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Items: 25

1.

Role of P-glycoprotein in the brain disposition of seletalisib: Evaluation of the potential for drug-drug interactions.

Nicolas JM, Chanteux H, Nicolaï J, Brouta F, Viot D, Rosseels ML, Gillent E, Bonnaillie P, Mathy FX, Long J, Helmer E.

Eur J Pharm Sci. 2019 Oct 31;142:105122. doi: 10.1016/j.ejps.2019.105122. [Epub ahead of print]

PMID:
31678424
2.

Off-line solid phase extraction and liquid chromatography-tandem mass spectrometry method for the quantitation of brivaracetam acid metabolites: Method validation and application to in vitro metabolism assays.

Bourgogne E, Culot B, Dell'Aiera S, Chanteux H, Stockis A, Nicolas JM.

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jun 1;1086:138-145. doi: 10.1016/j.jchromb.2018.04.018. Epub 2018 Apr 10.

PMID:
29665472
3.

Role of the OATP Transporter Family and a Benzbromarone-SensitiveEfflux Transporter in the Hepatocellular Disposition of Vincristine.

Nicolaï J, Thevelin L, Bing Q, Stieger B, Chanteux H, Augustijns P, Annaert P.

Pharm Res. 2017 Nov;34(11):2336-2348. doi: 10.1007/s11095-017-2241-0. Epub 2017 Aug 21.

4.

A Dual-Administration Microtracer Technique to Characterize the Absorption, Distribution, Metabolism, and Excretion of [14 C]Seletalisib (UCB5857) in Healthy Subjects.

Helmer E, Nicolas JM, Long J, Roffel AF, Jones E, Chanteux H, Diaz N, Garratt H, Bosje T.

J Clin Pharmacol. 2017 Dec;57(12):1582-1590. doi: 10.1002/jcph.954. Epub 2017 Jun 26.

PMID:
28650526
5.

Effect of Rifampin on the Disposition of Brivaracetam in Human Subjects: Further Insights into Brivaracetam Hydrolysis.

Stockis A, Watanabe S, Scheen AJ, Tytgat D, Gerin B, Rosa M, Chanteux H, Nicolas JM.

Drug Metab Dispos. 2016 Jun;44(6):792-9. doi: 10.1124/dmd.115.069161. Epub 2016 Mar 21.

PMID:
27002062
6.

Prediction of drug-drug interactions with carbamazepine-10,11-epoxide using a new in vitro assay for epoxide hydrolase inhibition.

Rosa M, Bonnaillie P, Chanteux H.

Xenobiotica. 2016 Dec;46(12):1076-1084. Epub 2016 Mar 3.

PMID:
26936324
7.

Brivaracetam, a selective high-affinity synaptic vesicle protein 2A (SV2A) ligand with preclinical evidence of high brain permeability and fast onset of action.

Nicolas JM, Hannestad J, Holden D, Kervyn S, Nabulsi N, Tytgat D, Huang Y, Chanteux H, Staelens L, Matagne A, Mathy FX, Mercier J, Stockis A, Carson RE, Klitgaard H.

Epilepsia. 2016 Feb;57(2):201-9. doi: 10.1111/epi.13267. Epub 2015 Dec 10.

8.

Cross-Species Differences in the Preclinical Pharmacokinetics of CT7758, an α4β1/α4β7 Integrin Antagonist.

Chanteux H, Staelens L, Mancel V, Gerin B, Boucaut D, Prakash C, Nicolas JM.

Drug Metab Dispos. 2015 Sep;43(9):1381-91. doi: 10.1124/dmd.115.064436. Epub 2015 Jul 7.

PMID:
26153275
9.

Brivaracetam and carbamazepine interaction in healthy subjects and in vitro.

Stockis A, Chanteux H, Rosa M, Rolan P.

Epilepsy Res. 2015 Jul;113:19-27. doi: 10.1016/j.eplepsyres.2015.03.003. Epub 2015 Mar 19.

PMID:
25986188
10.

N-alkylprotoporphyrin formation and hepatic porphyria in dogs after administration of a new antiepileptic drug candidate: mechanism and species specificity.

Nicolas JM, Chanteux H, Mancel V, Dubin GM, Gerin B, Staelens L, Depelchin O, Kervyn S.

Toxicol Sci. 2014 Oct;141(2):353-64. doi: 10.1093/toxsci/kfu131. Epub 2014 Jun 27.

11.

In vitro hydrolysis and transesterification of CDP323, an α4β1/α4β7 integrin antagonist ester prodrug.

Chanteux H, Rosa M, Delatour C, Prakash C, Smith S, Nicolas JM.

Drug Metab Dispos. 2014 Jan;42(1):153-61. doi: 10.1124/dmd.113.054049. Epub 2013 Oct 31.

PMID:
24179032
12.

Potential role for human P-glycoprotein in the transport of lacosamide.

Zhang C, Chanteux H, Zuo Z, Kwan P, Baum L.

Epilepsia. 2013 Jul;54(7):1154-60. doi: 10.1111/epi.12158. Epub 2013 Mar 29.

13.

Assessment of cytochrome P450 (1A2, 2B6, 2C9 and 3A4) induction in cryopreserved human hepatocytes cultured in 48-well plates using the cocktail strategy.

Gerin B, Dell'Aiera S, Richert L, Smith S, Chanteux H.

Xenobiotica. 2013 Apr;43(4):320-35. doi: 10.3109/00498254.2012.719088. Epub 2012 Nov 15.

PMID:
23153057
14.

Effect of gemfibrozil on the metabolism of brivaracetam in vitro and in human subjects.

Nicolas JM, Chanteux H, Rosa M, Watanabe S, Stockis A.

Drug Metab Dispos. 2012 Aug;40(8):1466-72. doi: 10.1124/dmd.112.045328. Epub 2012 Apr 26.

PMID:
22538270
15.

Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins.

Gerets HH, Tilmant K, Gerin B, Chanteux H, Depelchin BO, Dhalluin S, Atienzar FA.

Cell Biol Toxicol. 2012 Apr;28(2):69-87. doi: 10.1007/s10565-011-9208-4. Epub 2012 Jan 19.

16.
17.

Accumulation and oriented transport of ampicillin in Caco-2 cells from its pivaloyloxymethylester prodrug, pivampicillin.

Chanteux H, Van Bambeke F, Mingeot-Leclercq MP, Tulkens PM.

Antimicrob Agents Chemother. 2005 Apr;49(4):1279-88.

18.

Cellular pharmacokinetics and pharmacodynamics of the glycopeptide antibiotic oritavancin (LY333328) in a model of J774 mouse macrophages.

Van Bambeke F, Carryn S, Seral C, Chanteux H, Tyteca D, Mingeot-Leclercq MP, Tulkens PM.

Antimicrob Agents Chemother. 2004 Aug;48(8):2853-60.

19.

Intracellular pharmacodynamics of antibiotics.

Carryn S, Chanteux H, Seral C, Mingeot-Leclercq MP, Van Bambeke F, Tulkens PM.

Infect Dis Clin North Am. 2003 Sep;17(3):615-34. Review.

PMID:
14711080
20.

Intracellular accumulation and activity of ampicillin used as free drug and as its phthalimidomethyl or pivaloyloxymethyl ester (pivampicillin) against Listeria monocytogenes in J774 macrophages.

Chanteux H, Mingeot-Leclercq MP, Sonveaux E, Van Bambeke F, Tulkens PM.

J Antimicrob Chemother. 2003 Oct;52(4):610-5. Epub 2003 Sep 12.

PMID:
12972457
23.

Influence of P-glycoprotein inhibitors on accumulation of macrolides in J774 murine macrophages.

Seral C, Michot JM, Chanteux H, Mingeot-Leclercq MP, Tulkens PM, Van Bambeke F.

Antimicrob Agents Chemother. 2003 Mar;47(3):1047-51.

25.

Saccharomyces boulardii upgrades cellular adaptation after proximal enterectomy in rats.

Buts JP, De Keyser N, Marandi S, Hermans D, Sokal EM, Chae YH, Lambotte L, Chanteux H, Tulkens PM.

Gut. 1999 Jul;45(1):89-96.

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