Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 609

1.

Allostery in Its Many Disguises: From Theory to Applications.

Wodak SJ, Paci E, Dokholyan NV, Berezovsky IN, Horovitz A, Li J, Hilser VJ, Bahar I, Karanicolas J, Stock G, Hamm P, Stote RH, Eberhardt J, Chebaro Y, Dejaegere A, Cecchini M, Changeux JP, Bolhuis PG, Vreede J, Faccioli P, Orioli S, Ravasio R, Yan L, Brito C, Wyart M, Gkeka P, Rivalta I, Palermo G, McCammon JA, Panecka-Hofman J, Wade RC, Di Pizio A, Niv MY, Nussinov R, Tsai CJ, Jang H, Padhorny D, Kozakov D, McLeish T.

Structure. 2019 Apr 2;27(4):566-578. doi: 10.1016/j.str.2019.01.003. Epub 2019 Feb 7. Review.

2.

Drug Addiction: From Neuroscience to Ethics.

Farisco M, Evers K, Changeux JP.

Front Psychiatry. 2018 Nov 19;9:595. doi: 10.3389/fpsyt.2018.00595. eCollection 2018.

3.

The nicotinic acetylcholine receptor: a typical 'allosteric machine'.

Changeux JP.

Philos Trans R Soc Lond B Biol Sci. 2018 Jun 19;373(1749). pii: 20170174. doi: 10.1098/rstb.2017.0174. Review.

4.

Structural Identification of the Nicotinic Receptor Ion Channel.

Changeux JP.

Trends Neurosci. 2018 Feb;41(2):67-70. doi: 10.1016/j.tins.2017.11.003. Review.

PMID:
29405928
5.

Un-gating and allosteric modulation of a pentameric ligand-gated ion channel captured by molecular dynamics.

Martin NE, Malik S, Calimet N, Changeux JP, Cecchini M.

PLoS Comput Biol. 2017 Oct 25;13(10):e1005784. doi: 10.1371/journal.pcbi.1005784. eCollection 2017 Oct.

6.

Allosteric modulation as a unifying mechanism for receptor function and regulation.

Changeux JP, Christopoulos A.

Diabetes Obes Metab. 2017 Sep;19 Suppl 1:4-21. doi: 10.1111/dom.12959. Review.

PMID:
28880476
7.

Response by the authors.

Evers K, Changeux JP.

EMBO Rep. 2017 Jul 25. pii: e201744696. doi: 10.15252/embr.201744696. [Epub ahead of print] No abstract available.

8.

Climbing Brain Levels of Organisation from Genes to Consciousness.

Changeux JP.

Trends Cogn Sci. 2017 Mar;21(3):168-181. doi: 10.1016/j.tics.2017.01.004. Epub 2017 Feb 1. Review.

9.

Nicotine reverses hypofrontality in animal models of addiction and schizophrenia.

Koukouli F, Rooy M, Tziotis D, Sailor KA, O'Neill HC, Levenga J, Witte M, Nilges M, Changeux JP, Hoeffer CA, Stitzel JA, Gutkin BS, DiGregorio DA, Maskos U.

Nat Med. 2017 Mar;23(3):347-354. doi: 10.1038/nm.4274. Epub 2017 Jan 23.

10.

Nicotinic receptors in mouse prefrontal cortex modulate ultraslow fluctuations related to conscious processing.

Koukouli F, Rooy M, Changeux JP, Maskos U.

Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):14823-14828. doi: 10.1073/pnas.1614417113. Epub 2016 Dec 2.

11.

Proactive epigenesis and ethical innovation: A neuronal hypothesis for the genesis of ethical rules.

Evers K, Changeux JP.

EMBO Rep. 2016 Oct;17(10):1361-1364. Epub 2016 Sep 9. No abstract available.

12.

Biased Allostery.

Edelstein SJ, Changeux JP.

Biophys J. 2016 Sep 6;111(5):902-8. doi: 10.1016/j.bpj.2016.07.044.

13.

Allosteric Modulation as a Unifying Mechanism for Receptor Function and Regulation.

Changeux JP, Christopoulos A.

Cell. 2016 Aug 25;166(5):1084-1102. doi: 10.1016/j.cell.2016.08.015. Review. Retraction in: Diabetes Obes Metab. 2017 Sep;19 Suppl 1:4-21.

14.

Bradykinin Induces TRPV1 Exocytotic Recruitment in Peptidergic Nociceptors.

Mathivanan S, Devesa I, Changeux JP, Ferrer-Montiel A.

Front Pharmacol. 2016 Jun 23;7:178. doi: 10.3389/fphar.2016.00178. eCollection 2016.

15.

Towards a cognitive neuroscience of self-awareness.

Lou HC, Changeux JP, Rosenstand A.

Neurosci Biobehav Rev. 2017 Dec;83:765-773. doi: 10.1016/j.neubiorev.2016.04.004. Epub 2016 Apr 11. Review.

16.

Historical perspective: An INTERVIEW WITH JEAN-PIERRE CHANGEUX by Ernesto Carafoli.

Changeux JP, Carafoli E.

Biochem Biophys Res Commun. 2015 Nov 27;467(4):612-6. doi: 10.1016/j.bbrc.2015.10.046. Epub 2015 Oct 24. No abstract available.

PMID:
26467075
17.

[The 2000 years].

Peschanski M, Bergeron M, Boué A, Coppens Y, Changeux JP, Corvol P, Lazar P, Kahn A, Bichet DG, Friedlander G, Epelbaum J, Kroemer G, Chneiweiss H, Munnich A, Bouvier M, Jordan B, Frydman R, Morange M, Fougereau M.

Med Sci (Paris). 2015 Mar;31 Spec No 1:47-90. doi: 10.1051/medsci/201531s1005. Epub 2015 Jun 3. French. No abstract available.

18.

The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors.

Wieskopf JS, Mathur J, Limapichat W, Post MR, Al-Qazzaz M, Sorge RE, Martin LJ, Zaykin DV, Smith SB, Freitas K, Austin JS, Dai F, Zhang J, Marcovitz J, Tuttle AH, Slepian PM, Clarke S, Drenan RM, Janes J, Al Sharari S, Segall SK, Aasvang EK, Lai W, Bittner R, Richards CI, Slade GD, Kehlet H, Walker J, Maskos U, Changeux JP, Devor M, Maixner W, Diatchenko L, Belfer I, Dougherty DA, Su AI, Lummis SC, Imad Damaj M, Lester HA, Patapoutian A, Mogil JS.

Sci Transl Med. 2015 May 13;7(287):287ra72. doi: 10.1126/scitranslmed.3009986.

19.

The nicotinic acetylcholine receptor: From molecular biology to cognition.

Changeux JP, Corringer PJ, Maskos U.

Neuropharmacology. 2015 Sep;96(Pt B):135-6. doi: 10.1016/j.neuropharm.2015.03.024. Epub 2015 Apr 1. No abstract available.

PMID:
25842243
20.

The nicotinic acetylcholine receptor and its prokaryotic homologues: Structure, conformational transitions & allosteric modulation.

Cecchini M, Changeux JP.

Neuropharmacology. 2015 Sep;96(Pt B):137-49. doi: 10.1016/j.neuropharm.2014.12.006. Epub 2014 Dec 18. Review.

PMID:
25529272
21.

Protein dynamics and the allosteric transitions of pentameric receptor channels.

Changeux JP.

Biophys Rev. 2014;6(3-4):311-321. Epub 2014 Nov 29.

22.

αCGRP is essential for algesic exocytotic mobilization of TRPV1 channels in peptidergic nociceptors.

Devesa I, Ferrándiz-Huertas C, Mathivanan S, Wolf C, Luján R, Changeux JP, Ferrer-Montiel A.

Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18345-50. doi: 10.1073/pnas.1420252111. Epub 2014 Dec 8.

23.

Allosteric regulation of pentameric ligand-gated ion channels: an emerging mechanistic perspective.

Taly A, Hénin J, Changeux JP, Cecchini M.

Channels (Austin). 2014;8(4):350-60. Review.

24.

International Union of Basic and Clinical Pharmacology. XC. multisite pharmacology: recommendations for the nomenclature of receptor allosterism and allosteric ligands.

Christopoulos A, Changeux JP, Catterall WA, Fabbro D, Burris TP, Cidlowski JA, Olsen RW, Peters JA, Neubig RR, Pin JP, Sexton PM, Kenakin TP, Ehlert FJ, Spedding M, Langmead CJ.

Pharmacol Rev. 2014 Oct;66(4):918-47. doi: 10.1124/pr.114.008862.

PMID:
25026896
25.

Structural basis for cooperative interactions of substituted 2-aminopyrimidines with the acetylcholine binding protein.

Kaczanowska K, Harel M, Radić Z, Changeux JP, Finn MG, Taylor P.

Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10749-54. doi: 10.1073/pnas.1410992111. Epub 2014 Jul 8.

26.

Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation.

Sauguet L, Shahsavar A, Poitevin F, Huon C, Menny A, Nemecz À, Haouz A, Changeux JP, Corringer PJ, Delarue M.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):966-71. doi: 10.1073/pnas.1314997111. Epub 2013 Dec 23.

27.

50 years of allosteric interactions: the twists and turns of the models.

Changeux JP.

Nat Rev Mol Cell Biol. 2013 Dec;14(12):819-29. doi: 10.1038/nrm3695. Epub 2013 Oct 23. Review.

PMID:
24150612
28.

Intermediate closed state for glycine receptor function revealed by cysteine cross-linking.

Prevost MS, Moraga-Cid G, Van Renterghem C, Edelstein SJ, Changeux JP, Corringer PJ.

Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):17113-8. doi: 10.1073/pnas.1317009110. Epub 2013 Oct 1.

29.

The concept of allosteric modulation: an overview.

Changeux JP.

Drug Discov Today Technol. 2013 Summer;10(2):e223-8. doi: 10.1016/j.ddtec.2012.07.007. Review.

PMID:
24050272
30.

A gating mechanism of pentameric ligand-gated ion channels.

Calimet N, Simoes M, Changeux JP, Karplus M, Taly A, Cecchini M.

Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):E3987-96. doi: 10.1073/pnas.1313785110. Epub 2013 Sep 16. Review.

31.

The concept of allosteric interaction and its consequences for the chemistry of the brain.

Changeux JP.

J Biol Chem. 2013 Sep 20;288(38):26969-86. doi: 10.1074/jbc.X113.503375. Epub 2013 Jul 22. Review.

32.

The origins of allostery: from personal memories to material for the future.

Changeux JP.

J Mol Biol. 2013 May 13;425(9):1396-406. doi: 10.1016/j.jmb.2013.02.033. Epub 2013 Mar 20.

33.

Altered paralimbic interaction in behavioral addiction.

Rømer Thomsen K, Joensson M, Lou HC, Møller A, Gross J, Kringelbach ML, Changeux JP.

Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4744-9. doi: 10.1073/pnas.1302374110. Epub 2013 Mar 4.

34.

A hierarchical coherent-gene-group model for brain development.

Tsigelny IF, Kouznetsova VL, Baitaluk M, Changeux JP.

Genes Brain Behav. 2013 Mar;12(2):147-65. doi: 10.1111/gbb.12005. Epub 2012 Dec 28.

35.

The nicotinic acetylcholine receptor: the founding father of the pentameric ligand-gated ion channel superfamily.

Changeux JP.

J Biol Chem. 2012 Nov 23;287(48):40207-15. doi: 10.1074/jbc.R112.407668. Epub 2012 Oct 4. Review.

36.

Co-activation of VTA DA and GABA neurons mediates nicotine reinforcement.

Tolu S, Eddine R, Marti F, David V, Graupner M, Pons S, Baudonnat M, Husson M, Besson M, Reperant C, Zemdegs J, Pagès C, Hay YA, Lambolez B, Caboche J, Gutkin B, Gardier AM, Changeux JP, Faure P, Maskos U.

Mol Psychiatry. 2013 Mar;18(3):382-93. doi: 10.1038/mp.2012.83. Epub 2012 Jul 3.

PMID:
22751493
37.

Conscious processing: implications for general anesthesia.

Changeux JP.

Curr Opin Anaesthesiol. 2012 Aug;25(4):397-404. doi: 10.1097/ACO.0b013e32835561de. Review.

PMID:
22699320
38.

Structure and pharmacology of pentameric receptor channels: from bacteria to brain.

Corringer PJ, Poitevin F, Prevost MS, Sauguet L, Delarue M, Changeux JP.

Structure. 2012 Jun 6;20(6):941-56. doi: 10.1016/j.str.2012.05.003. Review.

39.

A neuronal model of predictive coding accounting for the mismatch negativity.

Wacongne C, Changeux JP, Dehaene S.

J Neurosci. 2012 Mar 14;32(11):3665-78. doi: 10.1523/JNEUROSCI.5003-11.2012.

40.

Allostery and the Monod-Wyman-Changeux model after 50 years.

Changeux JP.

Annu Rev Biophys. 2012;41:103-33. doi: 10.1146/annurev-biophys-050511-102222. Epub 2012 Jan 6. Review.

PMID:
22224598
41.

Deciding between conflicting motivations: what mice make of their prefrontal cortex.

Granon S, Changeux JP.

Behav Brain Res. 2012 Apr 15;229(2):419-26. doi: 10.1016/j.bbr.2011.11.011. Epub 2011 Nov 18.

PMID:
22108342
42.

Conformational selection or induced fit? 50 years of debate resolved.

Changeux JP, Edelstein S.

F1000 Biol Rep. 2011;3:19. doi: 10.3410/B3-19. Epub 2011 Sep 1.

43.

Alpha7-nicotinic receptors modulate nicotine-induced reinforcement and extracellular dopamine outflow in the mesolimbic system in mice.

Besson M, David V, Baudonnat M, Cazala P, Guilloux JP, Reperant C, Cloez-Tayarani I, Changeux JP, Gardier AM, Granon S.

Psychopharmacology (Berl). 2012 Mar;220(1):1-14. doi: 10.1007/s00213-011-2422-1. Epub 2011 Sep 8.

PMID:
21901321
44.

Modulation of the mouse prefrontal cortex activation by neuronal nicotinic receptors during novelty exploration but not by exploration of a familiar environment.

Bourgeois JP, Meas-Yeadid V, Lesourd AM, Faure P, Pons S, Maskos U, Changeux JP, Olivo-Marin JC, Granon S.

Cereb Cortex. 2012 May;22(5):1007-15. doi: 10.1093/cercor/bhr159. Epub 2011 Aug 1.

PMID:
21810785
45.

Emergent pharmacology of conscious experience: new perspectives in substance addiction.

Changeux JP, Lou HC.

FASEB J. 2011 Jul;25(7):2098-108. doi: 10.1096/fj.11-0702ufm. Review.

PMID:
21719514
46.

50th anniversary of the word "allosteric".

Changeux JP.

Protein Sci. 2011 Jul;20(7):1119-24. doi: 10.1002/pro.658. Epub 2011 Jun 10. Review.

47.

Experimental and theoretical approaches to conscious processing.

Dehaene S, Changeux JP.

Neuron. 2011 Apr 28;70(2):200-27. doi: 10.1016/j.neuron.2011.03.018. Review.

48.

Distinct contributions of nicotinic acetylcholine receptor subunit alpha4 and subunit alpha6 to the reinforcing effects of nicotine.

Exley R, Maubourguet N, David V, Eddine R, Evrard A, Pons S, Marti F, Threlfell S, Cazala P, McIntosh JM, Changeux JP, Maskos U, Cragg SJ, Faure P.

Proc Natl Acad Sci U S A. 2011 May 3;108(18):7577-82. doi: 10.1073/pnas.1103000108. Epub 2011 Apr 18.

49.

Prefrontal nicotinic receptors control novel social interaction between mice.

Avale ME, Chabout J, Pons S, Serreau P, De Chaumont F, Olivo-Marin JC, Bourgeois JP, Maskos U, Changeux JP, Granon S.

FASEB J. 2011 Jul;25(7):2145-55. doi: 10.1096/fj.10-178558. Epub 2011 Mar 14.

PMID:
21402717
50.

Antibodies against extracellular domains of α4 and α7 subunits alter the levels of nicotinic receptors in the mouse brain and affect memory: possible relevance to Alzheimer's pathology.

Lykhmus O, Koval L, Skok M, Zouridakis M, Zisimopoulou P, Tzartos S, Tsetlin V, Granon S, Changeux JP, Komisarenko S, Cloëz-Tayarani I.

J Alzheimers Dis. 2011;24(4):693-704. doi: 10.3233/JAD-2011-101842.

PMID:
21321393

Supplemental Content

Loading ...
Support Center