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Biochem Soc Trans. 2019 Jun 27. pii: BST20180414. doi: 10.1042/BST20180414. [Epub ahead of print]

An integrated transcriptional switch at the β-selection checkpoint determines T cell survival, development and leukaemogenesis.

Chann AS1,2,3, Russell SM4,2,3,5.

Author information

1
Centre for Micro-Photonics, Faculty of Science, Engineering and Technology, Swinburne University of Technology, Hawthorn, Victoria 3122, Australia.
2
Immune Signalling Laboratory, Peter MacCallum Cancer Centre, Parkville, Victoria 3000, Australia.
3
Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria 3010, Australia.
4
Centre for Micro-Photonics, Faculty of Science, Engineering and Technology, Swinburne University of Technology, Hawthorn, Victoria 3122, Australia sarah.russell@petermac.org.
5
Department of Pathology, The University of Melbourne, Parkville, Victoria 3010, Australia.

Abstract

In T cell development, a pivotal decision-making stage, termed β-selection, integrates a TCRβ checkpoint to coordinate survival, proliferation and differentiation to an αβ T cell. Here, we review how transcriptional regulation coordinates fate determination in early T cell development to enable β-selection. Errors in this transcription control can trigger T cell acute lymphoblastic leukaemia. We describe how the β-selection checkpoint goes awry in leukaemic transformation.

KEYWORDS:

T cells; cell differentiation; developmental biology

PMID:
31249100
DOI:
10.1042/BST20180414

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