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A meta-analysis of genome-wide association studies identifies three loci associated with stiffness index of the calcaneus.

Lu HF, Hung KS, Chu HW, Wong HS, Kim J, Choi BY, Kim MK, Tai YT, Ikegawa S, Cho EC, Chang WC.

J Bone Miner Res. 2019 Feb 19. doi: 10.1002/jbmr.3703. [Epub ahead of print]


Repurposing Nonheme Iron Hydroxylases To Enable Catalytic Nitrile Installation through an Azido Group Assistance.

Davidson M, McNamee M, Fan R, Guo Y, Chang WC.

J Am Chem Soc. 2019 Feb 18. doi: 10.1021/jacs.8b13906. [Epub ahead of print]


Two-Dimensional Regulation of CAR-T Cell Therapy with Orthogonal Switches.

Duong MT, Collinson-Pautz MR, Morschl E, Lu A, Szymanski SP, Zhang M, Brandt ME, Chang WC, Sharp KL, Toler SM, Slawin KM, Foster AE, Spencer DM, Bayle JH.

Mol Ther Oncolytics. 2018 Dec 20;12:124-137. doi: 10.1016/j.omto.2018.12.009. eCollection 2019 Mar 29.


Proton pump inhibitors therapy and the risk of pneumonia: a systematic review and meta-analysis of randomized controlled trials and observational studies.

Wang CH, Li CH, Hsieh R, Fan CY, Hsu TC, Chang WC, Hsu WT, Lin YY, Lee CC.

Expert Opin Drug Saf. 2019 Jan 31. doi: 10.1080/14740338.2019.1577820. [Epub ahead of print]


Effect of interactive cognitive-motor training on eye-hand coordination and cognitive function in older adults.

Chan PT, Chang WC, Chiu HL, Kao CC, Liu D, Chu H, Chou KR.

BMC Geriatr. 2019 Jan 28;19(1):27. doi: 10.1186/s12877-019-1029-y.


Tribbles Homolog 3 Involved in Radiation Response of Triple Negative Breast Cancer Cells by Regulating Notch1 Activation.

Lee YC, Wang WL, Chang WC, Huang YH, Hong GC, Wang HL, Chou YH, Tseng HC, Lee HT, Li ST, Chen HL, Wu CC, Yang HF, Wang BY, Chang WW.

Cancers (Basel). 2019 Jan 22;11(2). pii: E127. doi: 10.3390/cancers11020127.


Duration of early intervention for psychosis: 2 years versus 3 years.

Chen EY, Chang WC, Hui CL, Chan SK, Lee EH, Wong GH.

Hong Kong Med J. 2019 Feb;25 Suppl 2:10-14. No abstract available.


Incense burning smoke sensitizes lung cancer cells to EGFR TKI by inducing AREG expression.

Tu CY, Wang BW, Cheng FJ, Chen CH, Hsia TC, Wei YL, Chen CY, Hsieh IS, Yeh YL, Wang LY, Chen CM, Chang WC, Huang WC.

Am J Cancer Res. 2018 Dec 1;8(12):2575-2589. eCollection 2018.


Characteristics of noise-like pulse with broad bandwidth based on cascaded Raman scattering.

Chang WC, Lin JH, Liao TY, Yang CY.

Opt Express. 2018 Nov 26;26(24):31808-31816. doi: 10.1364/OE.26.031808.


An Individualized, Interactive Intervention Promotes Terminally Ill Cancer Patients' Prognostic Awareness and Reduces Cardiopulmonary Resuscitation Received in the Last Month of Life: Secondary Analysis of a Randomized Clinical Trial.

Chen CH, Chen JS, Wen FH, Chang WC, Chou WC, Hsieh CH, Hou MM, Tang ST.

J Pain Symptom Manage. 2019 Jan 10. pii: S0885-3924(19)30003-X. doi: 10.1016/j.jpainsymman.2019.01.002. [Epub ahead of print]


Improved hemostasis with plasma kinetic bipolar sealing device in the vaginal steps of laparoscopic-assisted vaginal hysterectomy.

Tu YA, Chang WC, Wu CJ, Sheu BC.

Taiwan J Obstet Gynecol. 2019 Jan;58(1):64-67. doi: 10.1016/j.tjog.2018.11.012.


Comparison of the hospitalization period after microvascular reconstruction flap in trismus patients: free anterolateral thigh flap versus free forearm flap.

Chang WC, Chang CF, Cheng CM, Yang CY, Chen YW.

Clin Oral Investig. 2019 Jan 7. doi: 10.1007/s00784-018-02799-4. [Epub ahead of print]


Rhein, An Anthraquinone Drug, Suppresses the NLRP3 Inflammasome and Macrophage Activation in Urate Crystal-Induced Gouty Inflammation.

Chang WC, Chu MT, Hsu CY, Wu YJ, Lee JY, Chen TJ, Chung WH, Chen DY, Hung SI.

Am J Chin Med. 2019;47(1):135-151. doi: 10.1142/S0192415X19500071. Epub 2019 Jan 7.


Impact of concomitant dyspepsia and irritable bowel syndrome on symptom burden in patients with gastroesophageal reflux disease.

Lei WY, Chang WC, Wen SH, Wong MW, Hung JS, Yi CH, Liu TT, Hsu CS, Orr WC, Vaezi MF, Pace F, Hsieh TC, Chen CL.

J Formos Med Assoc. 2018 Dec 21. pii: S0929-6646(18)30401-7. doi: 10.1016/j.jfma.2018.12.002. [Epub ahead of print]


Reaction Mechanism of a Nonheme Iron Enzyme Catalyzed Oxidative Cyclization via C-C Bond Formation.

Chang WC, Yang ZJ, Tu YH, Chien TC.

Org Lett. 2018 Dec 14. doi: 10.1021/acs.orglett.8b03670. [Epub ahead of print]


The dose-response effects of uric acid on the prevalence of metabolic syndrome and electrocardiographic left ventricular hypertrophy in healthy individuals.

Liu CW, Chen KH, Tseng CK, Chang WC, Wu YW, Hwang JJ.

Nutr Metab Cardiovasc Dis. 2019 Jan;29(1):30-38. doi: 10.1016/j.numecd.2018.10.001. Epub 2018 Oct 16.


Factors Associated With Successful Medication Discontinuation After a Randomized Clinical Trial of Relapse Prevention in First-Episode Psychosis: A 10-Year Follow-up.

Hui CLM, Honer WG, Lee EHM, Chang WC, Chan SKW, Chen EYH.

JAMA Psychiatry. 2019 Feb 1;76(2):217-219. doi: 10.1001/jamapsychiatry.2018.3120. No abstract available.


Gender differences in correlates of cognition in first-episode psychosis.

Li AWY, Hui CLM, Lee EHM, Chang WC, Chan SKW, Chen EYH.

Psychiatry Res. 2019 Jan;271:412-420. doi: 10.1016/j.psychres.2018.12.011. Epub 2018 Dec 3.


Anti-oral cancer effects of triptolide by downregulation of DcR3 in vitro, in vivo, and in preclinical patient-derived tumor xenograft model.

Yang CY, Lin CK, Hsieh CC, Tsao CH, Lin CS, Peng B, Chen YT, Ting CC, Chang WC, Lin GJ, Sytwu HK, Chen YW.

Head Neck. 2018 Dec 10. doi: 10.1002/hed.25554. [Epub ahead of print]


Differential cortical thinning of auditory cortex in first episode schizophrenia: Association with auditory verbal hallucinations.

Lee EHM, Camchong J, Skouras S, Hui CLM, Chan PY, Law EYL, Chong CSY, Chang WC, Chan SKW, Lo WTL, Chen EYH, Lim KO.

Schizophr Res. 2018 Dec 1. pii: S0920-9964(18)30665-0. doi: 10.1016/j.schres.2018.11.014. [Epub ahead of print] No abstract available.


Ameliorative effect of Ruellia tuberosa L. on hyperglycemia in type 2 diabetes mellitus and glucose uptake in mouse C2C12 myoblasts.

Ko CY, Lin RH, Zeng YM, Chang WC, Huang DW, Wu JS, Chang YF, Shen SC.

Food Sci Nutr. 2018 Oct 10;6(8):2414-2422. doi: 10.1002/fsn3.840. eCollection 2018 Nov.


Effective Targeting of TAG72+ Peritoneal Ovarian Tumors via Regional Delivery of CAR-Engineered T Cells.

Murad JP, Kozlowska AK, Lee HJ, Ramamurthy M, Chang WC, Yazaki P, Colcher D, Shively J, Cristea M, Forman SJ, Priceman SJ.

Front Immunol. 2018 Nov 19;9:2268. doi: 10.3389/fimmu.2018.02268. eCollection 2018.


Identification of Common Thalamocortical Dysconnectivity in Four Major Psychiatric Disorders.

Tu PC, Bai YM, Li CT, Chen MH, Lin WC, Chang WC, Su TP.

Schizophr Bull. 2018 Dec 1. doi: 10.1093/schbul/sby166. [Epub ahead of print]


Psychiatrists' opinion towards medication discontinuation in remitted first-episode psychosis: A multi-site study of the Asian Network for Early Psychosis.

Hui CL, Wong AK, Leung WW, Lee EH, Chan SK, Chang WC, Chen EY, Chan TC, Swapna V, Tagata H, Tsujino N, Nemoto T, Mizuno M, Kang NI, Kim SW, Chung YC.

Early Interv Psychiatry. 2018 Nov 28. doi: 10.1111/eip.12765. [Epub ahead of print]


Objective and subjective cognitive functioning in relation to psychopathology among women with early psychosis.

Tong ACY, Chang WC, Chan ANY, Lin JJ.

Early Interv Psychiatry. 2018 Nov 28. doi: 10.1111/eip.12760. [Epub ahead of print]


Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations.

Chang WC, Kudlacek J, Hlinka J, Chvojka J, Hadrava M, Kumpost V, Powell AD, Janca R, Maturana MI, Karoly PJ, Freestone DR, Cook MJ, Palus M, Otahal J, Jefferys JGR, Jiruska P.

Nat Neurosci. 2018 Dec;21(12):1742-1752. doi: 10.1038/s41593-018-0278-y. Epub 2018 Nov 26.


Cancer and mTOR inhibitors in kidney transplantation recipients.

Kao CC, Liu JS, Chang YK, Lin MH, Lin YC, Chen HH, Chang WC, Hsu CC, Wu MS.

PeerJ. 2018 Nov 8;6:e5864. doi: 10.7717/peerj.5864. eCollection 2018.


The role of symptoms and insight in mediating cognition and functioning in first episode psychosis.

Lee EHM, Hui CLM, Chan KPK, Chan PY, Law EYL, Chong CSY, Chang WC, Chan SKW, Lee WK, Lo AWF, Pang EPF, Cheung EFC, Yiu MGC, Chung DWS, Ng RMK, Yeung WS, Lo WTL, Chen EYH.

Schizophr Res. 2018 Nov 15. pii: S0920-9964(18)30660-1. doi: 10.1016/j.schres.2018.11.009. [Epub ahead of print]


Factors Predisposing Terminally Ill Cancer Patients' Preferences for Distinct Patterns/States of Life-Sustaining Treatments Over Their Last Six Months.

Wen FH, Chen JS, Chou WC, Chang WC, Hsieh CH, Tang ST.

J Pain Symptom Manage. 2019 Feb;57(2):190-198.e2. doi: 10.1016/j.jpainsymman.2018.11.008. Epub 2018 Nov 15.


dbPTM in 2019: exploring disease association and cross-talk of post-translational modifications.

Huang KY, Lee TY, Kao HJ, Ma CT, Lee CC, Lin TH, Chang WC, Huang HD.

Nucleic Acids Res. 2019 Jan 8;47(D1):D298-D308. doi: 10.1093/nar/gky1074.


Heterogeneous Fenton Reaction Enabled Selective Colon Cancerous Cell Treatment.

Lee KT, Lu YJ, Chiu SC, Chang WC, Chuang EY, Lu SY.

Sci Rep. 2018 Nov 8;8(1):16580. doi: 10.1038/s41598-018-34499-0.


Znf179 E3 ligase-mediated TDP-43 polyubiquitination is involved in TDP-43- ubiquitinated inclusions (UBI) (+)-related neurodegenerative pathology.

Lee YC, Huang WC, Lin JH, Kao TJ, Lin HC, Lee KH, Lin HC, Shen CJ, Chang WC, Huang CC.

J Biomed Sci. 2018 Nov 8;25(1):76. doi: 10.1186/s12929-018-0479-4.


PlantPAN3.0: a new and updated resource for reconstructing transcriptional regulatory networks from ChIP-seq experiments in plants.

Chow CN, Lee TY, Hung YC, Li GZ, Tseng KC, Liu YH, Kuo PL, Zheng HQ, Chang WC.

Nucleic Acids Res. 2019 Jan 8;47(D1):D1155-D1163. doi: 10.1093/nar/gky1081.


Transforming growth factor alpha promotes tumorigenesis and regulates epithelial-mesenchymal transition modulation in colon cancer.

Yu CY, Chang WC, Zheng JH, Hung WH, Cho EC.

Biochem Biophys Res Commun. 2018 Dec 2;506(4):901-906. doi: 10.1016/j.bbrc.2018.10.137. Epub 2018 Nov 2.


Genetic loci determining total immunoglobulin E levels from birth through adulthood.

Yao TC, Chung RH, Lin CY, Tsai PC, Chang WC, Yeh KW, Tsai MH, Liao SL, Hua MC, Lai SH, Chen LC, Chang SW, Yu YW, Hsu JY, Chang SC, Cheng WC, Hu D, Hong X, Burchard EG, Wang X, Tzeng JY, Tsai HJ, Huang JL.

Allergy. 2018 Oct 31. doi: 10.1111/all.13654. [Epub ahead of print] No abstract available.


Elucidating the Reaction Pathway of Decarboxylation-Assisted Olefination Catalyzed by a Mononuclear Non-Heme Iron Enzyme.

Yu CP, Tang Y, Cha L, Milikisiyants S, Smirnova TI, Smirnov AI, Guo Y, Chang WC.

J Am Chem Soc. 2018 Nov 14;140(45):15190-15193. doi: 10.1021/jacs.8b10077. Epub 2018 Nov 5.


Predicting first-episode psychosis patients who will never relapse over 10 years.

Hui CL, Honer WG, Lee EH, Chang WC, Chan SK, Chen ES, Pang EP, Lui SS, Chung DW, Yeung WS, Ng RM, Lo WT, Jones PB, Sham P, Chen EY.

Psychol Med. 2018 Oct 30:1-9. doi: 10.1017/S0033291718003070. [Epub ahead of print]


Correlation of proinflammatory cytokines levels and reduced gray matter volumes between patients with bipolar disorder and unipolar depression.

Chen MH, Chang WC, Hsu JW, Huang KL, Tu PC, Su TP, Li CT, Lin WC, Bai YM.

J Affect Disord. 2019 Feb 15;245:8-15. doi: 10.1016/j.jad.2018.10.106. Epub 2018 Oct 17.


Elements Involved in the Rsv3-Mediated Extreme Resistance against an Avirulent Strain of Soybean Mosaic Virus.

Alazem M, Tseng KC, Chang WC, Seo JK, Kim KH.

Viruses. 2018 Oct 24;10(11). pii: E581. doi: 10.3390/v10110581.


Integrative genomic analysis for the functional roles of ITPKC in bone mineral density.

Lu HF, Wong HS, Chen BK, Liao HT, Hsu YW, Ikegawa S, Cho EC, Hung KS, Chang WC.

Biosci Rep. 2018 Nov 30;38(6). pii: BSR20181481. doi: 10.1042/BSR20181481. Print 2018 Dec 21.


Assessment of treatment outcomes of interstitial cystitis with hydrodistention and bladder training by O'Leary-Sant Interstitial Cystitis Symptom and Problem Indices.

Huang MC, Hsieh CH, Chang WC, Chang ST, Lee MS.

Taiwan J Obstet Gynecol. 2018 Oct;57(5):718-721. doi: 10.1016/j.tjog.2018.08.019.


The effect of media reporting of a homicide committed by a patient with schizophrenia on the public stigma and knowledge of psychosis among the general population of Hong Kong.

Chan SKW, Li OWT, Hui CLM, Chang WC, Lee EHM, Chen EYH.

Soc Psychiatry Psychiatr Epidemiol. 2019 Jan;54(1):43-50. doi: 10.1007/s00127-018-1610-2. Epub 2018 Oct 12.


HLA Alleles and CYP2C9*3 as Predictors of Phenytoin Hypersensitivity in East Asians.

Su SC, Chen CB, Chang WC, Wang CW, Fan WL, Lu LY, Nakamura R, Saito Y, Ueta M, Kinoshita S, Sukasem C, Yampayon K, Kijsanayotin P, Nakkam N, Saksit N, Tassaneeyakul W, Aihara M, Lin YJ, Chang CJ, Wu T, Hung SI, Chung WH.

Clin Pharmacol Ther. 2019 Feb;105(2):476-485. doi: 10.1002/cpt.1190. Epub 2018 Sep 30.


Family Caregivers' Subjective Caregiving Burden, Quality of Life, and Depressive Symptoms Are Associated With Terminally Ill Cancer Patients' Distinct Patterns of Conjoint Symptom Distress and Functional Impairment in Their Last Six Months of Life.

Wen FH, Chen JS, Chou WC, Chang WC, Shen WC, Hsieh CH, Tang ST.

J Pain Symptom Manage. 2019 Jan;57(1):64-72. doi: 10.1016/j.jpainsymman.2018.09.009. Epub 2018 Sep 27.


Three-dimensional culture of chicken primordial germ cells (cPGCs) in defined media containing the functional polymer FP003.

Chen YC, Chang WC, Lin SP, Minami M, Jean C, Hayashi H, Rival-Gervier S, Kanaki T, Wu SC, Pain B.

PLoS One. 2018 Sep 21;13(9):e0200515. doi: 10.1371/journal.pone.0200515. eCollection 2018.


Evolution and Predictors of Patient-Caregiver Concordance on States of Life-Sustaining Treatment Preferences over Terminally Ill Cancer Patients' Last Six Months of Life.

Wen FH, Chou WC, Chen JS, Chang WC, Hsieh CH, Tang ST.

J Palliat Med. 2019 Jan;22(1):25-33. doi: 10.1089/jpm.2018.0307. Epub 2018 Sep 20.


Comparison of cognitive functions between first-episode schizophrenia patients, their unaffected siblings and individuals at clinical high-risk for psychosis.

Chu AOK, Chang WC, Chan SKW, Lee EHM, Hui CLM, Chen EYH.

Psychol Med. 2018 Sep 18:1-8. doi: 10.1017/S0033291718002726. [Epub ahead of print]


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