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High blood sugar levels but not diabetes mellitus significantly enhance oxaliplatin chemoresistance in patients with stage III colorectal cancer receiving adjuvant FOLFOX6 chemotherapy.

Yang IP, Miao ZF, Huang CW, Tsai HL, Yeh YS, Su WC, Chang TK, Chang SF, Wang JY.

Ther Adv Med Oncol. 2019 Aug 20;11:1758835919866964. doi: 10.1177/1758835919866964. eCollection 2019.


Garcimultiflorone K inhibits angiogenesis through Akt/eNOS- and mTOR-dependent pathways in human endothelial progenitor cells.

Yang CY, Chen C, Lin CY, Chen YH, Lin CY, Chi CW, Chen YJ, Liu SC, Chang TK, Tang CH, Lai YW, Tsai HJ, Chen JJ, Wang SW.

Phytomedicine. 2019 Apr 2;64:152911. doi: 10.1016/j.phymed.2019.152911. [Epub ahead of print]


Impact of a Dual-Ring Wound Protector on Outcome After Elective Surgery for Colorectal Cancer.

Chen CF, Tsai HL, Huang CW, Yeh YS, Ma CJ, Chang TK, Su WC, Wang JY.

J Surg Res. 2019 Jul 5;244:136-145. doi: 10.1016/j.jss.2019.06.014. [Epub ahead of print]


Antimicrobial Gold Nanoclusters: Recent Developments and Future Perspectives.

Yougbare S, Chang TK, Tan SH, Kuo JC, Hsu PH, Su CY, Kuo TR.

Int J Mol Sci. 2019 Jun 14;20(12). pii: E2924. doi: 10.3390/ijms20122924. Review.


Rapid assessment of heavy metal pollution using ion-exchange resin sachets and micro-XRF core-scanning.

Huang JS, Lin SC, Löwemark L, Liou SYH, Chang Q, Chang TK, Wei KY, Croudace IW.

Sci Rep. 2019 Apr 29;9(1):6601. doi: 10.1038/s41598-019-43015-x.


Pregnane X Receptor Activation Triggers Rapid ATP Release in Primed Macrophages That Mediates NLRP3 Inflammasome Activation.

Hudson G, Flannigan KL, Venu VKP, Alston L, Sandall CF, MacDonald JA, Muruve DA, Chang TKH, Mani S, Hirota SA.

J Pharmacol Exp Ther. 2019 Jul;370(1):44-53. doi: 10.1124/jpet.118.255679. Epub 2019 Apr 19.


Stabilization of E2-EPF UCP protein is implicated in hepatitis B virus-associated hepatocellular carcinoma progression.

Lim JH, Kim DG, Yu DY, Kang HM, Noh KH, Kim DS, Park D, Chang TK, Im DS, Jung CR.

Cell Mol Life Sci. 2019 Jul;76(13):2647-2662. doi: 10.1007/s00018-019-03066-9. Epub 2019 Mar 22.


Ubiquitination of MAP1LC3B by pVHL is associated with autophagy and cell death in renal cell carcinoma.

Kang HM, Noh KH, Chang TK, Park D, Cho HS, Lim JH, Jung CR.

Cell Death Dis. 2019 Mar 22;10(4):279. doi: 10.1038/s41419-019-1520-6.


Ectopic pancreas mimicking gastric submucosal tumour treated using robotic surgery.

Chang TK, Huang CW, Ma CJ, Su WC, Tsai HL, Wang JY.

J Minim Access Surg. 2019 Feb 18. doi: 10.4103/jmas.JMAS_1_19. [Epub ahead of print]


Outcome and prognosis of anaplastic large cell lymphoma in children: a report from the Taiwan Pediatric Oncology Group.

Chen SH, Chen JS, Jou ST, Wu KH, Hung IJ, Sheen JM, Lu MY, Chen BW, Jaing TH, Wang SC, Lin MT, Chang TK, Liu HC, Yang CP.

Leuk Lymphoma. 2019 Aug;60(8):1942-1949. doi: 10.1080/10428194.2018.1562182. Epub 2019 Jan 15.


Oncologic Outcomes in Metastatic Colorectal Cancer with Regorafenib with FOLFIRI as a Third- or Fourth-Line Setting.

Ma CJ, Huang CW, Chang TK, Tsai HL, Su WC, Yeh YS, Chen PJ, Wang JY.

Transl Oncol. 2019 Mar;12(3):502-512. doi: 10.1016/j.tranon.2018.12.003. Epub 2018 Dec 27.


Long-term safety and efficacy of deferasirox in patients with myelodysplastic syndrome, aplastic anemia and other rare anemia in Taiwan.

Ko BS, Chang MC, Chiou TJ, Chang TK, Chen YC, Lin SF, Chang CS, Lu YC, Yeh SP, Chen TY, Hwang WS.

Hematology. 2019 Dec;24(1):247-254. doi: 10.1080/16078454.2018.1557860.


The Proton-Coupled Monocarboxylate Transporter Hermes Is Necessary for Autophagy during Cell Death.

Velentzas PD, Zhang L, Das G, Chang TK, Nelson C, Kobertz WR, Baehrecke EH.

Dev Cell. 2018 Nov 5;47(3):281-293.e4. doi: 10.1016/j.devcel.2018.09.015. Epub 2018 Oct 11.


Treatment of childhood acute lymphoblastic leukemia with delayed first intrathecal therapy and omission of prophylactic cranial irradiation: Results of the TPOG-ALL-2002 study.

Yeh TC, Liang DC, Hou JY, Jaing TH, Lin DT, Yang CP, Peng CT, Hung IJ, Lin KH, Hsiao CC, Jou ST, Chiou SS, Chen JS, Wang SC, Chang TK, Wu KH, Sheen JM, Yen HJ, Chen SH, Lu MY, Li MJ, Chang TT, Huang TH, Chang YH, Chen SH, Yang YL, Chang HH, Chen BW, Lin PC, Cheng CN, Chao YH, Yang SH, Chao YY, Liu HC.

Cancer. 2018 Dec 1;124(23):4538-4547. doi: 10.1002/cncr.31758. Epub 2018 Oct 10.


The clincopathological variables to differentiate the nature of isolated pulmonary nodules in patients who received curative surgery for colorectal cancer.

Chang TK, Tsai HL, Su WC, Huang CW, Yeh YS, Ma CJ, Wang JY.

Asian J Surg. 2019 Feb;42(2):425-432. doi: 10.1016/j.asjsur.2018.08.002. Epub 2018 Sep 25.


Elastoplastic behavior of highly cross-linked and vitamin E-stabilized polyethylene - A biomechanical study.

Lu YC, Wu CY, Chang TK, Huang CH, Huang CH.

Clin Biomech (Bristol, Avon). 2018 Nov;59:152-158. doi: 10.1016/j.clinbiomech.2018.09.021. Epub 2018 Sep 20.


Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate.

Chang TK, Lawrence DA, Lu M, Tan J, Harnoss JM, Marsters SA, Liu P, Sandoval W, Martin SE, Ashkenazi A.

Mol Cell. 2018 Aug 16;71(4):629-636.e5. doi: 10.1016/j.molcel.2018.06.038.


Missense mutation of SPAST protein (I344K) results in loss of ATPase activity and prolonged the half-life, implicated in autosomal dominant hereditary spastic paraplegia.

Lim JH, Kang HM, Jung HR, Kim DS, Noh KH, Chang TK, Kim BJ, Sung DH, Cho HS, Chung KS, Kim NS, Jung CR.

Biochim Biophys Acta Mol Basis Dis. 2018 Oct;1864(10):3221-3233. doi: 10.1016/j.bbadis.2018.07.009. Epub 2018 Jul 11.


Gomphocarpus mosaic virus, a distinctive member of the genus Potyvirus.

Chang TK, Chen YK.

Arch Virol. 2018 Oct;163(10):2925-2928. doi: 10.1007/s00705-018-3940-5. Epub 2018 Jul 12.


Vps13D Encodes a Ubiquitin-Binding Protein that Is Required for the Regulation of Mitochondrial Size and Clearance.

Anding AL, Wang C, Chang TK, Sliter DA, Powers CM, Hofmann K, Youle RJ, Baehrecke EH.

Curr Biol. 2018 Jan 22;28(2):287-295.e6. doi: 10.1016/j.cub.2017.11.064. Epub 2018 Jan 4.


Medical treatment of a female patient with complicated Klippel-Trenaunay syndrome.

Huang FL, Chen HY, Chang TK.

Pediatr Neonatol. 2018 Oct;59(5):527-530. doi: 10.1016/j.pedneo.2017.11.013. Epub 2017 Nov 21. No abstract available.


Comparative analysis of ginsenosides in human glucocorticoid receptor binding, transactivation, and transrepression.

Hu C, Lau AJ, Wang R, Chang TKH.

Eur J Pharmacol. 2017 Nov 15;815:501-511. doi: 10.1016/j.ejphar.2017.10.019. Epub 2017 Oct 12.


Greywater treatment by granular filtration system using volcanic tuff and gravel media.

Albalawneh A, Chang TK, Alshawabkeh H.

Water Sci Technol. 2017 May;75(10):2331-2341. doi: 10.2166/wst.2017.102.


Pediatric acute lymphoblastic leukemia with t(1;19)/TCF3-PBX1 in Taiwan.

Yen HJ, Chen SH, Chang TY, Yang CP, Lin DT, Hung IJ, Lin KH, Chen JS, Hsiao CC, Chang TT, Chang TK, Peng CT, Lin MT, Jaing TH, Liu HC, Jou ST, Lu MY, Cheng CN, Sheen JM, Chiou SS, Hung GY, Wu KH, Yeh TC, Wang SC, Chen RL, Chang HH, Yang YL, Chen SH, Cheng SN, Chang YH, Chen BW, Hsieh YL, Huang FL, Ho WL, Wang JL, Chang CY, Chao YH, Lin PC, Chen YC, Liao YM, Lin TH, Shih LY, Liang DC.

Pediatr Blood Cancer. 2017 Oct;64(10). doi: 10.1002/pbc.26557. Epub 2017 Apr 24.


Negative Regulation of Human Pregnane X Receptor by MicroRNA-18a-5p: Evidence for Suppression of MicroRNA-18a-5p Expression by Rifampin and Rilpivirine.

Sharma D, Turkistani AA, Chang W, Hu C, Xu Z, Chang TKH.

Mol Pharmacol. 2017 Jul;92(1):48-56. doi: 10.1124/mol.116.107003. Epub 2017 Apr 13.


Performance Characterization of Dye-Sensitized Photovoltaics under Indoor Lighting.

Chen CY, Jian ZH, Huang SH, Lee KM, Kao MH, Shen CH, Shieh JM, Wang CL, Chang CW, Lin BZ, Lin CY, Chang TK, Chi Y, Chi CY, Wang WT, Tai Y, Lu MD, Tung YL, Chou PT, Wu WT, Chow TJ, Chen P, Luo XH, Lee YL, Wu CC, Chen CM, Yeh CY, Fan MS, Peng JD, Ho KC, Liu YN, Lee HY, Chen CY, Lin HW, Yen CT, Huang YC, Tsao CS, Ting YC, Wei TC, Wu CG.

J Phys Chem Lett. 2017 Apr 20;8(8):1824-1830. doi: 10.1021/acs.jpclett.7b00515. Epub 2017 Apr 10.


Constitutive androstane receptor regulates the intestinal mucosal response to injury.

Hudson GM, Flannigan KL, Erickson SL, Vicentini FA, Zamponi A, Hirota CL, Alston L, Altier C, Ghosh S, Rioux KP, Mani S, Chang TK, Hirota SA.

Br J Pharmacol. 2017 Jun;174(12):1857-1871. doi: 10.1111/bph.13787. Epub 2017 Apr 19.


Treatment for childhood acute lymphoblastic leukemia in Taiwan: Taiwan Pediatric Oncology Group ALL-2002 study emphasizing optimal reinduction therapy and central nervous system preventive therapy without cranial radiation.

Li MJ, Liu HC, Yen HJ, Jaing TH, Lin DT, Yang CP, Lin KH, Hung IJ, Jou ST, Lu MY, Hsiao CC, Peng CT, Chang TT, Wang SC, Lin MT, Chen JS, Chang TK, Hung GY, Wu KH, Yang YL, Chang HH, Chen SH, Yeh TC, Cheng CN, Lin PC, Chiou SS, Sheen JM, Cheng SN, Chen SH, Chang YH, Ho WL, Chao YH, Chen RL, Chen BW, Wang JL, Hsieh YL, Liao YM, Yang SH, Chang WH, Chao YY, Liang DC.

Pediatr Blood Cancer. 2017 Feb;64(2):234-241. doi: 10.1002/pbc.26142. Epub 2016 Oct 3.


Pregnane X Receptor Activation Attenuates Inflammation-Associated Intestinal Epithelial Barrier Dysfunction by Inhibiting Cytokine-Induced Myosin Light-Chain Kinase Expression and c-Jun N-Terminal Kinase 1/2 Activation.

Garg A, Zhao A, Erickson SL, Mukherjee S, Lau AJ, Alston L, Chang TK, Mani S, Hirota SA.

J Pharmacol Exp Ther. 2016 Oct;359(1):91-101. doi: 10.1124/jpet.116.234096. Epub 2016 Jul 20.


8.13  μm in length and CMOS compatible polarization beam splitter based on an asymmetrical directional coupler.

Hsu CW, Chang TK, Chen JY, Cheng YC.

Appl Opt. 2016 Apr 20;55(12):3313-8. doi: 10.1364/AO.55.003313.


Cell-based and in silico evidence against quercetin and structurally-related flavonols as activators of vitamin D receptor.

Lau AJ, Politi R, Yang G, Chang TK.

J Steroid Biochem Mol Biol. 2016 Oct;163:59-67. doi: 10.1016/j.jsbmb.2016.03.039. Epub 2016 Apr 1.


The effects of self-management intervention among middle-age adults with knee osteoarthritis.

Kao MH, Tsai YF, Chang TK, Wang JS, Chen CP, Chang YC.

J Adv Nurs. 2016 Aug;72(8):1825-37. doi: 10.1111/jan.12956. Epub 2016 Mar 31.


NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models.

Charych DH, Hoch U, Langowski JL, Lee SR, Addepalli MK, Kirk PB, Sheng D, Liu X, Sims PW, VanderVeen LA, Ali CF, Chang TK, Konakova M, Pena RL, Kanhere RS, Kirksey YM, Ji C, Wang Y, Huang J, Sweeney TD, Kantak SS, Doberstein SK.

Clin Cancer Res. 2016 Feb 1;22(3):680-90. doi: 10.1158/1078-0432.CCR-15-1631.


Outcomes Following Discontinuation of E. coli l-Asparaginase Upon Severe Allergic Reactions in Children With Acute Lymphoblastic Leukemia.

Yen HJ, Chang WH, Liu HC, Yeh TC, Hung GY, Wu KH, Peng CT, Chang YH, Chang TK, Hsiao CC, Sheen JM, Chao YH, Chang TT, Chiou SS, Lin PC, Wang SC, Lin MT, Ho WL, Chen YC, Liang DC.

Pediatr Blood Cancer. 2016 Apr;63(4):665-70. doi: 10.1002/pbc.25869. Epub 2015 Dec 24. Erratum in: Pediatr Blood Cancer. 2016 Jun;63(6):1131.


3-Hydroxyflavone and structural analogues differentially activate pregnane X receptor: Implication for inflammatory bowel disease.

Lau AJ, Chang TK.

Pharmacol Res. 2015 Oct;100:64-72. doi: 10.1016/j.phrs.2015.07.031. Epub 2015 Jul 31.


Blue-emitting heteroleptic Ir(III) phosphors with functional 2,3'-bipyridine or 2-(pyrimidin-5-yl)pyridine cyclometalates.

Duan T, Chang TK, Chi Y, Wang JY, Chen ZN, Hung WY, Chen CH, Lee GH.

Dalton Trans. 2015 Sep 7;44(33):14613-24. doi: 10.1039/c5dt01844g.


The effect of graft strength on knee laxity and graft in-situ forces after posterior cruciate ligament reconstruction.

Lai YS, Chen WC, Huang CH, Cheng CK, Chan KK, Chang TK.

PLoS One. 2015 May 22;10(5):e0127293. doi: 10.1371/journal.pone.0127293. eCollection 2015.


In vivo biological response to highly cross-linked and vitamin e-doped polyethylene--a particle-Induced osteolysis animal study.

Huang CH, Lu YC, Chang TK, Hsiao IL, Su YC, Yeh ST, Fang HW, Huang CH.

J Biomed Mater Res B Appl Biomater. 2016 Apr;104(3):561-7. doi: 10.1002/jbm.b.33426. Epub 2015 May 7.


Lead isotope characterization of petroleum fuels in Taipei, Taiwan.

Yao PH, Shyu GS, Chang YF, Chou YC, Shen CC, Chou CS, Chang TK.

Int J Environ Res Public Health. 2015 Apr 24;12(5):4602-16. doi: 10.3390/ijerph120504602.


The potential role of strontium ranelate in treating particle-induced osteolysis.

Lu YC, Chang TK, Yeh ST, Fang HW, Lin CY, Hsu LI, Huang CH, Huang CH.

Acta Biomater. 2015 Jul;20:147-154. doi: 10.1016/j.actbio.2015.03.034. Epub 2015 Apr 1.


Stress distribution of the patellofemoral joint in the anatomic V-shape and curved dome-shape femoral component: a comparison of resurfaced and unresurfaced patellae.

Huang CH, Hsu LI, Chang TK, Chuang TY, Shih SL, Lu YC, Chen CS, Huang CH.

Knee Surg Sports Traumatol Arthrosc. 2017 Jan;25(1):263-271. doi: 10.1007/s00167-014-3485-4. Epub 2014 Dec 25.


A secure operational model for mobile payments.

Chang TK.

ScientificWorldJournal. 2014;2014:626243. doi: 10.1155/2014/626243. Epub 2014 Oct 20.


Differential activation of human constitutive androstane receptor and its SV23 and SV24 splice variants by rilpivirine and etravirine.

Sharma D, Lau AJ, Sherman MA, Chang TK.

Br J Pharmacol. 2015 Mar;172(5):1263-76. doi: 10.1111/bph.12997. Epub 2015 Feb 10.


C for colored urine: acute hemolysis induced by high-dose ascorbic acid.

Huang YC, Chang TK, Fu YC, Jan SL.

Clin Toxicol (Phila). 2014 Nov;52(9):984. doi: 10.3109/15563650.2014.954124. No abstract available.


Evaluation of in situ generated valproyl 1-O-β-acyl glucuronide in valproic acid toxicity in sandwich-cultured rat hepatocytes.

Surendradoss J, Chang TK, Abbott FS.

Drug Metab Dispos. 2014 Nov;42(11):1834-42. doi: 10.1124/dmd.114.059352. Epub 2014 Aug 21.


The correlation between lateral bowing angle of the femur and the location of atypical femur fractures.

Chen LP, Chang TK, Huang TY, Kwok TG, Lu YC.

Calcif Tissue Int. 2014 Sep;95(3):240-7. doi: 10.1007/s00223-014-9887-y. Epub 2014 Jul 1.


Enrollment in Hispanic Serving Institutions as a Moderator of the Relationship Between Drinking Norms and Quantity of Alcohol Use Among Hispanic College Students.

Vaughan EL, Chang TK, Escobar OS, de Dios MA.

Subst Abus. 2015;36(3):314-7. doi: 10.1080/08897077.2014.932887. Epub 2014 Jun 24.


Geospatial disparities and the underlying causes of major cancers for women in Taiwan.

Chiang CT, Lian IeB, Chang YF, Chang TK.

Int J Environ Res Public Health. 2014 May 26;11(6):5613-27. doi: 10.3390/ijerph110605613.

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