Cai Y, Mistry K, Chauvet V, Somlo S, Caplan MJ.

J Biol Chem. 2009 Jul 31;284(31):21011-26. doi: 10.1074/jbc.M109.017756. Epub 2009 Jun 2.


Detecting the surface localization and cytoplasmic cleavage of membrane-bound proteins.

Chapin HC, Rajendran V, Capasso A, Caplan MJ.

Methods Cell Biol. 2009;94:223-39. doi: 10.1016/S0091-679X(08)94011-5. Epub 2009 Dec 23.

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